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Volumn 8, Issue SUPPL. 1, 2009, Pages

Insulin resistance and steatosis in chronic hepatitis C

Author keywords

Chronic hepatitis C; Diabetes mellitus; Insulin resistance; Steatosis

Indexed keywords

INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; LEPTIN; PEGINTERFERON; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA;

EID: 66749149895     PISSN: 16652681     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1665-2681(19)31829-0     Document Type: Article
Times cited : (50)

References (148)
  • 1
    • 33845388354 scopus 로고    scopus 로고
    • Insulin resistance and hepatitis C
    • Romero-Gomez M. Insulin resistance and hepatitis C. World J Gastroenterol 2006; 12: 7075-7080.
    • (2006) World J Gastroenterol , vol.12 , pp. 7075-7080
    • Romero-Gomez, M.1
  • 4
    • 0028618516 scopus 로고
    • Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population
    • Allison ME, Wreghitt T, Palmer CR, Alexander GJ. Evidence for a link between hepatitis C virus infection and diabetes mellitus in a cirrhotic population. J Hepatol 1994; 21: 1135-1139.
    • (1994) J Hepatol , vol.21 , pp. 1135-1139
    • Allison, M.E.1    Wreghitt, T.2    Palmer, C.R.3    Alexander, G.J.4
  • 5
    • 0033983645 scopus 로고    scopus 로고
    • Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease
    • Zein NN, Abdulkarim AS, Wiesner RH, Egan KS, Persing DH. Prevalence of diabetes mellitus in patients with end-stage liver cirrhosis due to hepatitis C, alcohol, or cholestatic disease. J Hepatol 2000; 32: 209-217.
    • (2000) J Hepatol , vol.32 , pp. 209-217
    • Zein, N.N.1    Abdulkarim, A.S.2    Wiesner, R.H.3    Egan, K.S.4    Persing, D.H.5
  • 6
    • 53249121480 scopus 로고    scopus 로고
    • Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis
    • White DL, Ratziu V, El-Serag HB. Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis. J Hepatol 2008; 49: 831-844.
    • (2008) J Hepatol , vol.49 , pp. 831-844
    • White, D.L.1    Ratziu, V.2    El-Serag, H.B.3
  • 9
    • 0347379939 scopus 로고    scopus 로고
    • Community-based study of hepatitis C virus infection and type 2 diabetes: An association affected by age and hepatitis severity status
    • Wang CS, Wang ST, Yao WJ, Chang TT, Chou P: Community-based study of hepatitis C virus infection and type 2 diabetes: an association affected by age and hepatitis severity status. Am J Epidemiol 2003; 158: 1154-1160.
    • (2003) Am J Epidemiol , vol.158 , pp. 1154-1160
    • Wang, C.S.1    Wang, S.T.2    Yao, W.J.3    Chang, T.T.4    Chou, P.5
  • 10
    • 0033779703 scopus 로고    scopus 로고
    • Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States
    • Mehta SH, Brancati FL, Sulkowski MS, Strathdee SA, Szklo M, Thomas DL. Prevalence of type 2 diabetes mellitus among persons with hepatitis C virus infection in the United States. Ann Intern Med 2000; 133: 592-599.
    • (2000) Ann Intern Med , vol.133 , pp. 592-599
    • Mehta, S.H.1    Brancati, F.L.2    Sulkowski, M.S.3    Strathdee, S.A.4    Szklo, M.5    Thomas, D.L.6
  • 12
    • 13744254182 scopus 로고    scopus 로고
    • Chronic hepatitis C and type II diabetes mellitus: A prospective cross-sectional study
    • Zein CO, Levy C, Basu A, Zein NN. Chronic hepatitis C and type II diabetes mellitus: a prospective cross-sectional study. Am J Gastroenterol 2005; 100: 48-55.
    • (2005) Am J Gastroenterol , vol.100 , pp. 48-55
    • Zein, C.O.1    Levy, C.2    Basu, A.3    Zein, N.N.4
  • 13
    • 0030198037 scopus 로고    scopus 로고
    • Diabetes mel-litus is associated with chronic hepatitis C but not chronic hepatitis B infection
    • Fraser GM, Harman I, Meller N, Niv Y, Porath A. Diabetes mel-litus is associated with chronic hepatitis C but not chronic hepatitis B infection. Isr J Med Sci 1996; 32: 526-530.
    • (1996) Isr J Med Sci , vol.32 , pp. 526-530
    • Fraser, G.M.1    Harman, I.2    Meller, N.3    Niv, Y.4    Porath, A.5
  • 14
    • 0029739641 scopus 로고    scopus 로고
    • High prevalence of hepatitis C virus infection in diabetic patients
    • Simo R, Hernandez C, Genesca J, Jardi R, Mesa J. High prevalence of hepatitis C virus infection in diabetic patients. Diabetes Care 1996; 19: 998-1000.
    • (1996) Diabetes Care , vol.19 , pp. 998-1000
    • Simo, R.1    Hernandez, C.2    Genesca, J.3    Jardi, R.4    Mesa, J.5
  • 21
    • 0345827848 scopus 로고    scopus 로고
    • The susceptibility of patients with type-2 diabetes to hepatitis C virus infection during long-term haemodialysis
    • Saxena AK, Panhotra BR. The susceptibility of patients with type-2 diabetes to hepatitis C virus infection during long-term haemodialysis. Swiss Med Wkly 2003; 133: 611-618.
