-
1
-
-
36248997755
-
Fragment-based drug discovery: What has it achieved so far?
-
DOI 10.2174/156802607782341082
-
Alex AA, Flocco MM. Fragment-based drug discovery: what has it achieved so far? Curr Top Med Chem. 2007;7(7):1544-67. (Pubitemid 350131014)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.16
, pp. 1544-1567
-
-
Alex, A.A.1
Flocco, M.M.2
-
2
-
-
0032126742
-
Mycolic acids: Structure, biosynthesis and physiological functions
-
DOI 10.1016/S0163-7827(98)00008-3, PII S0163782798000083
-
Barry CE 3rd, Lee RE, Mdluli K, Sampson AE, Schroeder BG, Slayden RA, Yuan Y. Mycolic acids: structure, biosynthesis and physiological functions. Prog Lipid Res. 1998;37(2-3): 143-79. (Pubitemid 28391410)
-
(1998)
Progress in Lipid Research
, vol.37
, Issue.2-3
, pp. 143-179
-
-
Barry III, C.E.1
Lee, R.E.2
Mdluli, K.3
Sampson, A.E.4
Schroeder, B.G.5
Slayden, R.A.6
Yuan, Y.7
-
4
-
-
34548861262
-
GSMN-TB: A web-based genome-scale network model of Mycobacterium tuberculosis metabolism
-
Beste DJ, Hooper T, Stewart G, Bonde B, Avignone-Rossa C, Bushell ME, Wheeler P, Klamt S, Kierzek AM, McFadden J. GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosis metabolism. Genome Biol. 2007;8(8):R89.
-
(2007)
Genome Biol.
, vol.8
, Issue.8
-
-
Beste, D.J.1
Hooper, T.2
Stewart, G.3
Bonde, B.4
Avignone-Rossa, C.5
Bushell, M.E.6
Wheeler, P.7
Klamt, S.8
Kierzek, A.M.9
McFadden, J.10
-
5
-
-
0030574268
-
Structure-based drug design
-
DOI 10.1038/384023a0
-
Blundell TL. Structure-based drug design. Nature. 1996;384(6604 Suppl): 23-6. (Pubitemid 26374536)
-
(1996)
Nature
, vol.384
, Issue.6604 SUPPL.
, pp. 23-26
-
-
Blundell, T.L.1
-
6
-
-
0036051992
-
High-throughput crystallography for lead discovery in drug design
-
Blundell TL, Jhoti H, Abell C. High-throughput crystallography for lead discovery in drug design. Nat Rev Drug Discov. 2002;1(1):45-54. (Pubitemid 37361403)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.1
, pp. 45-54
-
-
Blundell, T.L.1
Jhoti, H.2
Abell, C.3
-
7
-
-
33749262286
-
Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase
-
DOI 10.1021/jm060429m
-
Bosch J, Robien MA, Mehlin C, Boni E, Riechers A, Buckner FS, Van Voorhis WC, Myler PJ, Worthey EA, DeTitta G, Luft JR, Lauricella A, Gulde S, Anderson LA, Kalyuzhniy O, Neely HM, Ross J, Earnest TN, Soltis M, Schoenfeld L, Zucker F, Merritt EA, Fan E, Verlinde CL, Hol WG. Using fragment cocktail crystallography to assist inhibitor design of Trypanosoma brucei nucleoside 2-deoxyribosyltransferase. J Med Chem. 2006;49(49):5939-46. (Pubitemid 44484940)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.20
, pp. 5939-5946
-
-
Bosch, J.1
Robien, M.A.2
Mehlin, C.3
Boni, E.4
Riechers, A.5
Buckner, F.S.6
Van Voorhis, W.C.7
Myler, P.J.8
Worthey, E.A.9
DeTitta, G.10
Luft, J.R.11
Lauricella, A.12
Gulde, S.13
Anderson, L.A.14
Kalyuzhniy, O.15
Neely, H.M.16
Ross, J.17
Earnest, T.N.18
Soltis, M.19
Schoenfeld, L.20
Zucker, F.21
Merritt, E.A.22
Fan, E.23
Verlinde, C.L.M.J.24
Hol, W.G.J.25
more..
