-
1
-
-
36248949141
-
The endoplasmic reticulum and the unfolded protein response
-
Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007;18:716-731.
-
(2007)
Semin Cell Dev Biol
, vol.18
, pp. 716-731
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
2
-
-
85047683832
-
Liver injury in a1-antitrypsin deficiency: An aggregated protein induces mitochondrial injury
-
Perlmutter DH. Liver injury in a1-antitrypsin deficiency: an aggregated protein induces mitochondrial injury. J Clin Invest 2002;110:1579-1583.
-
(2002)
J Clin Invest
, vol.110
, pp. 1579-1583
-
-
Perlmutter, D.H.1
-
3
-
-
0033671965
-
Retention of mutant a1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response
-
Teckman JH, Perlmutter DH. Retention of mutant a1-antitrypsin Z in endoplasmic reticulum is associated with an autophagic response. Am J Physiol Gastrointest Liver Physiol 2000;279:G961-G974.
-
(2000)
Am J Physiol Gastrointest Liver Physiol
, vol.279
, pp. G961-G974
-
-
Teckman, J.H.1
Perlmutter, D.H.2
-
5
-
-
1942519766
-
Mitochondrial autophagy and injury in the liver in a1-antitrypsin deficiency
-
Teckman JH, An JK, Blomenkamp K, Schmidt B, Perlmutter D. Mitochondrial autophagy and injury in the liver in a1-antitrypsin deficiency. Am J Physiol Gastrointest Liver Physiol 2004;286:G851-G862.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
, pp. G851-G862
-
-
Teckman, J.H.1
An, J.K.2
Blomenkamp, K.3
Schmidt, B.4
Perlmutter, D.5
-
6
-
-
0025871941
-
A1-Antitrypsin is present within the primary granules of human polymorphonuclear leukocytes
-
Mason DY, Cramer EM,Masse JM, Crystal R, Bassot JM, Breton-Gorius J. a1-Antitrypsin is present within the primary granules of human polymorphonuclear leukocytes. Am J Pathol 1991;139:623-628.
-
(1991)
Am J Pathol
, vol.139
, pp. 623-628
-
-
Mason, D.Y.1
Cramer, E.M.2
Masse, J.M.3
Crystal, R.4
Bassot, J.M.5
Breton-Gorius, J.6
-
7
-
-
0024247866
-
The functional role of acute phase plasma proteinase inhibitors
-
Travis J, Shieh BH, Potempa J. The functional role of acute phase plasma proteinase inhibitors. Tokai J Exp Clin Med 1988;13:313-320.
-
(1988)
Tokai J Exp Clin Med
, vol.13
, pp. 313-320
-
-
Travis, J.1
Shieh, B.H.2
Potempa, J.3
-
8
-
-
77951970668
-
Anti-apoptotic effects of Z a1-antitrypsin in human bronchial epithelial cells
-
Greene CM, Miller SD, Carroll TP, Oglesby IK, Ahmed F, O'Mahony M, Taggart CC, McElvaney NG, O'Neill SJ. Anti-apoptotic effects of Z a1-antitrypsin in human bronchial epithelial cells. Eur Respir J 2010;35:1155-1163.
-
(2010)
Eur Respir J
, vol.35
, pp. 1155-1163
-
-
Greene, C.M.1
Miller, S.D.2
Carroll, T.P.3
Oglesby, I.K.4
Ahmed, F.5
O'Mahony, M.6
Taggart, C.C.7
McElvaney, N.G.8
O'Neill, S.J.9
-
9
-
-
85047684827
-
Alpha1-antitrypsin polymerization and the serpinopathies: Pathobiology and prospects for therapy
-
Lomas DA, Mahadeva R. Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy. J Clin Invest 2002;110:1585-1590.
-
(2002)
J Clin Invest
, vol.110
, pp. 1585-1590
-
-
Lomas, D.A.1
Mahadeva, R.2
-
10
-
-
0024550746
-
Molecular basis for defective secretion of the Z variant of human a1-proteinase inhibitor: Secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342
-
McCracken AA, Kruse KB, Brown JL. Molecular basis for defective secretion of the Z variant of human a1-proteinase inhibitor: secretion of variants having altered potential for salt bridge formation between amino acids 290 and 342. Mol Cell Biol 1989;9:1406-1414.