    • (2003) Swiss Med Wkly , vol.133 , pp. 611-618
    • Saxena, A.K.1    Panhotra, B.R.2
  • 22
    • 0033934875 scopus 로고    scopus 로고
    • Distribution of markers of hepatitis C virus infection throughout the body
    • Gowans EJ. Distribution of markers of hepatitis C virus infection throughout the body. Semin Liver Dis 2000; 20: 85-102.
    • (2000) Semin Liver Dis , vol.20 , pp. 85-102
    • Gowans, E.J.1
  • 23
    • 0031758094 scopus 로고    scopus 로고
    • Search for hepatitis C virus extrahepatic replication sites in patients with acquired immunodeficiency syndrome: Specific detection of negative-strand viral RNA in various tissues
    • Laskus T, Radkowski M, Wang LF, Vargas H, Rakela J. Search for hepatitis C virus extrahepatic replication sites in patients with acquired immunodeficiency syndrome: specific detection of negative-strand viral RNA in various tissues. Hepatology 1998; 28: 1398-1401.
    • (1998) Hepatology , vol.28 , pp. 1398-1401
    • Laskus, T.1    Radkowski, M.2    Wang, L.F.3    Vargas, H.4    Rakela, J.5
  • 24
    • 2342586877 scopus 로고    scopus 로고
    • High prevalence of glucose abnormalities in patients with hepatitis C virus infection: A multivariate analysis considering the liver injury
    • Lecube A, Hernandez C, Genesca J, Esteban JI, Jardi R, Simo R. High prevalence of glucose abnormalities in patients with hepatitis C virus infection: a multivariate analysis considering the liver injury. Diabetes Care 2004; 27: 1171-1175.
    • (2004) Diabetes Care , vol.27 , pp. 1171-1175
    • Lecube, A.1    Hernandez, C.2    Genesca, J.3    Esteban, J.I.4    Jardi, R.5    Simo, R.6
  • 30
    • 34249097401 scopus 로고    scopus 로고
    • Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: An epidemiological link with virological implication
    • Huang JF, Dai CY, Hwang SJ, Ho CK, Hsiao PJ, Hsieh MY, Lee LP, Lin ZY, Chen SC, Hsieh MY, et al. Hepatitis C viremia increases the association with type 2 diabetes mellitus in a hepatitis B and C endemic area: an epidemiological link with virological implication. Am J Gastroenterol 2007; 102: 1237-1243.
    • (2007) Am J Gastroenterol , vol.102 , pp. 1237-1243
    • Huang, J.F.1    Dai, C.Y.2    Hwang, S.J.3    Ho, C.K.4    Hsiao, P.J.5    Hsieh, M.Y.6    Lee, L.P.7    Lin, Z.Y.8    Chen, S.C.9    Hsieh, M.Y.10
  • 33
  • 34
    • 33845489288 scopus 로고    scopus 로고
    • Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection
    • Simo R, Lecube A, Genesca J, Esteban JI, Hernandez C. Sustained virological response correlates with reduction in the incidence of glucose abnormalities in patients with chronic hepatitis C virus infection. Diabetes Care 2006; 29: 2462-2466.
    • (2006) Diabetes Care , vol.29 , pp. 2462-2466
    • Simo, R.1    Lecube, A.2    Genesca, J.3    Esteban, J.I.4    Hernandez, C.5
  • 36
    • 29244484291 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Why does it really matter?
    • Asselah T, Rubbia-Brandt L, Marcellin P, Negro F. Steatosis in chronic hepatitis C: why does it really matter? Gut 2006; 55: 123-130.
    • (2006) Gut , vol.55 , pp. 123-130
    • Asselah, T.1    Rubbia-Brandt, L.2    Marcellin, P.3    Negro, F.4
  • 37
    • 0032146915 scopus 로고    scopus 로고
    • Host-and disease-specific factors affecting steatosis in chronic hepatitis C
    • Czaja AJ, Carpenter HA, Santrach PJ, Moore SB. Host-and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol 1998; 29: 198-206.
    • (1998) J Hepatol , vol.29 , pp. 198-206
    • Czaja, A.J.1    Carpenter, H.A.2    Santrach, P.J.3    Moore, S.B.4
  • 39
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi LE, Gambardella M, Andreana A, Tripodi MF, Utili R, Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 2001; 33: 1358-1364.
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.E.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 40
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T, Ratziu V, McHutchison J, Manns M, Goodman Z, Zeuzem S, Younossi Z, Albrecht J. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 2003; 38: 75-85.
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3    Manns, M.4    Goodman, Z.5    Zeuzem, S.6    Younossi, Z.7    Albrecht, J.8
  • 43
    • 51349122296 scopus 로고    scopus 로고
    • Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C
    • Cua IH, Hui JM, Kench JG, George J. Genotype-specific interactions of insulin resistance, steatosis, and fibrosis in chronic hepatitis C. Hepatology 2008; 48: 723-731.