-
8
-
-
41849092287
-
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration
-
DOI 10.1021/jm701437d
-
Caldwell JJ, Davies TG, Donald A, McHardy T, Rowlands MG, Aherne GW, Hunter LK, Taylor K, Ruddle R, Raynaud FI, Verdonk M, Workman P, Garrett MD, Collins I. Identification of 4-(4-Aminopiperidin-1-yl)-7H-pyrrolo[2, 3-d]pyrimidines as Selective Inhibitors of Protein Kinase B through Fragment Elaboration. J Med Chem. 2008;51(51):2147-57. (Pubitemid 351503270)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 2147-2157
-
-
Caldwell, J.J.1
Davies, T.G.2
Donald, A.3
McHardy, T.4
Rowlands, M.G.5
Aherne, G.W.6
Hunter, L.K.7
Taylor, K.8
Ruddle, R.9
Raynaud, F.I.10
Verdonk, M.11
Workman, P.12
Garrett, M.D.13
Collins, I.14
-
9
-
-
33947711645
-
New insights on the nature of latent tuberculosis infection and its treatment
-
Cardona PJ. New insights on the nature of latent tuberculosis infection and its treatment. Inflamm Allergy Drug Targets. 2007;6(6):27-39.
-
(2007)
Inflamm. Allergy Drug Targets
, vol.6
, Issue.6
, pp. 27-39
-
-
Cardona, P.J.1
-
10
-
-
33846419564
-
The use of biophysical methods increases success in obtaining liganded crystal structures
-
Chung CW. The use of biophysical methods increases success in obtaining liganded crystal structures. Acta Crystallogr D Biol Crystallogr. 2007;63(Pt 1):62-71.
-
(2007)
Acta Crystallogr. D Biol. Crystallogr.
, vol.63
, Issue.1 PART
, pp. 62-71
-
-
Chung, C.W.1
-
11
-
-
33746885488
-
Probing hot spots at protein-ligand binding sites: A fragment-based approach using biophysical methods
-
DOI 10.1021/jm060490r
-
Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods. J Med Chem. 2006;49(49):4992-5000. (Pubitemid 44201057)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.16
, pp. 4992-5000
-
-
Ciulli, A.1
Williams, G.2
Smith, A.G.3
Blundell, T.L.4
Abell, C.5
-
12
-
-
59449099151
-
Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate
-
Ciulli A, Scott DE, Ando M, Reyes F, Saldanha SA, Tuck KL, Chirgadze DY, Blundell TL, and Abell C. Inhibition of Mycobacterium tuberculosis pantothenate synthetase by analogues of the reaction intermediate. ChemBioChem. 2008;9(9):2606-2611.
-
(2008)
ChemBioChem
, vol.9
, Issue.9
, pp. 2606-2611
-
-
Ciulli, A.1
Scott, D.E.2
Ando, M.3
Reyes, F.4
Saldanha, S.A.5
Tuck, K.L.6
Chirgadze, D.Y.7
Blundell, T.L.8
Abell, C.9
-
13
-
-
0032508046
-
Deciphering the biology of mycobacterium tuberculosis from the complete genome sequence
-
DOI 10.1038/31159
-
Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, Gordon SV, Eiglmeier K, Gas S, Barry CE 3rd, Tekaia F, Badcock K, Basham D, Brown D, Chillingworth T, Connor R, Davies R, Devlin K, Feltwell T, Gentles S, Hamlin N, Holroyd S, Hornsby T, Jagels K, Krogh A, McLean J, Moule S, Murphy L, Oliver K, Osborne J, Quail MA, Rajandream MA, Rogers J, Rutter S, Seeger K, Skelton J, Squares R, Squares S, Sulston JE, Taylor K, Whitehead S, Barrell BG. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature. 1998;393(393):537-44. (Pubitemid 28319235)
-
(1998)
Nature
, vol.393
, Issue.6685
, pp. 537-544
-
-
Cole, S.T.1
Brosch, R.2
Parkhill, J.3
Garnier, T.4
Churcher, C.5
Harris, D.6
Gordon, S.V.7
Eiglmeier, K.8
Gas, S.9
Barry III, C.E.10
Tekaia, F.11
Badcock, K.12
Basham, D.13
Brown, D.14
Chillingworth, T.15
Connor, R.16
Davies, R.17
Devlin, K.18
Feltwell, T.19
Gentles, S.20
Hamlin, N.21
Holroyd, S.22
Hornsby, T.23
Jagels, K.24
Krogh, A.25
McLean, J.26
Moule, S.27
Murphy, L.28
Oliver, K.29
Osborne, J.30
Quail, M.A.31
Rajandream, M.-A.32
Rogers, J.33
Rutter, S.34
Seeger, K.35
Skelton, J.36
Squares, R.37
Squares, S.38
Sulston, J.E.39
Taylor, K.40
Whitehead, S.41
Barrell, B.G.42
more..
