-
1
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov, R. 2008. Origin and physiological roles of inflammation. Nature 454:428-435.
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
2
-
-
0037239057
-
Cytokine therapeutics for the treatment of sepsis: Why has nothing worked?
-
Remick, D. G. 2003. Cytokine therapeutics for the treatment of sepsis: why has nothing worked? Curr. Pharm. Des. 9:75-82.
-
(2003)
Curr. Pharm. Des.
, vol.9
, pp. 75-82
-
-
Remick, D.G.1
-
3
-
-
0036159842
-
Endotoxin tolerance: A review
-
West, M. A., and W. Heagy. 2002. Endotoxin tolerance: a review. Crit. Care Med. 30:S64-S73.
-
(2002)
Crit. Care Med.
, vol.30
-
-
West, M.A.1
Heagy, W.2
-
4
-
-
0030917203
-
Monocyte deactivation in septic patients: Restoration by IFN-gamma treatment
-
Docke, W. D., F. Randow, U. Syrbe, D. Krausch, K. Asadullah, P. Reinke, H. D. Volk, and W. Kox. 1997. Monocyte deactivation in septic patients: restoration by IFN-gamma treatment. Nat. Med. 3:678-681.
-
(1997)
Nat. Med.
, vol.3
, pp. 678-681
-
-
Docke, W.D.1
Randow, F.2
Syrbe, U.3
Krausch, D.4
Asadullah, K.5
Reinke, P.6
Volk, H.D.7
Kox, W.8
-
5
-
-
0025748883
-
Dysregulation of in vitro cytokine production by monocytes during sepsis
-
Munoz, C., J. Carlet, C. Fitting, B. Misset, J. P. Bleriot, and J. M. Cavaillon. 1991. Dysregulation of in vitro cytokine production by monocytes during sepsis. J. Clin. Invest. 88:1747-1754.
-
(1991)
J. Clin. Invest.
, vol.88
, pp. 1747-1754
-
-
Munoz, C.1
Carlet, J.2
Fitting, C.3
Misset, B.4
Bleriot, J.P.5
Cavaillon, J.M.6
-
6
-
-
0033082245
-
Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis
-
Flach, R., M. Majetschak, T. Heukamp, V. Jennissen, S. Flohe, J. Borgermann, U. Obertacke, and F. U. Schade. 1999. Relation of ex vivo stimulated blood cytokine synthesis to post-traumatic sepsis. Cytokine 11:173-178.
-
(1999)
Cytokine
, vol.11
, pp. 173-178
-
-
Flach, R.1
Majetschak, M.2
Heukamp, T.3
Jennissen, V.4
Flohe, S.5
Borgermann, J.6
Obertacke, U.7
Schade, F.U.8
-
7
-
-
0032697051
-
Release of proinflammatory cytokines by mitogen-stimulated peripheral blood mononuclear cells from critically ill multiple-trauma victims
-
Shahbazian, L. M., M. Jeevanandam, and S. R. Petersen. 1999. Release of proinflammatory cytokines by mitogen-stimulated peripheral blood mononuclear cells from critically ill multiple-trauma victims. Metabolism 48:1397-1401.
-
(1999)
Metabolism
, vol.48
, pp. 1397-1401
-
-
Shahbazian, L.M.1
Jeevanandam, M.2
Petersen, S.R.3
-
8
-
-
33745945755
-
Tolerance to microbial TLR ligands: Molecular mechanisms and relevance to disease
-
Medvedev, A. E., I. Sabroe, J. D. Hasday, and S. N. Vogel. 2006. Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J. Endotoxin Res. 12:133-150.
-
(2006)
J. Endotoxin Res.
, vol.12
, pp. 133-150
-
-
Medvedev, A.E.1
Sabroe, I.2
Hasday, J.D.3
Vogel, S.N.4
-
10
-
-
0027159611
-
Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A
-
Henricson, B. E., C. L. Manthey, P. Y. Perera, T. A. Hamilton, and S. N. Vogel. 1993. Dissociation of lipopolysaccharide (LPS)-inducible gene expression in murine macrophages pretreated with smooth LPS versus monophosphoryl lipid A. Infect. Immun. 61:2325-2333.
-
(1993)
Infect. Immun.
, vol.61
, pp. 2325-2333
-
-
Henricson, B.E.1
Manthey, C.L.2
Perera, P.Y.3
Hamilton, T.A.4
Vogel, S.N.5
-
11
-
-
0032522648
-
Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12
-
Shnyra, A., R. Brewington, A. Alipio, C. Amura, and D. C. Morrison. 1998. Reprogramming of lipopolysaccharide-primed macrophages is controlled by a counterbalanced production of IL-10 and IL-12. J. Immunol. 160:3729-3736.