    • (2008) Hepatology , vol.48 , pp. 723-731
    • Cua, I.H.1    Hui, J.M.2    Kench, J.G.3    George, J.4
  • 44
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004; 126: 586-597.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 46
    • 34347205995 scopus 로고    scopus 로고
    • Hepatitis C and steatosis
    • Bjornsson E, Angulo P. Hepatitis C and steatosis. Arch Med Res 2007; 38: 621-627.
    • (2007) Arch Med Res , vol.38 , pp. 621-627
    • Bjornsson, E.1    Angulo, P.2
  • 48
    • 0036727323 scopus 로고    scopus 로고
    • Steatosis in chronic hepatitis C: Relative contributions of obesity, diabetes mellitus, and alcohol
    • Monto A, Alonzo J, Watson JJ, Grunfeld C, Wright TL. Steatosis in chronic hepatitis C: relative contributions of obesity, diabetes mellitus, and alcohol. Hepatology 2002; 36: 729-736.
    • (2002) Hepatology , vol.36 , pp. 729-736
    • Monto, A.1    Alonzo, J.2    Watson, J.J.3    Grunfeld, C.4    Wright, T.L.5
  • 50
    • 0031055840 scopus 로고    scopus 로고
    • Analysis of histo-pathological manifestations of chronic hepatitis C virus infection with respect to virus genotype
    • Mihm S, Fayyazi A, Hartmann H, Ramadori G. Analysis of histo-pathological manifestations of chronic hepatitis C virus infection with respect to virus genotype. Hepatology 1997; 25: 735-739.
    • (1997) Hepatology , vol.25 , pp. 735-739
    • Mihm, S.1    Fayyazi, A.2    Hartmann, H.3    Ramadori, G.4
  • 55
    • 0036830436 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    • Kumar D, Farrell GC, Fung C, George J: Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response. Hepatology 2002; 36: 1266-1272.
    • (2002) Hepatology , vol.36 , pp. 1266-1272
    • Kumar, D.1    Farrell, G.C.2    Fung, C.3    George, J.4
  • 56
    • 10744224572 scopus 로고    scopus 로고
    • Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: Indirect evidence of a role of hepatitis C virus genotype 3 in steatosis
    • Castera L, Hezode C, Roudot-Thoraval F, Lonjon I, Zafrani ES, Pawlotsky JM, Dhumeaux D. Effect of antiviral treatment on evolution of liver steatosis in patients with chronic hepatitis C: indirect evidence of a role of hepatitis C virus genotype 3 in steatosis. Gut 2004; 53: 420-424.
    • (2004) Gut , vol.53 , pp. 420-424
    • Castera, L.1    Hezode, C.2    Roudot-Thoraval, F.3    Lonjon, I.4    Zafrani, E.S.5    Pawlotsky, J.M.6    Dhumeaux, D.7
  • 57
    • 0034987686 scopus 로고    scopus 로고
    • Quantitative assessment of fibrosis and steatosis in liver biopsies from patients with chronic hepatitis C
    • Zaitoun AM, Al Mardini H, Awad S, Ukabam S, Makadisi S, Record CO. Quantitative assessment of fibrosis and steatosis in liver biopsies from patients with chronic hepatitis C. J Clin Pathol 2001; 54: 461-465.
    • (2001) J Clin Pathol , vol.54 , pp. 461-465
    • Zaitoun, A.M.1    Al Mardini, H.2    Awad, S.3    Ukabam, S.4    Makadisi, S.5    Record, C.O.6
  • 60
  • 61
    • 12444303314 scopus 로고    scopus 로고
    • TNF-{alpha}, chronic hepatitis C and diabetes: A novel triad
    • Knobler H, Schattner A. TNF-{alpha}, chronic hepatitis C and diabetes: a novel triad. Qjm 2005; 98: 1-6.
    • (2005) Qjm , vol.98 , pp. 1-6
    • Knobler, H.1    Schattner, A.2
  • 63
    • 33746366223 scopus 로고    scopus 로고
    • Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study
    • Lecube A, Hernandez C, Genesca J, Simo R. Proinflammatory cytokines, insulin resistance, and insulin secretion in chronic hepatitis C patients: A case-control study. Diabetes Care 2006; 29: 1096-1101.
    • (2006) Diabetes Care , vol.29 , pp. 1096-1101
    • Lecube, A.1    Hernandez, C.2    Genesca, J.3    Simo, R.4
  • 64
    • 0032587240 scopus 로고    scopus 로고
    • The role of TNFalpha and TNF receptors in obesity and insulin resistance
    • Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 1999; 245: 621-625.
    • (1999) J Intern Med , vol.245 , pp. 621-625
    • Hotamisligil, G.S.1
  • 66
    • 0345017776 scopus 로고    scopus 로고
    • Impaired IRS-1/PI3-kinase signaling in patients with HCV: A mechanism for increased prevalence of type 2 diabetes
    • Aytug S, Reich D, Sapiro LE, Bernstein D, Begum N. Impaired IRS-1/PI3-kinase signaling in patients with HCV: a mechanism for increased prevalence of type 2 diabetes. Hepatology 2003; 38: 1384-1392.
    • (2003) Hepatology , vol.38 , pp. 1384-1392
    • Aytug, S.1    Reich, D.2    Sapiro, L.E.3    Bernstein, D.4    Begum, N.5
  • 67
    • 34248671715 scopus 로고    scopus 로고
    • The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms
    • Pazienza V, Clement S, Pugnale P, Conzelman S, Foti M, Mangia A, Negro F. The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms. Hepatology 2007; 45: 1164-1171.
