-
2
-
-
84892332537
-
-
Yamada Science Foundation, Japan
-
Sato, R., T. Omura, Y. Imai, and Y. Fujii-Kuriyama (eds) (1987). Cytochrome P450: New trends. Yamada Science Foundation, Japan.
-
(1987)
Cytochrome P450: New Trends.
-
-
Sato, R.1
Omura, T.2
Imai, Y.3
Fujii-Kuriyama, Y.4
-
4
-
-
84892256657
-
-
Academic Press, New York, NY
-
Fleischer, S. and L. Packer (eds) (1978). Methods in Enzymology, Volume 52: Biological Oxidations, Microsomal cytochrome P450, and other hemoprotein systems. Academic Press, New York, NY.
-
(1978)
Methods in Enzymology, Volume 52: Biological Oxidations, Microsomal Cytochrome P450, and Other Hemoprotein Systems.
-
-
Fleischer, S.1
Packer, L.2
-
5
-
-
0345006421
-
-
Academic Press, New York, NY
-
Johnson, E. F. and M. R. Waterman (eds) (1991). Methods in Enzymology, Volume 206: Cytochrome P450, Part A. Academic Press, New York, NY.
-
(1991)
Methods in Enzymology, Volume 206: Cytochrome P450, Part A.
-
-
Johnson, E.F.1
Waterman, M.R.2
-
6
-
-
0345006421
-
-
Academic Press, New York, NY
-
Johnson, E. F. and M. R. Waterman (eds) (1996). Methods in Enzymology, Volume 272: Cytochrome P450, Part B. Academic Press, New York, NY.
-
(1996)
Methods in Enzymology, Volume 272: Cytochrome P450, Part B.
-
-
Johnson, E.F.1
Waterman, M.R.2
-
7
-
-
18644368279
-
-
Academic Press, New York, NY
-
Johnson, E. F. and M. R. Waterman (eds) (2002). Methods in Enzymology, Volume 357: Cytochrome P450, Part C. Academic Press, New York, NY.
-
(2002)
Methods in Enzymology, Volume 357: Cytochrome P450, Part C.
-
-
Johnson, E.F.1
Waterman, M.R.2
-
14
-
-
8044248685
-
Rat hepatic cytochrome P-450: Comparative study of multiple isozymic forms
-
PR. Ortiz de Montellano ed., Plenum Press, New York, NY
-
Waxman, D. J. (1986). Rat hepatic cytochrome P-450: Comparative study of multiple isozymic forms. In PR. Ortiz de Montellano (ed.), Cytochrome P-450. Structure, Mechanism, and Biochemistry. Plenum Press, New York, NY, pp. 525-538.
-
(1986)
Cytochrome P-450. Structure, Mechanism, and Biochemistry.
, pp. 525-538
-
-
Waxman, D.J.1
-
15
-
-
0024236331
-
The molecular biology of cytochrome P450s
-
Gonzalez, F. J. (1989). The molecular biology of cytochrome P450s. Pharmacol. Rev. 40, 243-288.
-
(1989)
Pharmacol. Rev.
, vol.40
, pp. 243-288
-
-
Gonzalez, F.J.1
-
16
-
-
0036227791
-
Update information on human P450s
-
Guengerich, F. P. (2002). Update information on human P450s. Drug Metab. Rev. 34, 7-15.
-
(2002)
Drug Metab. Rev.
, vol.34
, pp. 7-15
-
-
Guengerich, F.P.1
-
17
-
-
0027756106
-
In vitro methods for assessing human hepatic drug metabolism: Their use in drug development
-
Wrighton, S. A., M. Van Den Branden, J. C. Stevens, L. A. Shipley, and B. J. Ring (1993). In vitro methods for assessing human hepatic drug metabolism: Their use in drug development. Drug Metab. Rev. 25, 453-484.
-
(1993)
Drug Metab. Rev.
, vol.25
, pp. 453-484
-
-
Wrighton, S.A.1
Van Den Branden, M.2
Stevens, J.C.3
Shipley, L.A.4
Ring, B.J.5
-
18
-
-
0028858960
-
Cytochrome P450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes
-
Newton, D. J., R. W. Wang, and A. Y. Lu (1995). Cytochrome P450 inhibitors. Evaluation of specificities in the in vitro metabolism of therapeutic agents by human liver microsomes, Drug Metab. Dispos. 23, 154-158.
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 154-158
-
-
Newton, D.J.1
Wang, R.W.2
Lu, A.Y.3
-
19
-
-
9044254525
-
P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature
-
Nelson, D. R., L. Koymans, T. Kamataki, J. J. Stegeman, R. Feyereisen, D. J. Waxman et al. (1996). P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6, 1-42.
-
(1996)
Pharmacogenetics
, vol.6
, pp. 1-42
-
-
Nelson, D.R.1
Koymans, L.2
Kamataki, T.3
Stegeman, J.J.4
Feyereisen, R.5
Waxman, D.J.6
-
20
-
-
0002888510
-
Human cytochrome P450 enzymes
-
P. R. Ortiz de Montellano ed., Plenum Press, New York, NY
-
Guengerich, F. P. (1995). Human cytochrome P450 enzymes. In P. R. Ortiz de Montellano (ed.), Cytochrome P450: Structure, Mechanism and Biochemistry. Plenum Press, New York, NY, pp. 473-574.
-
(1995)
Cytochrome P450: Structure, Mechanism and Biochemistry.
, pp. 473-574
-
-
Guengerich, F.P.1
-
21
-
-
84892246340
-
Human cytochrome P450 enzymes
-
P. R. Ortiz de Montellano ed., Plenum Press, New York, NY
-
Guengerich, F. P. (2004). Human cytochrome P450 enzymes. In, P. R. Ortiz de Montellano (ed.), Cytochrome P450: Structure, Mechanism and Biochemistry. Plenum Press, New York, NY, pp. 370-530.
-
(2004)
Cytochrome P450: Structure, Mechanism and Biochemistry.
, pp. 370-530
-
-
Guengerich, F.P.1
-
22
-
-
0030834058
-
Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
-
Rendic, S. and F. J. Di Carlo (1997). Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab. Rev. 29, 413-580.
-
(1997)
Drug Metab. Rev.
, vol.29
, pp. 413-580
-
-
Rendic, S.1
Di Carlo, F.J.2
-
23
-
-
0036223831
-
Summary of information on human CYP enzymes: Human P450 metabolism data
-
Rendic, S. (2002). Summary of information on human CYP enzymes: Human P450 metabolism data. Drug Metab. Rev. 34, 83-448.
-
(2002)
Drug Metab. Rev.
, vol.34
, pp. 83-448
-
-
Rendic, S.1
-
24
-
-
0038312064
-
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: Study with cDNA-expressed systems of the rat
-
Kobayashi, K., K. Urashima, N. Shimada, and K. Chiba (2003). Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: Study with cDNA-expressed systems of the rat. Drug Metab. Dispos. 31, 833-836.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 833-836
-
-
Kobayashi, K.1
Urashima, K.2
Shimada, N.3
Chiba, K.4
-
25
-
-
0036497073
-
Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed systems of the rat
-
Kobayashi, K., K. Urashima, N. Shimada, and K. Chiba (2002). Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed systems of the rat. Biochem. Pharmacol. 63, 889-896.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 889-896
-
-
Kobayashi, K.1
Urashima, K.2
Shimada, N.3
Chiba, K.4
-
26
-
-
0036893593
-
Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions
-
Yuan, R., S. Madani, X. X. Wei, K. Reynolds, and S. M. Huang (2002). Evaluation of cytochrome P450 probe substrates commonly used by the pharmaceutical industry to study in vitro drug interactions. Drug Metab. Dispos. 30, 1311-1319.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 1311-1319
-
-
Yuan, R.1
Madani, S.2
Wei, X.X.3
Reynolds, K.4
Huang, S.M.5
-
27
-
-
0031962621
-
Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes
-
Eagling, V. A., J. F. Tjia, and D. J. Back (1998). Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes. Br. J. Clin. Pharmacol. 45, 107-114.
-
(1998)
Br. J. Clin. Pharmacol.
, vol.45
, pp. 107-114
-
-
Eagling, V.A.1
Tjia, J.F.2
Back, D.J.3
-
28
-
-
0026537062
-
Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms
-
Fuhr, U, J. Doehmer, N. Battula, C. Wolfel, C. Kudla, Y. Keita et al. (1992). Biotransformation of caffeine and theophylline in mammalian cell lines genetically engineered for expression of single cytochrome P450 isoforms. Biochem. Pharmacol. 43, 225-235.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 225-235
-
-
Fuhr, U.1
Doehmer, J.2
Battula, N.3
Wolfel, C.4
Kudla, C.5
Keita, Y.6
-
29
-
-
0026906604
-
Caffeine as a probe for human cytochromes P450: Validation using cDNA expression, immunoinhibition and microsomal kinetic and inhibitor techniques
-
Tassaneeyakul, W., Z. Mohamed, D. J. Birkett, M. E. McManus, M. E. Verones, R. H. Tukey et al. (1992). Caffeine as a probe for human cytochromes P450: Validation using cDNA expression, immunoinhibition and microsomal kinetic and inhibitor techniques. Pharmacogenetics 2, 173-183.
-
(1992)
Pharmacogenetics
, vol.2
, pp. 173-183
-
-
Tassaneeyakul, W.1
Mohamed, Z.2
Birkett, D.J.3
McManus, M.E.4
Verones, M.E.5
Tukey, R.H.6
-
30
-
-
0027364928
-
Specificity of substrate and inhibitor probes for human cytochromes P450 1 Al and 1A2
-
Tassaneeyakul, W., D. J. Birkett, M. E. Veronese, M. E. McManus, R. H. Tukey, L. C. Quattrochi et al. (1993). Specificity of substrate and inhibitor probes for human cytochromes P450 1 Al and 1A2. J. Pharmacol. Exp. Ther. 265, 401-407.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.265
, pp. 401-407
-
-
Tassaneeyakul, W.1
Birkett, D.J.2
Veronese, M.E.3
McManus, M.E.4
Tukey, R.H.5
Quattrochi, L.C.6
-
31
-
-
0025294782
-
Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man
-
Sesardic, D., A. Boobis, B. Murray, S. Murray, J. Segura, R. De La Torre et al. (1990). Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man. Br. J. Clin. Pharmacol. 29, 651-663.
-
(1990)
Br. J. Clin. Pharmacol.
, vol.29
, pp. 651-663
-
-
Sesardic, D.1
Boobis, A.2
Murray, B.3
Murray, S.4
Segura, J.5
De La Torre, R.6
-
32
-
-
0027380074
-
Isoformselective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline
-
Kunze, K. L. and W. F. Trager (1993). Isoformselective mechanism-based inhibition of human cytochrome P450 1A2 by furafylline. Chem. Res. Toxicol. 6, 649-656.
-
(1993)
Chem. Res. Toxicol.
, vol.6
, pp. 649-656
-
-
Kunze, K.L.1
Trager, W.F.2
-
33
-
-
0028362263
-
Characterization of the inhibition of P4501A2 by furafylline
-
Clarke, S. E., A. D. Ayrton, and R. J. Chenery (1994). Characterization of the inhibition of P4501A2 by furafylline. Xenobiotica 24, 517-526.
-
(1994)
Xenobiotica
, vol.24
, pp. 517-526
-
-
Clarke, S.E.1
Ayrton, A.D.2
Chenery, R.J.3
-
34
-
-
0030094638
-
Theophylline metabolism in human liver microsomes: Inhibition studies
-
Tjia, J. F., J. Colbert, and D. J. Back (1996). Theophylline metabolism in human liver microsomes: Inhibition studies. J. Pharmacol. Exp. Ther. 276, 912-917.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.276
, pp. 912-917
-
-
Tjia, J.F.1
Colbert, J.2
Back, D.J.3
-
35
-
-
0024343858
-
Human cytochrome P-450PIA (P450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines, Proc
-
Butler, M. N., M. Iwasaki, F. P. Guengerich, and F. K. Kadlubar (1989). Human cytochrome P-450PIA (P450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines, Proc. Natl. Acad. Sci. USA, 86, 7696-7700.
-
(1989)
Natl. Acad. Sci. USA
, vol.86
, pp. 7696-7700
-
-
Butler, M.N.1
Iwasaki, M.2
Guengerich, F.P.3
Kadlubar, F.K.4
-
36
-
-
0034687092
-
Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants
-
Yun, C. H., G. P. Miller, and F. P. Guengerich (2000). Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants. Biochemistry 39, 11319-11329.
-
(2000)
Biochemistry
, vol.39
, pp. 11319-11329
-
-
Yun, C.H.1
Miller, G.P.2
Guengerich, F.P.3
-
37
-
-
0031717524
-
Inhibitory monoclonal antibodies to human cytochrome P450 1A2: Analysis of phenacetin O-deethylation in human liver
-
Yang, T. J., Y. Sai, K. W. Krausz, F. J. Gonzalez, and H. V. Gelboin (1998). Inhibitory monoclonal antibodies to human cytochrome P450 1A2: Analysis of phenacetin O-deethylation in human liver. Pharmacogenetics 8, 375-382.
-
(1998)
Pharmacogenetics
, vol.8
, pp. 375-382
-
-
Yang, T.J.1
Sai, Y.2
Krausz, K.W.3
Gonzalez, F.J.4
Gelboin, H.V.5
-
38
-
-
0031785065
-
Comparative inhibition of human cytochrome P450 1A1 and 1A2 by flavonoids
-
Zhai, S., R. Dai, F. K. Friedman, and R. E. Vestal (1998). Comparative inhibition of human cytochrome P450 1A1 and 1A2 by flavonoids. Drug Metab. Dispos. 26, 989-992.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 989-992
-
-
Zhai, S.1
Dai, R.2
Friedman, F.K.3
Vestal, R.E.4
-
39
-
-
0032499398
-
Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids
-
Lee, H., H. Yeom, Y. G. Kim, C. N. Yoon, C. Jin, J. S. Choi et al. (1998). Structure-related inhibition of human hepatic caffeine N3-demethylation by naturally occurring flavonoids. Biochem. Pharmacol. 55, 1369-1375.
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1369-1375
-
-
Lee, H.1
Yeom, H.2
Kim, Y.G.3
Yoon, C.N.4
Jin, C.5
Choi, J.S.6
-
40
-
-
0028106482
-
Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver
-
Burke, M. D., S. Thompson, R. J. Weaver, C. R. Wolf, and R. T. Mayer (1994). Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver. Biochem. Pharmacol. 48, 923-936.
-
(1994)
Biochem. Pharmacol.
, vol.48
, pp. 923-936
-
-
Burke, M.D.1
Thompson, S.2
Weaver, R.J.3
Wolf, C.R.4
Mayer, R.T.5
-
41
-
-
84892287817
-
Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities
-
Rodrigues, A. D. and R. A. Prough (1992). Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities. Meth. Enzymol. 206, 423431.
