Accurate determination of quadruplex binding affinity and potency of G-quadruplex-interactive telomerase inhibitors by use of a telomerase extension assay requires varying the primer concentration

Anti-Cancer Drug Design

Volumn 14, Issue 4, 1999, Pages 367-372

  Cathers, Brian E ^a,b   Sun, Daekyu ^c   Hurley, Laurence H ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b Axys Pharmaceuticals Inc   (United States)

^c CTRC Institute for Drug Development   (United States)

Author keywords

Anthraquinone; Assay; G quadruplex; Inhibition; Telomerase

Indexed keywords

BSU 1051; DNA; ENZYME INHIBITOR; PRIMER DNA; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG POTENCY; ENZYME ACTIVITY; ENZYME ASSAY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY;

ANTHRAQUINONES; ENZYME INHIBITORS; GUANINE; TELOMERASE;

EID: 0032723367     PISSN: 02669536     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Short Survey

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