    • (2007) Hepatology , vol.45 , pp. 1164-1171
    • Pazienza, V.1    Clement, S.2    Pugnale, P.3    Conzelman, S.4    Foti, M.5    Mangia, A.6    Negro, F.7
  • 68
    • 0034463918 scopus 로고    scopus 로고
    • A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1
    • Haruta T, Uno T, Kawahara J, Takano A, Egawa K, Sharma PM, Olefsky JM, Kobayashi M. A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol 2000, 14: 783-794.
    • (2000) Mol Endocrinol , vol.14 , pp. 783-794
    • Haruta, T.1    Uno, T.2    Kawahara, J.3    Takano, A.4    Egawa, K.5    Sharma, P.M.6    Olefsky, J.M.7    Kobayashi, M.8
  • 69
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 2002; 277: 42394-42398.
    • (2002) J Biol Chem , vol.277 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 70
    • 48449100910 scopus 로고    scopus 로고
    • Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C
    • Bernsmeier C, Duong FH, Christen V, Pugnale P, Negro F, Terracciano L, Heim MH. Virus-induced over-expression of protein phosphatase 2A inhibits insulin signalling in chronic hepatitis C. J Hepatol 2008; 49: 429-440.
    • (2008) J Hepatol , vol.49 , pp. 429-440
    • Bernsmeier, C.1    Duong, F.H.2    Christen, V.3    Pugnale, P.4    Negro, F.5    Terracciano, L.6    Heim, M.H.7
  • 71
    • 17044382863 scopus 로고    scopus 로고
    • Abid K, Pazienza V, de Gottardi A, Rubbia-Brandt L, Conne B, Pugnale P, Rossi C, Mangia A, Negro F. An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J Hepatol 2005; 42: 744-751.
    • Abid K, Pazienza V, de Gottardi A, Rubbia-Brandt L, Conne B, Pugnale P, Rossi C, Mangia A, Negro F. An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation. J Hepatol 2005; 42: 744-751.
  • 73
    • 34547449770 scopus 로고    scopus 로고
    • Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: Studies in vitro and in conditionally transgenic mice
    • Chang ML, Chen JC, Yeh CT, Sheen IS, Tai DI, Chang MY, Chiu CT, Lin DY, Bissell DM. Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: studies in vitro and in conditionally transgenic mice. World J Gastroenterol 2007; 13: 3472-3477.
    • (2007) World J Gastroenterol , vol.13 , pp. 3472-3477
    • Chang, M.L.1    Chen, J.C.2    Yeh, C.T.3    Sheen, I.S.4    Tai, D.I.5    Chang, M.Y.6    Chiu, C.T.7    Lin, D.Y.8    Bissell, D.M.9
  • 74
    • 0033880575 scopus 로고    scopus 로고
    • Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein
    • Hope RG, McLauchlan J. Sequence motifs required for lipid droplet association and protein stability are unique to the hepatitis C virus core protein. J Gen Virol 2000; 81: 1913-1925.
    • (2000) J Gen Virol , vol.81 , pp. 1913-1925
    • Hope, R.G.1    McLauchlan, J.2
  • 76
    • 34548130208 scopus 로고    scopus 로고
    • The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model
    • Hourioux C, Patient R, Morin A, Blanchard E, Moreau A, Trassard S, Giraudeau B, Roingeard P. The genotype 3-specific hepatitis C virus core protein residue phenylalanine 164 increases steatosis in an in vitro cellular model. Gut 2007; 56: 1302-1308.
    • (2007) Gut , vol.56 , pp. 1302-1308
    • Hourioux, C.1    Patient, R.2    Morin, A.3    Blanchard, E.4    Moreau, A.5    Trassard, S.6    Giraudeau, B.7    Roingeard, P.8
  • 77
    • 18244365866 scopus 로고    scopus 로고
    • Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: A model of viral-related steatosis
    • Perlemuter G, Sabile A, Letteron P, Vona G, Topilco A, Chretien Y, Koike K, Pessayre D, Chapman J, Barba G, et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. Faseb J 2002; 16: 185-194.
    • (2002) Faseb J , vol.16 , pp. 185-194
    • Perlemuter, G.1    Sabile, A.2    Letteron, P.3    Vona, G.4    Topilco, A.5    Chretien, Y.6    Koike, K.7    Pessayre, D.8    Chapman, J.9    Barba, G.10
  • 79
    • 0029047046 scopus 로고    scopus 로고
    • Lin MC, Gordon D, Wetterau JR. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res 1995; 36: 10731081.
    • Lin MC, Gordon D, Wetterau JR. Microsomal triglyceride transfer protein (MTP) regulation in HepG2 cells: insulin negatively regulates MTP gene expression. J Lipid Res 1995; 36: 10731081.
  • 80
    • 0242516072 scopus 로고    scopus 로고
    • Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: Roles of MAPKerk and MAPKp38
    • Au WS, Kung HF, Lin MC. Regulation of microsomal triglyceride transfer protein gene by insulin in HepG2 cells: roles of MAPKerk and MAPKp38. Diabetes 2003; 52: 1073-1080.