-
(1989)
Mol Cell Biol
, vol.9
, pp. 1406-1414
-
-
McCracken, A.A.1
Kruse, K.B.2
Brown, J.L.3
-
11
-
-
0026755363
-
The mechanism of Z a1-antitrypsin accumulation in the liver
-
Lomas DA, Evans DL, Finch JT, Carrell RW. The mechanism of Z a1-antitrypsin accumulation in the liver. Nature 1992;357:605-607.
-
(1992)
Nature
, vol.357
, pp. 605-607
-
-
Lomas, D.A.1
Evans, D.L.2
Finch, J.T.3
Carrell, R.W.4
-
12
-
-
0034282683
-
Oxidation of either methionine 351 or methionine 358 in a1-antitrypsin causes loss of anti-neutrophil elastase activity
-
Taggart C, Cervantes-Laurean D, Kim G, McElvaney NG, Wehr N, Moss J, Levine RL. Oxidation of either methionine 351 or methionine 358 in a1-antitrypsin causes loss of anti-neutrophil elastase activity. J Biol Chem 2000;275:27258-27265.
-
(2000)
J Biol Chem
, vol.275
, pp. 27258-27265
-
-
Taggart, C.1
Cervantes-Laurean, D.2
Kim, G.3
McElvaney, N.G.4
Wehr, N.5
Moss, J.6
Levine, R.L.7
-
13
-
-
0027945627
-
Conformational changes in serpins and the mechanism of a1-antitrypsin deficiency
-
Carrell RW, Whisstock J, Lomas DA. Conformational changes in serpins and the mechanism of a1-antitrypsin deficiency. Am J Respir Crit Care Med 1994;150:S171-S175.
-
(1994)
Am J Respir Crit Care Med
, vol.150
, pp. S171-S175
-
-
Carrell, R.W.1
Whisstock, J.2
Lomas, D.A.3
-
14
-
-
0027328108
-
A leucine-to-proline substitution causes a defective a1-antichymotrypsin allele associated with familial obstructive lung disease
-
Poller W, Faber JP, Weidinger S, Tief K, Scholz S, Fischer M, Olek K, Kirchgesser M, Heidtmann HH. A leucine-to-proline substitution causes a defective a1-antichymotrypsin allele associated with familial obstructive lung disease. Genomics 1993;17:740-743.
-
(1993)
Genomics
, vol.17
, pp. 740-743
-
-
Poller, W.1
Faber, J.P.2
Weidinger, S.3
Tief, K.4
Scholz, S.5
Fischer, M.6
Olek, K.7
Kirchgesser, M.8
Heidtmann, H.H.9
-
15
-
-
0034602778
-
Inactive conformation of the serpin a1-antichymotrypsin indicates two-stage insertion of the reactive loop: Implications for inhibitory function and conformational disease
-
Gooptu B, Hazes B, Chang WS, Dafforn TR, Carrell RW, Read RJ, Lomas DA. Inactive conformation of the serpin a1-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. Proc Natl Acad Sci USA 2000;97:67-72.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 67-72
-
-
Gooptu, B.1
Hazes, B.2
Chang, W.S.3
Dafforn, T.R.4
Carrell, R.W.5
Read, R.J.6
Lomas, D.A.7
-
16
-
-
2142768895
-
Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z a1-antitrypsin deficiency
-
Lawless MW, Greene CM, Mulgrew A, Taggart CC, O'Neill SJ, McElvaney NG. Activation of endoplasmic reticulum-specific stress responses associated with the conformational disease Z a1-antitrypsin deficiency. J Immunol 2004;172:5722-5726.
-
(2004)
J Immunol
, vol.172
, pp. 5722-5726
-
-
Lawless, M.W.1
Greene, C.M.2
Mulgrew, A.3
Taggart, C.C.4
O'Neill, S.J.5
McElvaney, N.G.6
-
17
-
-
33748789479
-
Mediators of endoplasmic reticulum stress-induced apoptosis
-
Szegezdi E, Logue SE, Gorman AM, Samali A. Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 2006;7:880-885.
