Hepcidin in iron metabolism

Current Protein and Peptide Science

Volumn 6, Issue 3, 2005, Pages 279-291

  Loréal, Olivier ^a   Haziza Pigeon, Christelle ^a   Troadec, Marie Bérengère ^a   Detivaud, Lénaïck ^a   Turlin, Bruno ^a   Courselaud, Brice ^a   Ilyin, Guennadi ^a   Brissot, Pierre ^a  

^a PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

Author keywords

Anemia of chronic diseases; Antimicrobial peptide; Genetic haemochromatosis; Hepatocyte; Hepcidin; Inflammation; Iron metabolism; Liver

Indexed keywords

ERYTHROPOIETIN; HEPCIDIN; HFE PROTEIN; IRON;

AMINO ACID SEQUENCE; ANEMIA; ANTIMICROBIAL ACTIVITY; BIOAVAILABILITY; CHEMICAL ANALYSIS; DISEASE ASSOCIATION; HEMOCHROMATOSIS; HUMAN; HYPOXIA; INFLAMMATORY DISEASE; INTESTINE CELL; IRON ABSORPTION; IRON KINETICS; IRON METABOLISM; IRON OVERLOAD; IRON THERAPY; LIVER CELL; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER FUNCTION; MACROPHAGE; MOLECULAR GENETICS; NONHUMAN; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REGULATORY MECHANISM; REVIEW; TREATMENT OUTCOME;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; GENE EXPRESSION; HEPATOCYTES; HUMANS; INFECTION; INFLAMMATION; IRON; LIVER DISEASES; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA;

EID: 20444476599     PISSN: 13892037     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389203054065392     Document Type: Review

References (87)