-
14
-
-
0141726877
-
A 'Rule of Three' for fragment-based lead discovery?
-
DOI 10.1016/S1359-6446(03)02831-9, PII S1359644603028319
-
Congreve M, Carr R, Murray C, Jhoti H. A 'rule of three' for fragment-based lead discovery? Drug Discov Today. 2003;8(8):876-7. (Pubitemid 37194496)
-
(2003)
Drug Discovery Today
, vol.8
, Issue.19
, pp. 876-877
-
-
Congreve, M.1
Carr, R.2
Murray, C.3
Jhoti, H.4
-
16
-
-
0035692794
-
WaterLOGSY as a method for primary NMR screening: Practical aspects and range of applicability
-
DOI 10.1023/A:1013302231549
-
Dalvit C, Fogliatto G, Stewart A, Veronesi M, Stockman B. WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability. J Biomol NMR. 2001;21(21):349-59. (Pubitemid 34071389)
-
(2001)
Journal of Biomolecular NMR
, vol.21
, Issue.4
, pp. 349-359
-
-
Dalvit, C.1
Fogliatto, G.2
Stewart, A.3
Veronesi, M.4
Stockman, B.5
-
17
-
-
33846076971
-
Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis
-
DOI 10.1107/S1744309106046823
-
Dias MV, Faím LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF Jr. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007;63(Pt 1):1-6. (Pubitemid 46067232)
-
(2007)
Acta Crystallographica Section F: Structural Biology and Crystallization Communications
, vol.63
, Issue.1
, pp. 1-6
-
-
Dias, M.V.B.1
Faim, L.M.2
Vasconcelos, I.B.3
De Oliveira, J.S.4
Basso, L.A.5
Santos, D.S.6
De Azevedo Jr., W.F.7
-
18
-
-
1942421808
-
Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae
-
DOI 10.1016/j.femsre.2003.10.001, PII S0168644503000901
-
Dover LG, Cerdeño-Tárraga AM, Pallen MJ, Parkhill J, Besra GS. Comparative cell wall core biosynthesis in the mycolated pathogens, Mycobacterium tuberculosis and Corynebacterium diphtheriae. FEMS Microbiol Rev. 2004;28(28):225-50. (Pubitemid 38510503)
-
(2004)
FEMS Microbiology Reviews
, vol.28
, Issue.2
, pp. 225-250
-
-
Dover, L.G.1
Cerdeno-Tarraga, A.M.2
Pallen, M.J.3
Parkhill, J.4
Besra, G.S.5
-
19
-
-
0034073375
-
Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice
-
DOI 10.1046/j.1365-2958.2000.01882.x
-
Dubnau E, Chan J, Raynaud C, Mohan VP, Lanéelle MA, Yu K, Quémard A, Smith I, Daffé M. Oxygenated mycolic acids are necessary for virulence of Mycobacterium tuberculosis in mice. Mol Microbiol. 2000;36(36):630-7. (Pubitemid 30258847)
-
(2000)
Molecular Microbiology
, vol.36
, Issue.3
, pp. 630-637
-
-
Dubnau, E.1
Chan, J.2
Raynaud, C.3
Mohan, V.P.4
Laneelle, M.-A.5
Yu, K.6
Quemard, A.7
Smith, I.8
Daffe, M.9
-
20
-
-
0025742991
-
The Mycobacterium tuberculosis shikimate pathway genes: Evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases
-
Garbe T, Servos S, Hawkins A, Dimitriadis G, Young D, Dougan G, Charles I. The Mycobacterium tuberculosis shikimate pathway genes: evolutionary relationship between biosynthetic and catabolic 3-dehydroquinases. Mol Gen Genet. 1991;228(228):385-92.
-
(1991)
Mol. Gen. Genet.
