Translational control of viral gene expression in eukaryotes

Microbiology and Molecular Biology Reviews

Volumn 64, Issue 2, 2000, Pages 239-280

  Michael Jr , Gale ^a   Seng Lai, Tan ^b   Katze, Michael G ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ELONGATION FACTOR; INITIATION FACTOR; MESSENGER RNA; VIRUS PROTEIN; VIRUS RNA;

EUKARYOTE; GENE EXPRESSION; INFLUENZA VIRUS; LIFE CYCLE; NONHUMAN; PROTEIN SYNTHESIS; REVIEW; RNA ANALYSIS; RNA TRANSLATION; TRANSLATION REGULATION; VIROGENESIS; VIROLOGY; VIRUS INFECTION; VIRUS PATHOGENESIS;

EUKARYOTA; INFLUENZA VIRUS;

EID: 0343431521     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/mmbr.64.2.239-280.2000     Document Type: Review

References (504)

1. Agol, V. I. 1998. Virus robustness and perseverance. Mol. Biol. 32:44-49.
2. Alama, A., F. Barbieri, M. Cagnoli, and G. Schettini. 1997. Antisense oligonucleotides as therapeutic agents. Pharmacol. Res. 36:171-178.
3. Ali, N., and A. Siddiqui. 1995. Interaction of polypyrimidine tract-binding protein with the 5′ noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J. Virol. 69:6367-6375.
4. Ali, N., C. Wang, and A. Siddiqui. 1995. Translation of hepatitis C virus genome. Princess Takamatsu Symp. 25:99-110.
5. Alonso-Caplen, F. V., M. G. Katze, and R. M. Krug. 1988. Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection. J. Virol. 62:1606-1616.
6. Alter, M. J. H. 1997. Epidemiology of hepatitis C. Hepatology 26:62-65.
7. Amoroso, P., M. Rapicetta, M. E. Tosti, A. Mele, E. Spada, S. Bounocore, G. Lettieri, P. Peirri, P. Chionne, A. R. Ciccaglione, and L. Sagliocca. 1998. Correlation between virus genotype and chronicity rate in acute hepatitis C. J. Hepatol. 28:939-944.
8. Andreansky, S., L. Soroceanu, E. R. Flotte, J. Chou, J. M. Markert, G. Y. Gillespie, B. Roizman, and R. J. Whitley. 1997. Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors. Cancer Res. 57:1502-1509.
9. Reference deleted.
10. Aranda, M., and A. Maule. 1998. Virus-induced host gene shutoff in animals and plants. Virology 243:261-267.
11. Arrick, B. A., A. L. Lee, R. L. Grendell, and R. Derynck. 1991. Inhibition of translation of transforming growth factor-β3 mRNA by its 5′ untranslated region. Mol. Cell. Biol. 11:4306-4313.
12. Atkins, J. F., and R. F. Gesteland. 1996. Regulatory recoding, p. 653-684. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
13. Avni, D., Y. Biberman, and O. Meyuhas. 1997. The 5′ terminal oligopyrimidine tract confers translational control on TOP mRNAs in a cell type- and sequence context-dependent manner. Nucleic Acids Res. 25:995-1001.
14. Babich, A., L. Feldman, J. Nevins, J. E. Darnell, and C. Weinberger. 1983. Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translation discrimination. Mol. Cell. Biol. 3:1212-1221.
15. Baier, L. J., T. Shors, S. T. Shors, and B. L. Jacobs. 1993. The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR. Nucleic Acids Res. 21:4830-4835.
16. Balachandran, S., C. N. Kim, W.-C. Yeh, T. W. Mak, and G. N. Barber. 1998. Activation of the dsRNA-dependent protein kinase, PKR, induces apoptosis through FADD-mediated death signaling. EMBO J. 17:6888-6902.
17. Banerjee, A. K. 1980. 5′-terminal cap structure in eucaryotic messenger ribonucleic acids. Microbiol. Rev. 44:175-205.
18. Barber, G. N., M. Wambach, S. Thompson, R. Jagus, and M. G. Katze. 1995. Mutants of the RNA-dependent protein kinase (PKR) lacking double-stranded RNA binding domain 1 can act as transdominant inhibitors and induce malignant transformation. Mol. Cell. Biol. 15:3138-3146.
19. Barber, G. N., M. Wambach, M.-L. Wong, T. E. Dever, A. G. Hinnebusch, and M. G. Katze. 1993. Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase. Proc. Natl. Acad. Sci. USA 90:4621-4625.
20. Beattie, E., K. L. Denzler, J. Tartaglia, M. E. Perkus, E. Paoletti, and B. L. Jacobs. 1995. Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene. J. Virol. 69:499-505.
21. Beattie, E., J. Tartaglia, and E. Paoletti. 1991. Vaccinia virus-encoded eIF-2α homolog abrogates the antiviral effect of interferon. Virology 183: 419-422.
22. Beloso, A., C. Martinez, J. Valcarcel, J. F. Santaren, and J. Ortin. 1992. Degradation of cellular mRNA during influenza virus infection: its possible role in protein synthesis shutoff. J. Gen. Virol. 73:575-581.
23. Belsham, G. J., and N. Sonenberg. 1996. RNA-protein interactions in regulation of picornavirus RNA translation. Microbiol. Rev. 60:499-511.
24. Benkirane, M., C. Neuveut, R. F. Chun, S. M. Smith, C. E. Samuel, A. Gatignol, and K.-T. Jeang. 1997. Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR. EMBO J. 16:611-624.
25. Beretta, L., A.-C. Gingras, Y. V. Svitkin, M. N. Hall, and N. Sonenberg. 1996. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits capdependent initiation of translation. EMBO J. 15:658-664.
26. Beretta, L., Y. V. Svitkin, and N. Sonenberg. 1996. Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection. J. Virol. 70:8993-8996.
27. Bernstein, P., S. W. Peltz, and J. Ross. 1989. The poly(A)-poly(A)-binding protein complex is a major determinant of mRNA stability in vitro. Mol. Cell. Biol. 9:659-670.
28. Bisbal, C., T. Salehzada, B. Lebleu, and B. Bayard. 1989. Characterization of two murine (2′-5′)(A)n-dependent endonucleases of different molecular mass. Eur. J. Biochem. 179:595-602.
29. r protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J. Virol. 63:2244-2252.
30. r protein kinase by poliovirus requires RNA. J. Virol. 67:791-800.
31. Blight, K. J., A. A. Kolykhalov, K. E. Reed, E. V. Vagapov, and C. M. Rice. 1998. Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets. Antiviral Ther. 3(Suppl. 3):71-81.
32. Blight, K. J., and C. M. Rice. 1997. Secondary structure determination of the conserved 98-base sequence at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 71:7345-7352.
33. Blondel, B., G. Duncan, T. Couderc, F. Delpeyroux, and F. ColbereGarapin. 1998. Molecular aspects of poliovirus biology with a special focus on the interactions with nerve cells. J. Neurovirol. 4:1-29.
34. Blyn, L. B., K. M. Swiderek, O. Richards, D. C. Stahl, B. L. Semler, and E. Ehrenfeld. 1996. Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5′ noncoding region: identification by automated liquid chromatography-tandem mass spectrometry. Proc. Nat. Acad. Sci. USA 93: 11115-11120.
35. Blyn, L. B., J. S. Towner, B. L. Semler, and E. Ehrenfeld. 1997. Requirement of poly(rC) binding protein 2 for translation of poliovirus RNA. J. Virol. 71:6243-6246.
36. Borman, A., M. T. Howell, J. G. Patton, and R. Jackson. 1993. The involvement of a spliceosome component in internal initiation of rhinovirus RNA translation. J. Gen. Virol. 74:1775-1788.
37. Borman, A. M., F. G. Deliat, and K. M. Kean. 1994. Sequences within the poliovirus internal ribosome entry segment control viral RNA synthesis. EMBO J. 13:3149-3157.
38. Borovjagin, A., T. Pestova, and I. Shatsky. 1994. Pyrimidine tract binding protein strongly stimulates in vitro encephalomyocarditis virus RNA translation at the level of preinitiation complex formation. FEBS Lett. 351:299-302.
39. Brand, S. R., R. Kobayashi, and M. B. Mathews. 1997. The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. J. Biol. Chem. 272:8388-8395.
40. Brierley, I., M. R. Meredith, A. J. Bloys, and T. G. Hagervall. 1997. Expression of a coronavirus ribosomal frameshift signal in Escherichia coli: influence of tRNA anticodon modification on frameshifting. J. Mol. Biol. 270:360-373.
41. Brown, B. A., and E. Ehrenfeld. 1979. Translation of poliovirus RNA in vitro: changes in cleavage pattern and initiation sites by ribosomal salt wash. Virology 97:396-405.
42. Brown, E. A., S. P. Day, R. W. Jansen, and S. M. Lemon. 1999. The 5′ nontranslated region of hepatitis A virus RNA: secondary structure and elements required for translation in vitro. J. Virol. 65:5828-5838.