-
(1992)
Meth. Enzymol.
, vol.206
, pp. 423431
-
-
Rodrigues, A.D.1
Prough, R.A.2
-
42
-
-
0025841777
-
Purification and characterization of human liver microsomal cytochrome P-450 2A6
-
Yun, C. H., T. Shimada, and F. P. Guengerich (1991). Purification and characterization of human liver microsomal cytochrome P-450 2A6. Mol. Pharmacol. 40, 679-685.
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 679-685
-
-
Yun, C.H.1
Shimada, T.2
Guengerich, F.P.3
-
43
-
-
0025022689
-
The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
-
Yamano, S., J. Tatsuno, and F. J. Gonzalez (1990). The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 29, 1322-1329.
-
(1990)
Biochemistry
, vol.29
, pp. 1322-1329
-
-
Yamano, S.1
Tatsuno, J.2
Gonzalez, F.J.3
-
44
-
-
0032812611
-
An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver
-
Sai, Y., T. J. Yang, K. W. Krausz, F. J. Gonzalez, and H. V. Gelboin (1999). An inhibitory monoclonal antibody to human cytochrome P450 2A6 defines its role in the metabolism of coumarin, 7-ethoxycoumarin and 4-nitroanisole in human liver. Pharmacogenetics 9, 229-237.
-
(1999)
Pharmacogenetics
, vol.9
, pp. 229-237
-
-
Sai, Y.1
Yang, T.J.2
Krausz, K.W.3
Gonzalez, F.J.4
Gelboin, H.V.5
-
45
-
-
0035024678
-
Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro
-
Zhang, W., T. Kilicarslan, R. F. Tyndale, and E. M. Sellers (2001). Evaluation of methoxsalen, tranylcypromine, and tryptamine as specific and selective CYP2A6 inhibitors in vitro. Drug Metab. Dispos. 29, 897-902
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 897-902
-
-
Zhang, W.1
Kilicarslan, T.2
Tyndale, R.F.3
Sellers, E.M.4
-
46
-
-
0035119491
-
In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (Tranylcypromine), and its nonamine analog, cyclopropylbenzene
-
Taavitsainen, P., R. Juvonen, and O. Pelkonen (2001). In vitro inhibition of cytochrome P450 enzymes in human liver microsomes by a potent CYP2A6 inhibitor, trans-2-phenylcyclopropylamine (Tranylcypromine), and its nonamine analog, cyclopropylbenzene. Drug Metab. Dispos. 29, 217-222.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 217-222
-
-
Taavitsainen, P.1
Juvonen, R.2
Pelkonen, O.3
-
47
-
-
0031149716
-
Inhibition of coumarin 7-hydroxylase activity in human liver microsomes
-
Draper, A. J., A. Madan, and A. Parkinson (1997). Inhibition of coumarin 7-hydroxylase activity in human liver microsomes. Arch. Biochem. Biophys. 341, 47-61.
-
(1997)
Arch. Biochem. Biophys.
, vol.341
, pp. 47-61
-
-
Draper, A.J.1
Madan, A.2
Parkinson, A.3
-
48
-
-
0031848620
-
(R) - (+) - Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6
-
Khojasteh-Bakht, S. C., L. L. Koenigs, R. M. Peter, W. F. Trager, and S. D. Nelson (1998). (R) - (+) - Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6. Drug Metab. Dispos. 26, 701-704.
-
(1998)
Drug Metab. Dispos.
, vol.26
, pp. 701-704
-
-
Khojasteh-Bakht, S.C.1
Koenigs, L.L.2
Peter, R.M.3
Trager, W.F.4
Nelson, S.D.5
-
49
-
-
0032516469
-
Mechanismbased inactivation of P450 2A6 by furanocoumarins
-
Koenigs, L. L. and W. F. Trager (1998). Mechanismbased inactivation of P450 2A6 by furanocoumarins. Biochemistry 37, 10047-10061.
-
(1998)
Biochemistry
, vol.37
, pp. 10047-10061
-
-
Koenigs, L.L.1
Trager, W.F.2
-
50
-
-
0029833258
-
Catalytic role of cytochrome P450 2B6 in N-demethylation of S-mephenytion
-
Heyn, H., R. B. White, and J. C. Stevens (1996). Catalytic role of cytochrome P450 2B6 in N-demethylation of S-mephenytion. Drug Metab. Dispos. 24, 948-954.
-
(1996)
Drug Metab. Dispos.
, vol.24
, pp. 948-954
-
-
Heyn, H.1
White, R.B.2
Stevens, J.C.3
-
51
-
-
0036647214
-
New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen
-
Stiborova, M., L. Borek-Dohalska, P. Hodek, J. Mraz, and E. Frei (2002). New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen. Arch. Biochem. Biophys. 403, 41-49.
-
(2002)
Arch. Biochem. Biophys.
, vol.403
, pp. 41-49
-
-
Stiborova, M.1
Borek-Dohalska, L.2
Hodek, P.3
Mraz, J.4
Frei, E.5
-
52
-
-
0030822760
-
Examination of purported probes of human CYP2B6
-
Ekins, S., M. Van Den Branden, B. J. Ring, and S. A. Wrighton (1997). Examination of purported probes of human CYP2B6. Pharmacogenetics 7, 165-179.
-
(1997)
Pharmacogenetics
, vol.7
, pp. 165-179
-
-
Ekins, S.1
Van Den Branden, M.2
Ring, B.J.3
Wrighton, S.A.4
-
53
-
-
0032811460
-
The role of CYP2B6 in human xenobiotic metabolism
-
Ekins, S. and S. A. Wrighton (1999). The role of CYP2B6 in human xenobiotic metabolism. Drug Metab. Rev. 31, 719-754.
-
(1999)
Drug Metab. Rev.
, vol.31
, pp. 719-754
-
-
Ekins, S.1
Wrighton, S.A.2
-
54
-
-
0036237885
-
Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism
-
Rae, J. M., N. V. Soukhova, D. A. Flockhart, and Z. Desta (2002). Triethylenethiophosphoramide is a specific inhibitor of cytochrome P450 2B6: Implications for cyclophosphamide metabolism. Drug Metab. Dispos. 30, 525-530.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 525-530
-
-
Rae, J.M.1
Soukhova, N.V.2
Flockhart, D.A.3
Desta, Z.4
-
55
-
-
0033810079
-
Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity
-
Faucette, S. R., R. L. Hawke, E. L. Lecluyse, S. S. Shord, B. Yan, R. M. Laethem et al. (2000). Validation of bupropion hydroxylation as a selective marker of human cytochrome P450 2B6 catalytic activity. Drug Metab. Dispos. 28, 1222-1230.
-
(2000)
Drug Metab. Dispos.
, vol.28
, pp. 1222-1230
-
-
Faucette, S.R.1
Hawke, R.L.2
Lecluyse, E.L.3
Shord, S.S.4
Yan, B.5
Laethem, R.M.6
-
56
-
-
84892324290
-
Clopidogrel and ticlopidine are specific mechanism-based inhibitors of human cytochrome P450 2B6
-
Prague, Czech Republic
-
Richter, T., K. Klein, T. E. Murdter, M. Eichelbaum, M. Schwab, and U. M. Zanger (2003). Clopidogrel and ticlopidine are specific mechanism-based inhibitors of human cytochrome P450 2B6. In Proceedings of the 13th International Conference on Cytochromes P450. Prague, Czech Republic, p. S119.
-
(2003)
Proceedings of the 13th International Conference on Cytochromes P450.
-
-
Richter, T.1
Klein, K.2
Murdter, T.E.3
Eichelbaum, M.4
Schwab, M.5
Zanger, U.M.6
-
57
-
-
0034791777
-
Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid
-
Dai, D., D. C. Zeldin, J. A. Blaisdell, B. Chanas, S. J. Coulter, B. I. Ghanayem et al. (2001). Polymorphisms in human CYP2C8 decrease metabolism of the anticancer drug paclitaxel and arachidonic acid, Pharmacogenetics 11, 597-607.
-
(2001)
Pharmacogenetics
, vol.11
, pp. 597-607
-
-
Dai, D.1
Zeldin, D.C.2
Blaisdell, J.A.3
Chanas, B.4
Coulter, S.J.5
Ghanayem, B.I.6
-
58
-
-
0027957132
-
Metabolism of taxol by human hepatic microsomes and human liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme
-
Harris, J. W., A. Rahman, B. R. Kim, F. P. Guengerich, and J. Collins (1994). Metabolism of taxol by human hepatic microsomes and human liver slices: Participation of cytochrome P450 3A4 and an unknown P450 enzyme. Cancer Res. 54, 4026-4035.
-
(1994)
Cancer Res.
, vol.54
, pp. 4026-4035
-
-
Harris, J.W.1
Rahman, A.2
Kim, B.R.3
Guengerich, F.P.4
Collins, J.5
-
59
-
-
0028036727
-
Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8
-
Rahman, A., K. R. Korzekwa, J. Grogan, F. J. Gonzalez, and J. W. Harris (1994). Selective biotransformation of taxol to 6 alpha-hydroxytaxol by human cytochrome P450 2C8. Cancer Res. 54, 5543-5546.
-
(1994)
Cancer Res.
, vol.54
, pp. 5543-5546
-
-
Rahman, A.1
Korzekwa, K.R.2
Grogan, J.3
Gonzalez, F.J.4
Harris, J.W.5
-
60
-
-
0036266778
-
Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively
-
Wen, X., J. S. Wang, J. T. Backman, J. Laitila, and P. J. Neuvonen (2002). Trimethoprim and sulfamethoxazole are selective inhibitors of CYP2C8 and CYP2C9, respectively. Drug Metab. Dispos. 30, 631-635.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 631-635
-
-
Wen, X.1
Wang, J.S.2
Backman, J.T.3
Laitila, J.4
Neuvonen, P.J.5
-
61
-
-
0038193696
-
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro
-
Wang, J. S. and C. L. De Vane (2003). Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R) - and (S)-methadone in vitro. Drug Metab. Dispos. 31, 742-747.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 742-747
-
-
Wang, J.S.1
De Vane, C.L.2
-
62
-
-
0033048695
-
Roles of human cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac
-
Tang, W, R. A. Stearns, R. W. Wang, S. H. Chiu, and T. A. Baillie (1999). Roles of human cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac. Chem. Res. Toxicol. 12, 192-199.
-
(1999)
Chem. Res. Toxicol.
, vol.12
, pp. 192-199
-
-
Tang, W.1
Stearns, R.A.2
Wang, R.W.3
Chiu, S.H.4
Baillie, T.A.5
-
63
-
-
0027264432
-
Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver
-
Leemann, T, C. Transon, and P. Dayer (1993). Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver. Life Sci. 52, 29-34.
-
(1993)
Life Sci.
, vol.52
, pp. 29-34
-
-
Leemann, T.1
Transon, C.2
Dayer, P.3
-
64
-
-
0026519541
-
Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions
-
Rettie, A. E., K. R. Korzekwa, K. L. Kunze, R. F. Lawrence, A. C. Eddy, T. Aoyama et al. (1992). Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: A role for P-4502C9 in the etiology of (S)-warfarin-drug interactions. Chem. Res. Toxicol. 5, 54-59.
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 54-59
-
-
Rettie, A.E.1
Korzekwa, K.R.2
Kunze, K.L.3
Lawrence, R.F.4
Eddy, A.C.5
Aoyama, T.6
-
65
-
-
0035028935
-
Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: Inhibition by sulfaphenazole, omeprazole, and ticlopidine
-
Giancarlo, G. M., K. Venkatakrishnan, B. W. Granda, L. L. Von Moltke, and D. J. Greenblatt (2001). Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: Inhibition by sulfaphenazole, omeprazole, and ticlopidine. Eur. J. Clin. Pharmacol. 57, 31-36.
-
(2001)
Eur. J. Clin. Pharmacol.
, vol.57
, pp. 31-36
-
-
Giancarlo, G.M.1
Venkatakrishnan, K.2
Granda, B.W.3
Von Moltke, L.L.4
Greenblatt, D.J.5
-
66
-
-
0025014594
-
Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily
-
Relling, M. V, T. Aoyama, F. J. Gonzalez, and U. A. Meyer (1989). Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J. Pharmacol. Exp. Ther. 252, 442-447.
-
(1989)
J. Pharmacol. Exp. Ther.
, vol.252
, pp. 442-447
-
-
Relling, M.V.1
Aoyama, T.2
Gonzalez, F.J.3
Meyer, U.A.4
-
67
-
-
0024354143
-
Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
-
Brian, W. R., P. K. Srivastava, D. R. Umbenhauer, R. S. Lloyd, and F. P. Guengerich (1989). Expression of a human liver cytochrome P-450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae. Biochemistry 28, 4993-4999.
-
(1989)
Biochemistry
, vol.28
, pp. 4993-4999
-
-
Brian, W.R.1
Srivastava, P.K.2
Umbenhauer, D.R.3
Lloyd, R.S.4
Guengerich, F.P.5
-
68
-
-
0025916087
-
Separation of human liver tolbutamine hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes
-
Srivastava, P. K., C. H. Yun, P. H. Beaune, C. Ged, and F. P. Guengerich (1991). Separation of human liver tolbutamine hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. Mol. Pharmacol. 40, 69-79.
-
(1991)
Mol. Pharmacol.
, vol.40
, pp. 69-79
-
-
Srivastava, P.K.1
Yun, C.H.2
Beaune, P.H.3
Ged, C.4
Guengerich, F.P.5
-
69
-
-
0029737485
-
Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9
-
Miners, J. O. and D. J. Birkett (1996). Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9. Meth. Enzymol. 272, 139-145.
-
(1996)
Meth. Enzymol.
, vol.272
, pp. 139-145
-
-
Miners, J.O.1
Birkett, D.J.2
-
70
-
-
0031856787
-
Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylation
-
Lasker, J. M., M. R. Wester, E. Aramsombatdee, and J. L. Raucy (1998). Characterization of CYP2C19 and CYP2C9 from human liver: Respective roles in microsomal tolbutamide, S-mephenytoin, and omeprazole hydroxylation. Arch. Biochem. Biophys. 353, 16-24.
-
(1998)
Arch. Biochem. Biophys.
, vol.353
, pp. 16-24
-
-
Lasker, J.M.1
Wester, M.R.2
Aramsombatdee, E.3
Raucy, J.L.4
-
71
-
-
0028078626
-
Thiophene derivatives as new mechanismbased inhibitors of cytochromes P450: Inactivation of yeast-expressed human liver P450 2C9 by tienilic acid
-
Lopez-Garcia, M. P., P. M. Dansette, and D. Mansuy (1993). Thiophene derivatives as new mechanismbased inhibitors of cytochromes P450: Inactivation of yeast-expressed human liver P450 2C9 by tienilic acid. Biochemistry 33, 166-175.
