N-cyclic bay-substituted perylene g-quadruplex ligands have selective antiproliferative effects on cancer cells and induce telomere damage

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1140-1156

  Casagrande, Valentina ^a   Salvati, Erica ^b   Alvino, Antonello ^a   Bianco, Armandodoriano ^a   Ciammaichella, Alina ^a   D'Angelo, Carmen ^b   Ginnari Satriani, Luca ^a   Serrilli, Anna Maria ^a   Iachettini, Sara ^b   Leonetti, Carlo ^b   Neidle, Stephen ^c   Ortaggi, Giancarlo ^a   Porru, Manuela ^b   Rizzo, Angela ^b   Franceschin, Marco ^a   Biroccio, Annamaria ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHROMOSOME PROTEIN; HISTONE H2AX; N,N' BIS(5 HYDROXY 3 OXAPENTYL) 1,7 BIS(1 PIPERIDINYL)PERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS(5 METHANESULFONYL 3 OXAPENTYL) 1,7 BIS(1 PIPERIDINYL)PERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS(5 METHANESULFONYL 3 OXAPENTYL) 1,7 DIBROMOPERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 1 [4 (3 DIMETHYLAMINOPROPYL) 1 PIPERAZINYL]PERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 1,7 [4 (3 DIMETHYLAMINOPROPYL) 1 PIPERAZINYL]PERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; N,N' BIS[2 (1 PIPERIDINO)ETHYL] 1,7 [4 METHYL 1 PIPERAZINYL]PERYLENE 3,4,9,10 TETRACARBOXYLIC DIIMIDE; PERYLENE; PROTEIN P53; PROTEIN POT1; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL DIVISION; CELL TRANSFORMATION; CHROMOSOME DAMAGE; CONTROLLED STUDY; DISSOCIATION; DNA DAMAGE; DRUG DETERMINATION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; TELOMERE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; HISTONES; HUMANS; LIGANDS; PERYLENE; PHOSPHORYLATION; PIPERIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; TELOMERE;

EID: 79952260703     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013665     Document Type: Article

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