1. Andrews, N.C. (1999) N. Engl. J. Med., 341, 1986-1995.
2. Brissot, P. and Deugnier, Y. (1999) In Oxford Textbook of Clinical Hepatology, Vol. 2 (Bircher J., Benhamou J. P., Mcintyre N., Rizetto M. and Rodes J., Ed.) pp. 1379-1391. Oxford University Press.
3. Weiss, G. (2002) Blood Rev., 16, 87-96.
4. Brissot, P. and Deugnier, Y. (1999) In Oxford Textbook of Clinical Hepatology, Vol. 1 (Bircher J., Benhamou J. P., Mcintyre N., Rizetto M. and Rodes J., Ed.) pp. 409-413. Oxford University Press.
5. Aisen, P., Leibman, A. and Pinkowitz, R.A. (1974) Adv. Exp. Med. Biol., 48, 125-140.
6. Seligman, P. A., Schleicher, R.B. and Allen, R.H. (1979) J. Biol. Chem., 254, 9943-9946.
7. McKie, A.T., Marciani, P., Rolfs, A., Brennan, K., Wehr, K., Barrow, D., Miret, S., Bomford, A., Peters, T.J., Farzaneh, F., Hediger, M.A., Hentze, M.W. and Simpson, R.J. (2000) Mol. Cell, 5, 299-309.
8. Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S.J., Moynihan, J., Paw, B.H., Drejer, A., Barut, B., Zapata, A., Law, T.C., Brugnara, C., Lux, S.E., Pinkus, G.S., Pinkus, J.L., Kingsley, P.D., Palis, J., Fleming, M.D., Andrews, N.C. and Zon, L.I. (2000) Nature, 409, 776-781.
9. Fleming, R.E. and Sly, W.S. (2001) J. Clin. Invest., 108, 521-522.
10. Brissot, P., Troadec, M.B. and Loréal, O. (2004) J. Hepatol., 40, 702-709.
11. McKie, A.T., Barrow, D., Latunde-Dada, G.O., Rolfs, A., Sager, G., Mudaly, E., Mudaly, M., Richardson, C., Barlow, D., Bomford, A., Peters, T. J., Raja, K.B., Shirali, S., Hediger, M.A., Farzaneh, F. and Simpson, R.J. (2001) Science, 291, 1755-1759.
12. Gunshin, H., Mackenzie, B., Berger, U.V., Gunshin Y., Romero, M.F., Boron, W.F., Nussberger, S, Gollan, J.L. and Hediger, M.A. (1997) Nature, 388, 482-488.
13. Fleming, M.D., Romano, M.A., Su, M.A., Garrick, L.M., Garrick, M.D. and Andrews, N.C. (1998) Proc. Natl. Acad. Sci. USA, 95, 1148-1153.
14. Vulpe, C.D., Kuo, Y.M., Murphy, T.L., Cowley, L., Askwith, C., Libina, N., Gitschier, J. and Anderson, G.J. (1999) Nat. Genet., 21, 195-199.
15. Conrad, M.E. and Umbreit, J.N. (2002) Blood Cells Mol. Dis., 29, 336-355.
16. Pietrangelo, A., Montosi, G., Totaro, A., Garuti, C., Conte, D., Cassanelli, S., Fraquelli, M., Sardini, C., Vasta, F. and Gasparini, P. (1999) N. Engl. J. Med, 341, 725-732.
17. Cazzola, M., Cremonesi, L., Papaioannou, M., Soriani, N., Kioumi, A., Charalambidou, A., Paroni, R., Romtsou, K., Levi, S., Ferrari, M., Arosio, P. and Christakis, J. (2002) Br. J. Haematol., 119, 539-546.
18. Devalia, V., Carter, K., Walker, A.P., Perkins, S.J., Worwood, M., May, A. and Dooley, J.S. (2002) Blood, 100, 695-697.
19. Montosi, G., Donovan, A., Totaro, A., Garuti, C., Pignatti, E., Cassanelli, S., Trenor, C.C., Gasparini, P., Andrews, N.C. and Pietrangelo, A. (2001). J. Clin. Invest., 108, 619-623.
20. Njajou, O.T., Vaessen, N., Mosse, J, Berghuis, B., van Dongen, J.W., Breuning, M. H., Snijders, P.J., Rutten, W.P., Sandkuijl, L.A., Oostra, B.A., van Duijn, C.M. and Heutink, P. (2001) Nat. Genet., 28, 213-214.
21. Wallace, D.F., Pedersen, P., Dixon, J.L., Stephenson, P., Searle, J.W., Powell, L.W. and Subramaniam, V.N. (2002) Blood, 100, 692-694.