43. Brown, E. J., and S. L. Schreiber. 1996. A signaling pathway to translational control. Cell 86:517-520.
44. Brown, P. O., and D. Botstein. 1999. Exploring the new world of the genome with DNA microarrays. Nat. Genet. 21:33-37.
45. Bruno, S., E. Silini, A. Crosignani, F. Borzio, G. Leandro, F. Bono, M. Asti, S. Rossi, A. Larghi, A. Cerino, M. Podda, and M. U. Mondelli. 1997. Hepatitis C virus genotypes and risk of hepatocellular carcinoma in cirrhosis: a prospective study. Hepatology 25:754-758.
46. Bukh, J., R. Miller, and R. Purcell. 1995. Genetic heterogeneity of hepatitis C virus: quasispecies and genotypes. Semin. Liver Dis. 15:41-63.
47. Buratti, E., M. Gerotto, P. Pontisso, A. Alberti, S. G. Tisminetzky, and F. E. Baralle. 1997. In vivo translational efficiency of different hepatitis C virus 5′-UTRs. FEBS Lett. 411:275-280.
48. Cao, J., and A. P. Geballe. 1994. Mutational analysis of the translational signal in the human cytomegalovirus gpUL4 (gp48) transcript leader by retroviral infection. Virology 205:151-160.
49. Cao, J., and A. P. Geballe. 1996. Inhibition of nascent-peptide release at translation termination. Mol. Cell. Biol. 16:7109-7114.
50. Cao, J., and A. P. Geballe. 1998. Ribosomal release without peptidyl tRNA hydrolysis at translation termination in a eukaryotic system. RNA 4:181-188.
51. Carpick, B. W., V. Graziano, D. Schneider, R. K. Maitra, X. Lee, and B. R. G. Williams. 1997. Characterization of the solution structure between the interferon-induced double-stranded RNA-activated protein kinase and HIV-1 transactivating region RNA. J. Biol. Chem. 272:9510-9516.
52. Carroll, K., O. Elroy-Stein, R. Moss, and R. Jagus. 1993. Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2α-specific protein kinase. J. Biol. Chem. 268:12837-12842.
53. Cassady, K. A., M. Gross, and B. Roizman. 1998. The second-site mutation in the herpes simplex virus recombinants lacking the gamma(1)34.5 genes precludes shutoff of protein synthesis by blocking the phosphorylation of eIF-2 alpha. J. Virol. 72:7005-7011.
54. Centrella, M., and J. Lucas-Lenard. 1982. Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity. J. Virol. 41:781-791.
55. Chang, H.-W., J. C. Watson, and B. L. Jacobs. 1992. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 89: 4825-4829.
56. Chee, M., R. Yang, E. Hubbell, A. Berno, X. C. Huang, D. Stern, J. Winkler, D. J. Lockhart, M. S. Morris, and S. P. A. Fodor. 1996. Accessing genetic information with high-density DNA arrays. Science 274:610-614.
57. Chen, C. Y., and P. Sarnow. 1995. Initiation of protein synthesis by the eukaryotic translation apparatus on circular RNAs. Science 268:415-417.
58. Chen, J.-J., and I. M. London. 1995. Regulation of protein synthesis by heme-regulated eIF-2α kinase. Trends Biochem. Sci. 20:105-108.
59. Chen, X. Y., H. S. Kang, L. X. Shen, M. Chamorro, H. E. Varmus, and I. Tinoco. 1996. A characteristic bent conformation of RNA pseudoknots promotes -1 frameshifting during translation of retroviral RNA. J. Mol. Biol. 260:479-483.
60. Choi, S. K., W. C. Merrick, W. L. Zoll, and T. E. Dever. 1998. Promotion of Met-tRNA(i)(Met) binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast. Science 280:1757-1760.
61. Chong, K. L., L. Feng, K. Schappert, E. Meurs, T. F. Donahue, J. D. Friesen, A. G. Hovanessian, and B. R. G. Williams. 1992. Human P68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2. EMBO J. 11:1553-1562.
62. r 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF2α and premature shutoff of protein synthesis after infection with γ34.5 mutants, of herpes simplex virus 1. Proc. Natl. Acad. Sci. USA 92:10516-10520.
63. Chung, S., M. Eckrich, B. N. Perrone, D. T. Kohn, and H. Furneaux. 1997. The Elav-like proteins bind to a conserved regulatory element in the 3′-untranslated region of GAP-43 mRNA. J. Biol. Chem. 272:6593-6598.
64. Clemens, M. J. 1993. The small RNAs of Epstein-Barr virus. Mol. Biol. Rep. 17:81-92.
65. Clemens, M. J. 1994. Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2. Mol. Biol. Rep. 19:201-210.
66. Clemens, M. J. 1996. Protein kinases that phosphorylate eIF-2 and eIF-2B, and their role in eukaryotic cell translational control, p. 139-172. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N. Y.
67. Clemens, M. J., and U.-A. Bommer. 1999. Translational control: the cancer connection. Int. J. Biochem. Cell Biol. 31:1-23.
68. Clemens, M. J., and A. Elia. 1997. The double-stranded RNA-dependent protein kinase PKR: structure and function. J. Interferon Cytokine Res. 17: 503-524.
69. Clemens, M. J., J. W. B. Hershey, A. G. Hovanessian, B. L. Jacobs, M. G. Katze, R. J. Kaufman, P. Lengyel, C. E. Samuel, G. C. Sen, and B. R. G. Williams. 1993. PKR: proposed nomenclature for the RNA-dependent protein kinase induced by interferon. J. Interferon Res. 13:241.
70. Clemens, M. J., K. G. Laing, I. W. Jeffrey, A. Schofield, T. V. Sharp, A. Elia, V. Matys, M. C. James, and V. J. Tilleray. 1994. Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs. Biochimie 76:770-778.
71. Collier, A. J., S. X. Tang, and R. M. Elliott. 1998. Translation efficiencies of the 5′ untranslated region from representatives of the six major genotypes of hepatitis C virus using a novel bicistronic reporter assay system. J. Gen. Virology 79:2359-2366.
72. Corbin, A., and J. L. Darlix. 1996. Functions of the 5′ leader of murine leukemia virus genomic RNA in virion structure, viral replication and pathogenesis, and MLV-derived vectors. Biochimie 78:632-638.
73. Cosentino, G. P., S. Venkatesan, F. C. Serluca, S. R. Green, M. B. Mathews, and N. Sonenberg. 1995. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proc. Natl. Acad. Sci. USA 92:9445-9449.
74. Craig, A. W., G. P. Cosentino, O. Donzé, and N. Sonenberg. 1996. The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L. J. Biol. Chem. 271:24526-24533.
75. Craig, A. W., A. Haghighat, A. T. Yu, and N. Sonenberg. 1998. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. Nature 392:520-523.
76. Cullen, B. R. 1991. Regulation of HIV-1 gene expression. FASEB J. 5: 2361-2368.
77. Darnell, J. E., Jr. 1998. Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. J. Interferon Cytokine Res. 18:549-554.
78. Das, A. T., B. Klaver, B. F. Klasens, J. B. vanWamel, and B. Berkhout. 1997. A conserved hairpin motif in the R-U5 region of the human immunodeficiency virus type 1 RNA genome is essential for replication. J. Virol. 71:2346-2356.
79. Das, S., P. Coward, and A. Dasgupta. 1994. A small yeast RNA selectively inhibits internal initiation of translation programmed by poliovirus RNA: specific interaction with cellular proteins that bind to the viral 5′-untranslated region. J. Virol. 68:7200-7211.
80. Das, S., D. J. Kenan, D. Bocskai, J. D. Keene, and A. Dasgupta. 1996. Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity. J. Virol. 70:1624-1632.
81. Das, S., M. Ott, A. Yamane, W. M. Tsai, M. Gromeier, F. Lahser, S. Gupta, and A. Dasgupta. 1998. A small yeast RNA blocks hepatitis C virus internal ribosome entry site (HCV IRES)-mediated translation and inhibits replication of a chimeric poliovirus under translational control of the HCV IRES element. J. Virol. 72:5638-5647.
82. Davies, M. V., H.-W. Chang, B. L. Jacobs, and R. J. Kaufman. 1993. The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms. J. Virol. 67:1688-1692.
83. Davies, M. V., O. Elroy-Stein, R. Jagus, B. Moss, and R. J. Kaufman. 1992. The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J. Virol. 66:1943-1950.
84. Davis, S., and J. C. Watson. 1996. In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3′ untranslated regions of human alpha-tropomyosin. Proc. Natl. Acad. Sci. USA 93:508-513.
85. Degnin, C. R., M. R. Schleiss, J. Cao, and A. P. Geballe. 1993. Translational inhibition mediated by a short upstream open reading frame in the human cytomegalovirus gpUL4 (gp48) transcript. J. Virol. 67:5514-5521.