, vol.228
, Issue.228
, pp. 385-392
-
-
Garbe, T.1
Servos, S.2
Hawkins, A.3
Dimitriadis, G.4
Young, D.5
Dougan, G.6
Charles, I.7
-
21
-
-
0028972283
-
The biosynthesis of cyclopanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2
-
DOI 10.1074/jbc.270.45.27292
-
George KM, Yuan Y, Sherman DR, Barry CE 3rd. The biosynthesis of cyclopropanated mycolic acids in Mycobacterium tuberculosis. Identification and functional analysis of CMAS-2. J Biol Chem. 1995;270(270):27292-8. (Pubitemid 3007299)
-
(1995)
Journal of Biological Chemistry
, vol.270
, Issue.45
, pp. 27292-27298
-
-
George, K.M.1
Yuan Ying2
Sherman, D.R.3
Barry, C.E.4
-
22
-
-
33847125327
-
Progress in type II dehydroquinase inhibitors: From concept to practice
-
DOI 10.1002/med.20076
-
González-Bello C, Castedo L. Progress in type II dehydroquinase inhibitors: from concept to practice. Med Res Rev. 2007;27(27):177-208. (Pubitemid 46281146)
-
(2007)
Medicinal Research Reviews
, vol.27
, Issue.2
, pp. 177-208
-
-
Gonzalez-Bello, C.1
Castedo, L.2
-
23
-
-
33746528061
-
Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis
-
DOI 10.1111/j.1365-2958.2006.05297.x
-
Gould TA, van de Langemheen H, Muñoz-Elías EJ, McKinney JD, Sacchettini JC. Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis. Mol Microbiol. 2006;61(61):940-7. (Pubitemid 44134171)
-
(2006)
Molecular Microbiology
, vol.61
, Issue.4
, pp. 940-947
-
-
Gould, T.A.1
Van De Langemheen, H.2
Munoz-Elias, E.J.3
McKinney, J.D.4
Sacchettini, J.C.5
-
24
-
-
0032979147
-
The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction
-
DOI 10.1038/9287
-
Gourley DG, Shrive AK, Polikarpov I, Krell T, Coggins JR, Hawkins AR, Isaacs NW, Sawyer L. The two types of 3-dehydroquinase have distinct structures but catalyze the same overall reaction. Nat Struct Biol. 1999;6(6):521-5. (Pubitemid 29252828)
-
(1999)
Nature Structural Biology
, vol.6
, Issue.6
, pp. 521-525
-
-
Gourley, D.G.1
Shrive, A.K.2
Polikarpov, I.3
Krell, T.4
Coggins, J.R.5
Hawkins, A.R.6
Isaacs, N.W.7
Sawyer, L.8
-
25
-
-
34547127671
-
Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria
-
DOI 10.1074/jbc.M702087200
-
Guerin ME, Kordulakova J, Schaeffer F, Svetlikova Z, Buschiazzo A, Giganti D, Gicquel B, Mikusova K, Jackson M, Alzari PM. Molecular recognition and interfacial catalysis by the essential phosphatidylinositol mannosyltransferase PimA from mycobacteria. J Biol Chem. 2007;282(282):20705-14. (Pubitemid 47100006)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.28
, pp. 20705-20714
-
-
Guerin, M.E.1
Kordulakova, J.2
Schaeffer, F.3
Svetlikova, Z.4
Buschiazzo, A.5
Giganti, D.6
Gicquel, B.7
Mikusova, K.8
Jackson, M.9
Alzari, P.M.10
-
26
-
-
33847381100
-
A decade of fragment-based drug design: Strategic advances and lessons learned
-
DOI 10.1038/nrd2220, PII NRD2220
-
Hajduk PJ, Greer J. A decade of fragment-based drug design: strategic advances and lessons learned. Nat Rev Drug Discov. 2007;6(6):211-9. (Pubitemid 46344625)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.3
, pp. 211-219
-
-
Hajduk, P.J.1
Greer, J.2
-
27
-
-
33751246776
-
Mechanism of Phosphoryl Transfer Catalyzed by Shikimate Kinase from Mycobacterium tuberculosis
-
DOI 10.1016/j.jmb.2006.09.001, PII S0022283606011685
-
Hartmann MD, Bourenkov GP, Oberschall A, Strizhov N, Bartunik HD. Mechanism of phosphoryl transfer catalyzed by shikimate kinase from Mycobacterium tuberculosis. J Mol Biol. 2006;364(364):411-23. (Pubitemid 44780995)
-
(2006)
Journal of Molecular Biology
, vol.364
, Issue.3
, pp. 411-423
-
-
Hartmann, M.D.1
Bourenkov, G.P.2
Oberschall, A.3
Strizhov, N.4
Bartunik, H.D.5
-
28
-
-
12344318177
-
Fragment-based lead discovery using X-ray crystallography
-
DOI 10.1021/jm0495778
-
Hartshorn MJ, Murray CW, Cleasby A, Frederickson M, Tickle IJ, Jhoti H. Fragment-based lead discovery using X-ray crystallography. J Med Chem. 2005;48(48):403-13. (Pubitemid 40139783)
-
(2005)
Journal of Medicinal Chemistry