-
(1998)
J. Immunol.
, vol.160
, pp. 3729-3736
-
-
Shnyra, A.1
Brewington, R.2
Alipio, A.3
Amura, C.4
Morrison, D.C.5
-
12
-
-
0030051294
-
Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro
-
Hirohashi, N., and D. C. Morrison. 1996. Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect. Immun. 64:1011-1015.
-
(1996)
Infect. Immun.
, vol.64
, pp. 1011-1015
-
-
Hirohashi, N.1
Morrison, D.C.2
-
13
-
-
0036838930
-
Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells
-
Medvedev, A. E., A. Lentschat, L. M. Wahl, D. T. Golenbock, and S. N. Vogel. 2002. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J. Immunol. 169:5209-5216.
-
(2002)
J. Immunol.
, vol.169
, pp. 5209-5216
-
-
Medvedev, A.E.1
Lentschat, A.2
Wahl, L.M.3
Golenbock, D.T.4
Vogel, S.N.5
-
14
-
-
34447525018
-
Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance
-
Medvedev, A. E., W. Piao, J. Shoenfelt, S. H. Rhee, H. Chen, S. Basu, L. M. Wahl, M. J. Fenton, and S. N. Vogel. 2007. Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance. J. Biol. Chem. 282:16042-16053.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 16042-16053
-
-
Medvedev, A.E.1
Piao, W.2
Shoenfelt, J.3
Rhee, S.H.4
Chen, H.5
Basu, S.6
Wahl, L.M.7
Fenton, M.J.8
Vogel, S.N.9
-
15
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
Kobayashi, K., L. D. Hernandez, J. E. Galan, C. A. Janeway, Jr., R. Medzhitov, and R. A. Flavell. 2002. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110:191-202.
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
Hernandez, L.D.2
Galan, J.E.3
Janeway Jr., C.A.4
Medzhitov, R.5
Flavell, R.A.6
-
16
-
-
38449086201
-
Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model
-
van 't Veer, C., P. S. van den Pangaart, M. A. van Zoelen, M. de Kruif, R. S. Birjmohun, E. S. Stroes, A. F. de Vos, and T. van der Poll. 2007. Induction of IRAK-M is associated with lipopolysaccharide tolerance in a human endotoxemia model. J. Immunol. 179:7110-7120.
-
(2007)
J. Immunol.
, vol.179
, pp. 7110-7120
-
-
van 't Veer, C.1
van den Pangaart, P.S.2
van Zoelen, M.A.3
de Kruif, M.4
Birjmohun, R.S.5
Stroes, E.S.6
de Vos, A.F.7
van der Poll, T.8
-
17
-
-
0034725584
-
Characterization of interleukin-1 receptor-associated kinase in normal and endotoxintolerant cells
-
Li, L., S. Cousart, J. Hu, and C. E. McCall. 2000. Characterization of interleukin-1 receptor-associated kinase in normal and endotoxintolerant cells. J. Biol. Chem. 275:23340-23345.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23340-23345
-
-
Li, L.1
Cousart, S.2
Hu, J.3
McCall, C.E.4
-
18
-
-
0030868909
-
The interleukin-1 receptorassociated kinase is degraded by proteasomes following its phosphorylation
-
Yamin, T. T., and D. K. Miller. 1997. The interleukin-1 receptorassociated kinase is degraded by proteasomes following its phosphorylation. J. Biol. Chem. 272:21540-21547.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 21540-21547
-
-
Yamin, T.T.1
Miller, D.K.2
-
19
-
-
34250823515
-
Gene-specific control of inflammation by TLR-induced chromatin modifications
-
Foster, S. L., D. C. Hargreaves, and R. Medzhitov. 2007. Gene-specific control of inflammation by TLR-induced chromatin modifications. Nature 447:972-978.
-
(2007)
Nature
, vol.447
, pp. 972-978
-
-
Foster, S.L.1
Hargreaves, D.C.2
Medzhitov, R.3
-
20
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa, R., T. Naka, H. Tsutsui, M. Fujimoto, A. Kimura, T. Abe, E. Seki, S. Sato, O. Takeuchi, K. Takeda, S. Akira, K. Yamanishi, I. Kawase, K. Nakanishi, and T. Kishimoto. 2002. SOCS-1 participates in negative regulation of LPS responses. Immunity 17:677-687.
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
Naka, T.2
Tsutsui, H.3
Fujimoto, M.4
Kimura, A.5
Abe, T.6
Seki, E.7
Sato, S.8
Takeuchi, O.9
Takeda, K.10
Akira, S.11
Yamanishi, K.12
Kawase, I.13
Nakanishi, K.14
Kishimoto, T.15
-
21
-
-
33846700754
-
Activation of PKR: An open and shut case?
-
Cole, J. L. 2007. Activation of PKR: an open and shut case? Trends Biochem. Sci. 32:57-62.