86. de la Luna, S., P. Fortes, A. Beloso, and J. Ortin. 1995. Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs. J. Virol. 68:2427-2433.
87. Der, S. D., Y.-L. Yang, C. Weissman, and B. R. G. Williams. 1997. A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc. Natl. Acad. Sci. USA 94:3279-3283.
88. Der, S. D., A. Zhou, B. R. G. Williams, and R. H. Silverman. 1998. Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95:15623-15628.
89. Dever, T. E., J.-J. Chen, G. N. Barber, A. M. Cigan, L. Feng, T. F. Donahue, I. M. London, M. G. Katze, and A. G. Hinnebusch. 1993. Mammalian eukaryotic initiation factor eIF2α kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast. Proc. Natl. Acad. Sci. USA 90:4616-4620.
90. Diaz, J. J., D. Simonin, T. Masse, P. Deviller, K. Kindbeiter, L. Denoroy, and J. J. Madjar. 1993. The herpes simplex virus type 1 US11 gene product is a phosphorylated protein found to be non-specifically associated with both ribosomal subunits. J. Gen. Virol. 74:397-406.
91. Dolph, P. J., J. Juang, and R. J. Schneider. 1990. Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex. J. Virol. 64:2669-2677.
92. Domingo, E., E. Baranowski, C. M. Ruiz-Jarabo, A. M. Martin-Hernandez, J. C. Saiz, and C. Escarmis. 1998. Quasispecies structure and persistence of RNA viruses. Emerging Infect. Dis. 4:521-527.
93. Reference deleted.
94. Dominguez, D. I., L. A. Ryabova, M. M. Pooggin, W. Schmidt-Puchta, J. Fütterer, and T. Hohn. 1998. Ribosome shunting in cauliflower mosaic virus: identification of an essential and sufficient structural element. J. Biol. Chem. 273:3669-3678.
95. Donze, O., J. Dostie, and N. Sonenberg. 1999. Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and Fas receptor expression. Virology 256:322-329.
96. Donze, O., R. Jagus, A. E. Koromilas, J. W. B. Hershey, and N. Sonenberg. 1995. Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J. 14:3828-3834.
97. Doohan, J. P., and C. E. Samuel. 1992. Biosynthesis of reovirus-specified polypeptides: ribosome pausing during the translation of reovirus S1 mRNA. Virology 186:409-425.
98. Doohan, J. P., and C. E. Samuel. 1993. Biosynthesis of reovirus-specified polypeptides. J. Biol. Chem. 268:18313-18320.
99. Dorner, A. J., B. L. Semler, R. J. Jackson, R. Hanecak, E. Duprey, and E. Wimmer. 1984. In vitro translation of poliovirus RNA: utilization of internal initiation sites in reticulocyte lysate. J. Virol. 50:507-514.
100. Ehrenfeld, E. 1982. Poliovirus-induced inhibition of host-cell protein synthesis. Cell 28:435-436.
101. Ehrenfeld, E. 1996. Initiation of translation by picornavirus RNAs, p. 549-574. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
102. Enami, K., T. A. Sato, S. Nakada, and M. Enami. 1994. Influenza virus NS1 protein stimulates translation of the M1 protein. J. Virol. 68:1432-1437.
103. Enomoto, N., I. Sakuma, Y. Asahina, M. Kurosaki, T. Murakami, C. Yamamoto, Y. Ogura, N. Izumi, F. Maruno, and C. Sato. 1996. Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection. N. Engl. J. Med. 334:77-81.
104. Enomoto, N., I. Sakuma, Y. Asahina, M. Kurosaki, T. Murankami, C. Yamamoto, N. Izumi, F. Marumo, and C. Sato. 1995. Comparison of fulllength sequences of interferon-sensitive and resistant hepatitis C virus 1b. J. Clin. Investig. 96:224-230.
105. Fadden, P., T. A. J. Haystead, and J. C. Lawrence. 1997. Identification of phosphorylation sites in the translational regulator, PHAS-I, that are controlled by insulin and rapamycin in rat adipocytes. J. Biol. Chem. 272: 10240-10247.
106. Fajardo, J. E., and A. J. Shatkin. 1990. Translation of bicistronic viral mRNA in transfected cells: regulation at the level of elongation. Proc. Natl. Acad. Sci. USA 87:328-332.
107. Falcone, D., and D. W. Andrews. 1991. Both the 5′ untranslated region and the sequences surrounding the start site contribute to efficient initiation of translation in vitro. Mol. Cell. Biol. 11:2656-2664.
108. Farabaugh, P. J. 1996. Programmed translational frameshifting. Annu. Rev. Genetics 30:507-528.
109. Fehrmann, F., R. Welker, and H. G. Krausslich. 1997. Intracisternal A-type particles express their proteinase in a separate reading frame by translational frameshifting, similar to D-type retroviruses. Virology 235:352-359.
110. Feigenblum, D., and R. J. Schneider. 1993. Modification of eukaryotic initiation factor 4F during infection by influenza virus. J. Virol. 67:3027-3035.
111. Felsenstein, K. M., and S. P. Goff. 1988. Expression of the gag-pol fusion protein of Moloney murine leukemia virus without gag protein does not induce virion formation or proteolytic processing. J. Virol. 62:2179-2182.
112. Felsenstein, K. M., and S. P. Goff. 1992. Mutational analysis of the gag-pol junction of Moloney murine leukemia virus: requirements for expression of the gag-pol fusion protein. J. Virol. 66:6601-6611.
113. Feng, G.-S., K. L. Chong, A. Kumara, and B. R. G. Williams. 1992. Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc. Natl. Acad. Sci. USA 89:5447-5451.
114. Fenwick, M. L., and J. Clark. 1982. Early and delayed shut-off of host protein synthesis in cells infected with herpes simplex virus. J. Gen. Virol. 61:121-125.
115. Fernadez, I., G. Castellano, M. J. Domingo, A. Fuertes, F. Colina, F. Canga, F. J. de la Cruz, A. G. de la Camara, and J. A. Solis. 1997. Influence of viral genotype and the level of viremia on the severity of liver injury and the response to interferon therapy. Scand. J. Gastroenterol. 32:7-76.
116. Fesq, H., M. Bacher, M. Nain, and D. Gemsa. 1994. Programmed cell death (apoptosis) in human monocytes infected by influenza virus. Immunobiology 190:175-182.
117. Fields, B. N. 1990. Virology. Raven Press, New York, N.Y.
118. Finco, T. S., J. K. Westwick, J. L. Norris, A. A. Beg, C. J. Der, and A. S. Baldwin, Jr. 1997. Oncogenic Ha-Ras-induced signaling activates NF-κB transcriptional activity, which is required for cellular transformation. J. Biol. Chem. 272:24113-24116.
119. Fortes, P., A. Beloso, and J. Ort'in. 1994. Influenza virus NS1 protein inhibits pre-mRNA splicing and blocks mRNA nucleocytoplasmic transport. EMBO J. 13:704-712.
120. Frederickson, R. M., and N. Sonenberg. 1992. Signal transduction and regulation of translation initiation. Semin. Cell Biol. 3:107-115.
121. Fried, M., and J. Hoofnagle. 1995. Therapy of hepatitis C. Semin. Liver Dis. 15:82-91.
122. Furuya, T., and M. M. C. Lai. 1993. Three different cellular proteins bind to complementary sites on the 5′-end-positive and 3′-negative strands of mouse hepatitis virus RNA. J. Virol. 67:7215-7222.
123. Fütterer, J., K. Gordon, J.-M. Bonneville, H. Sanfacon, B. Pisan, J. R. Penswick, and T. Hohn. 1988. Differential inhibition of downstream gene expression by the cauliflower mosaic virus 35S RNA leader. Nucleic Acids Res. 16:8377-8390.
124. Fütterer, J., Z. Kiss-L'aszl'o, and T. Hohn. 1993. Nonlinear ribosome migration on cauliflower mosaic virus 35S RNA. Cell 73:789-802.
125. Galabru, J., M. G. Katze, N. Robert, and A. G. Hovanessian. 1989. The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase. Eur. J. Biochem. 178:581-589.
126. Reference deleted.
127. Reference deleted.
128. rIPK. Mol. Cell. Biol. 18:859-871.
129. Gale, M., Jr., C. M. Blakely, B. Kwieciszewski, S.-L. Tan, M. Dossett, M. J. Korth, S. J. Polyak, D. R. Gretch, and M. G. Katze. 1998. Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation. Mol. Cell. Biol. 18:5208-5218.
130. Gale, M., Jr., and M. G. Katze. 1997. What happens inside lentivirus or influenza virus infected cells: insights into regulation of cellular and viral protein synthesis. Methods Companion Methods Enzymol. 11:383-401.
131. Gale, M., Jr., and M. G. Katze. 1998. Molecular mechanisms of interferon resistance mediated by viral-directed inhibition of PKR, the interferon-induced protein kinase. Pharmacol. Ther. 78:29-46.