    • (2003) Diabetes , vol.52 , pp. 1073-1080
    • Au, W.S.1    Kung, H.F.2    Lin, M.C.3
  • 82
    • 0035068318 scopus 로고    scopus 로고
    • Hepatitis C virus induced hypobetalipoproteinemia: A possible mechanism for steatosis in chronic hepatitis C
    • Serfaty L, Andreani T, Giral P, Carbonell N, Chazouilleres O, Poupon R. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001; 34: 428-434.
    • (2001) J Hepatol , vol.34 , pp. 428-434
    • Serfaty, L.1    Andreani, T.2    Giral, P.3    Carbonell, N.4    Chazouilleres, O.5    Poupon, R.6
  • 84
    • 0036165333 scopus 로고    scopus 로고
    • Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein
    • Okuda M, Li K, Beard MR, Showalter LA, Scholle F, Lemon SM, Weinman SA. Mitochondrial injury, oxidative stress, and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 2002; 122: 366-375.
    • (2002) Gastroenterology , vol.122 , pp. 366-375
    • Okuda, M.1    Li, K.2    Beard, M.R.3    Showalter, L.A.4    Scholle, F.5    Lemon, S.M.6    Weinman, S.A.7
  • 85
    • 33751372117 scopus 로고    scopus 로고
    • Mechanisms and significance of liver steatosis in hepatitis C virus infection
    • Negro F. Mechanisms and significance of liver steatosis in hepatitis C virus infection. World J Gastroenterol 2006; 12: 6756-6765.
    • (2006) World J Gastroenterol , vol.12 , pp. 6756-6765
    • Negro, F.1
  • 86
    • 33846833767 scopus 로고    scopus 로고
    • Very low density lipoprotein and low density lipoprotein isolated from patients with hepatitis C infection induce altered cellular lipid metabolism
    • Napolitano M, Giuliani A, Alonzi T, Mancone C, D'Offizi G, Tripodi M, Bravo E. Very low density lipoprotein and low density lipoprotein isolated from patients with hepatitis C infection induce altered cellular lipid metabolism. J Med Virol 2007; 79: 254-258.
    • (2007) J Med Virol , vol.79 , pp. 254-258
    • Napolitano, M.1    Giuliani, A.2    Alonzi, T.3    Mancone, C.4    D'Offizi, G.5    Tripodi, M.6    Bravo, E.7
  • 89
    • 31644451456 scopus 로고    scopus 로고
    • Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acylCoA transferase 1A
    • Cheng Y, Dharancy S, Malapel M, Desreumaux P. Hepatitis C virus infection down-regulates the expression of peroxisome proliferator-activated receptor alpha and carnitine palmitoyl acylCoA transferase 1A. World J Gastroenterol 2005; 11: 7591-7596.
    • (2005) World J Gastroenterol , vol.11 , pp. 7591-7596
    • Cheng, Y.1    Dharancy, S.2    Malapel, M.3    Desreumaux, P.4
  • 90
    • 23044450214 scopus 로고    scopus 로고
    • Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver
    • Yamaguchi A, Tazuma S, Nishioka T, Ohishi W, Hyogo H, Nomura S, Chayama K. Hepatitis C virus core protein modulates fatty acid metabolism and thereby causes lipid accumulation in the liver. Dig Dis Sci 2005; 50: 1361-1371.
    • (2005) Dig Dis Sci , vol.50 , pp. 1361-1371
    • Yamaguchi, A.1    Tazuma, S.2    Nishioka, T.3    Ohishi, W.4    Hyogo, H.5    Nomura, S.6    Chayama, K.7
  • 93
  • 95
    • 34247636649 scopus 로고    scopus 로고
    • Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: Genotype-3a core has a stronger effect than genotype-1b core
    • Jackel-Cram C, Babiuk LA, Liu Q. Up-regulation of fatty acid synthase promoter by hepatitis C virus core protein: genotype-3a core has a stronger effect than genotype-1b core. J Hepatol 2007, 46:999-1008.
    • (2007) J Hepatol , vol.46 , pp. 999-1008
    • Jackel-Cram, C.1    Babiuk, L.A.2    Liu, Q.3
  • 99
    • 0033607281 scopus 로고    scopus 로고
    • Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor
    • Agnello V, Abel G, Elfahal M, Knight GB, Zhang QX. Hepatitis C virus and other flaviviridae viruses enter cells via low density lipoprotein receptor. Proc Natl Acad Sci USA 1999; 96: 12766-12771.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12766-12771
    • Agnello, V.1    Abel, G.2    Elfahal, M.3    Knight, G.B.4    Zhang, Q.X.5
  • 103
    • 0032994264 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: Differential effects on signal transduction pathways
    • Svegliati-Baroni G, Ridolfi F, Di Sario A, Casini A, Marucci L, Gaggiotti G, Orlandoni P, Macarri G, Perego L, Benedetti A, et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology 1999; 29: 1743-1751.
    • (1999) Hepatology , vol.29 , pp. 1743-1751
    • Svegliati-Baroni, G.1    Ridolfi, F.2    Di Sario, A.3    Casini, A.4    Marucci, L.5    Gaggiotti, G.6    Orlandoni, P.7    Macarri, G.8    Perego, L.9    Benedetti, A.10
  • 104
    • 0034802171 scopus 로고    scopus 로고
    • High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: A potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis
    • Paradis V, Perlemuter G, Bonvoust F, Dargere D, Parfait B, Vidaud M, Conti M, Huet S, Ba N, Buffet C, et al. High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis. Hepatology 2001; 34: 738-744.