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 57-62
-
-
Cole, J.L.1
-
22
-
-
0343431521
-
Translational control of viral gene expression in eukaryotes
-
Gale, M., Jr., S. L. Tan, and M. G. Katze. 2000. Translational control of viral gene expression in eukaryotes. Microbiol. Mol. Biol. Rev. 64:239-280.
-
(2000)
Microbiol. Mol. Biol. Rev.
, vol.64
, pp. 239-280
-
-
Gale Jr., M.1
Tan, S.L.2
Katze, M.G.3
-
24
-
-
0035555301
-
TIRAP: An adapter molecule in the Toll signaling pathway
-
Horng, T., G. M. Barton, and R. Medzhitov. 2001. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2:835-841.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 835-841
-
-
Horng, T.1
Barton, G.M.2
Medzhitov, R.3
-
25
-
-
0034663942
-
The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin
-
Goh, K. C., M. J. deVeer, and B. R. Williams. 2000. The protein kinase PKR is required for p38 MAPK activation and the innate immune response to bacterial endotoxin. EMBO J. 19:4292-4297.
-
(2000)
EMBO J.
, vol.19
, pp. 4292-4297
-
-
Goh, K.C.1
de Veer, M.J.2
Williams, B.R.3
-
26
-
-
1642617628
-
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
-
Hsu, L. C., J. M. Park, K. Zhang, J. L. Luo, S. Maeda, R. J. Kaufman, L. Eckmann, D. G. Guiney, and M. Karin. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428:341-345.
-
(2004)
Nature
, vol.428
, pp. 341-345
-
-
Hsu, L.C.1
Park, J.M.2
Zhang, K.3
Luo, J.L.4
Maeda, S.5
Kaufman, R.J.6
Eckmann, L.7
Guiney, D.G.8
Karin, M.9
-
27
-
-
63649116570
-
Ubiquitylation in innate and adaptive immunity
-
Bhoj, V. G., and Z. J. Chen. 2009. Ubiquitylation in innate and adaptive immunity. Nature 458:430-437.
-
(2009)
Nature
, vol.458
, pp. 430-437
-
-
Bhoj, V.G.1
Chen, Z.J.2
-
28
-
-
59649086030
-
Nonproteolytic functions of ubiquitin in cell signaling
-
Chen, Z. J., and L. J. Sun. 2009. Nonproteolytic functions of ubiquitin in cell signaling. Mol. Cell 33:275-286.
-
(2009)
Mol. Cell
, vol.33
, pp. 275-286
-
-
Chen, Z.J.1
Sun, L.J.2
-
29
-
-
58149240784
-
The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling
-
Moynagh, P. N. 2009. The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling. Trends Immunol. 30:33-42.
-
(2009)
Trends Immunol.
, vol.30
, pp. 33-42
-
-
Moynagh, P.N.1
-
31
-
-
31344467156
-
Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation
-
Mansell, A., R. Smith, S. L. Doyle, P. Gray, J. E. Fenner, P. J. Crack, S. E. Nicholson, D. J. Hilton, L. A. O'Neill, and P. J. Hertzog. 2006. Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation. Nat. Immunol. 7:148-155.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 148-155
-
-
Mansell, A.1
Smith, R.2
Doyle, S.L.3
Gray, P.4
Fenner, J.E.5
Crack, P.J.6
Nicholson, S.E.7
Hilton, D.J.8
O'Neill, L.A.9
Hertzog, P.J.10
-
32
-
-
0031038169
-
Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome
-
Lam, Y. A., W. Xu, G. N. DeMartino, and R. E. Cohen. 1997. Editing of ubiquitin conjugates by an isopeptidase in the 26S proteasome. Nature 385:737-740.
-
(1997)
Nature
, vol.385
, pp. 737-740
-
-
Lam, Y.A.1
Xu, W.2
DeMartino, G.N.3
Cohen, R.E.4
-
33
-
-
49549117842
-
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
-
Newton, K., M. L. Matsumoto, I. E. Wertz, D. S. Kirkpatrick, J. R. Lill, J. Tan, D. Dugger, N. Gordon, S. S. Sidhu, F. A. Fellouse, L. Komuves, D. M. French, R. E. Ferrando, C. Lam, D. Compaan, C. Yu, I. Bosanac, S. G. Hymowitz, R. F. Kelley, and V. M. Dixit. 2008. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134:668-678.
-
(2008)
Cell
, vol.134
, pp. 668-678
-
-
Newton, K.1
Matsumoto, M.L.2
Wertz, I.E.3
Kirkpatrick, D.S.4
Lill, J.R.5
Tan, J.6
Dugger, D.7
Gordon, N.8
Sidhu, S.S.9
Fellouse, F.A.10
Komuves, L.11
French, D.M.12
Ferrando, R.E.13
Lam, C.14
Compaan, D.15
Yu, C.16
Bosanac, I.17
Hymowitz, S.G.18
Kelley, R.F.19
Dixit, V.M.20
more..