132. Gale, M., Jr., M. J. Korth, and M. G. Katze. 1998. Repression of the PKR protein kinase by hepatitis C virus: a potential mechanism for interferon resistance. Clin. Diagn. Virol. 10:157-162.
133. Gale, M., Jr., M. J. Korth, N. M. Tang, S.-L. Tan, D. A. Hopkins, T. E. Dever, S. J. Polyak, D. R. Gretch, and M. G. Katze. 1997. Evidence that hepatitis C virus resistance to interferon is mediated through repression of the PKR protein kinase by the nonstructural 5A protein. Virology 230:217-227.
134. Gale, M., Jr., B. Kwieciszewski, M. Dossett, H. Nakao, and M. G. Katze. 1999. Anti-apoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J. Virol. 73:6506-6516.
135. IPK and vaccinia virus K3L is mediated by unique domains: implications for kinase regulation. Mol. Cell. Biol. 16:4172-4181.
136. Gallie, D. R. 1991. The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency. Genes Dev. 5:2108-2116.
137. Gallie, D. R. 1996. Translational control of cellular and viral mRNAs. Plant Mol. Biol. 32:145-158.
138. Gallie, D. R. 1998. A tale of two termini: a functional interaction between the termini of an mRNA is a prerequisite for efficient translation initiation. Gene 216:1-11.
139. Garcia-Sastre, A., A. Egorov, D. Matassov, S. Brandt, D. E. Levy, J. E. Durbin, P. Palese, and T. Muster. 1999. Influenza A virus lacking the NS1 gene replicates in interferon-deficient systems. Virology 252:324-330.
140. Garfinkel, M. S., and M. G. Katze. 1992. Translational control by influenza virus: selective and cap-dependent translation of viral mRNAs in infected cells. J. Biol. Chem. 267:9383-9390.
141. Garfinkel, M. S., and M. G. Katze. 1993. How does influenza virus regulate gene expression at the level of mRNA translation? Let us count the ways. Gene Expression 3:109-118.
142. Garfinkel, M. S., and M. G. Katze. 1993. Translational control by influenza virus: selective translation is mediated by sequences within the viral mRNA 5′-untranslated region. J. Biol. Chem. 268:22223-22226.
143. Garfinkel, M. S., and M. G. Katze. 1994. Influenza virus control of protein synthesis. Sci. Am. 1994(issue on Science and Medicine):64-73.
144. + concentrations and the regulation of protein synthesis in sindbis virus-infected chick cells. Virology 96:108-120.
145. Gaughan, D. J., and A. S. Whitehead. 1999. Function and biological applications of catalytic nucleic acids. Biochim. Biophys. Acta 1445:1-20.
146. Geballe, A. P. 1996. Translational control mediated by upstream AUG codons, p. 173-197. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory, Plainview, N.Y.
147. Geballe, A. P., and E. S. Mocarski. 1988. Translational control of cytomegalovirus gene expression is mediated by upstream AUG codons. J. Virol. 62: 3334-3340.
148. Geballe, A. P., and D. R. Morris. 1994. Initiation codons within 5′-leaders of mRNAs as regulators of translation. Trends Biochem. Sci. 19:159-164.
149. Gehrke, L., L. E. Hann, and R. L. Kaspar. 1994. Translational control of gene expression. Annu. Rep. Med. Chem. 29:248-254.
150. Geiss, G. K., R. E. Bumgarner, M. An, M. B. Agy, A. van't Wout, E. Hammersmark, V. Carter, D. Upchurch, J. I. Mullins, and M. G. Katze. 2000. Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays. Virology 266:8-16.
151. Gesteland, R. F., and J. F. Atkins. 1996. Recoding: dynamic reprogramming of translation. Annu. Rev. Biochem. 65:741-768.
152. Giege, R., M. Sissler, and C. Florentz. 1998. Universal rules and idiosyncratic features in tRNA identity. Nucleic Acids Res. 26:5017-5035.
153. Gingras, A.-C., B. Raught, and N. Sonenberg. 1999. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu. Rev. Biochem. 68:963.
154. Gingras, A. C., S. G. Kennedy, M. A. OLeary, N. Sonenberg, and N. Hay. 1998. 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. Genes Dev. 12:502-513.
155. Gingras, A. C., Y. Svitkin, G. J. Belsham, A. Pause, and N. Sonenberg. 1996. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proc. Natl. Acad. Sci. USA 93: 5578-5583.
156. Glass, M. J., and D. F. Summers. 1992. A cis-acting element within the hepatitis A virus 5′ non-coding region required for in vitro translation. Virus Res. 26:15-31.
157. Godefroy-Colburn, T., C. Thivent, and L. Pink. 1985. Translational discrimination between the four RNAs of alfalfa mosaic virus: a quantitative evaluation. Eur. J. Biochem. 147:541-548.
158. Goldenberg, D., N. Mador, M. J. Ball, A. Panet, and I. Steiner. 1997. The abundant latency-associated transcripts of herpes simplex virus type 1 are bound to polyribosomes in cultured neuronal cells and during latent infection in mouse trigeminal ganglia. J. Virol. 71:2897-2904.
159. Goldenberg, D., N. Mador, A. Panet, and I. Steiner. 1998. Tissue specific distribution of the herpes simplex virus type 1 latency-associated transcripts on polyribosomes during latent infection. J. Neurovirol. 4:426-432.
160. Gottlieb, E., and J. A. Stelitz. 1989. Function of the mammalian La protein: evidence for its action in transcription termination by RNA polymerase III. EMBO J. 8:851-861.
161. Gradi, A., Y. V. Svitkin, H. Imataka, and N. Sonenberg. 1998. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection Proc. Natl. Acad. Sci. USA 95:11089-11094.
162. Graff, J., J. Cha, L. B. Blyn, and E. Ehrenfeld. 1998. Interaction of poly(rC) binding protein 2 with the 5′ noncoding region of hepatitis A virus RNA and its effects on translation. J. Virol. 72:9668-9675.
163. Gray, N. K., and M. Wickens. 1998. Control of translation initiation in animals. Annu. Rev. Cell Dev. Biol. 14:399-458.
164. Greco, A., A. M. Laurent, and J. J. Madjar. 1997. Repression of beta-actin synthesis and persistence of ribosomal protein synthesis after infection of HeLa cells by herpes simplex virus type 1 infection are under translational control. Mol. Gen. Genet. 256:320-327.
165. Green, S. R., and M. B. Mathews. 1992. Two RNA binding motifs in the double-stranded RNA activated protein kinase, DAI. Genes Dev. 6:2478-2490.
166. Greenspan, D., P. Palese, and M. Krystal. 1988. Two nuclear location signals in the influenza virus NS1 nonstructural protein. J. Virol. 62:3020-3026.
167. Gromeier, M., L. Alexander, and E. Wimmer. 1999. Internal ribosome entry site substitution eliminates meurovirulence in intergeneric poliovirus recombinants. Proc. Natl. Acad. Sci. USA 93:2370-2375.
168. Gromeier, M., B. Bossert, M. Arita, A. Nomoto, and E. Wimmer. 1999. Dual stem-loops within the poliovirus internal ribosomal entry site control neurovirulence. J. Virol. 73:958-964.
169. Gunnery, S. A., P. Rice, H. D. Robertson, and M. B. Mathews. 1990. Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 87:8687-8691.
170. Gygi, S. P., D. K. M. Han, A.-C. Gingras, N. Sonenberg, and R. Aebersold.
171. Gygi, S. P., Y. Rochon, B. R. Franza, and R. Aebersold. 1999. Correlation between protein and mRNA abundance in yeast. Mol. Cell. Biol. 19:1720-1730.
172. Haghighat, A., S. Mader, A. Pause, and N. Sonenberg. 1995. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. EMBO J. 14:5701-5709.
173. Haghighat, A., and N. Sonenberg. 1997. eIF4G dramatically enhances the binding of eIF4E to the mRNA 5′-cap structure. J. Biol. Chem. 272:21677-21680.
174. Haghighat, A., Y. Svitkin, I. Novoa, E. Kuechler, T. Skern, and N. Sonenberg. 1996. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase. J. Virol. 70:8444-8450.
175. Hanecak, R., V. BrownDriver, M. C. Fox, R. F. Azad, S. Furusako, C. Nozaki, C. Ford, H. Sasmor, and K. P. Anderson. 1996. Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes. J. Virol. 70:5203-5212.
176. Hanks, S. K., A. M. Quinn, and T. Hunter. 1988. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science 241:42-52.
177. Hann, L. E., A. C. Webb, J. M. Cai, and L. Gehrke. 1997. Identification of a competitive translation determinant in the 3′ untranslated region of alfalfa mosaic virus coat protein mRNA. Mol. Cell. Biol. 17:2005-2013.
178. Harding, H. P., Y. Zhang, and D. Ron. 1999. Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397:271-274.
179. Hardwick, J. M. 1997. Virus-induced apoptosis. Adv. Pharmacol. 41:295-336.
180. Hardwicke, M. A., and R. M. Sandri-Goldin. 1994. The herpes simplex virus regulatory protein ICP27 contributes to the decrease in cellular mRNA levels during infection. J. Virol. 68:4797-4810.
