Selective G-quadruplex ligands: The significant role of side chain charge density in a series of perylene derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 14, 2009, Pages 3903-3908

  Micheli, Emanuela ^a   Lombardo, Caterina Maria ^b   D'Ambrosio, Danilo ^a   Franceschin, Marco ^a   Neidle, Stephen ^b   Savino, Maria ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

CD spectroscopy; Competition experiments; FRET; G quadruplex DNA; Perylene derivatives; Polyamines; Telomerase inhibitors; TRAP assay; UV vis absorption

Indexed keywords

DOUBLE STRANDED DNA; GENOMIC DNA; PERYLENE; PERYLENE POLYAMINE CONJUGATE; POLYAMINE DERIVATIVE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; DRUG CONJUGATION; DRUG DESIGN; DRUG SELECTIVITY; DRUG TARGETING; FLUORESCENCE RESONANCE ENERGY TRANSFER; MOLECULAR RECOGNITION; STRUCTURE ACTIVITY RELATION; TELOMERIC REPEAT AMPLIFICATION PROTOCOL; ULTRAVIOLET SPECTROSCOPY;

ANTINEOPLASTIC AGENTS; CIRCULAR DICHROISM; FLUORESCENCE RESONANCE ENERGY TRANSFER; G-QUADRUPLEXES; HUMANS; LIGANDS; PERYLENE; POLYAMINES; TELOMERASE; TELOMERE;

EID: 67649647842     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.106     Document Type: Article

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