The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2292-2304

  Franceschin, Marco ^a   Lombardo, Caterina Maria ^a   Pascucci, Emanuela ^a   D'Ambrosio, Danilo ^a   Micheli, Emanuela ^a   Bianco, Armandodoriano ^a   Ortaggi, Giancarlo ^a   Savino, Maria ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

G quadruplex; Polyamine side chained perylene derivatives; Telomerase inhibitors

Indexed keywords

IMIDE; N,N' BIS(12 ACETAMIDO 4,9 DIAZADODECYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(12 AMINO 4,9 DIAZADODECYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(5 ISOPROPYLAMINO 3 AZA PENTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(7 ACETAMIDO 4 AZAHEPTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(7 AMINO 4 AZAHEPTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMDE; N,N' BIS(7 DIMETHYLAMINO 4 AZA HEPTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(8 ACETAMIDO 3,6 DIAZAOCTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; N,N' BIS(8 AMINO 3,6 DIAZAOCTYL) 3,4,9,10 PERYLENETETRACARBOXYLIC DIIMIDE; PERYLENE; POLYAMINE DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; DNA RECOMBINATION; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; ENZYME INHIBITION; GENE EXPRESSION; PHYSICAL CHEMISTRY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN SECONDARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; SOLUBILITY; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; ULTRAVIOLET SPECTROSCOPY;

CATIONS; DNA; ENZYME INHIBITORS; G-QUADRUPLEXES; HUMANS; HYDROGEN BONDING; IMIDES; MODELS, MOLECULAR; PERYLENE; POLYAMINES; PROTEIN STRUCTURE, TERTIARY; SPECTROPHOTOMETRY; TELOMERASE;

EID: 40749091190     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.065     Document Type: Article

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