181. Hardy, W. R., and R. M. Sandri-Goldin. 1994. Herpes simplex virus inhibits host cell splicing, and regulatory protein ICP27 is required for this effect. J. Virol. 68:7790-7799.
182. Harford, J. B. 1995. Translation-targeted therapeutics for viral diseases. Gene Expression 4:357-367.
183. Hatada, E., and R. Fukuda. 1992. Binding of influenza A virus NS1 protein to dsRNA in vitro. J. Gen. Virol. 73:3325-3329.
184. Hatada, E., S. Saito, and R. Fukuda. 1999. Mutant influenza viruses with a defective NS1 protein cannot block the activation of PKR in infected cells. J. Virol. 73:2425-2433.
185. Hatfield, D., Y. X. Feng, B. J. Lee, A. Rein, G. J. Levin, and S. Oroszlan. 1989. Chromatographic analysis of the aminoacyl-tRNAs which are required for translation of codons at and around the ribosomalframeshift sites of HIV, HTLV-1, and BLV. Virology 173:736-742.
186. Hatfield, D., and S. Oroszlan. 1990. The where, what and how of ribosomal frameshifting in retroviral protein synthesis. Trends Biochem. Sci. 15:186-190.
187. Hayes, B. W., G. C. Telling, M. M. Myat, J. F. Williams, and S. F. Flint. 1990. The adenovirus L4 100-kDa protein is necessary for efficient translation of viral late mRNA species. J. Virol. 64:2732-2742.
188. - herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the α47 gene. J. Virol. 71:6049-6054.
189. He, B., J. Chou, D. A. Liebermann, B. Huffman, and B. Roizman. 1996. The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells. J. Virol. 70:84-90.
190. He, B., M. Gross, and B. Roizman. 1997. The gamma(1)34.5 protein of herpes simplex virus I complexes with protein phosphatase 1 alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 94:843-848.
191. Hellen, C. U. T., T. V. Pestova, M. Litterst, and E. Wimmer. 1994. The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5′ nontranslated region. J. Virol. 68:941-950.
192. Hellen, C. U. T., and E. Wimmer. 1994. Translation of encephalomyocarditis virus RNA: parameters influencing the selection of the internal initiation site. EMBO J. 13:1673-1681.
193. Hellen, C. U. T., and E. Wimmer. 1995. Translation of encephalomyocarditis virus RNA by internal ribosome entry. Curr. Top. Microbiol. Immunol. 203:31-63.
194. Hellen, C. U. T., H. W. Witherall, M. Schmid, S. H. Shin, T. V. Pestova, A. Gil, and E. Wimmer. 1993. A cytomplasmic 57-kDa protein that is required for translation of picornavirus RNA by internal ribosome entry is identical to the nuclear pyrimidine tract-binding protein. Proc. Natl. Acad. Sci. USA 90:7642-7646.
195. Hemmings-Mieszczak, M., G. Steger, and T. Hohn. 1997. Alternative structures of the cauliflower mosaic virus 35 S RNA leader: Implications for viral expression and replication. J. Mol. Biol. 267:1075-1088.
196. Hemmings-Mieszczak, M., G. Steger, and T. Hohn. 1998. Regulation of CaMV 35 S RNA translation is mediated by a stable hairpin in the leader. RNA 4:101-111.
197. Hentze, M. W. 1997. eIF4G: a multipurpose ribosome adapter? Science 275:500-501.
198. Hershey, J. W. B. 1991. Translational control in mammalian cells. Annu. Rev. Biochem. 60:717-755.
199. Hershey, J. W. B., M. B. Mathews, and N. Sonenberg (ed.). Translational control. 1996. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
200. Herson, D., A. Schmidt, S. Seal, A. Marcus, and L. van Vloten-Doting. 1979. Competitive mRNA translation in an in vitro system from wheat germ. J. Biol. Chem. 254:8245-8249.
201. Hinnebusch, A. G. 1994. The eIF-2α kinases: regulators of protein synthesis in starvation and stress. Semin. Cell Biol. 5:417-426.
202. Hinnebusch, A. G. 1996. Translational control of GCN4: gene-specific regulation by phosphorylation of eIF2, p. 199-244. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
203. Hohn, T., D. I. Dominguez, N. ScharerHernandez, W. Schmidt-Puchta, M. Hemmings-Mieszczak, and J. Fütterer. 1988. Ribosome shunting in eukaryotes: what the viruses tell me. p. 84-95. In A look beyond transcription.
204. Honda, M., M. R. Beard, L. H. Ping, and S. M. Lemon. 1999. A phylogenetically conserved stem-loop structure at the 5′ border of the internal ribosome entry site of hepatitis C virus is required for cap-independent viral translation. J. Virol. 73:1165-1174.
205. Honda, M., E. A. Brown, and S. M. Lemon. 1996. Stability of a stem-loop involving the initiator AUG controls the efficiency of internal initiation of translation on hepatitis C virus RNA. RNA 2:955-968.
206. Honda, M., L. H. Ping, R. A. Rijnbrand, E. Amphlett, B. Clarke, D. Rowlands, and S. M. Lemon. 1996. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology 222:31-42.
207. Honda, M., R. Rijnbrand, G. Abell, D. Kim, and S. M. Lemon. 1999. Natural variation in translational activities of the 5′ nontranslated RNAs of hepatitis C virus genotypes 1a and 1b: evidence for a long-range RNA-RNA interaction outside of the internal ribosome entry site. J. Virol. 73:4941-4951.
208. Hoofnagle, J. H. 1994. Therapy of acute and chronic viral hepatitis. Adv. Intern. Med. 39:241-275.
209. Houser-Scott, F., P. Ansel-McKinney, J. M. Cai, and L. Gehrke. 1997. In vitro genetic selection analysis of alfalfa mosaic virus coat protein binding to 3′-terminal AUGC repeats in the viral RNAs. J. Virol. 71:2310-2319.
210. Huang, J., and R. J. Schneider. 1991. Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein. Cell 65:271-280.
211. Hwang, L. H., C. L. Hsieh, A. Yen, Y. L. Chung, and D. S. Chen. 1998. Involvement of the 5′ proximal coding sequences of hepatitis C virus with internal initiation of viral translation. Biochem. Biophys. Res. Commun. 252:455-460.
212. Icely, P. L., P. Gros, J. J. M. Bergeron, A. Devault, D. E. H. Afar, and J. C. Bell. 1991. TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J. Biol. Chem. 266:16073-16077.
213. Iino, S., K. Hino, and K. Yasuda. 1994. Current state of interferon therapy for chronic hepatitis C. Intervirology 37:87-100.
214. Imataka, H., A. Gradi, and N. Sonenberg. 1998. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. EMBO J. 17:7480-7489.
215. Inglis, S. C. 1982. Inhibition of host protein synthesis and degradation of cellular mRNAs during infection by influenza and Herpes simplex virus. Mol. Cell. Biol. 2:1644-1648.
216. Ito, T., and M. M. C. Lai. 1997. Determination of the secondary structure of and cellular protein binding to the 3′ untranslated region of the hepatitis C virus RNA genome. J. Virol. 71:8698-8706.
217. Ito, T., and M. M. C. Lai. 1999. An internal polyprimidine-tract-binding protein-binding site in the hepatitis C virus RNA attenuates translation, which is relieved by the 3′-untranslated region. Virology 254:288-296.
218. Ito, T., S. M. Tahara, and M. C. Lai. 1998. The 3′-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site. J. Virol. 72:8789-8796.
219. Jacks, T., H. D. Madhani, F. R. Masiarz, and H. E. Varmus. 1988. Signals for ribosomal frameshifting in the Rous sarcoma virus gag-pol region. Cell 55:447-458.
220. Jacks, T., and H. E. Varmus. 1985. Expression of the Rous sarcoma virus pol gene by ribosomal frameshifting. Science 230:1237-1242.
221. Jackson, R. J. 1996. A comparative view of initiation site selection mechanisms, p. 71-112. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
222. Jackson, R. J., M. T. Howell, and A. Kaminski. 1990. The novel mechanism of initiation of picornavirus RNA translation. Trends Biochem. Sci. 15:477-483.
223. Jackson, R. J., and A. Kaminski. 1995. Internal initiation of translation in eukaryotes: the picornavirus paradigm and beyond. RNA 1:985-1000.
224. Jacobs, B. L., and R. E. Ferguson. 1991. The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon. J. Virol. 65:5102-5104.
225. Jacobson, A. 1996. Poly(A) metabolism and translation: the closed-loop model, p. 451-480. In S. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
226. Jang, S. K., M. V. Davies, R. J. Kaufman, and E. Wimmer. 1989. Initiation of protein synthesis by internal entry of ribosomes into the 5′ nontranslated region of encephalomyocarditis virus RNA in vivo. J. Virol. 63:1651-1660.