-
(1993)
Biochemistry
, vol.33
, pp. 166-175
-
-
Lopez-Garcia, M.P.1
Dansette, P.M.2
Mansuy, D.3
-
72
-
-
0027468338
-
Human liver P450s expressed in yeast as tools for reactive metabolite formation studies: Oxidative activation of tienilic acid by P450 2C9 and P450 2C10
-
Lopez-Garcia, M. R, P. M. Dansette, P. Valadon, C. Amar, P. H. Beaune, F. P. Guengerich et al. (1993). Human liver P450s expressed in yeast as tools for reactive metabolite formation studies: Oxidative activation of tienilic acid by P450 2C9 and P450 2C10. Eur. J. Biochem. 213, 223-232.
-
(1993)
Eur. J. Biochem.
, vol.213
, pp. 223-232
-
-
Lopez-Garcia, M.R.1
Dansette, P.M.2
Valadon, P.3
Amar, C.4
Beaune, P.H.5
Guengerich, F.P.6
-
73
-
-
0022574425
-
Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction
-
Shimada, T., K. S. Misono, and F. P. Guengerich (1986). Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J. Biol. Chem. 261, 909-921.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 909-921
-
-
Shimada, T.1
Misono, K.S.2
Guengerich, F.P.3
-
74
-
-
0024439393
-
Warfarin as a probe of cytochromes P450 function
-
Kaminsky, L. S. (1989). Warfarin as a probe of cytochromes P450 function. Drug Metab. Rev. 20, 479-487.
-
(1989)
Drug Metab. Rev.
, vol.20
, pp. 479-487
-
-
Kaminsky, L.S.1
-
75
-
-
0019741894
-
Production and application of antibodies to rat liver cytochrome P-450
-
Kaminsky, L. S., M. J. Fasco, and F. P. Guengerich (1981). Production and application of antibodies to rat liver cytochrome P-450. Meth. Enzymol. 74, 262-272.
-
(1981)
Meth. Enzymol.
, vol.74
, pp. 262-272
-
-
Kaminsky, L.S.1
Fasco, M.J.2
Guengerich, F.P.3
-
76
-
-
0028858604
-
Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P-4502C9 activity
-
Lang, D. and R. Bocker (1995). Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P-4502C9 activity. J. Chromatogr. Biomed. Appl. 672, 305-309.
-
(1995)
J. Chromatogr. Biomed. Appl.
, vol.672
, pp. 305-309
-
-
Lang, D.1
Bocker, R.2
-
77
-
-
0033564329
-
Comparison of the substrate specificities of human liver cytochrome P450s 2C9 and 2C18: Application to the design of a specific substrate of CYP 2C18
-
Minoletti, C., S. Dijols, P. M. Dansette, and D. Mansuy (1999). Comparison of the substrate specificities of human liver cytochrome P450s 2C9 and 2C18: Application to the design of a specific substrate of CYP 2C18. Biochemistry 38, 7828-7836.
-
(1999)
Biochemistry
, vol.38
, pp. 7828-7836
-
-
Minoletti, C.1
Dijols, S.2
Dansette, P.M.3
Mansuy, D.4
-
78
-
-
0035887069
-
Interaction of new sulfaphenazole derivatives with human liver cytochrome P450 2Cs: Structural determinants required for selective recognition by CYP 2C9 and for inhibition of human CYP 2Cs
-
Ha-Duong, N. T., C. Marques-Soares, S. Dijols, M. A. Sari, P. M. Dansette, and D. Mansuy Interaction of new sulfaphenazole derivatives with human liver cytochrome P450 2Cs: Structural determinants required for selective recognition by CYP 2C9 and for inhibition of human CYP 2Cs. Arch. Biochem. Biophys. 394, 189-200.
-
Arch. Biochem. Biophys.
, vol.394
, pp. 189-200
-
-
Ha-Duong, N.T.1
Marques-Soares, C.2
Dijols, S.3
Sari, M.A.4
Dansette, P.M.5
Mansuy, D.6
-
79
-
-
0027445449
-
Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation
-
Wrighton, S. A., J. C. Stevens, G. W. Becker, and M. Van Den Branden (1993). Isolation and characterization of human liver cytochrome P450 2C19: Correlation between 2C19 and S-mephenytoin 4'-hydroxylation. Arch. Biochem. Biophys. 306, 240-245.
-
(1993)
Arch. Biochem. Biophys.
, vol.306
, pp. 240-245
-
-
Wrighton, S.A.1
Stevens, J.C.2
Becker, G.W.3
Van Den Branden, M.4
-
80
-
-
0028279041
-
Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans
-
Goldstein, J. A., M. B. Faletto, M. Romkes-Sparks, T. Sullivan, S. Kitareewan, J. L. Raucy et al. (1994). Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans. Biochemistry 33, 1743-1752.
-
(1994)
Biochemistry
, vol.33
, pp. 1743-1752
-
-
Goldstein, J.A.1
Faletto, M.B.2
Romkes-Sparks, M.3
Sullivan, T.4
Kitareewan, S.5
Raucy, J.L.6
-
81
-
-
0036179579
-
(+)-N-3-Benzylnirvanol and (-)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19
-
Suzuki, H., M. B. Kneller, R. L. Haining, and W. F. Trager, A. E. Rettie (2002). (+)-N-3-Benzylnirvanol and (-)-N-3-benzyl-phenobarbital: New potent and selective in vitro inhibitors of CYP2C19. Drug Metab. Dispos. 30, 235-239.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 235-239
-
-
Suzuki, H.1
Kneller, M.B.2
Haining, R.L.3
Trager, W.F.4
Rettie, A.E.5
-
82
-
-
0037369493
-
Verification of the selectivity of (+) N-3-benzylnirvanol as a CYP2C19 inhibitor
-
Walsky, R. L. and R. S. Obach (2003). Verification of the selectivity of (+) N-3-benzylnirvanol as a CYP2C19 inhibitor. Drug Metab. Dispos. 31, 343.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 343
-
-
Walsky, R.L.1
Obach, R.S.2
-
83
-
-
0035834052
-
Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19
-
Ha-Duong, NT., S. Dijols, A. C. Macherey, J. A. Goldstein, P. M. Dansette, and D. Mansuy (2001). Ticlopidine as a selective mechanism-based inhibitor of human cytochrome P450 2C19. Biochemistry 40, 12112-12122.
-
(2001)
Biochemistry
, vol.40
, pp. 12112-12122
-
-
Ha-Duong, N.T.1
Dijols, S.2
Macherey, A.C.3
Goldstein, J.A.4
Dansette, P.M.5
Mansuy, D.6
-
84
-
-
0035699870
-
Inhibition by ticlopidine and its derivatives of human liver cytochrome P450. Mechanism-based inactivation of CYP 2C19 by ticlopidine
-
Ha-Duong, N. T., S. Dijols, A. C. Macherey, P. M. Dansette, and D. Mansuy (2001). Inhibition by ticlopidine and its derivatives of human liver cytochrome P450. Mechanism-based inactivation of CYP 2C19 by ticlopidine. Adv. Exp. Med. Biol. 500, 145-148.
-
(2001)
Adv. Exp. Med. Biol.
, vol.500
, pp. 145-148
-
-
Ha-Duong, N.T.1
Dijols, S.2
Macherey, A.C.3
Dansette, P.M.4
Mansuy, D.5
-
85
-
-
0023154962
-
Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism
-
Gonzalez, F. J., T. Matsunaga, K. Nagata, U. A. Meyer, D. W. Nebert, J. Pastewka et al. (1987). Debrisoquine 4-hydroxylase: Characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism. DNA 6, 149-161.
-
(1987)
DNA
, vol.6
, pp. 149-161
-
-
Gonzalez, F.J.1
Matsunaga, T.2
Nagata, K.3
Meyer, U.A.4
Nebert, D.W.5
Pastewka, J.6
-
86
-
-
0022980052
-
Debrisoquine/sparteinetype polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol
-
Gut, J., T. Catin, P. Dayer, T. Kronbach, U. Zanger, and U. A. Meyer (1986). Debrisoquine/sparteinetype polymorphism of drug oxidation. Purification and characterization of two functionally different human liver cytochrome P-450 isozymes involved in impaired hydroxylation of the prototype substrate bufuralol. J. Biol. Chem. 261, 11734-11743.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 11734-11743
-
-
Gut, J.1
Catin, T.2
Dayer, P.3
Kronbach, T.4
Zanger, U.5
Meyer, U.A.6
-
87
-
-
0026324040
-
Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6
-
Kronbach, T. (1991). Bufuralol, dextromethorphan, and debrisoquine as prototype substrates for human P450IID6. Meth. Enzymol. 206, 509-517.
-
(1991)
Meth. Enzymol.
, vol.206
, pp. 509-517
-
-
Kronbach, T.1
-
88
-
-
0021345446
-
Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs
-
Otton, S. V., T. Inaba, and W. Kalow (1984). Competitive inhibition of sparteine oxidation in human liver by beta-adrenoceptor antagonists and other cardiovascular drugs. Life Sci. 34, 73-80.
-
(1984)
Life Sci.
, vol.34
, pp. 73-80
-
-
Otton, S.V.1
Inaba, T.2
Kalow, W.3
-
89
-
-
0037369622
-
Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: Comparison with fluoxetine and quinidine
-
Bertelsen, K. M., K. Venkatakrishnan, L. L. Von Moltke, R. S. Obach, and D. J. Greenblatt (2003). Apparent mechanism-based inhibition of human CYP2D6 in vitro by paroxetine: Comparison with fluoxetine and quinidine. Drug Metab. Dispos. 31, 289-293.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 289-293
-
-
Bertelsen, K.M.1
Venkatakrishnan, K.2
Von Moltke, L.L.3
Obach, R.S.4
Greenblatt, D.J.5
-
90
-
-
0026568846
-
The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes
-
Bloomer, J. C., F. R. Woods, R. E. Haddock, M. S. Lennard, and G. T. Tucker (1992). The role of cytochrome P4502D6 in the metabolism of paroxetine by human liver microsomes. Br. J. Clin. Pharmacol. 33, 521-523.
-
(1992)
Br. J. Clin. Pharmacol.
, vol.33
, pp. 521-523
-
-
Bloomer, J.C.1
Woods, F.R.2
Haddock, R.E.3
Lennard, M.S.4
Tucker, G.T.5
-
91
-
-
0026576928
-
Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism
-
Sindrup, S. H., K. Brosen, and L. F. Gram (1992). Pharmacokinetics of the selective serotonin reuptake inhibitor paroxetine: Nonlinearity and relation to the sparteine oxidation polymorphism. Clin. Pharmacol. Ther. 51, 288-295.
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 288-295
-
-
Sindrup, S.H.1
Brosen, K.2
Gram, L.F.3
-
92
-
-
0026606822
-
The relationship between paroxetine and the sparteine oxidation polymorphism
-
Sindrup, S. H., K. Brosen, L. F. Gram, J. Hallas, E. Skjelbo, A. Allen et al. (1992). The relationship between paroxetine and the sparteine oxidation polymorphism. Clin. Pharmacol. Ther. 51, 278-287.
-
(1992)
Clin. Pharmacol. Ther.
, vol.51
, pp. 278-287
-
-
Sindrup, S.H.1
Brosen, K.2
Gram, L.F.3
Hallas, J.4
Skjelbo, E.5
Allen, A.6
-
93
-
-
0024557660
-
Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 dbl activity
-
Dayer, P., T. Leemann, and R. Striberni (1989). Dextromethorphan O-demethylation in liver microsomes as a prototype reaction to monitor cytochrome P-450 dbl activity. Clin. Pharmacol. Ther. 45, 34-40.
-
(1989)
Clin. Pharmacol. Ther.
, vol.45
, pp. 34-40
-
-
Dayer, P.1
Leemann, T.2
Striberni, R.3
-
94
-
-
0029774120
-
14C]dextromethorphan as substrate
-
14C]dextromethorphan as substrate. Meth. Enzymol. 272, 186-195.
-
(1996)
Meth. Enzymol.
, vol.272
, pp. 186-195
-
-
Rodrigues, A.D.1
-
95
-
-
0034998765
-
Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1 H-imidazol-5-yl) methyl]-l-piperazinyl]pyrimidine
-
Palamanda, J. R., C. N. Casciano, L. A. Norton, R. P. Clement, L. V. Favreau, C. Lin et al. (2001). Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1 H-imidazol-5-yl) methyl]-l-piperazinyl]pyrimidine. Drug Metab. Dispos. 29, 863-867.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 863-867
-
-
Palamanda, J.R.1
Casciano, C.N.2
Norton, L.A.3
Clement, R.P.4
Favreau, L.V.5
Lin, C.6
-
96
-
-
0028918999
-
Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation
-
Yamazaki, H., Z. Guo, and F. P. Guengerich (1995). Selectivity of cytochrome P4502E1 in chlorzoxazone 6-hydroxylation. Drug Metab. Dispos. 23, 438-440.
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 438-440
-
-
Yamazaki, H.1
Guo, Z.2
Guengerich, F.P.3
-
97
-
-
0025223625
-
Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1
-
Peter, R., R. Bocker, P. H. Beaune, M. Iwasaki, F. P. Guengerich, and C. S. Yang (1990). Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1. Chem. Res. Toxicol. 3, 566-573.
-
(1990)
Chem. Res. Toxicol.
, vol.3
, pp. 566-573
-
-
Peter, R.1
Bocker, R.2
Beaune, P.H.3
Iwasaki, M.4
Guengerich, F.P.5
Yang, C.S.6
-
98
-
-
0025857783
-
Erratum
-
Erratum in: Chem. Res. Toxicol. 4, 389, 1991.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 389
-
-
-
99
-
-
0022852729
-
Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro. Increased effectiveness after induction by pyrazole and 4-methylpyrazole
-
Feierman, D. E. and A. I. Cederbaum (1986). Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro. Increased effectiveness after induction by pyrazole and 4-methylpyrazole. Biochem. J. 239, 671-677.
-
(1986)
Biochem. J.
, vol.239
, pp. 671-677
-
-
Feierman, D.E.1
Cederbaum, A.I.2
-
100
-
-
0026319304
-
Induction, purification, and characterization of cytochrome P450IIE1
-
Yang, C. S., C. J. Patten, H. Ishizaki, and J. S. H. Yoo (1992). Induction, purification, and characterization of cytochrome P450IIE1. Meth. Enzymol. 206, 595-603.
-
(1992)
Meth. Enzymol.