, vol.48
, Issue.2
, pp. 403-413
-
-
Hartshorn, M.J.1
Murray, C.W.2
Cleasby, A.3
Frederickson, M.4
Tickle, I.J.5
Jhoti, H.6
-
29
-
-
27344436962
-
Measurements of binding thermodynamics in drug discovery
-
DOI 10.1016/S1359-6446(05)03610-X, PII S135964460503610X
-
Holdgate GA, Ward WH. Measurements of binding thermodynamics in drug discovery. Drug Discov Today. 2005;10(10):1543-50. (Pubitemid 41527197)
-
(2005)
Drug Discovery Today
, vol.10
, Issue.22
, pp. 1543-1550
-
-
Holdgate, G.A.1
Ward, W.H.J.2
-
30
-
-
34548267729
-
Structure-based approaches to drug discovery against tuberculosis
-
DOI 10.2174/138920307781369445
-
Holton SJ, Weiss MS, Tucker PA, Wilmanns M. Structure-based approaches to drug discovery against tuberculosis. Curr Protein Pept Sci. 2007;8(8):365-75. (Pubitemid 47317042)
-
(2007)
Current Protein and Peptide Science
, vol.8
, Issue.4
, pp. 365-375
-
-
Holton, S.J.1
Weiss, M.S.2
Tucker, P.A.3
Wilmanns, M.4
-
31
-
-
1942453243
-
Ligand efficiency: A useful metric for lead selection
-
DOI 10.1016/S1359-6446(04)03069-7, PII S1359644604030697
-
Hopkins AL, Groom CR, Alex A. Ligand efficiency: a useful metric for lead selection. Drug Discov Today. 2004;9(9):430-1. (Pubitemid 38510559)
-
(2004)
Drug Discovery Today
, vol.9
, Issue.10
, pp. 430-431
-
-
Hopkins, A.L.1
Groom, C.R.2
Alex, A.3
-
32
-
-
33144470698
-
Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors
-
DOI 10.1021/jm050850v
-
Howard N, Abell C, Blakemore W, Chessari G, Congreve M, Howard S, Jhoti H, Murray CW, Seavers LC, van Montfort RL. Application of fragment screening and fragment linking to the discovery of novel thrombin inhibitors. J Med Chem. 2006;49(49):1346-55. (Pubitemid 43271886)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.4
, pp. 1346-1355
-
-
Howard, N.1
Abell, C.2
Blakemore, W.3
Chessari, G.4
Congreve, M.5
Howard, S.6
Jhoti, H.7
Murray, C.W.8
Seavers, L.C.A.9
Van Montfort, R.L.M.10
-
33
-
-
0037192859
-
Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis
-
DOI 10.1074/jbc.M111698200
-
Huang CC, Smith CV, Glickman MS, Jacobs WR Jr, Sacchettini JC. Crystal structures of mycolic acid cyclopropane synthases from Mycobacterium tuberculosis. J Biol Chem. 2002;277(277):11559-69. (Pubitemid 34952927)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.13
, pp. 11559-11569
-
-
Huang, C.-C.1
Smith, C.V.2
Glickman, M.S.3
Jacobs, W.R.4
Sacchettini, J.C.5
-
34
-
-
0028854034
-
Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation
-
Jones G, Willet P, Glen RC. Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation. J Mol Biol. 1995;245(245):43-53.
-
(1995)
J. Mol. Biol.
, vol.245
, Issue.245
, pp. 43-53
-
-
Jones, G.1
Willet, P.2
Glen, R.C.3
-
35
-
-
0031552362
-
Development and validation of a genetic algorithm for flexible docking
-
DOI 10.1006/jmbi.1996.0897
-
Jones G, Willet P, Glen RC, Leach AR, Taylor R. Development and validation of a genetic algorithm for flexible docking. J Mol Biol. 1997;267(267):727-48. (Pubitemid 27170693)
-
(1997)
Journal of Molecular Biology
, vol.267
, Issue.3
, pp. 727-748
-
-
Jones, G.1
Willett, P.2
Glen, R.C.3
Leach, A.R.4
Taylor, R.5
-
37
-
-
0142132056
-
Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of Mycobacterium species
-
DOI 10.1074/jbc.M303639200
-
Korduláková J, Gilleron M, Puzo G, Brennan PJ, Gicquel B, Mikusová K, Jackson M. Identification of the required acyltransferase step in the biosynthesis of the phosphatidylinositol mannosides of mycobacterium species. J Biol Chem. 2003;278(278):36285-95. (Pubitemid 37139953)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.38
, pp. 36285-36295
-
-
Kordulakova, J.1
Gilleron, M.2
Puzo, G.3
Brennan, P.J.4
Gicquel, B.5
Mikusova, K.6
Jackson, M.7
-
38
-
-
4344711355
-
Theory and applications of NMR-based screening in pharmaceutical research
-
Lepre CA, Moore JM, Peng JW. Theory and applications of NMR-based screening in pharmaceutical research. Chem Rev. 2004;104(104):3641-76.