22. Jouanolle, A.M., Douabin-Gicquel, V., Halimi, C., Loréal, O., Fergelot, P., Delacour, T., de Lajarte-Thirouard, A.S., Turlin, B., Le Gall, J.Y., Cadet, E., Rochette, J., David, V. and Brissot, P. (2003) J. Hepatol., 39, 286-289.
23. Barton, J.C., (2000) In Hemochromatosis. Genetics, Pathophysiology, Diagnosis and Treatment. (Barton, J.C., Edwards, C.Q., Eds.). Cambridge University Press, Cambridge.
24. Krause, A., Neitz, S., Mägert, H.J., Schulz, A., Forssmann, W.G., Schulz-Knappe, P. and Adermann, K. ( 2000) FEBS Lett., 480, 147-150.
25. Park, C.H., Valore, E.V., Waring, A.J. and Ganz, T. (2001) J. Biol Chem., 276, 7806-7810.
26. Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot P. and Loréal, O. (2001) J. Biol. Chem., 276, 7811-7819.
27. Hancock, R.E. and Diamond, G. (2000) Trends Microbiol., 8, 402-410.
28. Diatchenko, L., Lau, Y.F., Campbell, A.P., Chenchik, A., Moqadam, F., Huang, B., Lukyanov, S., Lukyanov, K., Gurskaya, N., Sverdlov, E.D. and Siebert, P.D. (1996) Proc. Natl. Acad. Sci. USA, 93, 6025-6030.
29. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A. and Vaulont, S. (2001) Proc. Natl. Acad. Sci. USA, 98, 8780-8785.
30. Courselaud, B., Pigeon, C., Inoue, Y., Inoue, J., Gonzalez, F.J., Leroyer, P., Gilot, D., Boudjema, K., Guguen-Guillouzo, C., Brissot, P., Loréal, O. and Ilyin, G. (2002) J. Biol. Chem., 277, 41163-41170.
31. Ilyin, G., Courselaud, B., Troadec, M.B., Pigeon, C., Alizadeh, M., Leroyer, P., Brissot, P. and Loréal, O. (2003) FEBS Lett., 542, 22-26.
32. Brissot, P., Troadec, M.B. and Loréal, O. (2004) Curr. Hematol. Rep., 3, 107-115.
33. Shike, H., Lauth, X., Westerman, M.E., Ostland, V.E., Carlberg, J.M., Van Olst, J.C., Shimizu, C., Bulet, P. and Burns, J.C. (2002) Eur. J. Biochem., 269, 2232-2237.
34. Douglas, S.E., Gallant, J.W., Liebscher, R.S., Dacanay, A. and Tsoi, S.C. (2003) Dev. Comp. Immunol., 27, 589-601.
35. Hunter, H.N., Fulton, D.B., Ganz, T. and Vogel, H.J. (2002) J. Biol. Chem., 277, 37597-37603.
36. Nemeth, E., Valore, E.V., Territo, M., Schiller, G., Lichtenstein, A. and Ganz, T. (2003) Blood, 101, 2461-2643.
37. Mazur, A., Feillet-Coudray, C., Romier, B., Bayle, D,, Gueux, E., Ruivard, M., Coudray, C. and Rayssiguier, Y. (2003) Metabolism, 52, 1229-1231.
38. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A. and Vaulont, S. (2002) Proc. Natl. Acad. Sci. USA, 99, 4596-4601.
39. Fleming, R.E. and Sly, W.S. (2001) Proc. Natl. Acad. Sci. USA, 98, 8160-8162.
40. Roetto, A., Papanikolaou, G., Politou, M., Alberti, F., Girelli, D., Christakis, J., Loukopoulos, D. and Camaschella, C. (2003) Nat. Genet., 33, 21-22.
41. Roetto, A., Daraio, F., Porporato, P., Caruso, R., Cox, T.M., Cazzola, M., Gasparini, P., Piperno, A. and Camaschella, C. (2004) Blood, 103, 2407-2409.
42. Gehrke, S.G., Kulaksiz, H., Herrmann, T., Riedel, H.D., Bents, K., Veltkamp, C. and Stremmel, W. (2003) Blood, 102, 371-376.
43. Frazer, D.M., Wilkins, S.J., Becker, E.M., Vulpe, C.D., McKie, A.T., Trinder, D. and Anderson, G.J. (2002) Gastroenterology, 123, 835-844.