-
(2006)
EMBO Rep
, vol.7
, pp. 880-885
-
-
Szegezdi, E.1
Logue, S.E.2
Gorman, A.M.3
Samali, A.4
-
18
-
-
46549087438
-
A1-Antitrypsin deficiency: A conformational disease associated with lung and liver manifestations
-
Greene CM, Miller SD, Carroll T, McLean C, O'Mahony M, Lawless MW, O'Neill SJ, Taggart CC, McElvaney NG. a1-Antitrypsin deficiency: a conformational disease associated with lung and liver manifestations. J Inherit Metab Dis 2008;31:21-34.
-
(2008)
J Inherit Metab Dis
, vol.31
, pp. 21-34
-
-
Greene, C.M.1
Miller, S.D.2
Carroll, T.3
McLean, C.4
O'Mahony, M.5
Lawless, M.W.6
O'Neill, S.J.7
Taggart, C.C.8
McElvaney, N.G.9
-
19
-
-
1942520367
-
Nrf2 signaling in coordinated activation of antioxidant gene expression
-
Jaiswal AK. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med 2004;36:1199-1207.
-
(2004)
Free Radic Biol Med
, vol.36
, pp. 1199-1207
-
-
Jaiswal, A.K.1
-
20
-
-
72549115279
-
Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: The role of Nrf2-regulated proteasomal activity
-
Malhotra D, Thimmulappa R, Vij N, Navas-Acien A, Sussan T, Merali S, Zhang L, Kelsen SG, Myers A, Wise R, et al. Heightened endoplasmic reticulum stress in the lungs of patients with chronic obstructive pulmonary disease: the role of Nrf2-regulated proteasomal activity. Am J Respir Crit Care Med 2009;180:1196-1207.
-
(2009)
Am J Respir Crit Care Med
, vol.180
, pp. 1196-1207
-
-
Malhotra, D.1
Thimmulappa, R.2
Vij, N.3
Navas-Acien, A.4
Sussan, T.5
Merali, S.6
Zhang, L.7
Kelsen, S.G.8
Myers, A.9
Wise, R.10
-
21
-
-
77952770299
-
Evidence for unfolded protein response activation in monocytes from individuals with a1-antitrypsin deficiency
-
Carroll T, Greene CM, O'Connor CA, Nolan A, O'Neill SJ, McElvaney NG. Evidence for unfolded protein response activation in monocytes from individuals with a1-antitrypsin deficiency. J Immunol 2010;184: 4538-4546.
-
(2010)
J Immunol
, vol.184
, pp. 4538-4546
-
-
Carroll, T.1
Greene, C.M.2
O'Connor, C.A.3
Nolan, A.4
O'Neill, S.J.5
McElvaney, N.G.6
-
22
-
-
2442432416
-
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and b-induced cell death
-
Hitomi J, Katayama T, Eguchi Y, Kudo T, Taniguchi M, Koyama Y, Manabe T, Yamagishi S, Bando Y, Imaizumi K, et al. Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and b-induced cell death. J Cell Biol 2004;165:347-356.
-
(2004)
J Cell Biol
, vol.165
, pp. 347-356
-
-
Hitomi, J.1
Katayama, T.2
Eguchi, Y.3
Kudo, T.4
Taniguchi, M.5
Koyama, Y.6
Manabe, T.7
Yamagishi, S.8
Bando, Y.9
Imaizumi, K.10
-
23
-
-
12244288323
-
BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis
-
Elyaman W, Terro F, Suen KC, Yardin C, Chang RC, Hugon J. BAD and Bcl-2 regulation are early events linking neuronal endoplasmic reticulum stress to mitochondria-mediated apoptosis. Brain Res Mol Brain Res 2002;109:233-238.
-
(2002)
Brain Res Mol Brain Res
, vol.109
, pp. 233-238
-
-
Elyaman, W.1
Terro, F.2
Suen, K.C.3
Yardin, C.4
Chang, R.C.5
Hugon, J.6
-
24
-
-
0035957929
-
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
-
Yoneda T, Imaizumi K, Oono K, Yui D, Gomi F, Katayama T, Tohyama M. Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress. J Biol Chem 2001; 276:13935-13940.
-
(2001)
J Biol Chem
, vol.276
, pp. 13935-13940
-
-
Yoneda, T.1
Imaizumi, K.2
Oono, K.3
Yui, D.4
Gomi, F.5
Katayama, T.6
Tohyama, M.7
-
25
-
-
34547921190
-
Tauroursodeoxycholic acid inhibits apoptosis induced by Z a1-antitrypsin via inhibition of bad
-
Miller SD, Greene CM, McLean C, Lawless MW, Taggart CC, O'Neill SJ, McElvaney NG. Tauroursodeoxycholic acid inhibits apoptosis induced by Z a1-antitrypsin via inhibition of bad. Hepatology 2007;46:496-503.