-
(2004)
Chem. Rev.
, vol.104
, Issue.104
, pp. 3641-3676
-
-
Lepre, C.A.1
Moore, J.M.2
Peng, J.W.3
-
39
-
-
52149109119
-
Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma
-
press
-
Liao YL, Sun YM, Chau GY, Chau YP, Lai TC, Wang JL, Horng JT, Hsiao M, Tsou AP. Identification of SOX4 target genes using phylogenetic footprinting-based prediction from expression microarrays suggests that overexpression of SOX4 potentiates metastasis in hepatocellular carcinoma. Oncogene. 2008; in press.
-
(2008)
Oncogene
-
-
Liao, Y.L.1
Sun, Y.M.2
Chau, G.Y.3
Chau, Y.P.4
Lai, T.C.5
Wang, J.L.6
Horng, J.T.7
Hsiao, M.8
Tsou, A.P.9
-
40
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 2001;46(1-3): 3-26. (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
41
-
-
4143121255
-
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
-
DOI 10.1016/j.ab.2004.04.031, PII S0003269704003756
-
Lo MC, Aulabaugh A, Jin G, Cowling R, Bard J, Malamas M, Ellestad G. Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery. Anal Biochem. 2004;332(332):153-9. (Pubitemid 39099482)
-
(2004)
Analytical Biochemistry
, vol.332
, Issue.1
, pp. 153-159
-
-
Lo, M.-C.1
Aulabaugh, A.2
Jin, G.3
Cowling, R.4
Bard, J.5
Malamas, M.6
Ellestad, G.7
-
42
-
-
0034823890
-
Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor
-
DOI 10.1021/ja0100120
-
Mayer M, Meyer B. Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. J Am Chem Soc. 2001;123(123):6108-17. (Pubitemid 32888480)
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.25
, pp. 6108-6117
-
-
Mayer, M.1
Meyer, B.2
-
43
-
-
0342794213
-
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase
-
McKinney JD, Höner zu Bentrup K, Muñoz-Elías EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG. Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase. Nature. 2000;406(406):735-8.
-
(2000)
Nature
, vol.406
, Issue.406
, pp. 735-738
-
-
McKinney, J.D.1
Bentrup, N.H.K.2
Muñoz-Elías, E.J.3
Miczak, A.4
Chen, B.5
Chan, W.T.6
Swenson, D.7
Sacchettini, J.C.8
Jacobs Jr., W.R.9
Russell, D.G.10
-
44
-
-
0036773752
-
The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis
-
Parish T, Stoker NG. The common aromatic amino acid biosynthesis pathway is essential in Mycobacterium tuberculosis. Microbiology. 2002;148(Pt 10):3069-77. (Pubitemid 35243706)
-
(2002)
Microbiology
, vol.148
, Issue.10
, pp. 3069-3077
-
-
Parish, T.1
Stoker, N.G.2
-
45
-
-
45749109114
-
Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring
-
Radestock S, Weil T, Renner S. Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring. J Chem Inf Model. 2008;48(48):1104-17.