    • (2001) Hepatology , vol.34 , pp. 738-744
    • Paradis, V.1    Perlemuter, G.2    Bonvoust, F.3    Dargere, D.4    Parfait, B.5    Vidaud, M.6    Conti, M.7    Huet, S.8    Ba, N.9    Buffet, C.10
  • 107
    • 11244323975 scopus 로고    scopus 로고
    • Impact of steatosis on progression of fibrosis in patients with mild hepatitis C
    • Fartoux L, Chazouilleres O, Wendum D, Poupon R, Serfaty L. Impact of steatosis on progression of fibrosis in patients with mild hepatitis C. Hepatology 2005; 41: 82-87.
    • (2005) Hepatology , vol.41 , pp. 82-87
    • Fartoux, L.1    Chazouilleres, O.2    Wendum, D.3    Poupon, R.4    Serfaty, L.5
  • 108
    • 40949112265 scopus 로고    scopus 로고
    • The presence of steatosis and elevation of alanine aminotransferase levels are associated with fibrosis progression in chronic hepatitis C with non-response to interferon therapy
    • Kurosaki M, Matsunaga K, Hirayama I, Tanaka T, Sato M, Komatsu N, Umeda N, Hosokawa T, Ueda K, Tsuchiya K, et al. The presence of steatosis and elevation of alanine aminotransferase levels are associated with fibrosis progression in chronic hepatitis C with non-response to interferon therapy. J Hepatol 2008; 48: 736-742.
    • (2008) J Hepatol , vol.48 , pp. 736-742
    • Kurosaki, M.1    Matsunaga, K.2    Hirayama, I.3    Tanaka, T.4    Sato, M.5    Komatsu, N.6    Umeda, N.7    Hosokawa, T.8    Ueda, K.9    Tsuchiya, K.10
  • 111
    • 33745566007 scopus 로고    scopus 로고
    • Diabetes mellitus is associated with hepatic encephalopathy in patients with HCV cirrhosis
    • Sigal SH, Stanca CM, Kontorinis N, Bodian C, Ryan E. Diabetes mellitus is associated with hepatic encephalopathy in patients with HCV cirrhosis. Am J Gastroenterol 2006; 101: 1490-1496.
    • (2006) Am J Gastroenterol , vol.101 , pp. 1490-1496
    • Sigal, S.H.1    Stanca, C.M.2    Kontorinis, N.3    Bodian, C.4    Ryan, E.5
  • 112
    • 33749180285 scopus 로고    scopus 로고
    • Higher prevalence and severity of hepatic encephalopathy in patients with HCV cirrhosis and diabetes mellitus: Is presence of autonomic neuropathy the missing part of the puzzle?
    • Thuluvath PJ. Higher prevalence and severity of hepatic encephalopathy in patients with HCV cirrhosis and diabetes mellitus: is presence of autonomic neuropathy the missing part of the puzzle? Am J Gastroenterol 2006; 101: 2244-2246.
    • (2006) Am J Gastroenterol , vol.101 , pp. 2244-2246
    • Thuluvath, P.J.1
  • 114
    • 0842321807 scopus 로고    scopus 로고
    • Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    • El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004; 126: 460-468.
    • (2004) Gastroenterology , vol.126 , pp. 460-468
    • El-Serag, H.B.1    Tran, T.2    Everhart, J.E.3
  • 115
    • 33644660193 scopus 로고    scopus 로고
    • Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C
    • Kumar D, Farrell GC, Kench J, George J. Hepatic steatosis and the risk of hepatocellular carcinoma in chronic hepatitis C. J Gastroenterol Hepatol 2005; 20: 1395-1400.
    • (2005) J Gastroenterol Hepatol , vol.20 , pp. 1395-1400
    • Kumar, D.1    Farrell, G.C.2    Kench, J.3    George, J.4
  • 117
    • 34948827036 scopus 로고    scopus 로고
    • Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C
    • Tanaka A, Uegaki S, Kurihara H, Aida K, Mikami M, Nagashima I, Shiga J, Takikawa H. Hepatic steatosis as a possible risk factor for the development of hepatocellular carcinoma after eradication of hepatitis C virus with antiviral therapy in patients with chronic hepatitis C. World J Gastroenterol 2007; 13: 5180-5187.
    • (2007) World J Gastroenterol , vol.13 , pp. 5180-5187
    • Tanaka, A.1    Uegaki, S.2    Kurihara, H.3    Aida, K.4    Mikami, M.5    Nagashima, I.6    Shiga, J.7    Takikawa, H.8
  • 118
    • 0043037223 scopus 로고    scopus 로고
    • High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C
    • Bressler BL, Guindi M, Tomlinson G, Heathcote J. High body mass index is an independent risk factor for nonresponse to antiviral treatment in chronic hepatitis C. Hepatology 2003; 38: 639-644.
