Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK/p38 MAPK and p53 activity

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 708, Issue 1-2, 2011, Pages 1-10

  Li, Wei Wei ^a   Gao, Xiu Mei ^b   Wang, Xue Mei ^a   Guo, Hao ^b   Zhang, Bo Li ^a,b  

^a PEKING UNIVERSITY FIRST HOSPITAL   (China)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Alzheimer's disease; Caspase 3; DNA oxidation; Oxidative stress; P53

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA TOCOPHEROL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; DNA; GLUTATHIONE; HYDROGEN PEROXIDE; ICARIIN; JANUS KINASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DAMAGE; CELL DEATH; CELL PROTECTION; CELL STRAIN; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DNA DAMAGE; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NEUROPROTECTION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

ANIMALS; APOPTOSIS; CASPASE 3; CELL SURVIVAL; FLAVONOIDS; HYDROGEN PEROXIDE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PHOSPHORYLATION; RATS;

ANIMALIA; EPIMEDIUM BREVICORNUM;

EID: 79952449960     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.12.017     Document Type: Article

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