-
(2008)
J. Chem. Inf Model
, vol.48
, Issue.48
, pp. 1104-1117
-
-
Radestock, S.1
Weil, T.2
Renner, S.3
-
46
-
-
0036796061
-
A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis
-
DOI 10.1038/nm765
-
Sambandamurthy VK, Wang X, Chen B, Russell RG, Derrick S, Collins FM, Morris SL, Jacobs WR Jr. A pantothenate auxotroph of Mycobacterium tuberculosis is highly attenuated and protects mice against tuberculosis. Nat Med. 2002;8(8):1171-4. (Pubitemid 35175974)
-
(2002)
Nature Medicine
, vol.8
, Issue.10
, pp. 1171-1174
-
-
Sambandamurthy, V.K.1
Wang, X.2
Chen, B.3
Russell, R.G.4
Derrick, S.5
Collins, F.M.6
Morris, S.L.7
Jacobs Jr., W.R.8
-
47
-
-
0033871202
-
Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis
-
DOI 10.1038/77964
-
Sharma V, Sharma S, Hoener zu Bentrup K, McKinney JD, Russell DG, Jacobs WR Jr, Sacchettini JC. Structure of isocitrate lyase, a persistence factor of Mycobacterium tuberculosis. Nat Struct Biol. 2000;7(7):663-8. (Pubitemid 30636678)
-
(2000)
Nature Structural Biology
, vol.7
, Issue.8
, pp. 663-668
-
-
Sharma, V.1
Sharma, S.2
Hoener Zu Bentrup, K.3
McKinney, J.D.4
Russell, D.G.5
Jacobs Jr., W.R.6
Sacchettini, J.C.7
-
48
-
-
33646887220
-
DBMODELING: A database applied to the study of protein targets from genome projects
-
DOI 10.1385/CBB:44:3:366
-
Silveira NJ, Bonalumi CE, Uchõa HB, Pereira JH, Canduri F, de Azevedo WF. DBMODELING: a database applied to the study of protein targets from genome projects. Cell Biochem Biophys. 2006;44(44):366-74. (Pubitemid 43780392)
-
(2006)
Cell Biochemistry and Biophysics
, vol.44
, Issue.3
, pp. 366-374
-
-
Da Silveira, N.J.F.1
Bonalumi, C.E.2
Uchoa, H.B.3
Pereira, J.H.4
Canduri, F.5
De Azevedo Jr., W.F.6
-
49
-
-
33646238683
-
Molecular models of protein targets from Mycobacterium tuberculosis
-
Silveira NJ, Uchôa HB, Pereira JH, Canduri F, Basso LA, Palma MS, Santos DS, de Azevedo WF Jr. Molecular models of protein targets from Mycobacterium tuberculosis. J Mol Model. 2005;11(11):160-6.
-
(2005)
J. Mol. Model
, vol.11
, Issue.11
, pp. 160-166
-
-
Silveira, N.J.1
Uchôa, H.B.2
Pereira, J.H.3
Canduri, F.4
Basso, L.A.5
Palma, M.S.6
Santos, D.S.7
De Azevedo Jr., W.F.8
-
50
-
-
0042568725
-
Pharmacophylogenomics: Genes, evolution and drug targets
-
Searls DB. Pharmacophylogenomics: genes, evolution and drug targets. Nat Rev Drug Discov. 2003;2(2):613-23. (Pubitemid 37361765)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.8
, pp. 613-623
-
-
Searls, D.B.1
-
51
-
-
0037449771
-
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis
-
DOI 10.1074/jbc.M209248200
-
Smith CV, Huang CC, Miczak A, Russell DG, Sacchettini JC, Höner zu Bentrup K. Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis. J Biol Chem. 2003;17; 278 (278):1735-43. (Pubitemid 36801408)
-
(2003)
Journal of Biological Chemistry
, vol.278
, Issue.3
, pp. 1735-1743
-
-
Smith, C.V.1
Huang, C.-C.2
Miczak, A.3
Russell, D.G.4
Sacchettini, J.C.5
Honer zu Bentrup, K.6
-
52
-
-
33749558124
-
New light for science: synchrotron radiation in structural medicine
-
DOI 10.1016/j.tibtech.2006.09.006, PII S016777990600240X
-
Sorensen TL, McAuley KE, Flaig R, Duke EM. New light for science: synchrotron radiation in structural medicine. Trends Biotechnol. 2006;24(24):500-8. (Pubitemid 44537458)
-
(2006)
Trends in Biotechnology
, vol.24
, Issue.11
, pp. 500-508
-
-
Sorensen, T.L.-M.1
McAuley, K.E.2
Flaig, R.3
Duke, E.M.H.4
-
53
-
-
33947651030
-
Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis
-
DOI 10.2174/156802607780059781
-
Tonge PJ, Kisker C, Slayden RA. Development of modern InhA inhibitors to combat drug resistant strains of Mycobacterium tuberculosis. Curr Top Med Chem. 2007;7(7):489-98. (Pubitemid 46488289)
-
(2007)
Current Topics in Medicinal Chemistry
, vol.7
, Issue.5
, pp. 489-498
-
-
Tonge, P.J.1
Kisker, C.2
Slayden, R.A.3
-
54
-
-
47049104883
-
Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism
-
Toscano MD, Payne RJ, Chiba A, Kerbarh O, Abell C. Nanomolar inhibition of type II dehydroquinase based on the enolate reaction mechanism. ChemMedChem. 2007;2(2):101-12.