, vol.206
, pp. 595-603
-
-
Yang, C.S.1
Patten, C.J.2
Ishizaki, H.3
Yoo, J.S.H.4
-
101
-
-
0027487006
-
Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques
-
Tassaneeyakul, W., M. E. Veronese, D. J. Birkett, F. J. Gonzalez, and J. O. Miners (1993). Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques. Biochem. Pharmacol. 46, 1975-1981.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1975-1981
-
-
Tassaneeyakul, W.1
Veronese, M.E.2
Birkett, D.J.3
Gonzalez, F.J.4
Miners, J.O.5
-
102
-
-
0026035519
-
Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects
-
Guengerich, F. P., D. H. Kim, and M. Iwasaki (1991). Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 4, 168-179.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 168-179
-
-
Guengerich, F.P.1
Kim, D.H.2
Iwasaki, M.3
-
103
-
-
0032977948
-
Lack of singledose disulfiram effects on cytochrome P-450 2C 9, 2C 19, 2D6, and 3A4 activities: Evidence for specificity toward P-450 2E1
-
Kharasch, E. D., D. C. Hankins, C. Jubert, K. E. Thummel, and J. K. Taraday (1999). Lack of singledose disulfiram effects on cytochrome P-450 2C 9, 2C 19, 2D6, and 3A4 activities: Evidence for specificity toward P-450 2E1. Drug Metab. Dispos. 27, 717-723.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 717-723
-
-
Kharasch, E.D.1
Hankins, D.C.2
Jubert, C.3
Thummel, K.E.4
Taraday, J.K.5
-
104
-
-
0028174881
-
Evaluation of triacetyloleandomycin, α-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450
-
Chang, T. K. H., F. J. Gonzalez, and D. J. Waxman (1994). Evaluation of triacetyloleandomycin, α-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. Arch. Biochem. Biophys. 311, 437-442.
-
(1994)
Arch. Biochem. Biophys.
, vol.311
, pp. 437-442
-
-
Chang, T.K.H.1
Gonzalez, F.J.2
Waxman, D.J.3
-
105
-
-
0022975115
-
Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase
-
Wrighton, S. A., P. E. Thomas, D. T. Molowa, M. Haniu, J. E. Shively, S. L. Maines et al. (1986). Characterization of ethanol-inducible human liver N-nitrosodimethylamine demethylase. Biochemistry 25, 6731-6735.
-
(1986)
Biochemistry
, vol.25
, pp. 6731-6735
-
-
Wrighton, S.A.1
Thomas, P.E.2
Molowa, D.T.3
Haniu, M.4
Shively, J.E.5
Maines, S.L.6
-
106
-
-
0023877321
-
Metabolism of N-nitrosodialkylamines by human liver microsomes
-
Yoo, J. S., F. P. Guengerich, and C. S. Yang (1988). Metabolism of N-nitrosodialkylamines by human liver microsomes. Cancer Res. 48, 1499-1504.
-
(1988)
Cancer Res.
, vol.48
, pp. 1499-1504
-
-
Yoo, J.S.1
Guengerich, F.P.2
Yang, C.S.3
-
107
-
-
0026744568
-
Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes
-
Yamazaki, H., Y. Inui, C. H. Yun, M. Mimura, F. R. Guengerich, and T. Shimada (1992). Cytochrome P450 2E1 and 2A6 enzymes as major catalysts for metabolic activation of N-nitrosodialkylamines and tobacco-related nitrosamines in human liver microsomes. Carcinogenesis 13, 1789-1794.
-
(1992)
Carcinogenesis
, vol.13
, pp. 1789-1794
-
-
Yamazaki, H.1
Inui, Y.2
Yun, C.H.3
Mimura, M.4
Guengerich, F.R.5
Shimada, T.6
-
108
-
-
0026691523
-
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009)
-
Yamazaki, H., Y. Oda, Y. Funae, S. Imaoka, Y. Inui, F. P. Guengerich et al. (1992). Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). Carcinogenesis 13, 979-985.
-
(1992)
Carcinogenesis
, vol.13
, pp. 979-985
-
-
Yamazaki, H.1
Oda, Y.Y.F.2
Imaoka, S.3
Inui, Y.4
Guengerich, F.P.5
-
109
-
-
0023929834
-
Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme
-
Waxman, D. J., C. Attisano, F. P. Guengerich, and D. P. Lapenson (1988). Human liver microsomal steroid metabolism: Identification of the major microsomal steroid hormone 6 beta-hydroxylase cytochrome P-450 enzyme. Arch. Biochem. Biophys. 263, 424-436.
-
(1988)
Arch. Biochem. Biophys.
, vol.263
, pp. 424-436
-
-
Waxman, D.J.1
Attisano, C.2
Guengerich, F.P.3
Lapenson, D.P.4
-
110
-
-
0027223881
-
Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme
-
Gillam, E. M., T. Baba, B. R. Kim, S. Ohmori, and F. P. Guengerich (1993). Expression of modified human cytochrome P450 3A4 in Escherichia coli and purification and reconstitution of the enzyme. Arch. Biochem. Biophys. 305, 123-131.
-
(1993)
Arch. Biochem. Biophys.
, vol.305
, pp. 123-131
-
-
Gillam, E.M.1
Baba, T.2
Kim, B.R.3
Ohmori, S.4
Guengerich, F.P.5
-
111
-
-
0025184340
-
Mechanism-based inactivation of human liver cytochrome P-450 IIIA4 by gestodene
-
Guengerich, F. P. (1990). Mechanism-based inactivation of human liver cytochrome P-450 IIIA4 by gestodene. Chem. Res. Toxicol. 3, 363-371.
-
(1990)
Chem. Res. Toxicol.
, vol.3
, pp. 363-371
-
-
Guengerich, F.P.1
-
112
-
-
0022998708
-
Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism
-
Guengerich, F. P., M. V. Martin, P. H. Beaune, P. Kremers, T. Wolff, and D. J. Waxman (1986). Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. J. Biol. Chem. 261, 5051-5060.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 5051-5060
-
-
Guengerich, F.P.1
Martin, M.V.2
Beaune, P.H.3
Kremers, P.4
Wolff, T.5
Waxman, D.J.6
-
113
-
-
0023858226
-
Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
-
Gonzalez, F. J., B. J. Schmid, M. Umeno, O. W. Mcbride, J. P. Hardwick, U. A. Meyer et al. (1988). Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 7, 79-86.
-
(1988)
DNA
, vol.7
, pp. 79-86
-
-
Gonzalez, F.J.1
Schmid, B.J.2
Umeno, M.3
Mcbride, O.W.4
Hardwick, J.P.5
Meyer, U.A.6
-
114
-
-
0025860978
-
Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 II1A4
-
Guengerich, F. P, W. R. Brian, M. Iwasaki, M. A. Sari, C. Bäärnhielm, and P. Berntsson (1991). Oxidation of dihydropyridine calcium channel blockers and analogues by human liver cytochrome P-450 II1A4. J. Med. Chem. 34, 1838-1844.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1838-1844
-
-
Guengerich, F.P.1
Brian, W.R.2
Iwasaki, M.3
Sari, M.A.4
Bäärnhielm, C.5
Berntsson, P.6
-
115
-
-
0028568243
-
Oral triazolam is potentially hazardous to patients receiving systemic antimycotics
-
Varhe, A., M. B. Klaus, T. Olkkola, and P. J. Neuvonen (1994). Oral triazolam is potentially hazardous to patients receiving systemic antimycotics. Clin. Pharmacol. Then 56, 601-607.
-
(1994)
Clin. Pharmacol. Then
, vol.56
, pp. 601-607
-
-
Varhe, A.1
Klaus, M.B.2
Olkkola, T.3
Neuvonen, P.J.4
-
116
-
-
0041301863
-
Identification of an inducible form of cytochrome P-450 in human liver
-
Watkins, P. B., S. A. Wrighton, P. Maurel, E. G. Schuetz, G. Mendez-Picon, G. A. Parker et al. (1985). Identification of an inducible form of cytochrome P-450 in human liver. Proc. Natl. Acad. Sci. USA 82, 6310-6314.
-
(1985)
Proc. Natl. Acad. Sci. USA
, vol.82
, pp. 6310-6314
-
-
Watkins, P.B.1
Wrighton, S.A.2
Maurel, P.3
Schuetz, E.G.4
Mendez-Picon, G.5
Parker, G.A.6
-
117
-
-
0024556650
-
Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450
-
Watkins, P. B., S. A. Murray, L. G. Winkelman, D. M. Heuman, S. A. Wrighton, and P. S. Guzelian (1989). Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. J. Clin. Invest. 83, 688-697.
-
(1989)
J. Clin. Invest.
, vol.83
, pp. 688-697
-
-
Watkins, P.B.1
Murray, S.A.2
Winkelman, L.G.3
Heuman, D.M.4
Wrighton, S.A.5
Guzelian, P.S.6
-
118
-
-
0027253615
-
Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4
-
Thummel, K. E., C. A. Lee, K. L. Kunze, S. D. Nelson, and J. T. Slattery (1993). Oxidation of acetaminophen to N-acetyl-p-aminobenzoquinone imine by human CYP3A4. Biochem. Pharmacol. 45, 1563-1569.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 1563-1569
-
-
Thummel, K.E.1
Lee, C.A.2
Kunze, K.L.3
Nelson, S.D.4
Slattery, J.T.5
-
119
-
-
0025670512
-
Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme
-
Renaud, J. P., C. Cullin, D. Pompon, P. Beaune, and D. Mansuy (1990). Expression of human liver cytochrome P450 IIIA4 in yeast. A functional model for the hepatic enzyme. Eur. J. Biochem. 194:889-896.
-
(1990)
Eur. J. Biochem.
, vol.194
, pp. 889-896
-
-
Renaud, J.P.1
Cullin, C.2
Pompon, D.3
Beaune, P.4
Mansuy, D.5
-
120
-
-
0024373348
-
Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4
-
Kronbach, T., D. Mathys, M. Umeno, F. J. Gonzalez, and U. A. Meyer (1989). Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol. Pharmacol. 36, 89-96.
-
(1989)
Mol. Pharmacol.
, vol.36
, pp. 89-96
-
-
Kronbach, T.1
Mathys, D.2
Umeno, M.3
Gonzalez, F.J.4
Meyer, U.A.5
-
121
-
-
0028114619
-
Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients
-
Thummel, K. E., D. D. Shen, T. D. Podoll, K. L. Kunze, W. F. Trager, P. S. Hartwell et al. (1994). Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients. J. Pharmacol. Exp. Ther. 271, 549-556.
-
(1994)
J. Pharmacol. Exp. Ther.
, vol.271
, pp. 549-556
-
-
Thummel, K.E.1
Shen, D.D.2
Podoll, T.D.3
Kunze, K.L.4
Trager, W.F.5
Hartwell, P.S.6
-
122
-
-
84892227407
-
Azamulin is superior to ketoconazole as a selective CYP3A inhibitor probe
-
Abstracts from the 11th North American 1SSX Meeting, Orlando, FL, USA, Oct. 27-Oct. 31, Abs. 355
-
Stresser, M. D., M. I. Broudy, S. S. Dehal, C. J. Patten, and C. L. Crespi (2002). Azamulin is superior to ketoconazole as a selective CYP3A inhibitor probe. Drug Metab. Rev. Abstracts from the 11th North American 1SSX Meeting, Orlando, FL, USA, Oct. 27-Oct. 31, Vol. 34, Abs. 355, p. 178.
-
(2002)
Drug Metab. Rev.
, vol.34
, pp. 178
-
-
Stresser, M.D.1
Broudy, M.I.2
Dehal, S.S.3
Patten, C.J.4
Crespi, C.L.5
-
123
-
-
0030582402
-
Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes
-
Jang, G. R., S. A. Wrighton, and L. Z. Benet (1996). Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochem. Pharmacol. 52, 753-761.
-
(1996)
Biochem. Pharmacol.
, vol.52
, pp. 753-761
-
-
Jang, G.R.1
Wrighton, S.A.2
Benet, L.Z.3
-
124
-
-
0033061072
-
Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486)
-
He, K., T. F. Woolf, and P. F. Hollenberg (1999). Mechanism-based inactivation of cytochrome P-450-3A4 by mifepristone (RU486). J. Pharmacol. Exp. Ther. 288, 791-797.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.288
, pp. 791-797
-
-
He, K.1
Woolf, T.F.2
Hollenberg, P.F.3
-
125
-
-
0036707616
-
Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: Selective inactivation of P450 3A4
-
Khan, K. K., Y. Q. He, M. A. Correia, and J. R. Halpert (2002). Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: Selective inactivation of P450 3A4. Drug Metab. Dispos. 30, 985-990.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 985-990
-
-
Khan, K.K.1
He, Y.Q.2
Correia, M.A.3
Halpert, J.R.4
-
126
-
-
0032773854
-
Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation
-
Jones, D. R., J. C. Gorski, M. A. Hamman, B. S. Mayhew, S. Rider, and S. D. Hall (1999). Diltiazem inhibition of cytochrome P-450 3A activity is due to metabolite intermediate complex formation. J. Pharmacol. Exp. Ther. 290, 1116-1125.
-
(1999)
J. Pharmacol. Exp. Ther.
, vol.290
, pp. 1116-1125
-
-
Jones, D.R.1
Gorski, J.C.2
Hamman, M.A.3
Mayhew, B.S.4
Rider, S.5
Hall, S.D.6
-
127
-
-
0025161416
-
Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)
-
Wrighton, S. A., W. R. Brian, M. A. Sari, M. Iwasaki, F. P. Guengerich, J. L. Raucy et al. (1990). Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3). Mol. Pharmacol. 38, 207-213.
-
(1990)
Mol. Pharmacol.
, vol.38
, pp. 207-213
-
-
Wrighton, S.A.1
Brian, W.R.2
Sari, M.A.3
Iwasaki, M.4
Guengerich, F.P.5
Raucy, J.L.6
-
128
-
-
0028912205
-
Expression of cytochrome P450 3A5 in Escherichia coli: Effects of 5' modification, purification, spectral characterization, reconstitution conditions, and catalytic activities
-
Gillam, E. M., Z. Guo, Y. F. Ueng, H. Yamazaki, I. Cock, P. E. Reilly et al. (1995). Expression of cytochrome P450 3A5 in Escherichia coli: Effects of 5' modification, purification, spectral characterization, reconstitution conditions, and catalytic activities. Arch. Biochem. Biophys. 317, 374-384.
-
(1995)
Arch. Biochem. Biophys.
, vol.317
, pp. 374-384
-
-
Gillam, E.M.1
Guo, Z.2
Ueng, Y.F.3
Yamazaki, H.4
Cock, I.5
Reilly, P.E.6
-
129
-
-
85030134509
-
Erratum
-
Erratum in: Arch. Biochem. Biophys. 318, 498, 1995.
-
(1995)
Arch. Biochem. Biophys.