227. Jang, S. K., H. G. Krausslich, M. J. H. Nicklin, A. C. Duke, A. C. Palmenberg, and E. Wimmer. 1988. A segment of the 5′ nontranslated region of the encephalomyocarditis virus RNA directs internal entry of ribosomes during in vitro translation. J. Virol. 62:2636-2643.
228. Jang, S. K., T. V. Pestova, C. U. T. Hellen, G. W. Witherell, and E. Wimmer. 1990. Cap-independent translation of picornavirus RNAs: Structure and function of the internal ribosomal entry site. Enzyme 44:292-309.
229. Jang, S. K., and E. Wimmer. 1990. Cap-independent translation of encephalomyocarditis virus RNA: structural requirements of the internal ribosome entry site and involvement of a 57kD RNA binding protein. Genes Dev. 4:1560-1572.
230. Jaramillo, M. L., N. Abraham, and J. C. Bell. 1995. The interferon system: a review with emphasis on the role of PKR in growth control. Cancer Investig. 13:327-338.
231. Jefferies, H. B., and G. Thomas. 1994. Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation. J. Biol. Chem. 269: 4367-4372.
232. Jefferies, H. B. J., and G. Thomas. 1996. Ribosomal protein S6 phosphorylation and signal transduction, p. 389-409. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
233. Joachims, M., P. C. Van-Breugel, and R. E. Lloyd. 1999. Cleavage of poly(A)-binding protein by enterovirus proteases concurrent with inhibition of translation in vitro. J. Virol. 73:718-727.
234. Johannes, G., M. S. Carter, M. B. Eisen, P. O. Brown, and P. Sarnow. 1999. Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using cDNA microarray. Proc. Natl. Acad. Sci. USA 96:13118-13123.
235. Johannes, G., and P. Sarnow. 1998. Cap-independent polysomal association of natural mRNAs encoding c-myc, BiP, and eIF4G conferred by internal ribosome entry sites. RNA 4:1500-1513.
236. Johnston, M. 1998. Gene chips: array of hope for understanding gene regulation. Curr. Biol. 8:R171-R174.
237. Joshi, B., A.-L. Cai, B. D. Keiper, W. B. Minich, R. Mendez, C. M. Beach, J. Stepinski, R. Stolarski, E. Darzynkiewicz, and R. E. Rhoads. 1995. Phosphorylation of eukaryotic protein synthesis initiation factor 4E at ser-209. J. Biol. Chem. 270:14597-14603.
238. Kaminski, A., S. L. Hunt, J. G. Patton, and R. J. Jackson. 1995. Direct evidence that polypyrimidine tract binding protein (PTB) is essential for internal initiation of translation of encephalomyocarditis virus RNA. RNA 1:924-938.
239. Kaminski, A., and R. J. Jackson. 1998. The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute. RNA 4:626-638.
240. Kato, N., M. Hijikata, Y. Ootsuyama, M. Nakagawa, S. Ohkoshi, T. Sugimura, and K. Shimotohno. 1990. Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc. Natl. Acad. Sci. USA 87:9524-9528.
241. r protein kinase. Semin. Virol. 4:259-268.
242. Katze, M. G. 1993. The regulation of the interferon-induced dsRNA activated protein kinase in virus-infected cells by viral and cellular gene products. Semin. Virol. 10:501-508.
243. Katze, M. G. 1995. The war against the interferon-induced, double-stranded RNA-activated protein kinase: can viruses win? J. Interferon Res. 12:241-248.
244. Katze, M. G. 1996. Translational control in cells infected with influenza virus and reovirus, p. 607-630. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
245. Katze, M. G., and M. B. Agy. 1990. Regulation of viral and cellular RNA turnover in cells infected by eukaryotic viruses including HIV-1. Enzyme 44:332-346.
246. Katze, M. G., Y. T. Chen, and R. M. Krug. 1984. Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells. Cell 37:483-490.
247. Katze, M. G., D. DeCorato, and R. M. Krug. 1986. Cellular mRNA translation is blocked at both initiation and elongation after infection by influenza virus or adenovirus. J. Virol. 60:1027-1039.
248. r protein kinase to regulate its autophosphorylation and activity. EMBO J. 6:689-697.
249. Katze, M. G., B. M. Detjen, B. Safer, and R. M. Krug. 1986. Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol. Cell. Biol. 6:1741-1750.
250. Katze, M. G., and R. M. Krug. 1984. Metabolism and expression of RNA polymerase II transcripts in influenza virus infected cells. Mol. Cell. Biol. 4: 2198-2206.
251. Katze, M. G., and R. M. Krug. 1990. Translational control in influenza virus-infected cells. Enzyme 44:265-277.
252. Katze, M. G., J. Lara, and M. Wambach. 1989. Nontranslated cellular mRNAs are associated with cytoskeletal framework in influenza virus or adenovirus infected cells. Virology 169:312-322.
253. r protein kinase. J. Virol. 62:3710-3717.
254. r protein kinase in a cell-free system. Mol. Cell. Biol. 11:5497-5505.
255. Kawagishi-Kobayashi, M., J. B. Silverman, T. L. Ung, and T. E. Dever. 1997. Regulation of the protein kinase PKR by the vaccinia virus pseudosubstrate inhibitor K3L is dependent on residues conserved between the K3L protein and the PKR substrate eIF-2α. Mol. Cell. Biol. 17:4146-4158.
256. Kawaguchi, Y., R. Bruni, and B. Roizman. 1997. Interaction of herpes simplex virus 1 alpha regulatory protein ICP0 with elongation factor 1 delta: ICP0 affects translational machinery. J. Virol. 71:1019-1024.
257. Kawaguchi, Y., C. VanSant, and B. Roizman. 1998. Eukaryotic elongation factor 1 delta is hyperphosphorylated by the protein kinase encoded by the U(L)13 gene of herpes simplex virus 1. J. Virol. 72:1731-1736.
258. Keiper, B. D., W. Gan, and R. E. Rhoads. 1999. Protein synthesis initiation factor 4G. Int. J. Biochem. Cell Biol. 31:37-48.
259. Kerekatte, V., B. D. Keiper, C. Badorff, A. L. Cai, K. U. Knowlton, and R. E. Rhoads. 1999. Cleavage of poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? J. Virol. 73:709-717.
260. Kimura, T., K. Nakayama, J. Penninger, M. Kitagawa, H. Harada, T. Matsuyama, N. Tanaka, R. Kamijo, J. Vilcek, T. W. Mak, and T. Taniguchi. 1994. Involvement of the IRF-1 transcription factor in antiviral responses to interferons. Science 264:1921-1924.
261. Kirchhoff, S., A. E. Koromilas, F. Schaper, M. Grashof, N. Sonenberg, and H. Hauser. 1995. IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR. Oncogene 11:439-445.
262. Knee, R., and P. R. Murphy. 1997. Regulation of gene expression by natural antisense RNA transcripts. Neurochem. Int. 31:379-392.
263. Koff, R. S. 1997. Therapy in chronic hepatitis C: say goodbye to the 6-month interferon regimen. Am. J. Gastroenterol. 91:2072-2074.
264. Kolupaeva, V. G., C. T. Hellen, and I. N. Shatsky. 1996. Structural analysis of the interaction of the pyrimidine tract-binding protein with the internal ribosomal entry site of encephalomyocarditis virus and foot-and-mouth disease virus RNAs. RNA 2:1199-1212.
265. Kolykhalov, A. A., S. M. Fienstone, and C. M. Rice. 1996. Identification of a highly conserved sequence element at the 3′ terminus of hepatitis C virus genome RNA. J. Virol. 70:3363-3371.
266. Koromilas, A. E., C. Cantin, A. W. B. Craig, R. Jagus, J. Hiscott, and N. Sonenberg. 1995. The interferon-inducible protein kinase PKR modulates the transcriptional activation of immunoglobulin kappa gene. J. Biol. Chem. 270:25426-25434.
267. Korth, M. J., and M. G. Katze. 1997. mRNA metabolism and cancer, p. 265-280. In J. Harford and D. Morris (ed.), mRNA metabolism and post-transcriptional gene regulation. Wiley-Liss, Inc., New York, N.Y.
268. Korth, M. J., C. N. Lyons, M. Wambach, and M. G. Katze. 1996. Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase. Gene 170:181-188.
269. Kozak, M. 1986. Influences of mRNA secondary structure on initiation by eukaryotic ribosomes. Proc. Natl. Acad. Sci. USA 83:2850-2854.
270. Kozak, M. 1986. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukarotic ribosomes. Cell 44: 283-292.
271. Kozak, M. 1991. An analysis of vertebrate mRNA sequences: intimations of translational control. J. Cell Biol. 115:887-903.
272. Kozak, M. 1992. Regulation of translation in eukaryotic systems. Annu. Rev. Cell Biol. 8:197-225.
273. Krausslich, H. G., M. J. H. Nicklin, H. Toyoda, D. Etchison, and E. Wimmer. 1987. Poliovirus proteinase 2A induces cleavage of eukaryotic initiation factor 4F polypeptide P220. J. Virol. 61:2711-2718.