-
(2007)
Hepatology
, vol.46
, pp. 496-503
-
-
Miller, S.D.1
Greene, C.M.2
McLean, C.3
Lawless, M.W.4
Taggart, C.C.5
O'Neill, S.J.6
McElvaney, N.G.7
-
26
-
-
34248658381
-
Alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis
-
Petrache I, Fijalkowska I, Medler TR, Skirball J, Cruz P, Zhen L, Petrache HI, Flotte TR, Tuder RM. Alpha-1 antitrypsin inhibits caspase-3 activity, preventing lung endothelial cell apoptosis. Am J Pathol 2006;169:1155-1166.
-
(2006)
Am J Pathol
, vol.169
, pp. 1155-1166
-
-
Petrache, I.1
Fijalkowska, I.2
Medler, T.R.3
Skirball, J.4
Cruz, P.5
Zhen, L.6
Petrache, H.I.7
Flotte, T.R.8
Tuder, R.M.9
-
27
-
-
45949100033
-
Endothelial a1-antitrypsin attenuates cigarette smoke induced apoptosis in vitro
-
Aldonyte R, Hutchinson TE, Jin B, Brantly M, Block E, Patel J, Zhang J. Endothelial a1-antitrypsin attenuates cigarette smoke induced apoptosis in vitro. COPD 2008;5:153-162.
-
(2008)
COPD
, vol.5
, pp. 153-162
-
-
Aldonyte, R.1
Hutchinson, T.E.2
Jin, B.3
Brantly, M.4
Block, E.5
Patel, J.6
Zhang, J.7
-
28
-
-
60149106099
-
Perk-dependent regulation of iap translation during ER stress
-
Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA. Perk-dependent regulation of iap translation during ER stress. Oncogene 2009;28:910-920.
-
(2009)
Oncogene
, vol.28
, pp. 910-920
-
-
Hamanaka, R.B.1
Bobrovnikova-Marjon, E.2
Ji, X.3
Liebhaber, S.A.4
Diehl, J.A.5
-
29
-
-
54049155149
-
C-iap1 and c-iap2 are critical mediators of tumor necrosis factor alpha (TNFa)-induced NF-kB activation
-
Varfolomeev E, Goncharov T, Fedorova AV, Dynek JN, Zobel K, Deshayes K, Fairbrother WJ, Vucic D. C-iap1 and c-iap2 are critical mediators of tumor necrosis factor alpha (TNFa)-induced NF-kB activation. J Biol Chem 2008;283:24295-24299.
-
(2008)
J Biol Chem
, vol.283
, pp. 24295-24299
-
-
Varfolomeev, E.1
Goncharov, T.2
Fedorova, A.V.3
Dynek, J.N.4
Zobel, K.5
Deshayes, K.6
Fairbrother, W.J.7
Vucic, D.8
-
30
-
-
0029595282
-
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
-
Rothe M, Pan MG, Henzel WJ, Ayres TM, Goeddel DV. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995;83:1243-1252.
-
(1995)
Cell
, vol.83
, pp. 1243-1252
-
-
Rothe, M.1
Pan, M.G.2
Henzel, W.J.3
Ayres, T.M.4
Goeddel, D.V.5
-
31
-
-
0031755020
-
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
-
Shi Y, Vattem KM, Sood R, An J, Liang J, Stramm L, Wek RC. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol Cell Biol 1998;18:7499-7509.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 7499-7509
-
-
Shi, Y.1
Vattem, K.M.2
Sood, R.3
An, J.4
Liang, J.5
Stramm, L.6
Wek, R.C.7
-
32
-
-
36048999753
-
Iap antagonists induce autoubiquitination of c-IAPs, NF-kB activation, and TNFa-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, Fedorova AV, Kayagaki N, Garg P, Zobel K, Dynek JN, Elliott LO, Wallweber HJ, et al. Iap antagonists induce autoubiquitination of c-IAPs, NF-kB activation, and TNFa-dependent apoptosis. Cell 2007;131:669-681.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
Fedorova, A.V.4
Kayagaki, N.5
Garg, P.6
Zobel, K.7
Dynek, J.N.8
Elliott, L.O.9
Wallweber, H.J.10
-
34
-
-
2442488539
-
Z a1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant
-
Mulgrew AT, Taggart CC, LawlessMW, Greene CM, Brantly ML, O'Neill SJ, McElvaney NG. Z a1-antitrypsin polymerizes in the lung and acts as a neutrophil chemoattractant. Chest 2004;125:1952-1957.