, vol.318
, pp. 498
-
-
-
130
-
-
0028234586
-
Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily
-
Gorski, J. C., S. D. Hall, D. R. Jones, M. Van Den Branden, and S. A. Wrighton (1994). Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily. Biochem. Pharmacol. 47, 1643-1653.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 1643-1653
-
-
Gorski, J.C.1
Hall, S.D.2
Jones, D.R.3
Vanden Branden, M.4
Wrighton, S.A.5
-
131
-
-
0032829243
-
Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily
-
Gorski, J. C, D. R. Jones, M. A. Hamman, S. A. Wrighton, and S. D. Hall (1999). Biotransformation of alprazolam by members of the human cytochrome P4503A subfamily. Xenobiotica 29, 931-944.
-
(1999)
Xenobiotica
, vol.29
, pp. 931-944
-
-
Gorski, J.C.1
Jones, D.R.2
Hamman, M.A.3
Wrighton, S.A.4
Hall, S.D.5
-
132
-
-
0036320872
-
Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7
-
Williams, J. A., B. J. Ring, V. E. Cantrell, D. R. Jones, J. Eckstein, K. Ruterbories et al. (2002). Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7. Drug Metab. Dispos. 30, 883-891.
-
(2002)
Drug Metab. Dispos.
, vol.30
, pp. 883-891
-
-
Williams, J.A.1
Ring, B.J.2
Cantrell, V.E.3
Jones, D.R.4
Eckstein, J.5
Ruterbories, K.6
-
133
-
-
0038101411
-
Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies
-
Parimoo, B., V. M. Mishin, C. M. Busch, and P. E. Thomas (2003). Identification of epitopes on cytochrome P450 3A4/5 recognized by monoclonal antibodies. Arch. Biochem. Biophys. 414, 244-254.
-
(2003)
Arch. Biochem. Biophys.
, vol.414
, pp. 244-254
-
-
Parimoo, B.1
Mishin, V.M.2
Busch, C.M.3
Thomas, P.E.4
-
134
-
-
0023200455
-
P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate
-
Kitada, M., T. Kamataki, K. Itahashi, T. Rikihisa, and Y. Kanakubo (1987). P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate. J. Biol. Chem. 262, 13534-13537.
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 13534-13537
-
-
Kitada, M.1
Kamataki, T.2
Itahashi, K.3
Rikihisa, T.4
Kanakubo, Y.5
-
135
-
-
0242276321
-
CYP3A4 and CYP3A7-mediated carbamazepine 10, 11-epoxidation are activated by differential endogenous steroids
-
Nakamura, H., N. Torimoto, I. Ishii, N. Ariyoshi, H. Nakasa, S. Ohmori et al. (2003). CYP3A4 and CYP3A7-mediated carbamazepine 10, 11-epoxidation are activated by differential endogenous steroids. Drug Metab. Dispos. 31, 432-438.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 432-438
-
-
Nakamura, H.1
Torimoto, N.2
Ishii, I.3
Ariyoshi, N.4
Nakasa, H.5
Ohmori, S.6
-
136
-
-
0031259757
-
Expression of cytochrome P450 3A7 in Escherichia coll. Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase
-
Gillam, E. M., R. M. Wunsch, Y. F. Ueng, T. Shimada, P. E. Reilly, T. Kamataki et al. (1997). Expression of cytochrome P450 3A7 in Escherichia coll. Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase. Arch. Biochem. Biophys. 346, 81-90.
-
(1997)
Arch. Biochem. Biophys.
, vol.346
, pp. 81-90
-
-
Gillam, E.M.1
Wunsch, R.M.2
Ueng, Y.F.3
Shimada, T.4
Reilly, P.E.5
Kamataki, T.6
-
137
-
-
0027931396
-
Purification and cDNA cloning of human liver CYP4A fatty acid ω-hydroxylase
-
Kawashima, H., E. Kusunose, Y. Kikuta, H. Kinoshita, S. Tanaka, S. Yamamoto et al. (1994). Purification and cDNA cloning of human liver CYP4A fatty acid ω-hydroxylase. J. Biochem. 116, 74-80.
-
(1994)
J. Biochem.
, vol.116
, pp. 74-80
-
-
Kawashima, H.1
Kusunose, E.2
Kikuta, Y.3
Kinoshita, H.4
Tanaka, S.5
Yamamoto, S.6
-
138
-
-
0030297422
-
Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes
-
Powell, P. K., I. Wolf, and J. M. Lasker (1996). Identification of CYP4A11 as the major lauric acid omega-hydroxylase in human liver microsomes. Arch. Biochem. Biophys. 335, 219-226.
-
(1996)
Arch. Biochem. Biophys.
, vol.335
, pp. 219-226
-
-
Powell, P.K.1
Wolf, I.2
Lasker, J.M.3
-
139
-
-
0028151666
-
Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes
-
Clarke, S. E., S. J. Baldwin, J. C. Bloomer, A. D. Ayrton, R. S. Sozio, and R. J. Chenery (1994). Lauric acid as a model substrate for the simultaneous determination of cytochrome P450 2E1 and 4A in hepatic microsomes. Chem. Res. Toxicol. 7, 836-842.
-
(1994)
Chem. Res. Toxicol.
, vol.7
, pp. 836-842
-
-
Clarke, S.E.1
Baldwin, S.J.2
Bloomer, J.C.3
Ayrton, A.D.4
Sozio, R.S.5
Chenery, R.J.6
-
140
-
-
0029568002
-
Validation of the (omega-1)-hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1
-
Amet, Y, F. Berthou, S. Baird, Y. Dreano, J. P. Bail, and J. F. Menez (1995). Validation of the (omega-1) - hydroxylation of lauric acid as an in vitro substrate probe for human liver CYP2E1. Biochem. Pharmacol. 50, 1775-1782.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 1775-1782
-
-
Amet, Y.1
Berthou, F.2
Baird, S.3
Dreano, Y.4
Bail, J.P.5
Menez, J.F.6
-
141
-
-
0037228554
-
Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone
-
Savas, U., M. H. Hsu, and E. F. Johnson (2003). Differential regulation of human CYP4A genes by peroxisome proliferators and dexamethasone. Arch. Biochem. Biophys. 409, 212-220.
-
(2003)
Arch. Biochem. Biophys.
, vol.409
, pp. 212-220
-
-
Savas, U.1
Hsu, M.H.2
Johnson, E.F.3
-
142
-
-
0008834287
-
10-(imidazolyl)-decanoic acid (10-IDA) is a selective and potent inhibitor of CYP4A9/11
-
Abstracts from the 10th North American ISSX Meeting, Indianapolis, IN, USA, Vol. 32 Suppl. 2, Abs. 188
-
Oglivie, B. W., S. M. Otradovec, B. L. Paris, J. A. Scheinkoenig, P. W. Carrott, S. P. Loecker et al. (2000). 10-(imidazolyl)-decanoic acid (10-IDA) is a selective and potent inhibitor of CYP4A9/11. Drug. Metab. Rev. Abstracts from the 10th North American ISSX Meeting, Indianapolis, IN, USA, Vol. 32(Suppl. 2), Abs. 188, p. 230.
-
(2000)
Drug. Metab. Rev.
, pp. 230
-
-
Oglivie, B.W.1
Otradovec, S.M.2
Paris, B.L.3
Scheinkoenig, J.A.4
Carrott, P.W.5
Loecker, S.P.6
-
143
-
-
0034764957
-
HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme
-
Miyata, N., K. Taniguchi, T. Seki, T. Ishimoto, M. Sato-Watanabe, Y. Yasuda et al. (2001). HET0016, a potent and selective inhibitor of 20-HETE synthesizing enzyme. Br. J. Pharmacol. 133, 325-329.
-
(2001)
Br. J. Pharmacol.
, vol.133
, pp. 325-329
-
-
Miyata, N.1
Taniguchi, K.2
Seki, T.3
Ishimoto, T.4
Sato-Watanabe, M.5
Yasuda, Y.6
-
144
-
-
0031808169
-
Metabolism of arachidonic acid to 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11
-
Powell, P. K., I. Wolf, R. Jin, and J. M. Lasker (1998). Metabolism of arachidonic acid to 20-hydroxy-5, 8, 11, 14-eicosatetraenoic acid by P450 enzymes in human liver: Involvement of CYP4F2 and CYP4A11. J. Pharmacol. Exp. Ther. 285, 1327-1336.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.285
, pp. 1327-1336
-
-
Powell, P.K.1
Wolf, I.2
Jin, R.3
Lasker, J.M.4
-
145
-
-
0032213301
-
Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4
-
Jin, R., D. R. Koop, J. L. Raucy, and J. M. Asker (1998). Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4. Arch. Biochem. Biophys. 359, 89-98.
-
(1998)
Arch. Biochem. Biophys.
, vol.359
, pp. 89-98
-
-
Jin, R.1
Koop, D.R.2
Raucy, J.L.3
Asker, J.M.4
-
146
-
-
0034660506
-
Promoter activity and regulation of the CYP4F2 leukotrieneB (4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells
-
Zhang, X., L. Chen, and J. P. Hardwick (2000). Promoter activity and regulation of the CYP4F2 leukotrieneB (4) omega-hydroxylase gene by peroxisomal proliferators and retinoic acid in HepG2 cells. Arch. Biochem. Biophys. 378, 364-376.
-
(2000)
Arch. Biochem. Biophys.
, vol.378
, pp. 364-376
-
-
Zhang, X.1
Chen, L.2
Hardwick, J.P.3
-
147
-
-
0021150830
-
Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes
-
Shak, S. and I. Goldstein (1984). Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. J. Biol. Chem. 259, 10181-10187.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 10181-10187
-
-
Shak, S.1
Goldstein, I.2
-
148
-
-
0034809149
-
CDNA cloning and expression of CYP4F12, a novel human cytochrome P450
-
Bylund, J., M. Bylund, and E. H. Oliw (2001). cDNA cloning and expression of CYP4F12, a novel human cytochrome P450. Biochem. Biophys. Res. Commun. 280, 892-897.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.280
, pp. 892-897
-
-
Bylund, J.1
Bylund, M.2
Oliw, E.H.3
-
149
-
-
0028872676
-
Immunochemical determination of human cholesterol 7 alpha-hydroxylase
-
Maeda, Y. R., G. Eggertsen, B. Nyberg, T. Setoguchi, K. I. Okuda, K. Einarsson et al. (1995). Immunochemical determination of human cholesterol 7 alpha-hydroxylase. Eur. J. Biochem. 228, 144-148.
-
(1995)
Eur. J. Biochem.
, vol.228
, pp. 144-148
-
-
Maeda, Y.R.1
Eggertsen, G.2
Nyberg, B.3
Setoguchi, T.4
Okuda, K.I.5
Einarsson, K.6
-
150
-
-
0033106423
-
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns
-
Gafvels, M., M. Olin, B. P. Chowdhary, T. Raudsepp, U. Andersson, B. Persson et al. (1999). Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: Eukaryotic cytochrome P-450 gene devoid of introns. Genomics 56, 184-196.
-
(1999)
Genomics
, vol.56
, pp. 184-196
-
-
Gafvels, M.1
Olin, M.2
Chowdhary, B.P.3
Raudsepp, T.4
Andersson, U.5
Persson, B.6
-
151
-
-
0035064593
-
Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin
-
Chun, Y. J., S. Y. Ryu, T. C. Jeong, and M. Y. Kim (2001). Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin. Drug. Metab. Dispos. 29, 389-393.
-
(2001)
Drug. Metab. Dispos.
, vol.29
, pp. 389-393
-
-
Chun, Y.J.1
Ryu, S.Y.2
Jeong, T.C.3
Kim, M.Y.4
-
152
-
-
0020434524
-
Purification and characterization of liver microsomal cytochromes P-450: Electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone
-
Guengerich, F. P., G. A. Dannan, S. T. Wright, M. V. Martin, and L. S. Kaminsky (1982). Purification and characterization of liver microsomal cytochromes P-450: Electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or beta-naphthoflavone. Biochemistry 21, 6019-6030.
-
(1982)
Biochemistry
, vol.21
, pp. 6019-6030
-
-
Guengerich, F.P.1
Dannan, G.A.2
Wright, S.T.3
Martin, M.V.4
Kaminsky, L.S.5
-
153
-
-
0025194581
-
High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat
-
Sesardic, D., R. J. Edwards, D. S. Davies, R. E. Thomas, W. Levin, and A. R. Boobis (1990). High affinity phenacetin O-deethylase is catalysed specifically by cytochrome P450d (P450IA2) in the liver of the rat. Biochem. Pharmacol. 39, 489-498.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 489-498
-
-
Sesardic, D.1
Edwards, R.J.2
Davies, D.S.3
Thomas, R.E.4
Levin, W.5
Boobis, A.R.6
-
154
-
-
0027973024
-
Theophylline N-demethylations as probes for P4501A1 and P4501A2
-
Sarkar, M. A. and B. J. Jackson (1994). Theophylline N-demethylations as probes for P4501A1 and P4501A2. Drug Metab. Dispos. 22, 827-834.
-
(1994)
Drug Metab. Dispos.
, vol.22
, pp. 827-834
-
-
Sarkar, M.A.1
Jackson, B.J.2
-
155
-
-
0035890772
-
A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis
-
Chun, Y. J., S. Kim, D. Kim, S. K. Lee, and F. P. Guengerich (2001). A new selective and potent inhibitor of human cytochrome P450 1B1 and its application to antimutagenesis. Cancer Res. 61, 8164-8170.
-
(2001)
Cancer Res.
, vol.61
, pp. 8164-8170
-
-
Chun, Y.J.1
Kim, S.2
Kim, D.3
Lee, S.K.4
Guengerich, F.P.5
-
156
-
-
0036172417
-
Erratum
-
Erratum in: Cancer Res. 62, 1232, 2002.
-
(2002)
Cancer Res.
, vol.62
, pp. 1232
-
-
-
157
-
-
0031694273
-
Selectivity of polycyclic inhibitors for human cytochrome P450s 1A 1, 1A2, and 1B1
-
Shimada, T., H. Yamazaki, M. Foroozesh, N. E. Hopkins, W. L. Alworth, F. P. Guengerich (1998). Selectivity of polycyclic inhibitors for human cytochrome P450s 1A 1, 1A2, and 1B1. Chem. Res. Toxicol. 11, 1048-1056.
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 1048-1056
-
-
Shimada, T.1
Yamazaki, H.2
Foroozesh, M.3
Hopkins, N.E.4
Alworth, W.L.5
Guengerich, F.P.6
-
158
-
-
0033815520
-
Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P4501B1 variants in Escherichia coli
-
Shimada, X, F. Tsumura, E. M. Gillam, F. P. Guengerich, and K. Inoue (2000). Roles of NADPH-P450 reductase in the O-deethylation of 7-ethoxycoumarin by recombinant human cytochrome P4501B1 variants in Escherichia coli. Protein Expr. Purif. 20, 73-80.
-
(2000)
Protein Expr. Purif.