    • (2003) Hepatology , vol.38 , pp. 639-644
    • Bressler, B.L.1    Guindi, M.2    Tomlinson, G.3    Heathcote, J.4
  • 119
    • 0042322996 scopus 로고    scopus 로고
    • Obesity and its nurturing effect on hepatitis C
    • McCullough AJ. Obesity and its nurturing effect on hepatitis C. Hepatology 2003; 38: 557-559.
    • (2003) Hepatology , vol.38 , pp. 557-559
    • McCullough, A.J.1
  • 122
    • 48249114330 scopus 로고    scopus 로고
    • Weight affect relapse rates in latinos with genotype 2/3 chronic hepatitis C (CHC) treated with peg IFN alfa-2a (Pegasys) 180 mcg/week and 800 mg daily of ribavirin for 24 weeks
    • Rodriguez-Torres M, Rios-Bedoya CF, Ortiz-Lasanta G, Purcell-Arevalo D, Marxuach-Cuetara A, Jimenez-Rivera J. Weight affect relapse rates in latinos with genotype 2/3 chronic hepatitis C (CHC) treated with peg IFN alfa-2a (Pegasys) 180 mcg/week and 800 mg daily of ribavirin for 24 weeks. J Med Virol 2008; 80: 1576-1580.
    • (2008) J Med Virol , vol.80 , pp. 1576-1580
    • Rodriguez-Torres, M.1    Rios-Bedoya, C.F.2    Ortiz-Lasanta, G.3    Purcell-Arevalo, D.4    Marxuach-Cuetara, A.5    Jimenez-Rivera, J.6
  • 124
    • 33645129025 scopus 로고    scopus 로고
    • Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis?
    • Tarantino G, Conca P, Ariello M, Mastrolia M. Does a lower insulin resistance affect antiviral therapy response in patients suffering from HCV related chronic hepatitis? Gut 2006; 55: 585.
    • (2006) Gut , vol.55 , pp. 585
    • Tarantino, G.1    Conca, P.2    Ariello, M.3    Mastrolia, M.4
  • 125
    • 33745560465 scopus 로고    scopus 로고
    • Impact of obesity on treatment of chronic hepatitis C
    • Charlton MR, Pockros PJ, Harrison SA. Impact of obesity on treatment of chronic hepatitis C. Hepatology 2006; 43: 1177-1186.
    • (2006) Hepatology , vol.43 , pp. 1177-1186
    • Charlton, M.R.1    Pockros, P.J.2    Harrison, S.A.3
  • 126
    • 47149097081 scopus 로고    scopus 로고
    • Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C
    • Jonsson JR, Barrie HD, O'Rourke P, Clouston AD, Powell EE. Obesity and steatosis influence serum and hepatic inflammatory markers in chronic hepatitis C. Hepatology 2008; 48: 80-87.
    • (2008) Hepatology , vol.48 , pp. 80-87
    • Jonsson, J.R.1    Barrie, H.D.2    O'Rourke, P.3    Clouston, A.D.4    Powell, E.E.5
  • 128
    • 0036788253 scopus 로고    scopus 로고
    • Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C
    • Kamal SM, Fehr J, Roesler B, Peters T, Rasenack JW. Peginterferon alone or with ribavirin enhances HCV-specific CD4 T-helper 1 responses in patients with chronic hepatitis C. Gastroenterology 2002; 123: 1070-1083.
    • (2002) Gastroenterology , vol.123 , pp. 1070-1083
    • Kamal, S.M.1    Fehr, J.2    Roesler, B.3    Peters, T.4    Rasenack, J.W.5
  • 131
    • 33644829597 scopus 로고    scopus 로고
    • High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection
    • Wang AY, Hickman IJ, Richards AA, Whitehead JP, Prins JB, Macdonald GA. High molecular weight adiponectin correlates with insulin sensitivity in patients with hepatitis C genotype 3, but not genotype 1 infection. Am J Gastroenterol 2005; 100: 2717-2723.
    • (2005) Am J Gastroenterol , vol.100 , pp. 2717-2723
    • Wang, A.Y.1    Hickman, I.J.2    Richards, A.A.3    Whitehead, J.P.4    Prins, J.B.5    Macdonald, G.A.6
  • 132
    • 0030052322 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C
    • Larrea E, Garcia N, Qian C, Civeira MP, Prieto J. Tumor necrosis factor alpha gene expression and the response to interferon in chronic hepatitis C. Hepatology 1996; 23: 210-217.
    • (1996) Hepatology , vol.23 , pp. 210-217
    • Larrea, E.1    Garcia, N.2    Qian, C.3    Civeira, M.P.4    Prieto, J.5
  • 133
    • 22744435914 scopus 로고    scopus 로고
    • Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy
    • D'Souza R, Sabin CA, Foster GR. Insulin resistance plays a significant role in liver fibrosis in chronic hepatitis C and in the response to antiviral therapy. Am J Gastroenterol 2005; 100: 1509-1515.
    • (2005) Am J Gastroenterol , vol.100 , pp. 1509-1515
    • D'Souza, R.1    Sabin, C.A.2    Foster, G.R.3
  • 134
    • 59149086369 scopus 로고    scopus 로고
    • Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis c patients receiving peginterferon Alpha-2b plus ribavirin
    • Chu CJ, Lee SD, Hung TH, Lin HC, Hwang SJ, Lee FY, Lu RH, Yu MI, Chang CY, Yang PL, et al. Insulin resistance is a major determinant of sustained virological response in genotype 1 chronic hepatitis c patients receiving peginterferon Alpha-2b plus ribavirin. Aliment Pharmacol Ther 2008.