-
34
-
-
0036319517
-
A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways
-
Sato, S., O. Takeuchi, T. Fujita, H. Tomizawa, K. Takeda, and S. Akira. 2002. A variety of microbial components induce tolerance to lipopolysaccharide by differentially affecting MyD88-dependent and -independent pathways. Int. Immunol. 14:783-791.
-
(2002)
Int. Immunol.
, vol.14
, pp. 783-791
-
-
Sato, S.1
Takeuchi, O.2
Fujita, T.3
Tomizawa, H.4
Takeda, K.5
Akira, S.6
-
35
-
-
67649813235
-
Regulation of signaling by non-degradative ubiquitination
-
O'Neill, L. A. 2009. Regulation of signaling by non-degradative ubiquitination. J. Biol. Chem. 284:8209.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8209
-
-
O'Neill, L.A.1
-
36
-
-
0035019156
-
Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells
-
Wysocka, J., P. T. Reilly, and W. Herr. 2001. Loss of HCF-1-chromatin association precedes temperature-induced growth arrest of tsBN67 cells. Mol. Cell. Biol. 21:3820-3829.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3820-3829
-
-
Wysocka, J.1
Reilly, P.T.2
Herr, W.3
-
37
-
-
41549107522
-
Cytokine signaling modules in inflammatory responses
-
O'Shea, J. J., and P. J. Murray. 2008. Cytokine signaling modules in inflammatory responses. Immunity 28:477-487.
-
(2008)
Immunity
, vol.28
, pp. 477-487
-
-
O'Shea, J.J.1
Murray, P.J.2
-
38
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo, I., T. Hanada, K. Inagaki-Ohara, H. Mori, D. Aki, M. Ohishi, H. Yoshida, M. Kubo, and A. Yoshimura. 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17:583-591.
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
Hanada, T.2
Inagaki-Ohara, K.3
Mori, H.4
Aki, D.5
Ohishi, M.6
Yoshida, H.7
Kubo, M.8
Yoshimura, A.9
-
39
-
-
11144224785
-
Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of Toll-like receptor signaling
-
Gingras, S., E. Parganas, A. de Pauw, J. N. Ihle, and P. J. Murray. 2004. Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of Toll-like receptor signaling. J. Biol. Chem. 279:54702-54707.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 54702-54707
-
-
Gingras, S.1
Parganas, E.2
de Pauw, A.3
Ihle, J.N.4
Murray, P.J.5
-
40
-
-
39149094587
-
The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
-
Kim, Y. G., J. H. Park, M. H. Shaw, L. Franchi, N. Inohara, and G. Nunez. 2008. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28:246-257.
-
(2008)
Immunity
, vol.28
, pp. 246-257
-
-
Kim, Y.G.1
Park, J.H.2
Shaw, M.H.3
Franchi, L.4
Inohara, N.5
Nunez, G.6
-
41
-
-
33746596969
-
RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection
-
Bennett, R. L., W. L. Blalock, D. M. Abtahi, Y. Pan, S. A. Moyer, and W. S. May. 2006. RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 108:821-829.
-
(2006)
Blood
, vol.108
, pp. 821-829
-
-
Bennett, R.L.1
Blalock, W.L.2
Abtahi, D.M.3
Pan, Y.4
Moyer, S.A.5
May, W.S.6
-
42
-
-
0032480017
-
PACT, a protein activator of the interferon-induced protein kinase, PKR
-
Patel, R. C., and G. C. Sen. 1998. PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J. 17:4379-4390.
-
(1998)
EMBO J.
, vol.17
, pp. 4379-4390
-
-
Patel, R.C.1
Sen, G.C.2
-
43
-
-
0014122519
-
Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235
-
McIntire, F. C., H. W. Sievert, G. H. Barlow, R. A. Finley, and A. Y. Lee. 1967. Chemical, physical, biological properties of a lipopolysaccharide from Escherichia coli K-235. Biochemistry 6:2363-2372.
-
(1967)
Biochemistry
, vol.6
, pp. 2363-2372
-
-
McIntire, F.C.1
Sievert, H.W.2
Barlow, G.H.3
Finley, R.A.4
Lee, A.Y.5
-
44
-
-
28544453333
-
Chromosome alignment and segregation regulated by ubiquitination of survivin
-
Vong, Q. P., K. Cao, H. Y. Li, P. A. Iglesias, and Y. Zheng. 2005. Chromosome alignment and segregation regulated by ubiquitination of survivin. Science 310:1499-1504.
-
(2005)
Science
, vol.310
, pp. 1499-1504
-
-
Vong, Q.P.1
Cao, K.2
Li, H.Y.3
Iglesias, P.A.4
Zheng, Y.5
|