, vol.20
, pp. 73-80
-
-
Shimada, X.1
Tsumura, F.2
Gillam, E.M.3
Guengerich, F.P.4
Inoue, K.5
-
159
-
-
0033858044
-
Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A 1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17beta-estradiol in female Sprague-Dawley rats
-
Badawi, A. F., E. L. Cavalieri, and E. G. Rogan (2000). Effect of chlorinated hydrocarbons on expression of cytochrome P450 1A 1, 1A2 and 1B1 and 2- and 4-hydroxylation of 17beta-estradiol in female Sprague-Dawley rats. Carcinogenesis 21, 1593-1599.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1593-1599
-
-
Badawi, A.F.1
Cavalieri, E.L.2
Rogan, E.G.3
-
160
-
-
0029796550
-
17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1
-
Hayes, C. L., D. C. Spink, B. C. Spink, J. Q. Cao, N. J. Walker, and T. R. Sutter (1996). 17 beta-estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. USA 93, 9776-9781.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9776-9781
-
-
Hayes, C.L.1
Spink, D.C.2
Spink, B.C.3
Cao, J.Q.4
Walker, N.J.5
Sutter, T.R.6
-
161
-
-
0023442649
-
Isozyme specificity of testosterone 7α-hydroxylation in rat hepatic microsomes: Is cytochrome P-450a the sole catalyst?
-
Levin, W., P. E. Thomas, D. E. Ryan, and A. W. Wood (1987). Isozyme specificity of testosterone 7α-hydroxylation in rat hepatic microsomes: Is cytochrome P-450a the sole catalyst? Arch. Biochem. Biophys. 258, 630-635.
-
(1987)
Arch. Biochem. Biophys.
, vol.258
, pp. 630-635
-
-
Levin, W.1
Thomas, P.E.2
Ryan, D.E.3
Wood, A.W.4
-
162
-
-
0020624336
-
Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver
-
Waxman, D. J., A. Ko, and C. Walsh (1983). Regioselectivity and stereoselectivity of androgen hydroxylations catalyzed by cytochrome P-450 isozymes purified from phenobarbital-induced rat liver. J. Biol. Chem. 258, 11937-11947.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 11937-11947
-
-
Waxman, D.J.1
Ko, A.2
Walsh, C.3
-
163
-
-
0023837746
-
Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereoselectivity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression
-
Waxman, D. J. (1988). Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereoselectivity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochem. Pharmacol. 37, 71-84.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 71-84
-
-
Waxman, D.J.1
-
164
-
-
0021112308
-
19 steroids by five highly purified and reconstituted rat hepatic cytochrome P450 isozymes
-
19 steroids by five highly purified and reconstituted rat hepatic cytochrome P450 isozymes. J. Biol. Chem. 258, 8839-8847.
-
(1983)
J. Biol. Chem.
, vol.258
, pp. 8839-8847
-
-
Wood, A.W.1
Ryan, D.R.2
Thomas, P.E.3
Levin, W.4
-
165
-
-
0026324283
-
Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function
-
Arlotto, M. P., J. M. Trant, and R. W. Estabrook (1992). Measurement of steroid hydroxylation reactions by high-performance liquid chromatography as indicator of P450 identity and function. Meth. Enzymol. 206, 454-462.
-
(1992)
Meth. Enzymol.
, vol.206
, pp. 454-462
-
-
Arlotto, M.P.1
Trant, J.M.2
Estabrook, R.W.3
-
166
-
-
0026717011
-
12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2
-
Smith, S. J., K. R. Korzekwa, T. Aoyama, F. J. Gonzalez, J. F. Darbyshire, K. Sugiyama et al. (1992). 12 alpha-hydroxytestosterone. A hitherto unidentified testosterone metabolite produced by cytochrome P-450 2A2. Drug Metab. Dispos. 20, 566-571.
-
(1992)
Drug Metab. Dispos.
, vol.20
, pp. 566-571
-
-
Smith, S.J.1
Korzekwa, K.R.2
Aoyama, T.3
Gonzalez, F.J.4
Darbyshire, J.F.5
Sugiyama, K.6
-
167
-
-
0024532593
-
Secobarbital-mediated inactivation of rat liver cytochrome P-450b: A mechanistic reappraisal
-
Lunetta, J. M., K. Sugiyama, and M. A. Correia (1989). Secobarbital-mediated inactivation of rat liver cytochrome P-450b: A mechanistic reappraisal. Mol. Pharmacol. 35, 10-17.
-
(1989)
Mol. Pharmacol.
, vol.35
, pp. 10-17
-
-
Lunetta, J.M.1
Sugiyama, K.2
Correia, M.A.3
-
168
-
-
0029862643
-
Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital
-
He, K., A. M. Falick, B. Chen, F. Nilsson, and M. A. Correia (1996). Identification of the heme adduct and an active site peptide modified during mechanism-based inactivation of rat liver cytochrome P450 2B1 by secobarbital. Chem. Res. Toxicol. 9, 614-622.
-
(1996)
Chem. Res. Toxicol.
, vol.9
, pp. 614-622
-
-
He, K.1
Falick, A.M.2
Chen, B.3
Nilsson, F.4
Correia, M.A.5
-
169
-
-
0022350885
-
Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome (s) P-450 by phenobarbital and other xenobiotics in the rat
-
Lubet, R. A., R. T. Mayer, J. W. Cameron, R. W. Nims, M. D. Burke, T. Wolff et al. (1985). Dealkylation of pentoxyresorufin: A rapid and sensitive assay for measuring induction of cytochrome (s) P-450 by phenobarbital and other xenobiotics in the rat. Arch. Biochem. Biophys. 238, 43-48.
-
(1985)
Arch. Biochem. Biophys.
, vol.238
, pp. 43-48
-
-
Lubet, R.A.1
Mayer, R.T.2
Cameron, J.W.3
Nims, R.W.4
Burke, M.D.5
Wolff, T.6
-
170
-
-
0025214645
-
Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form (s) of rat liver cytochrome P-450
-
Halpert, J., J. Y. Jaw, C. Balfour, and L. S. Kaminsky (1990). Selective inactivation by chlorofluoroacetamides of the major phenobarbital-inducible form (s) of rat liver cytochrome P-450. Drug Metab. Dispos. 18, 168-174.
-
(1990)
Drug Metab. Dispos.
, vol.18
, pp. 168-174
-
-
Halpert, J.1
Jaw, J.Y.2
Balfour, C.3
Kaminsky, L.S.4
-
172
-
-
0030720486
-
Inactivation of cytochrome P450s 2B 1, 2B 4, 2B6, and 2B11 by arylalkynes
-
Roberts, E. S., N. E. Hopkins, M. Foroozesh, W. L. Alworth, J. R. Halpert, and P. F. Hollenberg et al. (1997). Inactivation of cytochrome P450s 2B 1, 2B 4, 2B6, and 2B11 by arylalkynes. Drug Metab. Dispos. 25, 1242-1248.
-
(1997)
Drug Metab. Dispos.
, vol.25
, pp. 1242-1248
-
-
Roberts, E.S.1
Hopkins, N.E.2
Foroozesh, M.3
Alworth, W.L.4
Halpert, J.R.5
Hollenberg, P.F.6
-
173
-
-
0023643411
-
Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P-450 isozymes
-
Swinney, D. C., D. E. Ryan, P. E. Thomas, and W. Levin (1987). Regioselective progesterone hydroxylation catalyzed by eleven rat hepatic cytochrome P-450 isozymes. Biochemistry 26, 7073-7083.
-
(1987)
Biochemistry
, vol.26
, pp. 7073-7083
-
-
Swinney, D.C.1
Ryan, D.E.2
Thomas, P.E.3
Levin, W.4
-
174
-
-
0024548434
-
Specific inactivation by 17β-substituted steroids of rabbit and rat liver cytochromes P-450 responsible for progesterone 21-hydroxylation
-
Halpert, J., J. Y. Jaw, and C. Balfour (1989). Specific inactivation by 17β-substituted steroids of rabbit and rat liver cytochromes P-450 responsible for progesterone 21-hydroxylation. Mol. Pharmacol. 34, 148-156.
-
(1989)
Mol. Pharmacol.
, vol.34
, pp. 148-156
-
-
Halpert, J.1
Jaw, J.Y.2
Balfour, C.3
-
175
-
-
0038312064
-
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: Study with cDNA-expressed systems of the rat
-
Kobayashi, K., K. Urashima, N. Shimada, and K. Chiba (2003). Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: Study with cDNA-expressed systems of the rat. Drug Metab. Dispos. 31, 833-836.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 833-836
-
-
Kobayashi, K.1
Urashima, K.2
Shimada, N.3
Chiba, K.4
-
176
-
-
0034869012
-
Mechanism-based inactivation of CYP2C11 by diclofenac
-
Masubuchi, Y., A. Ose, and T. Horie (2001). Mechanism-based inactivation of CYP2C11 by diclofenac. Drug Metab. Dispos. 29, 1190-1195.
-
(2001)
Drug Metab. Dispos.
, vol.29
, pp. 1190-1195
-
-
Masubuchi, Y.1
Ose, A.2
Horie, T.3
-
177
-
-
0030992926
-
Cytochrome P4502C11 is a target of diclofenac covalent binding in rats
-
Shen, S., S. J. Hargus, B. M. Martin, and L. R. Pohl (1997). Cytochrome P4502C11 is a target of diclofenac covalent binding in rats. Chem. Res. Toxicol. 10, 420-423.
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 420-423
-
-
Shen, S.1
Hargus, S.J.2
Martin, B.M.3
Pohl, L.R.4
-
178
-
-
0021719860
-
Purification, characterization, and pituitary regulation of the sex-specific cytochrome P-450 15 beta-hydroxylase from liver microsomes of untreated female rats
-
MacGeoch, C., E. T. Morgan, J. Halpert, and J. A. Gustafsson (1984). Purification, characterization, and pituitary regulation of the sex-specific cytochrome P-450 15 beta-hydroxylase from liver microsomes of untreated female rats. J. Biol. Chem. 259, 15433-15439.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 15433-15439
-
-
MacGeoch, C.1
Morgan, E.T.2
Halpert, J.3
Gustafsson, J.A.4
-
179
-
-
0031574143
-
Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity
-
Wan, J., S. Imaoka, T. Chow, T. Hiroi, Y. Yabusaki, and Y. Funae (1997). Expression of four rat CYP2D isoforms in Saccharomyces cerevisiae and their catalytic specificity. Arch. Biochem. Biophys. 348, 383-390.
-
(1997)
Arch. Biochem. Biophys.
, vol.348
, pp. 383-390
-
-
Wan, J.1
Imaoka, S.2
Chow, T.3
Hiroi, T.4
Yabusaki, Y.5
Funae, Y.6
-
180
-
-
0032911164
-
Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver
-
Chow, T., S. Imaoka, T. Hiroi, and Y. Funae (1999). Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver. Drug Metab. Dispos. 27, 188-192.
-
(1999)
Drug Metab. Dispos.
, vol.27
, pp. 188-192
-
-
Chow, T.1
Imaoka, S.2
Hiroi, T.3
Funae, Y.4
-
181
-
-
0030430272
-
Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine
-
Lin, L. Y., M. Fujimoto, E. W. Distefano, D. A. Schmitz, A. Jayasinghe, and A. K. Cho (1996). Selective mechanism-based inactivation of rat CYP2D by 4-allyloxymethamphetamine. J. Pharmacol. Exp. Then 277, 595-603.
-
(1996)
J. Pharmacol. Exp. Then
, vol.277
, pp. 595-603
-
-
Lin, L.Y.1
Fujimoto, M.2
Distefano, E.W.3
Schmitz, D.A.4
Jayasinghe, A.5
Cho, A.K.6
-
182
-
-
0021236705
-
Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism
-
Larrey, D., L. M. Distlerath, G. A. Dannan, G. R. Wilkinson, and F. P. Guengerich (1984). Purification and characterization of the rat liver microsomal cytochrome P-450 involved in the 4-hydroxylation of debrisoquine, a prototype for genetic variation in oxidative drug metabolism. Biochemistry 23, 2787-2795.
-
(1984)
Biochemistry
, vol.23
, pp. 2787-2795
-
-
Larrey, D.1
Distlerath, L.M.2
Dannan, G.A.3
Wilkinson, G.R.4
Guengerich, F.P.5
-
183
-
-
0035165936
-
Chlorzoxazone: A probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachlorideintoxicated rat
-
Tanaka, E. (2001). Chlorzoxazone: A probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachlorideintoxicated rat. Hum. Exp. Toxicol. 20, 381-385.
-
(2001)
Hum. Exp. Toxicol.
, vol.20
, pp. 381-385
-
-
Tanaka, E.1
-
184
-
-
0034085366
-
Chlorzoxazone: A probe drug whose metabolism can be used to monitor toluene exposure in rats
-
Mizuno, D., E. Tanaka, K. Tanno, and S. Misawa (2000). Chlorzoxazone: A probe drug whose metabolism can be used to monitor toluene exposure in rats. Arch. Toxicol. 74, 139-144.
-
(2000)
Arch. Toxicol.
, vol.74
, pp. 139-144
-
-
Mizuno, D.1
Tanaka, E.2
Tanno, K.3
Misawa, S.4
-
185
-
-
0031873912
-
Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1, 2-dichloroethylene
-
Mathews, J. M., A. S. Etheridge, J. H. Raymer, S. R. Black, D. W. Pulliam Jr., and J. R. Bucher (1998). Selective inhibition of cytochrome P450 2E1 in vivo and in vitro with trans-1, 2-dichloroethylene. Chem. Res. Toxicol 11, 778-785.
-
(1998)
Chem. Res. Toxicol
, vol.11
, pp. 778-785
-
-
Mathews, J.M.1
Etheridge, A.S.2
Raymer, J.H.3
Black, S.R.4
Pulliam Jr., D.W.5
Bucher, J.R.6
-
186
-
-
0026652491
-
Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid
-
Yoo, J. S., T. J. Smith, S. M. Ning, M. J. Lee, R. E. Thomas, and C. S. Yang (1992). Modulation of the levels of cytochromes P450 in rat liver and lung by dietary lipid. Biochem. Pharmacol. 43, 2535-2542.
-
(1992)
Biochem. Pharmacol.
, vol.43
, pp. 2535-2542
-
-
Yoo, J.S.1
Smith, T.J.2
Ning, S.M.3
Lee, M.J.4
Thomas, R.E.5
Yang, C.S.6
-
187
-
-
0026691523
-
Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009)
-
Yamazaki, H., Y. Oda, Y. Funae, S. Imaoka, Y. Inui, F. P. Guengerich et al. (1992). Participation of rat liver cytochrome P450 2E1 in the activation of N-nitrosodimethylamine and N-nitrosodiethylamine to products genotoxic in an acetyltransferase-overexpressing Salmonella typhimurium strain (NM2009). Carcinogenesis 13, 979-985.