-
(2004)
Chest
, vol.125
, pp. 1952-1957
-
-
Mulgrew, A.T.1
Taggart, C.C.2
Lawless, M.W.3
Greene, C.M.4
Brantly, M.L.5
O'Neill, S.J.6
McElvaney, N.G.7
-
35
-
-
19944430698
-
Polymers of Z a1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo
-
Mahadeva R, Atkinson C, Li Z, Stewart S, Janciauskiene S, Kelley DG, Parmar J, Pitman R, Shapiro SD, Lomas DA. Polymers of Z a1-antitrypsin co-localize with neutrophils in emphysematous alveoli and are chemotactic in vivo. Am J Pathol 2005;166:377-386.
-
(2005)
Am J Pathol
, vol.166
, pp. 377-386
-
-
Mahadeva, R.1
Atkinson, C.2
Li, Z.3
Stewart, S.4
Janciauskiene, S.5
Kelley, D.G.6
Parmar, J.7
Pitman, R.8
Shapiro, S.D.9
Lomas, D.A.10
-
36
-
-
65349083154
-
Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency
-
McLean C, Greene CM, McElvaney NG. Gene targeted therapeutics for liver disease in alpha-1 antitrypsin deficiency. Biologics 2009;3: 63-75.
-
(2009)
Biologics
, vol.3
, pp. 63-75
-
-
McLean, C.1
Greene, C.M.2
McElvaney, N.G.3
-
37
-
-
0035803583
-
Functional anatomy of siRNAs for mediating efficient RNai in Drosophila melanogaster embryo lysate
-
Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T. Functional anatomy of siRNAs for mediating efficient RNai in Drosophila melanogaster embryo lysate. EMBO J 2001;20:6877-6888.
-
(2001)
EMBO J
, vol.20
, pp. 6877-6888
-
-
Elbashir, S.M.1
Martinez, J.2
Patkaniowska, A.3
Lendeckel, W.4
Tuschl, T.5
-
39
-
-
34547943486
-
In vivo post-transcriptional gene silencing of a1-antitrypsin by adeno-associated virus vectors expressing siRNA
-
Cruz PE, Mueller C, Cossette TL, Golant A, Tang Q, Beattie SG, Brantly M, Campbell-Thompson M, Blomenkamp KS, Teckman JH, et al. In vivo post-transcriptional gene silencing of a1-antitrypsin by adeno-associated virus vectors expressing siRNA. Lab Invest 2007;87: 893-902.
-
(2007)
Lab Invest
, vol.87
, pp. 893-902
-
-
Cruz, P.E.1
Mueller, C.2
Cossette, T.L.3
Golant, A.4
Tang, Q.5
Beattie, S.G.6
Brantly, M.7
Campbell-Thompson, M.8
Blomenkamp, K.S.9
Teckman, J.H.10
-
40
-
-
41649115210
-
Sequence-and target-independent angiogenesis suppression by siRNA via TLR3
-
Kleinman ME, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi JZ, Albuquerque RJ, Yamasaki S, Itaya M, Pan Y, et al. Sequence-and target-independent angiogenesis suppression by siRNA via TLR3. Nature 2008;452:591-597.
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
Chandrasekaran, V.4
Nozaki, M.5
Baffi, J.Z.6
Albuquerque, R.J.7
Yamasaki, S.8
Itaya, M.9
Pan, Y.10
-
41
-
-
0026341239
-
Sequence-selective recognition of DNA by strand displacement with a thyminesubstituted polyamide
-
Nielsen PE, Egholm M, Berg RH, Buchardt O. Sequence-selective recognition of DNA by strand displacement with a thyminesubstituted polyamide. Science 1991;254:1497-1500.