-
(2007)
ChemMedChem
, vol.2
, Issue.2
, pp. 101-112
-
-
Toscano, M.D.1
Payne, R.J.2
Chiba, A.3
Kerbarh, O.4
Abell, C.5
-
55
-
-
0042863345
-
Latent tuberculosis: Mechanisms of host and bacillus that contribute to persistent infection
-
DOI 10.1016/S1473-3099(03)00741-2
-
Tufariello JM, Chan J, Flynn JL. Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection. Lancet Infect Dis. 2003;3(3):578-90. (Pubitemid 37064537)
-
(2003)
Lancet Infectious Diseases
, vol.3
, Issue.9
, pp. 578-590
-
-
Tufariello, J.M.1
Chan, J.2
Flynn, J.L.3
-
56
-
-
41849134287
-
5-tert-butyl-N-pyrazol-4-yl-4,5,6,7-tetrahydrobenzo[d]isoxazole-3- carboxamide derivatives as novel potent inhibitors of Mycobacterium tuberculosis pantothenate synthetase: Initiating a quest for new antitubercular drugs
-
DOI 10.1021/jm701372r
-
Velaparthi S, Brunsteiner M, Uddin R, Wan B, Franzblau SG, Petukhov PA. 5-tert-Butyl-N-pyrazol-4-yl-4, 5, 6, 7-tetrahydrobenzo[d]isoxazole-3-carboxamide Derivatives as Novel Potent Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase: Initiating a Quest for New Antitubercular Drugs. J Med Chem. 2008;51(51):1999-2002. (Pubitemid 351503254)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.7
, pp. 1999-2002
-
-
Velaparthi, S.1
Brunsteiner, M.2
Uddin, R.3
Wan, B.4
Franzblau, S.G.5
Petukhov, P.A.6
-
57
-
-
0034984196
-
The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily
-
DOI 10.1016/S0969-2126(01)00604-9, PII S0969212601006049
-
von Delft F, Lewendon A, Dhanaraj V, Blundell TL, Abell C, Smith AG. The crystal structure of E. coli pantothenate synthetase confirms it as a member of the cytidylyltransferase superfamily. Structure. 2001;9(9):439-50. (Pubitemid 32497271)
-
(2001)
Structure
, vol.9
, Issue.5
, pp. 439-450
-
-
Von Delft, F.1
Lewendon, A.2
Dhanaraj, V.3
Blundell, T.L.4
Abell, C.5
Smith, A.G.6
-
58
-
-
32344437061
-
Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action
-
DOI 10.1021/bi051873e
-
Wang S, Eisenberg D. Crystal structure of the pantothenate synthetase from Mycobacterium tuberculosis, snapshots of the enzyme in action. Biochemistry. 2006;45(45):1554-61. (Pubitemid 43222099)
-
(2006)
Biochemistry
, vol.45
, Issue.6
, pp. 1554-1561
-
-
Wang, S.1
Eisenberg, D.2
-
59
-
-
33846874537
-
A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase
-
DOI 10.1177/1087057106296484
-
White EL, Southworth K, Ross L, Cooley S, Gill RB, Sosa MI, Manouvakhova A, Rasmussen L, Goulding C, Eisenberg D, Fletcher TM 3rd. A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase. J Biomol Screen. 2007;12(12):100-5. (Pubitemid 46224924)
-
(2007)
Journal of Biomolecular Screening
, vol.12
, Issue.1
, pp. 100-105
-
-
White, E.L.1
Southworth, K.2
Ross, L.3
Cooley, S.4
Gill, R.B.5
Sosa, M.I.6
Manouvakhova, A.7
Rasmussen, L.8
Goulding, C.9
Eisenberg, D.10
Fletcher III, T.M.11
-
60
-
-
0003635217
-
-
WHO Report, planning, financing, WHO/HTM/TB/2008.393
-
WHO Report 2008, Global tuberculosis control-surveillance, planning, financing, WHO/HTM/TB/2008.393
-
(2008)
Global Tuberculosis Control-Surveillance
-
-
-
61
-
-
38049084041
-
A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease.
-
Worth CL, Bickerton GR, Schreyer A, Forman JR, Cheng TM, Lee S, Gong S, Burke DF, Blundell TL. A structural bioinformatics approach to the analysis of nonsynonymous single nucleotide polymorphisms (nsSNPs) and their relation to disease., J Bioinform Comput Biol. 2007;5(5):1297-318.
-
(2007)
J. Bioinform Comput. Biol.
, vol.5
, Issue.5
, pp. 1297-1318
-
-
Worth, C.L.1
Bickerton, G.R.2
Schreyer, A.3
Forman, J.R.4
Cheng, T.M.5
Lee, S.6
Gong, S.7
Burke, D.F.8
Blundell, T.L.9
|