-
(1992)
Carcinogenesis
, vol.13
, pp. 979-985
-
-
Yamazaki, H.1
Oda, Y.2
Funae, Y.3
Imaoka, S.4
Inui, Y.5
Guengerich, F.P.6
-
188
-
-
0025872079
-
Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites
-
Brady, J. F., H. Ishizakt, J. M. Fukuto, M. C. Lin, A. Fadel, J. M. Gapac et al. (1991). Inhibition of cytochrome P-450 2E1 by diallyl sulfide and its metabolites. Chem. Res. Toxicol. 4, 642-647.
-
(1991)
Chem. Res. Toxicol.
, vol.4
, pp. 642-647
-
-
Brady, J.F.1
Ishizakt, H.2
Fukuto, J.M.3
Lin, M.C.4
Fadel, A.5
Gapac, J.M.6
-
189
-
-
0030992920
-
Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats
-
Jin, L. and T. A. Baillie (1997). Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats. Chem. Res. Toxicol. 10, 318-327.
-
(1997)
Chem. Res. Toxicol.
, vol.10
, pp. 318-327
-
-
Jin, L.1
Baillie, T.A.2
-
190
-
-
0034089655
-
Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone
-
Premdas, P. D., R. J. Bowers, and P. G. Forkert (2000). Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone. J. Pharmacol. Exp. Then 293, 1112-1120.
-
(2000)
J. Pharmacol. Exp. Then
, vol.293
, pp. 1112-1120
-
-
Premdas, P.D.1
Bowers, R.J.2
Forkert, P.G.3
-
191
-
-
0025209985
-
Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities
-
Ishizaki, H., J. F. Brady, S. M. Ning, and C. S. Yang (1990). Effect of phenethyl isothiocyanate on microsomal N-nitrosodimethylamine metabolism and other monooxygenase activities. Xenobiotica 20, 255-264.
-
(1990)
Xenobiotica
, vol.20
, pp. 255-264
-
-
Ishizaki, H.1
Brady, J.F.2
Ning, S.M.3
Yang, C.S.4
-
192
-
-
0023654735
-
Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450
-
Sonderfan, A. J., M. P. Arlotto, D. R. Dutton, S. K. McMillen, and A. Parkinson (1987). Regulation of testosterone hydroxylation by rat liver microsomal cytochrome P-450. Arch. Biochem. Biophys. 255, 27-41.
-
(1987)
Arch. Biochem. Biophys.
, vol.255
, pp. 27-41
-
-
Sonderfan, A.J.1
Arlotto, M.P.2
Dutton, D.R.3
McMillen, S.K.4
Parkinson, A.5
-
193
-
-
0026577117
-
Specifically designed thiosteroids as active site-directed probes for functional dissection of cytochrome P-450 3A isozymes
-
Underwood, M. C., J. R. Cashman, and M. A. Correia (1992). Specifically designed thiosteroids as active site-directed probes for functional dissection of cytochrome P-450 3A isozymes. Chem. Res. Toxicol. 5, 42-53.
-
(1992)
Chem. Res. Toxicol.
, vol.5
, pp. 42-53
-
-
Underwood, M.C.1
Cashman, J.R.2
Correia, M.A.3
-
194
-
-
0021800943
-
Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p
-
Wrighton, S. A., P. Maurel, E. G. Schuetz, P. B. Watkins, B. Young, and P. S. Guzelian (1985). Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p. Biochemistry 24, 2171-2178.
-
(1985)
Biochemistry
, vol.24
, pp. 2171-2178
-
-
Wrighton, S.A.1
Maurel, P.2
Schuetz, E.G.3
Watkins, P.B.4
Young, B.5
Guzelian, P.S.6
-
195
-
-
0023024338
-
Macrolide antibiotics inhibit the degradation of the glucocorticoid- responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture
-
Watkins, P. B., S. A. Wrighton, E. G. Schuetz, P. Maurel, and P. S. Guzelian (1986). Macrolide antibiotics inhibit the degradation of the glucocorticoid-responsive cytochrome P-450p in rat hepatocytes in vivo and in primary monolayer culture. J. Biol. Chem. 261, 6264-6271.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 6264-6271
-
-
Watkins, P.B.1
Wrighton, S.A.2
Schuetz, E.G.3
Maurel, P.4
Guzelian, P.S.5
-
196
-
-
0033656861
-
Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones
-
Wang, H., K. L. Napoli, and H. W. Strobel (2000). Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. Mol. Cell. Biochem. 213, 127-135.
-
(2000)
Mol. Cell. Biochem.
, vol.213
, pp. 127-135
-
-
Wang, H.1
Napoli, K.L.2
Strobel, H.W.3
-
197
-
-
0037229516
-
Rat liver CYP3A9: Structure-function relationships to its human liver orthologs: Site-directed mutagenesis to an efficient progesterone dihydroxylase
-
Xue, L., V. G. Zgoda, B. Arison, and M. A. Correia (2003). Rat liver CYP3A9: Structure-function relationships to its human liver orthologs: Site-directed mutagenesis to an efficient progesterone dihydroxylase. Arch. Biochem. Biophys. 409, 113-126.
-
(2003)
Arch. Biochem. Biophys.
, vol.409
, pp. 113-126
-
-
Xue, L.1
Zgoda, V.G.2
Arison, B.3
Correia, M.A.4
-
198
-
-
0019949059
-
Cytochrome P-450 induction by clofibrate: Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid)
-
Gibson, G. G., T. C. Orton, and P. P. Tamburini (1982). Cytochrome P-450 induction by clofibrate: Purification and properties of a hepatic cytochrome P-450 relatively specific for the 12- and 11-hydroxylation of dodecanoic acid (lauric acid). Biochem. J. 203, 161-168.
-
(1982)
Biochem. J.
, vol.203
, pp. 161-168
-
-
Gibson, G.G.1
Orton, T.C.2
Tamburini, P.P.3
-
199
-
-
0024241108
-
The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids
-
CaJacob, C. A., W. K. Chan, E. Shepard, and P. R. Ortiz De Montellano (1988). The catalytic site of rat hepatic lauric acid omega-hydroxylase. Protein versus prosthetic heme alkylation in the omega-hydroxylation of acetylenic fatty acids. J. Biol. Chem. 263, 18640-18649.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 18640-18649
-
-
Ca Jacob, C.A.1
Chan, W.K.2
Shepard, E.3
Ortiz De Montellano, P.R.4
-
200
-
-
0021345344
-
Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids
-
Ortiz De Montellano, P. R. and N. O. Reich (1984). Specific inactivation of hepatic fatty acid hydroxylases by acetylenic fatty acids. J. Biol. Chem. 259, 4136-1141.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 4136-1141
-
-
Ortiz De Montellano, P.R.1
Reich, N.O.2
-
201
-
-
0026326790
-
Reversed-phase highperformance liquid chromatography assay of cholesterol 7 alpha-hydroxylase
-
Chiang, J. Y (1991). Reversed-phase highperformance liquid chromatography assay of cholesterol 7 alpha-hydroxylase. Meth. Enzymol. 206, 483-491.
-
(1991)
Meth. Enzymol.
, vol.206
, pp. 483-491
-
-
Chiang, J.Y.1
-
202
-
-
0024401849
-
Acetaminophen activation by human liver cytochromes P450IIE1 and P4501A2
-
Raucy, J. L., J. M. Lasker, C. S. Lieber, and M. Black (1989). Acetaminophen activation by human liver cytochromes P450IIE1 and P4501A2. Arch. Biochem. Biophys. 271, 270-283.
-
(1989)
Arch. Biochem. Biophys.
, vol.271
, pp. 270-283
-
-
Raucy, J.L.1
Lasker, J.M.2
Lieber, C.S.3
Black, M.4
-
203
-
-
0032525015
-
Alcohol-mediated increases in acetaminophen hepatotoxicity: Role of CYP2E and CYP3A
-
Sinclair, J., E. Jeffery, S. Wrighton, V. Kostrubsky, J. Szakacs, S. Wood, and P. Sinclair (1998). Alcohol-mediated increases in acetaminophen hepatotoxicity: role of CYP2E and CYP3A. Biochem. Pharmacol. 55, 1557-1565.
-
(1998)
Biochem. Pharmacol.
, vol.55
, pp. 1557-1565
-
-
Sinclair, J.1
Jeffery, E.2
Wrighton, S.3
Kostrubsky, V.4
Szakacs, J.5
Wood, S.6
Sinclair, P.7
-
204
-
-
0023706607
-
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography
-
Imaoka, S., K. Inoue, and Y. Funae (1988). Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: Simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography. Arch. Biochem. Biophys. 265, 159-170.
-
(1988)
Arch. Biochem. Biophys.
, vol.265
, pp. 159-170
-
-
Imaoka, S.1
Inoue, K.2
Funae, Y.3
-
205
-
-
0023552178
-
Inactivation of multiple hepatic cytochrome P-450 isozymes in rats by allylisopropylacetamide: Mechanistic implications
-
Bornheim, L. M., M. C. Underwood, P. Caldera, A. E. Rettie, W. F. Trager, S. A. Wrighton et al. (1987). Inactivation of multiple hepatic cytochrome P-450 isozymes in rats by allylisopropylacetamide: Mechanistic implications. Mol. Pharmacol. 32, 299-308.
-
(1987)
Mol. Pharmacol.
, vol.32
, pp. 299-308
-
-
Bornheim, L.M.1
Underwood, M.C.2
Caldera, P.3
Rettie, A.E.4
Trager, W.F.5
Wrighton, S.A.6
-
206
-
-
0011321904
-
Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds
-
J. B. Schenkman and D. Kupfer eds, Pergamon Press, New York, NY
-
Nebert, D. W (1982). Genetic differences in the induction of monooxygenase activities by polycyclic aromatic compounds. In J. B. Schenkman and D. Kupfer (eds), Hepatic Cytochrome P-450 Monooxygenase System. Pergamon Press, New York, NY, pp. 269-291.
-
(1982)
Hepatic Cytochrome P-450 Monooxygenase System.
, pp. 269-291
-
-
Nebert, D.W.1
-
207
-
-
0017831699
-
Direct fluorometric methods for measuring mixedfunction oxidase activity
-
Prough, R. A., M. D. Burke, and R. T. Mayer (1978). Direct fluorometric methods for measuring mixedfunction oxidase activity. Meth. Enzymol. 52, 372-377.
-
(1978)
Meth. Enzymol.
, vol.52
, pp. 372-377
-
-
Prough, R.A.1
Burke, M.D.2
Mayer, R.T.3
-
208
-
-
0015838231
-
Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide dependent mixed function oxidase of hepatic microsomes. Role of the Type I drug binding site of cytochrome P-450
-
Correia, M. A. and G. J. Mannering (1973). Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide dependent mixed function oxidase of hepatic microsomes. Role of the Type I drug binding site of cytochrome P-450. Mol. Pharmacol. 9, 470-485.
-
(1973)
Mol. Pharmacol.
, vol.9
, pp. 470-485
-
-
Correia, M.A.1
Mannering, G.J.2
-
209
-
-
0022913310
-
Dissociation of cytochrome P-450 inactivation and induction
-
Ortiz De Montellano, P. R. and A. K. Costa (1986). Dissociation of cytochrome P-450 inactivation and induction. Arch. Biochem. Biophys. 251, 514-524.
-
(1986)
Arch. Biochem. Biophys.
, vol.251
, pp. 514-524
-
-
Ortiz De Montellano, P.R.1
Costa, A.K.2
-
210
-
-
0023898529
-
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of 1-aminobenzotriazole (ABT)
-
Mico, B. A., D. A. Federowicz, M. G. Ripple, and W. Kerns (1988). In vivo inhibition of oxidative drug metabolism by, and acute toxicity of 1-aminobenzotriazole (ABT). Biochem. Pharmacol. 37, 2515-2519.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 2515-2519
-
-
Mico, B.A.1
Federowicz, D.A.2
Ripple, M.G.3
Kerns, W.4
-
211
-
-
77957186623
-
1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats
-
Mugford, C. A., M. Mortillo, B. A. Mico, and J. B. Tarloff (1992). 1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 19, 43-49.
-
(1992)
Fundam. Appl. Toxicol.
, vol.19
, pp. 43-49
-
-
Mugford, C.A.1
Mortillo, M.2
Mico, B.A.3
Tarloff, J.B.4
-
212
-
-
0029562838
-
Effect of cimetidine on hepatic cytochrome P450: Evidence for formation of a metabolite-intermediate complex
-
Levine, M. and G. D. Bellward (1995). Effect of cimetidine on hepatic cytochrome P450: Evidence for formation of a metabolite-intermediate complex. Drug Metab. Dispos. 23, 1407-1411.
-
(1995)
Drug Metab. Dispos.
, vol.23
, pp. 1407-1411
-
-
Levine, M.1
Bellward, G.D.2
-
213
-
-
0031885475
-
In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats
-
Levine, M., E. Y. Law, S. M. Bandiera, T. K. Chang, and G. D. Bellward (1998). In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats. J. Pharmacol. Exp. Ther. 284, 493-199.
-
(1998)
J. Pharmacol. Exp. Ther.
, vol.284
, pp. 493-199
-
-
Levine, M.1
Law, E.Y.2
Bandiera, S.M.3
Chang, T.K.4
Bellward, G.D.5
-
214
-
-
0021824926
-
Drug interactions with cimetidine: An update
-
Gerber, M. C., G. A. Tejwani, N. Gerber, and J. R. Bianchine (1985). Drug interactions with cimetidine: An update. Pharmacol. Ther. 27, 353-370.
-
(1985)
Pharmacol. Ther.
, vol.27
, pp. 353-370
-
-
Gerber, M.C.1
Tejwani, G.A.2
Gerber, N.3
Bianchine, J.R.4
-
215
-
-
0023815132
-
Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactions
-
Smith, S. R. and M. J. Kendall (1988). Ranitidine versus cimetidine. A comparison of their potential to cause clinically important drug interactions. Clin. Pharmacokinet. 15, 44-56.
-
(1988)
Clin. Pharmacokinet.
, vol.15
, pp. 44-56
-
-
Smith, S.R.1
Kendall, M.J.2
-
216
-
-
0023447289
-
Degradation of rat hepatic cytochrome P-450 heme by 3, 5-dicarbethoxy-2, 6-dimethyl-4-ethyl-l, 4-dihydropyridine to irreversibly bound protein adducts
-
Correia, M. A., C. Decker, K. Sugiyama, P. Caldera, L. Bornheim, S. A. Wrighton et al. (1987). Degradation of rat hepatic cytochrome P-450 heme by 3, 5-dicarbethoxy-2, 6-dimethyl-4-ethyl-l, 4-dihydropyridine to irreversibly bound protein adducts. Arch. Biochem. Biophys. 258, 436-451.
