Presenilin-2 mutation causes early amyloid accumulation and memory impairment in a transgenic mouse model of Alzheimer's disease

Journal of Biomedicine and Biotechnology

Volumn 2011, Issue , 2011, Pages

  Shimizu, Takahiko ^a   Toda, Toshihiko ^a,b   Noda, Yoshihiro ^a   Ito, Genzo ^c   Maeda, Masahiro ^c  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b JAC Inc   (Japan)

^c Immuno Biological Laboratories Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; AMYLOID PROTEIN; PRESENILIN 2; AMYLOID; AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BRAIN LEVEL; CONTROLLED STUDY; CROSS BREEDING; FEMALE; GENE MUTATION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEARNING DISORDER; LIFESPAN; MALE; MEMORY DISORDER; MOUSE; MUTATIONAL ANALYSIS; NEUROPATHOLOGY; NONHUMAN; ONSET AGE; PROTEIN AGGREGATION; PROTEIN SYNTHESIS REGULATION; SPATIAL MEMORY; STRAIN DIFFERENCE; TASK PERFORMANCE; TRANSGENIC MOUSE; WESTERN BLOTTING; ANIMAL; BRAIN; DISEASE MODEL; GENETICS; KAPLAN MEIER METHOD; LONGEVITY; MAZE TEST; METABOLISM; MUTATION; PATHOLOGY; PHENOTYPE; SOLUBILITY;

MUS; MUS MUSCULUS;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; BLOTTING, WESTERN; BRAIN; DISEASE MODELS, ANIMAL; FEMALE; KAPLAN-MEIER ESTIMATE; LONGEVITY; MALE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; MUTATION; PHENOTYPE; PRESENILIN-2; SOLUBILITY;

EID: 79952236194     PISSN: 11107243     EISSN: 11107251     Source Type: Journal    
DOI: 10.1155/2011/617974     Document Type: Article

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