-
(1991)
Science
, vol.254
, pp. 1497-1500
-
-
Nielsen, P.E.1
Egholm, M.2
Berg, R.H.3
Buchardt, O.4
-
42
-
-
0020417286
-
Self-splicing RNA: Autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena
-
Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of tetrahymena. Cell 1982;31:147-157.
-
(1982)
Cell
, vol.31
, pp. 147-157
-
-
Kruger, K.1
Grabowski, P.J.2
Zaug, A.J.3
Sands, J.4
Gottschling, D.E.5
Cech, T.R.6
-
43
-
-
0032992064
-
Ribozymemediated specific gene replacement of the a1-antitrypsin gene in human hepatoma cells
-
Ozaki I, Zern MA, Liu S, Wei DL, Pomerantz RJ, Duan L. Ribozymemediated specific gene replacement of the a1-antitrypsin gene in human hepatoma cells. J Hepatol 1999;31:53-60.
-
(1999)
J Hepatol
, vol.31
, pp. 53-60
-
-
Ozaki, I.1
Zern, M.A.2
Liu, S.3
Wei, D.L.4
Pomerantz, R.J.5
Duan, L.6
-
44
-
-
0034969249
-
Prevention of polymerization of M and Z a1-antitrypsin (a1-AT) with trimethylamine n-oxide: Implications for the treatment of a1-at deficiency
-
Devlin GL, Parfrey H, Tew DJ, Lomas DA, Bottomley SP. Prevention of polymerization of M and Z a1-antitrypsin (a1-AT) with trimethylamine n-oxide: implications for the treatment of a1-at deficiency. Am J Respir Cell Mol Biol 2001;24:727-732.
-
(2001)
Am J Respir Cell Mol Biol
, vol.24
, pp. 727-732
-
-
Devlin, G.L.1
Parfrey, H.2
Tew, D.J.3
Lomas, D.A.4
Bottomley, S.P.5
-
45
-
-
33646689560
-
Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis
-
Sharp LK, Mallya M, Kinghorn KJ, Wang Z, Crowther DC, Huntington JA, Belorgey D, Lomas DA. Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis. FEBS J 2006;273:2540-2552.
-
(2006)
FEBS J
, vol.273
, pp. 2540-2552
-
-
Sharp, L.K.1
Mallya, M.2
Kinghorn, K.J.3
Wang, Z.4
Crowther, D.C.5
Huntington, J.A.6
Belorgey, D.7
Lomas, D.A.8
-
46
-
-
0034652248
-
Chemical chaperones mediate increased secretion of mutant a1-antitrypsin (a1-at) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in a1-at deficiency
-
Burrows JA, Willis LK, Perlmutter DH. Chemical chaperones mediate increased secretion of mutant a1-antitrypsin (a1-at) Z: a potential pharmacological strategy for prevention of liver injury and emphysema in a1-at deficiency. Proc Natl Acad Sci USA 2000;97:1796-1801.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1796-1801
-
-
Burrows, J.A.1
Willis, L.K.2
Perlmutter, D.H.3
-
47
-
-
0034695450
-
Glucosidase and mannosidase inhibitors mediate increased secretion of mutant alpha1 antitrypsin Z
-
Marcus NY, Perlmutter DH. Glucosidase and mannosidase inhibitors mediate increased secretion of mutant alpha1 antitrypsin Z. J Biol Chem 2000;275:1987-1992.
-
(2000)
J Biol Chem
, vol.275
, pp. 1987-1992
-
-
Marcus, N.Y.1
Perlmutter, D.H.2
-
48
-
-
0036510604
-
6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization: Implications for the prevention of Z a1-antitrypsinrelated cirrhosis
-
Mahadeva R, Dafforn TR, Carrell RW, Lomas DA. 6-mer peptide selectively anneals to a pathogenic serpin conformation and blocks polymerization: implications for the prevention of Z a1-antitrypsinrelated cirrhosis. J Biol Chem 2002;277:6771-6774.
-
(2002)
J Biol Chem
, vol.277
, pp. 6771-6774
-
-
Mahadeva, R.1
Dafforn, T.R.2
Carrell, R.W.3
Lomas, D.A.4
-
49
-
-
4143133190
-
Inhibiting polymerization: New therapeutic strategies for Z a1-antitrypsinrelated emphysema
-
Parfrey H, Dafforn TR, Belorgey D, Lomas DA, Mahadeva R. Inhibiting polymerization: new therapeutic strategies for Z a1-antitrypsinrelated emphysema. Am J Respir Cell Mol Biol 2004;31:133-139.