-
(1987)
Arch. Biochem. Biophys.
, vol.258
, pp. 436-451
-
-
Correia, M.A.1
Decker, C.2
Sugiyama, K.3
Caldera, P.4
Bornheim, L.5
Wrighton, S.A.6
-
217
-
-
0018769008
-
A class of strong inhibitors of microsomal monooxygenases: The ellipticines
-
Lesca, P., E. Rafidinarivo, P. Le Cointe, and D. Mansuy (1979). A class of strong inhibitors of microsomal monooxygenases: The ellipticines. Chem. Biol. Interact. 24, 189-198.
-
(1979)
Chem. Biol. Interact.
, vol.24
, pp. 189-198
-
-
Lesca, P.1
Rafidinarivo, E.2
Le Cointe, P.3
Mansuy, D.4
-
218
-
-
0027364928
-
Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2
-
Tassaneeyakul, W., D. J. Birkett, M. E. Veronese, M. E. McManus, R. H. Tukey, L. C. Quattrochi et al. (1993). Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J. Pharmacol. Exp. Ther. 265, 401-407.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.265
, pp. 401-407
-
-
Tassaneeyakul, W.1
Birkett, D.J.2
Veronese, M.E.3
McManus, M.E.4
Tukey, R.H.5
Quattrochi, L.C.6
-
219
-
-
0036219021
-
Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update
-
Hemeryck, A. and F. M. Belpaire (2002). Selective serotonin reuptake inhibitors and cytochrome P-450 mediated drug-drug interactions: An update. Curr. Drug. Metab. 3, 13-37.
-
(2002)
Curr. Drug. Metab.
, vol.3
, pp. 13-37
-
-
Hemeryck, A.1
Belpaire, F.M.2
-
220
-
-
0030867948
-
Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs
-
Richelson, E. (1997). Pharmacokinetic drug interactions of new antidepressants: A review of the effects on the metabolism of other drugs. Mayo Clin. Proc. 72, 835-847.
-
(1997)
Mayo Clin. Proc.
, vol.72
, pp. 835-847
-
-
Richelson, E.1
-
221
-
-
0022495133
-
Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats
-
Letteron, P., V. Descatoire, D. Larrey, M. Tinel, J. Geneve, and D. Pessayre (1986). Inactivation and induction of cytochrome P-450 by various psoralen derivatives in rats. J. Pharmacol. Exp. Ther. 238, 685-692.
-
(1986)
J. Pharmacol. Exp. Ther.
, vol.238
, pp. 685-692
-
-
Letteron, P.1
Descatoire, V.2
Larrey, D.3
Tinel, M.4
Geneve, J.5
Pessayre, D.6
-
222
-
-
0032558386
-
Mechanismbased inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins
-
Koenigs, L. L. and W. F. Trager (1998). Mechanismbased inactivation of cytochrome P450 2B1 by 8-methoxypsoralen and several other furanocoumarins. Biochemistry 37, 13184-13193.
-
(1998)
Biochemistry
, vol.37
, pp. 13184-13193
-
-
Koenigs, L.L.1
Trager, W.F.2
-
223
-
-
0019835546
-
Inhibitors of cytochrome P-450s and their mechanism of action
-
Testa, B. and P. Jenner (1981). Inhibitors of cytochrome P-450s and their mechanism of action. Drug Metab. Rev. 12, 1-117.
-
(1981)
Drug Metab. Rev.
, vol.12
, pp. 1-117
-
-
Testa, B.1
Jenner, P.2
-
224
-
-
0020530615
-
Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: Purification, characterization, and interactions with metyrapone and cytochrome b5
-
Waxman, D. J. and C. Walsh (1983). Cytochrome P-450 isozyme 1 from phenobarbital-induced rat liver: Purification, characterization, and interactions with metyrapone and cytochrome b5. Biochemistry 22, 4846-4855.
-
(1983)
Biochemistry
, vol.22
, pp. 4846-4855
-
-
Waxman, D.J.1
Walsh, C.2
-
225
-
-
0015511655
-
Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide
-
Franklin, M. R. (1972). Inhibition of hepatic oxidative xenobiotic metabolism by piperonyl butoxide. Biochem. Pharmacol. 21, 3287-3299.
-
(1972)
Biochem. Pharmacol.
, vol.21
, pp. 3287-3299
-
-
Franklin, M.R.1
-
226
-
-
0016238393
-
Interaction of methylenedioxyphenyl (1, 3-benzodioxole) compounds with enzymes and their effects on mammals
-
Hodgson, E. and R. M. Philpot (1974). Interaction of methylenedioxyphenyl (1, 3-benzodioxole) compounds with enzymes and their effects on mammals. Drug. Metab. Rev. 3, 231-301.
-
(1974)
Drug. Metab. Rev.
, vol.3
, pp. 231-301
-
-
Hodgson, E.1
Philpot, R.M.2
-
227
-
-
0016325433
-
The formation of complexes absorbing at 455 nm from cytochrome P-450 and metabolites of compounds related to SKF 525-A
-
Buening, M. K. and Franklin, M. R. (1974). The formation of complexes absorbing at 455 nm from cytochrome P-450 and metabolites of compounds related to SKF 525-A. Drug Metab. Dispos. 2, 386-390.
-
(1974)
Drug Metab. Dispos.
, vol.2
, pp. 386-390
-
-
Buening, M.K.1
Franklin, M.R.2
-
228
-
-
78651165715
-
The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature
-
Omura, T. and R. Sato (1964). The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239, 2370-2378.
-
(1964)
J. Biol. Chem.
, vol.239
, pp. 2370-2378
-
-
Omura, T.1
Sato, R.2
-
229
-
-
0000921783
-
The spectrophotometric measurement of turbid suspensions of cytochromes associated with drug metabolism
-
C. F. Chignell ed., Appleton-Century-Crofts, New York, NY
-
Estabrook, R. W., J. A. Peterson, J. Baron, and A. G. Hildebrandt (1972). The spectrophotometric measurement of turbid suspensions of cytochromes associated with drug metabolism. In C. F. Chignell (ed.), Methods in Pharmacology, Vol. 2. Appleton-Century-Crofts, New York, NY, pp. 303-350.
-
(1972)
Methods in Pharmacology
, vol.2
, pp. 303-350
-
-
Estabrook, R.W.1
Peterson, J.A.2
Baron, J.3
Hildebrandt, A.G.4
-
230
-
-
0017168412
-
Quantitative determination of cytochrome P-450 in rat liver homogenate
-
Matsubara, T., M. Koike, A. Touchi, Y. Tochino, and K. Sugeno (1976). Quantitative determination of cytochrome P-450 in rat liver homogenate, Anal. Biochem. 75, 596-603.
-
(1976)
Anal. Biochem.
, vol.75
, pp. 596-603
-
-
Matsubara, T.1
Koike, M.2
Touchi, A.3
Tochino, Y.4
Sugeno, K.5
-
231
-
-
0018405140
-
Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene
-
Ryan, D. E., P. E. Thomas, D. Korzeniowski, and W. Levin (1979). Separation and characterization of highly purified forms of liver microsomal cytochrome P-450 from rats treated with polychlorinated biphenyls, phenobarbital, and 3-methylcholanthrene. J. Biol. Chem. 254, 1365-1374.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 1365-1374
-
-
Ryan, D.E.1
Thomas, P.E.2
Korzeniowski, D.3
Levin, W.4
-
232
-
-
0021333633
-
Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats
-
Ryan, D. E., S. Iida, A. W. Wood, P. E. Thomas, C. S. Lieber, and W. Levin (1984). Characterization of three highly purified cytochromes P-450 from hepatic microsomes of adult male rats. J. Biol. Chem. 259, 1239-1250.
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 1239-1250
-
-
Ryan, D.E.1
Iida, S.2
Wood, A.W.3
Thomas, P.E.4
Lieber, C.S.5
Levin, W.6
-
233
-
-
0019161825
-
Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms
-
Ryan, D. E., P. E. Thomas, and W. Levin (1980). Hepatic microsomal cytochrome P-450 from rats treated with isosafrole. Purification and characterization of four enzymic forms. J. Biol. Chem. 255, 7941-7955.
-
(1980)
J. Biol. Chem.
, vol.255
, pp. 7941-7955
-
-
Ryan, D.E.1
Thomas, P.E.2
Levin, W.3
-
234
-
-
0017794351
-
Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy
-
Jefcoate, C. R. (1978). Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy. Meth. Enzymol. 52, 258-279.
-
(1978)
Meth. Enzymol.
, vol.52
, pp. 258-279
-
-
Jefcoate, C.R.1
-
235
-
-
50449100139
-
The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties
-
Omura, T. and R. Sato (1964). The carbon monoxide-binding pigment of liver microsomes. II. Solubilization, purification, and properties. J. Biol. Chem. 239, 2379-2385.
-
(1964)
J. Biol. Chem.
, vol.239
, pp. 2379-2385
-
-
Omura, T.1
Sato, R.2
-
236
-
-
0016729058
-
Cumene hydroperoxidemediated formation of inhibited complexes of methylenedioxyphenyl compounds with cytochrome P450
-
Elcombe, C. R., J. Bridges, R. H. Nimmo-Smith, and J. Werringloer (1975). Cumene hydroperoxidemediated formation of inhibited complexes of methylenedioxyphenyl compounds with cytochrome P450. Biochem. Soc. Trans. 3, 967-970.
-
(1975)
Biochem. Soc. Trans.
, vol.3
, pp. 967-970
-
-
Elcombe, C.R.1
Bridges, J.2
Nimmo-Smith, R.H.3
Werringloer, J.4
-
237
-
-
0015310991
-
The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice
-
Philpot, R. M. and E. Hodgson (1972). The effect of piperonyl butoxide concentration on the formation of cytochrome P-450 difference spectra in hepatic microsomes from mice. Mol. Pharmacol. 8, 204-214.
-
(1972)
Mol. Pharmacol.
, vol.8
, pp. 204-214
-
-
Philpot, R.M.1
Hodgson, E.2
-
238
-
-
0017717638
-
Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes
-
Franklin, M. R. (1977). Inhibition of mixed-function oxidations by substrates forming reduced cytochrome P-450 metabolic-intermediate complexes. Pharmacol. Ther. A. 2, 227-245.
-
(1977)
Pharmacol. Ther. A.
, vol.2
, pp. 227-245
-
-
Franklin, M.R.1
-
239
-
-
0026346377
-
Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds
-
Franklin, M. R. (1991). Cytochrome P450 metabolic intermediate complexes from macrolide antibiotics and related compounds. Meth. Enzymol. 206, 559-573.
-
(1991)
Meth. Enzymol.
, vol.206
, pp. 559-573
-
-
Franklin, M.R.1
-
240
-
-
0020632391
-
Formation of inactive cytochrome P-450 Fe (II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats
-
Larrey, D., M. Tinel, and D. Pessayre (1983). Formation of inactive cytochrome P-450 Fe (II)-metabolite complexes with several erythromycin derivatives but not with josamycin and midecamycin in rats. Biochem. Pharmacol. 32, 1487-1493.
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 1487-1493
-
-
Larrey, D.1
Tinel, M.2
Pessayre, D.3
-
241
-
-
0024271473
-
In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: Comparison with troleandomycin and erythromycin
-
Delaforge, M., E. Sartori, and D. Mansuy (1988). In vivo and in vitro effects of a new macrolide antibiotic roxithromycin on rat liver cytochrome P-450: Comparison with troleandomycin and erythromycin. Chem. Biol. Interact. 68, 179-188.
-
(1988)
Chem. Biol. Interact.
, vol.68
, pp. 179-188
-
-
Delaforge, M.1
Sartori, E.2
Mansuy, D.3
-
242
-
-
0000756628
-
The molar light absorption of pyridine ferroprotoporphyrin (Pyridine Haemochromogen)
-
Paul, K. G., H. Theorell, and A. Akeson (1953). The molar light absorption of pyridine ferroprotoporphyrin (Pyridine Haemochromogen). Acta. Chem. Scand. 7, 1284-1287.
-
(1953)
Acta. Chem. Scand.
, vol.7
, pp. 1284-1287
-
-
Paul, K.G.1
Theorell, H.2
Akeson, A.3
-
243
-
-
0017868128
-
Spectral characterization of human hemoglobin and its derivatives
-
Waterman, M. R. (1978). Spectral characterization of human hemoglobin and its derivatives. Meth. Enzymol. 52, 456-463.
-
(1978)
Meth. Enzymol.
, vol.52
, pp. 456-463
-
-
Waterman, M.R.1
-
244
-
-
0001202995
-
Pigments of rat liver microsomes
-
Klingenberg, M. (1958). Pigments of rat liver microsomes. Arch. Biochem. Biophys. 75, 376-386.
-
(1958)
Arch. Biochem. Biophys.
, vol.75
, pp. 376-386
-
-
Klingenberg, M.1
-
247
-
-
0002254766
-
Analysis and characterization of enzymes
-
A. W. Hayes ed., Raven Press, Ltd., New York, NY
-
Guengerich, F. P. (1994). Analysis and characterization of enzymes. In A. W. Hayes (ed.), Principles and Methods of Toxicology. Raven Press, Ltd., New York, NY. pp. 1259-1313.
-
(1994)
Principles and Methods of Toxicology.
, pp. 1259-1313
-
-
Guengerich, F.P.1
-
248
-
-
73849173955
-
Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization, and kinetic studies
-
Phillips, A. H. and R. G. Langdon (1962). Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization, and kinetic studies. J. Biol. Chem. 237, 2652-2660.
-
(1962)
J. Biol. Chem.
, vol.237
, pp. 2652-2660
-
-
Phillips, A.H.1
Langdon, R.G.2
-
249
-
-
0017795019
-
Purification and properties of NADPH-cytochrome P-450 reductase
-
Strobel, H. W and J. D. Dignam (1978). Purification and properties of NADPH-cytochrome P-450 reductase. Meth. Enzymol. 52, 89-96.
-
(1978)
Meth. Enzymol.
, vol.52
, pp. 89-96
-
-
Strobel, H.W.1
Dignam, J.D.2
-
250
-
-
0032497361
-
Structure-function relationships of human liver cytochromes P450 3A: Aflatoxin B1 metabolism as a probe
-
Wang, H., R. Dick, H. Yin, E. Licad-Coles, D. Kroetz, G. Szklarz et al. (1998). Structure-function relationships of human liver cytochromes P450 3A: Aflatoxin B1 metabolism as a probe. Biochemistry 37, 12536-12545.
-
(1998)
Biochemistry
, vol.37
, pp. 12536-12545
-
-
Wang, H.1
Dick, R.2
Yin, H.3
Licad-Coles, E.4
Kroetz, D.5
Szklarz, G.6
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