    • (2008) Aliment Pharmacol Ther
    • Chu, C.J.1    Lee, S.D.2    Hung, T.H.3    Lin, H.C.4    Hwang, S.J.5    Lee, F.Y.6    Lu, R.H.7    Yu, M.I.8    Chang, C.Y.9    Yang, P.L.10
  • 135
    • 36549032819 scopus 로고    scopus 로고
    • Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3
    • Poustchi H, Negro F, Hui J, Cua IH, Brandt LR, Kench JG, George J. Insulin resistance and response to therapy in patients infected with chronic hepatitis C virus genotypes 2 and 3. J Hepatol 2008; 48: 28-34.
    • (2008) J Hepatol , vol.48 , pp. 28-34
    • Poustchi, H.1    Negro, F.2    Hui, J.3    Cua, I.H.4    Brandt, L.R.5    Kench, J.G.6    George, J.7
  • 137
    • 33645114359 scopus 로고    scopus 로고
    • Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1
    • Walsh MJ, Jonsson JR, Richardson MM, Lipka GM, Purdie DM, Clouston AD, Powell EE. Non-response to antiviral therapy is associated with obesity and increased hepatic expression of suppressor of cytokine signalling 3 (SOCS-3) in patients with chronic hepatitis C, viral genotype 1. Gut 2006; 55: 529-535.
    • (2006) Gut , vol.55 , pp. 529-535
    • Walsh, M.J.1    Jonsson, J.R.2    Richardson, M.M.3    Lipka, G.M.4    Purdie, D.M.5    Clouston, A.D.6    Powell, E.E.7
  • 138
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-medi-ated antiviral and antiproliferative activities
    • Song MM, Shuai K. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-medi-ated antiviral and antiproliferative activities. J Biol Chem 1998; 273: 35056-35062.
    • (1998) J Biol Chem , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 139
    • 34447290890 scopus 로고    scopus 로고
    • HCV and diabetes. A two-question-based reappraisal
    • Lonardo A, Carulli N, Loria P. HCV and diabetes. A two-question-based reappraisal. Dig Liver Dis 2007; 39: 753-761.
    • (2007) Dig Liver Dis , vol.39 , pp. 753-761
    • Lonardo, A.1    Carulli, N.2    Loria, P.3
  • 141
    • 46349099383 scopus 로고    scopus 로고
    • Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin
    • Overbeck K, Genne D, Golay A, Negro F. Pioglitazone in chronic hepatitis C not responding to pegylated interferon-alpha and ribavirin. J Hepatol 2008; 49: 295-298.
    • (2008) J Hepatol , vol.49 , pp. 295-298
    • Overbeck, K.1    Genne, D.2    Golay, A.3    Negro, F.4
  • 143
    • 0037301686 scopus 로고    scopus 로고
    • Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies
    • Castera L, Hezode C, Roudot-Thoraval F, Bastie A, Zafrani ES, Pawlotsky JM, Dhumeaux D. Worsening of steatosis is an independent factor of fibrosis progression in untreated patients with chronic hepatitis C and paired liver biopsies. Gut 2003; 52: 288-292.
    • (2003) Gut , vol.52 , pp. 288-292
    • Castera, L.1    Hezode, C.2    Roudot-Thoraval, F.3    Bastie, A.4    Zafrani, E.S.5    Pawlotsky, J.M.6    Dhumeaux, D.7
  • 144
    • 0036318464 scopus 로고    scopus 로고
    • Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C
    • Serfaty L, Poujol-Robert A, Carbonell N, Chazouilleres O, Poupon RE, Poupon R. Effect of the interaction between steatosis and alcohol intake on liver fibrosis progression in chronic hepatitis C. Am J Gastroenterol 2002; 97: 1807-1812.
    • (2002) Am J Gastroenterol , vol.97 , pp. 1807-1812
    • Serfaty, L.1    Poujol-Robert, A.2    Carbonell, N.3    Chazouilleres, O.4    Poupon, R.E.5    Poupon, R.6
  • 145
    • 0036892355 scopus 로고    scopus 로고
    • Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients
    • Westin J, Nordlinder H, Lagging M, Norkrans G, Wejstal R. Steatosis accelerates fibrosis development over time in hepatitis C virus genotype 3 infected patients. J Hepatol 2002; 37: 837-842.
    • (2002) J Hepatol , vol.37 , pp. 837-842
    • Westin, J.1    Nordlinder, H.2    Lagging, M.3    Norkrans, G.4    Wejstal, R.5
  • 146
  • 147
  • 148
    • 0029974710 scopus 로고    scopus 로고
    • Fibrosis and other histological features in chronic hepatitis C virus infection: A statistical model
    • Wong VS, Wight DG, Palmer CR, Alexander GJ. Fibrosis and other histological features in chronic hepatitis C virus infection: a statistical model. J Clin Pathol 1996; 49: 465-469.
    • (1996) J Clin Pathol , vol.49 , pp. 465-469
    • Wong, V.S.1    Wight, D.G.2    Palmer, C.R.3    Alexander, G.J.4


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