-
(2004)
Am J Respir Cell Mol Biol
, vol.31
, pp. 133-139
-
-
Parfrey, H.1
Dafforn, T.R.2
Belorgey, D.3
Lomas, D.A.4
Mahadeva, R.5
-
50
-
-
0042858320
-
Targeting a surface cavity of a1-antitrypsin to prevent conformational disease
-
Parfrey H, Mahadeva R, Ravenhill NA, Zhou A, Dafforn TR, Foreman RC, Lomas DA. Targeting a surface cavity of a1-antitrypsin to prevent conformational disease. J Biol Chem 2003;278:33060-33066.
-
(2003)
J Biol Chem
, vol.278
, pp. 33060-33066
-
-
Parfrey, H.1
Mahadeva, R.2
Ravenhill, N.A.3
Zhou, A.4
Dafforn, T.R.5
Foreman, R.C.6
Lomas, D.A.7
-
51
-
-
33750725161
-
Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z a1-antitrypsin
-
Chang YP, Mahadeva R, Chang WS, Shukla A, Dafforn TR, Chu YH. Identification of a 4-mer peptide inhibitor that effectively blocks the polymerization of pathogenic Z a1-antitrypsin. Am J Respir Cell Mol Biol 2006;35:540-548.
-
(2006)
Am J Respir Cell Mol Biol
, vol.35
, pp. 540-548
-
-
Chang, Y.P.1
Mahadeva, R.2
Chang, W.S.3
Shukla, A.4
Dafforn, T.R.5
Chu, Y.H.6
-
52
-
-
72949086203
-
Small-molecule peptides inhibit Z a1-antitrypsin polymerization
-
Chang YP, Mahadeva R, Chang WS, Lin SC, Chu YH. Small-molecule peptides inhibit Z a1-antitrypsin polymerization. J Cell Mol Med 2008;13:2304-2316.
-
(2008)
J Cell Mol Med
, vol.13
, pp. 2304-2316
-
-
Chang, Y.P.1
Mahadeva, R.2
Chang, W.S.3
Lin, S.C.4
Chu, Y.H.5
-
53
-
-
67650514352
-
Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant a1-antitrypsin deficiency
-
Kelly E, Greene CM, Carroll TP, McElvaney NG, O'Neill SJ. Selenoprotein S/SEPS1 modifies endoplasmic reticulum stress in Z variant a1-antitrypsin deficiency. J Biol Chem 2009;284:16891-16897.
-
(2009)
J Biol Chem
, vol.284
, pp. 16891-16897
-
-
Kelly, E.1
Greene, C.M.2
Carroll, T.P.3
McElvaney, N.G.4
O'Neill, S.J.5
-
54
-
-
34547122903
-
The anti-inflammatory effects of selenium are mediated through 15-deoxy-d12,14-prostaglandin J2 in macrophages
-
Vunta H, Davis F, Palempalli UD, Bhat D, Arner RJ, Thompson JT, Peterson DG, Reddy CC, Prabhu KS. The anti-inflammatory effects of selenium are mediated through 15-deoxy-d12,14-prostaglandin J2 in macrophages. J Biol Chem 2007;282:17964-17973.
-
(2007)
J Biol Chem
, vol.282
, pp. 17964-17973
-
-
Vunta, H.1
Davis, F.2
Palempalli, U.D.3
Bhat, D.4
Arner, R.J.5
Thompson, J.T.6
Peterson, D.G.7
Reddy, C.C.8
Prabhu, K.S.9
-
55
-
-
0038442808
-
Characterization of mammalian selenoproteomes
-
Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science 2003;300:1439-1443.
-
(2003)
Science
, vol.300
, pp. 1439-1443
-
-
Kryukov, G.V.1
Castellano, S.2
Novoselov, S.V.3
Lobanov, A.V.4
Zehtab, O.5
Guigo, R.6
Gladyshev, V.N.7
-
56
-
-
28244462778
-
Selenium in cancer prevention: A review of the evidence and mechanism of action
-
Rayman MP. Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 2005;64:527-542.
-
(2005)
Proc Nutr Soc
, vol.64
, pp. 527-542
-
-
Rayman, M.P.1
|