44. Weinstein, D.A., Roy, C.N., Fleming, M.D., Loda, M.F., Wolfsdorf, J.I. and Andrews, N.C. (2002) Blood, 100, 3776-3781.
45. Nicolas, G., Chauvet, C., Viatte, L., Danan, J.L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. and Vaulont S. (2002) J. Clin. Invest., 110, 1037-1044.
46. Courselaud, B., Troadec, M.B., Fruchon, S., Ilyin, G., Borot, N., Leroyer, P., Coppin, H., Brissot, P., Roth, M.P. and Loréal, O. (2004) Blood Cells Mol. Dis., 32, 283-299.
47. Feder, J.N., Gnirke, A., Thomas, W., Tsuchihashi, Z., Ruddy, D.A., Basava, A., Dormishian, F., Domingo Jr, R., Ellis, M.C., Fullan, A., Hinton, L.M., Jones, N.L., Kimmel, B.E., Kronmal, G.S., Lauer, P., Lee, V.K., Loeb, D.B., Mapa, F.A., McClelland, E., Meyer, N.C., Mintier, G.A., Moeller, N., Moore, T., Morikang, E., Wolff, R.R. et al. (1996) Nat. Genet., 13, 399-408.
48. Zhou, X.Y., Tomatsu, S., Fleming, R.E., Parkkila, S., Waheed, A., Jiang, J., Fei, Y., Brunt, E.M., Ruddy, D.A., Prass, C.E., Schatzman, R.C., O'Neill, R., Britton, R.S., Bacon, B.R. and Sly, W.S. (1998) Proc. Natl. Acad. Sci. USA, 95, 2492-2497.
49. Levy, J.E., Montross, L.K., Cohen, D.E., Fleming, M.D. and Andrews, N.C. (1999) Blood, 94, 9-11.
50. Bahram, S., Gilfillan, S., Kuhn, L.C., Moret, R., Schulze, J.B., Lebeau, A. and Schumann, K. (1999) Proc. Natl. Acad. Sci. USA, 96, 13312-13317.
51. Ahmad, K.A., Ahmann, JR., Migas, M.C., Waheed, A., Britton, R.S., Bacon, B.R., Sly, W.S. and Fleming, R.E. (2002) Blood Cells Mol. Dis. 29, 361-366.
52. Nicolas, G., Viatte L., Lou, D.Q., Bennoun M., Beaumont C., Kahn A., Andrews, N.C. and Vaulont S. (2003) Nat. Genet., 34, 97-101.
53. Bridle, K.R., Frazer, D.M., Wilkins, S.J., Dixon, J.L., Purdie, D.M., Crawford, D.H., Subramaniam, V.N., Powell, L.W., Anderson, G.J. and Ram, G.A. (2003) Lancet, 361, 669-673.
54. Beutler, E., Felitti, V.J., Koziol, J.A., Ho, N.J. and Gelbart, T. (2002) Lancet, 359, 211-218.
55. Sanchez, M., Villa, M., Ingelmo, M., Sanz, C., Bruguera, M., Ascaso, C. and Oliva, R. (2003) J. Hepatol., 38, 745-750.
56. Nicolas, G., Andrews, N.C., Kahn, A. and Vaulont, S. (2004) Blood, 103, 2841-2843.
57. Papanikolaou, G., Samuels, M.E., Ludwig, E.H., MacDonald, M.L., Franchini, P.L., Dube, M.P., Andres, L., MacFarlane, J., Sakellaropoulos, N., Politou, M., Nemeth, E., Thompson, J., Risler, J. K., Zaborowska, C., Babakaiff, R., Radomski, C.C., Pape, T.D., Davidas, O., Christakis, J., Brissot, P., Lockitch, G., Ganz, T., Hayden, MR. and Goldberg, Y.P. (2004) Nat. Genet., 36, 77-82.
58. Crichton, R. (2001) In Inorganic Biochemistry of Iron Metabolism, 2nd Edition (Crichton, R., Ed.). pp. 107-114. Wiley & Sons, Chichester.
59. Yeaman, M.R. and Yount, N.Y. (2003) Phamacol. Rev., 55, 27-55.
60. Yeh, K.Y., Yeh, M. and Glass, J. (2004) Am. J. Physiol. Gastrointest. Liver. Physiol, 286, G385-G394.
61. Ganz, T. (2003) Blood, 102, 783-788.
62. Darlington, G.J., Wang, N. and Hanson, R.W. (1995) Curr. Opin. Genet. Dev., 5, 565-570.
63. Deugnier, Y., Turlin, B., le Quilleuc, D., Moirand, R., Loréal, O., Messner, M., Meunier, B., Brissot, P. and Launois, B. (1997) Am. J. Surg. Pathol., 21, 669-675.