274. Krug, R. M., F. Alonso-Caplen, I. Julkunen, and M. G. Katze. 1989. Expression and replication of the influenza virus genome, p. 89-152. In R. M. Krug (ed.), Influenza viruses. Plenum Publishing Corp., New York, N.Y.
275. Krug, R. M., M. Shaw, B. Broni, G. Shapiro, and O. Haller. 1985. Inhibition of influenza viral messenger RNA synthesis in cells expressing the interferon-induced Mx gene product. J. Virol. 56:201-206.
276. Kruys, V., and G. Huez. 1994. Translational control of cytokine expression by 3′ UA-rich sequences. Biochimie 76:862-866.
277. Kumar, A., Y.-L. Yang, V. Flati, S. Der, S. Kadereit, A. Deb, J. Haque, L. Reis, C. Weissmann, and B. R. G. Williams. 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-κB. EMBO J. 16:406-416.
278. Kurosaki, M., N. Enomoto, T. Murakami, I. Sakuma, Y. Asahina, C. Yamamoto, T. Ikeda, S. Tozuka, N. Izumi, F. Marumo, and C. Sato. 1997. Analysis of genotypes and amino acid residues 2209 to 2248 of the NS5A region of hepatitis C virus in relation to the response to interferon-β therapy. Hepatology 25:750-753.
279. Kwong, A. D., and N. Frenkel. 1987. Herpes simplex virus-infected cells contain a function(s) that destabilizes both host and viral mRNAs. Proc. Natl. Acad. Sci. USA 84:1926-1930.
280. Kwong, A. D., J. A. Kruper, and N. Frenkel. 1988. Herpes simplex virus virion host shutoff function. J. Virol. 62:912-921.
281. Laine, R. O., R. G. Hutson, and M. S. Kilberg. 1996. Eukaryotic gene expression: metabolite control by amino acids. Prog. Nucleic Acid Res. Mol. Biol. 53:219-248.
282. Lam, Q., C. A. Smibert, K. E. Koop, C. Lavery, J. P. Capone, S. P. Weinheimer, and J. R. Smiley. 1996. Herpes simplex virus VP16 rescues viral mRNA from destruction by the virion host shutoff function. EMBO J. 15: 2575-2581.
283. Lamphear, B. J., R. Kirchweger, T. Skern, and R. E. Rhoads. 1995. Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation. J. Biol. Chem. 270:21975-21983.
284. r 66,000 subunits. J. Biol. Chem. 267:10729-10736.
285. Laurent, A. M., J. J. Madjar, and A. Greco. 1998. Translational control of viral and host protein synthesis during the course of herpes simplex virus type 1 infection: evidence that initiation of translation is the limiting step. J. Gen. Virol. 79:2765-2775.
286. Lawson, T. G., B. K. Ray, J. T. Dodds, J. A. Grifo, R. D. Abramson, W. C. Merrick, D. F. Betsch, H. L. Weith, and R. E. Thach. 1986. Influence of 5′ proximal secondary structure on the translational efficiency of eukaryotic mRNAs and on their interaction with initiation factors. J. Biol. Chem. 261: 13979-13989.
287. Lazaris-Karatzas, A., K. S. Mantine, and N. Sonenberg. 1990. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345:544-547.
288. Lazarowitz, S. G., R. W. Compans, and P. W. Choppin. 1971. Influenza virus structural and nonstructural proteins in infected cells and their plasma membrane. Virology 46:830-843.
289. Le, H., R. L. Tanguay, M. L. Balasta, C. C. Wei, K. S. Browning, A. M. Metz, D. J. Goss, and D. R. Gallie. 1997. Translation initiation factors eIF-iso4G and eIF-4B interact with the poly(A)-binding protein and increase its RNA binding activity. J. Biol. Chem. 272:16247-16255.
290. Le, S. Y., A. Siddiqui, and J. V. Maizel. 1996. A common structural core in the internal ribosome entry sites of picornavirus, hepatitis C virus, and pestivirus. Virus Genes 12:135-147.
291. Lee, J. H., S. K. Choi, A. Roll-Mecak, S. K. Burley, and T. E. Dever. 1999. Universal conservation in translation initiation revealed by human and archaeal homologs of bacterial translation initiation factor IF2. Proc. Natl. Acad. Sci. USA 96:4342-4347.
292. Lee, K. A. W., and N. Sonenberg. 1982. Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc. Natl. Acad. Sci. USA 79:3447-3451.
293. Lee, S. B., and M. Esteban. 1994. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. Virology 199:491-496.
294. Lee, T. G., N. Tang, S. Thompson, J. Miller, and M. G. Katze. 1994. The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins. Mol. Cell. Biol. 14:2331-2342.
295. r 68,000 from influenza virus-infected cells. Proc. Natl. Acad. Sci. USA 87:6208-6212.
296. Lee, T. G., J. Tomita, A. G. Hovanessian, and M. G. Katze. 1992. Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase. J. Biol. Chem. 267: 14238-14243.
297. Lenardo, M. J., C.-M. Fan, T. Maniatis, and D. Baltimore. 1989. The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell 57:287-294.
298. Lenk, R., and S. Penman. 1979. The cytoskeleton framework and poliovirus metabolism. Cell 16:289-301.
299. Lennon, G. G., and H. Lehrach. 1991. Hybridization analyses of arrayed cDNA libraries. Trends Genet. 7:314-317.
300. Lewis, J. D., and E. Izaurralde. 1997. The role of the cap structure in RNA processing and nuclear export. Eur. J. Biochem. 247:462-469.
301. Li, J., and R. A. Petryshyn. 1991. Activation of the double-stranded RNA-dependent eIF-2α kinase by cellular RNA from 3T3-F442A cells. Eur. J. Biochem. 195:41-48.
302. Li, X., and S. L. Rhode III. 1993. The parvovirus H-1 NS2 protein affects viral gene expression through sequences in the 3′ untranslated region. Virology 194:10-19.
303. Licis, N., J. Vanduin, Z. Baklava, and V. Berzins. 1998. Long-range translational coupling in single-stranded RNA bacteriophages: an evolutionary analysis. Nucleic Acids Res. 26:3242-3246.
304. Lin, C. H., and J. G. Patton. 1995. Regulation of alternative 3′ splice site selection by constitutive splicing factors. RNA 1:234-245.
305. Lin, T.-A., X. Kong, T. A. J. Haystead, A. Pause, G. Belsham, N. Sonenberg, and J. C. Lawrence, Jr. 1994. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266:653-656.
306. Lindquist, S., and R. Petersen. 1990. Selective translation and degradation of heat-shock messenger RNAs in Drosophila. Enzyme 44:147-166.
307. Lloyd, R. M., and A. J. Shatkin. 1992. Translational stimulation by reovirus polypeptide 3: substitution for VAI RNA and inhibition of phosphorylation of the α subunit of eukaryotic initiation factor 2. J. Virol. 66:6878-6884.
308. Lockhart, D. J., H. Dong, M. C. Byrne, M. T. Follettie, M. V. Gallo, M. S. Chee, M. Mittmann, C. Wang, M. Kobayashi, H. Horton, and E. L. Brown. 1996. Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat. Biotechnol. 14:1675-1680.
309. Lodish, H. F., and M. Porter. 1980. Translational control of protein synthesis after infection by vesicular stomatitis virus. J. Virol. 36:719-733.
310. Logan, J., and T. Shenk. 1984. Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection. Proc. Natl. Acad. Sci. USA 81:3655-3659.
311. Lu, Y., X.-Y. Qian, and R. M. Krug. 1994. The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing. Genes Dev. 8:1817-1828.
312. Lu, Y., M. Wambach, M. G. Katze, and R. M. Krug. 1995. Binding of the influenza virus NS1 protein to double-stranded RNA inhibits the activation of the protein kinase that phosphorylates the eIF-2 translation initiation factor. Virology 214:222-228.
313. Maciejewski, J. P., and S. C. St. Jeor. 1999. Human cytomegalovirus infection of human hematopoietic progenitor cells. Leuk. Lymphoma 33:1-13.
314. Maitra, R. K., N. McMillan, S. Desai, J. McSwiggen, A. G. Hovanessian, G. Sen, B. R. G. Williams, and R. H. Silverman. 1994. HIV-1 TAR RNA has an intrinsic ability to activate interferon-inducible enzymes. Virology 204: 823-827.
315. Makkinje, A., H. Xiong, M. Li, and Z. Damuni. 1995. Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase. J. Biol. Chem. 270:14824-14826.
316. Manche, L., S. R. Green, C. Schmedt, and M. B. Mathews. 1992. Interactions between dsRNA regulators and the protein kinase, DAI. Mol. Cell. Biol. 12:5238-5248.
