A new cytochrome P450 belonging to the 107L subfamily is responsible for the efficient hydroxylation of the drug terfenadine by Streptomyces platensis

Archives of Biochemistry and Biophysics

Volumn 508, Issue 1, 2011, Pages 54-63

  Lombard, Murielle ^a   Salard, Isabelle ^b   Sari, Marie Agnès ^a   Mansuy, Daniel ^a   Buisson, Didier ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b UNIVERSITÉ D EVRY VAL D ESSONNE   (France)

^c MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

Author keywords

Actinomycete; Antihistamine; Biotransformation; CYP107L; CYP2J2; Ferredoxin reductase; Macrolides; Oxidation; P450terf; PikC; Xenobiotics

Indexed keywords

CYTOCHROME P450; CYTOCHROME P450 107L; EBASTINE; FERREDOXIN; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TERFENADINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BIOTRANSFORMATION; DRUG HYDROXYLATION; DRUG OXIDATION; DRUG TRANSFORMATION; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME PURIFICATION; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES; STREPTOMYCES PLATENSIS;

AMINO ACID SEQUENCE; CYTOCHROME P-450 ENZYME SYSTEM; HYDROXYLATION; INTRACELLULAR SPACE; MOLECULAR SEQUENCE DATA; OXIDATION-REDUCTION; SEQUENCE ANALYSIS, DNA; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY; TERFENADINE; XENOBIOTICS;

SPINACIA OLERACEA; STREPTOMYCES; STREPTOMYCES PLATENSIS;

EID: 79952440752     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2011.01.008     Document Type: Article

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