64. Turlin, B., Juguet, F., Moirand, R., Le Quilleuc, D., Loréal, O., Campion, J.P., Launois, B., Ramee, M.P., Brissot, P. and Deugnier Y. (1995) Hepatology, 22, 446-450.
65. Lou, D.Q., Nicolas, G., Lesbordes, J.C., Viatte, L., Grimber, G., Szajnert, M.F., Kahn, A. and Vaulont, S. (2003) Blood, 103, 2816-2821.
66. Laftah, A.H., Ramesh, B., Simpson, R.J., Solanky, N., Bahram, S., Schumann, K., Debnam, E.S. and Srai, S.K. (2004) Blood, 103, 3940-3944.
67. Lebron, J.A., Bennett, M.J., Vaughn, D.E., Chirino, A.J., Snow, P.M., Mintier, G.A., Feder, J.N. and Bjorkman, P.J. (1998) Cell, 93, 111-123.
68. Bennett, M.J., Lebron, J.A. and Bjorkman, P.J. (2000) Nature, 403, 46-53.
69. Parkkila, S., Waheed, A., Britton, R.S., Feder, J.N., Tsuchihashi, Z., Schatzman, R.C., Bacon, BR. and Sly, W.S. (1997) Proc. Natl. Acad. Sci. USA, 94, 2534-2539.
70. Parkkila, S., Parkkila, A.K., Waheed, A., Britton, R.S., Zhou, X.Y., Fleming, R.E., Tomatsu, S., Bacon, B.R. and Sly, W.S. (2000) Haematologica, 85, 340-345.
71. Waheed, A., Grubb,, J.H., Zhou, X.Y., Tomatsu, S., Fleming, R.E., Costaldi, M.E., Britton, R.S., Bacon, B.R. and Sly, W.S. (2002) Proc. Natl. Acad Sci. USA, 99, 3117-3122.
72. Montosi, G., Paglia, P., Garuti, C., Guzman, C.A., Bastin, J.M., Colombo, M.P. and Pietrangelo, A. (2000) Blood, 96, 1125-1129.
73. Roetto, A., Totaro, A., Piperno, A., Piga, A., Longo, F., Garozzo, G., Cali, A., De Gobbi, M., Gasparini, P. and Camaschella, C. (2001) Blood, 97, 2555-2560.
74. Fleming, M.D., Trenor 3rd, C.C., Su, M.A., Foernzler, D., Beier, D.R., Dietrich, W.F. and Andrews N.C. (1997) Nat. Genet., 16, 383-386.
75. Canonne-Hergaux, F., Zhang, A.S,, Ponka, P. and Gros, P. (2001) Blood, 98, 3823-3830.
76. Tabuchi, M., Yoshimori, T., Yamaguchi, K., Yoshida, T. and Kishi, F. (2000) J. Biol. Chem., 275, 22220-22228.
77. Kaplan, J. and O'Halloran, T.V. (1996) Science, 271, 1510-1512.
78. Dupic, F., Fruchon, S., Bensaid, M., Borot, N., Radosavljevic, M., Loréal, O., Brissot, P., Giffillan, S., Bahram, S., Coppin, H. and Roth, M.P. (2002) Gastroenterology, 122, 745-751.
79. Muckenthaler, M., Roy, C.N., Custodio, A.O., Minana, B., DeGraaf, J., Montross, L. K., Andrews, N.C. and Hentze, M.W. (2003) Nat. Genet., 34, 102-107.
80. Merryweather-Clarke, A.T., Cadet, E., Bomford, A., Capron, D., Viprakasit, V., Miller, A., McHugh, P.J., Chapman, R.W., Pointon, J.J., Wimhurst, V.L., Livesey, K.J., Tanphaichitr, V., Rochette, J. and Robson, K.J. (2003) Hum. Mol. Genet., 12, 2241-2247.
81. Adamsky, K., Weizer, O., Amariglio, N., Breda, L., Harmelin, A., Rivella, S., Rachmilewitz, E. and Rechavi, G. (2004) Br. J. Haematol, 124, 123-124.
82. Zoumbos, N.C., Djeu, J.Y. and Young, N.S. (1984) J. Immunol., 133, 769-774.
83. Means, R.T. and Krantz, S.B. (1991) Blood, 78, 2564-2567.
84. Means, R.T. (1995) Stem Cells, 13, 32-37.
85. Deugnier, Y., Turlin, B. and Loréal, O. (1998) J. Hepatol., 28, Suppl. 1, 21-25.
86. Dallalio, G., Fleury, T. and Means, R.T. (2003) Br. J. Haematol., 122, 996-1000.
87. Klüver, E., Schulz, A., Forssmann, W.G. and Adermann, K. (2002) J. Pept. Res., 59, 241-248.