317. Maran, A., R. K. Maitra, A. Kumar, B. Dong, W. Xiao, G. Li, B. R. G. Williams, P. F. Torrence, and R. H. Silverman. 1994. Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science 265:789-792.
318. Marcotrigiano, J., A. C. Gingras, N. Sonenberg, and S. K. Burley. 1997. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell 89:951-961.
319. Marczinke, B., R. Fisher, M. Vidakovic, A. J. Bloys, and I. Brierley. 1998. Secondary structure and mutational analysis of the ribosomal frameshift signal of Rous sarcoma virus. J. Mol. Biol. 284:205-225.
320. Mathews, M. B. 1990. Control of translation in adenovirus-infected cells. Enzyme 44:250-264.
321. Mathews, M. B. 1993. Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors. Semin. Virol. 4:247-258.
322. Mathews, M. B. 1996. Interactions between viruses and the cellular machinery for protein synthesis, p. 505-548. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
323. Mathews, M. B., and T. Shenk. 1991. Adenovirus virus-associated RNA and translation control. J. Virol. 65:5657-5662.
324. McCarthy, J. E. G. 1998. Postranscriptional control of gene expression in yeast. Microbiol. Mol. Biol. Rev. 62:1492-1553.
325. 1 and TAR RNAs. Virology 206:511-519.
326. McHutchison, J. G., S. C. Gordon, E. R. Schiff, M. L. Shiffman, W. M. Lee, Z. D. Goodman, M. H. Ling, S. Cort, and J. K. Albrecht for the Interferon Interventional Therapy Group. 1998. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. N. Engl. J. Med. 339:1485-1492.
327. McMillan, N. A. J., R. F. Chun, D. P. Siderovski, J. Galabru, W. M. Toone, C. E. Samuel, T. W. Mak, A. G. Hovanessian, K.-T. Jeang, and B. R. G. Williams. 1995. HIV-1 Tat directly interacts with the interferon-induced, double-stranded RNA-dependent kinase, PKR. Virology 213:413-424.
328. Meerovitch, K., J. Pelletier, and N. Sonenberg. 1989. A cellular protein that binds to the 5′-noncoding region of poliovirus RNA: implications for internal translation initiation. Genes Dev. 13:1026-1034.
329. Meerovitch, K., and N. Sonenberg. 1993. Internal initiation of picornavirus RNA translation. Semin. Virol. 4:504.1-504.11.
330. Meerovitch, K., Y. V. Svitkin, H. S. Lee, F. Lejbkowicz, D. J. Kenan, E. K. L. Chan, V. I. Agol, J. D. Keene, and N. Sonenberg. 1993. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. J. Virol. 67:3798-3807.
331. Mellits, K. H., M. Kostura, and M. B. Mathews. 1990. Interaction of adenovirus VA RNA1 with the protein kinase DAI: nonequivalence of binding and function. Cell 61:843-852.
332. IPK, the cellular inhibitor of PKR. Proc. Natl. Acad. Sci. USA 94:97-102.
333. IPK, is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity. J. Biol. Chem. 274:3797-3803.
334. Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
335. Merrick, W. C., and J. W. B. Hershey. 1996. The pathway and mechanism of eukaryotic protein synthesis, p. 31-70. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
336. Meurs, E., K. L. Chong, J. Galabru, N. Thomas, I. Kerr, B. R. G. Williams, and A. G. Hovanessian. 1990. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Cell 62:379-390.
337. Meurs, E. F., J. Galabru, G. N. Barber, M. G. Katze, and A. G.
338. Mohr, I., and Y. Gluzman. 1996. A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function. EMBO J. 15:4759-4766.
339. Morley, S. J. 1997. Signalling through either the p38 or ERK mitogen-activated protein (MAP) kinase pathway is obligatory for phorbol ester and T cell receptor complex (TCR-CD3)-stimulated phosphorylation of initiation factor (eIF) 4E in Jurkat T cells. FEBS Lett. 418:327-332.
340. Morley, S. J., P. S. Curtis, and V. M. Pain. 1997. eIF4G: Translation's mystery factor begins to yield its secrets. RNA 3:1085-1104.
341. Morley, S. J., and L. McKendrick. 1997. Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells. J. Biol. Chem. 272:17887-17893.
342. Mueller, P. P., and A. G. Hinnebusch. 1986. Multiple upstream AUG codons mediate translational control of GCN4. Cell 45:201-207.
343. Mulvey, M., J. Poppers, A. Ladd, and I. Mohr. 1999. A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function. J. Virol. 73:3375-3385.
344. Mundschau, L. J., and D. V. Faller. 1995. Platelet-derived growth factor signal transduction through the interferon-inducible kinase PKR. J. Biol. Chem. 270:3100-3106.
345. Munemitsu, S. M., and C. E. Samuel. 1988. Biosynthesis of reovirus-specified polypeptides: effect of point mutation of the sequences flanking the 5′-proximal AUG initiator codons of the reovirus S1 and S4 genes on the efficiency of mRNA translation. Virology 163:643-646.
346. Müller, U., U. Steinhoff, L. F. L. Reis, S. Hemmi, J. Pavlovic, R. M. Zinkernagel, and M. Aguet. 1994. Functional role of type I and type II interferons in antiviral defense. Science 264:1918-1921.
347. Nanbru, C., I. Lafon, S. Audigier, M. C. Gensac, S. Vagner, G. Huez, and A. C. Prats. 1997. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site. J. Biol. Chem. 272:32061-32066.
348. Neumann, A. U., N. P. Lam, H. Dahari, D. R. Gretch, T. E. Wiley, T. J. Layden, and A. S. Perelson. 1999. Hepatitis C virus dynamics in vivo and the antiviral efficacy of interferon-α therapy. Science 282:103-107.
349. Ng, T. I., Y. E. Chang, and B. Roizman. 1997. Infected cell protein 22 of herpes simplex virus 1 regulates the expression of virion host shutoff gene U(L)41. Virology 234:226-234.
350. Nguyen, C., D. Rocha, S. Granjeaud, M. Baldit, K. Bernard, P. Naquet, and B. R. Jordan. 1995. Differential gene expression in the murine thymus assayed by quantitative hybridization of arrayed cDNA clones. Genomics 20:207-216.
351. Nicholson, R., J. Pelletier, S.-Y. Le, and N. Sonenberg. 1991. Structural and functional analysis of the ribosone landing pad of poliovirus type 2 - in vivo translation studies. J. Virol. 65:5886-5894.
352. Nishioka, Y., and S. Silverstein. 1977. Degradation of cellular mRNA during infection by herpes simplex virus. Proc. Natl. Acad. Sci. USA 74: 2370-2374.
353. O'Brien, V. 1998. Viruses and apoptosis. J. Gen. Virol. 79:1833-1845.
354. Ohlmann, T., M. Rau, V. M. Pain, and S. J. Morley. 1996. The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. EMBO J. 15:1371-1382.
355. Ohsawa, M., N. Shingu, H. Miwa, H. Yoshihara, M. Kubo, H. Tsukuma, H. Teshima, M. Hashimoto, and K. Aozasa. 1999. Risk of non-Hodgkin's lymphoma in patients with hepatitis C virus infection. Int. J. Cancer 80:237-239.
356. Okuda, K. 1998. Hepatitis C and hepatocellular carcinoma. J. Gastroenterol. Hepatol. 13:294-298.
357. Ortega, L. G., M. D. McCotter, G. L. Henry, S. J. McCormack, D. C. Thomis, and C. E. Samuel. 1996. Mechanism of interferon action. Biochemical and genetic evidence for the intermolecular association of the RNA-dependent protein kinase PKR from human cells. Virology 215:31-39.
358. Overton, H., D. McMillan, L. Hope, and P. Wong-Kai-In. 1994. Production of host shutoff-defective mutants of herpes simplex virus type 1 by inactivation of the UL13 gene. Virology 202:97-106.
359. Pain, V. M. 1996. Initiation of protein synthesis in eukaryotic cells. Eur. J. Biochem. 236:747-771.
360. Pardigon, N., and J. H. Strauss. 1992. Cellular proteins bind to the 3′ end of Sindbis virus minus-strand RNA. J. Virol. 66:1007-1015.
361. Park, Y.-W., and M. G. Katze. 1995. Translational control by influenza virus: identification of cis-acting sequences and trans-acting factors which may regulate selective viral mRNA translation. J. Biol. Chem. 270:28433-28439.
362. Park, Y.-W., J. Wilusz, and M. G. Katze. 1999. Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1. Proc. Natl. Acad. Sci. USA 96: 6694-6699.
363. Patel, R., and G. C. Sen. 1992. Identification of the double stranded RNA-binding domain of the human interferon-inducible protein kinase. J. Biol. Chem. 267:7871-7876.
364. Patel, R. C., P. Stanton, N. M. J. McMillan, B. R. G. Williams, and G. C. Sen. 1995. The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo. Proc. Natl. Acad. Sci. USA 92: 8283-8287.
365. Patel, R. C., P. Stanton, and G. C. Sen. 1996. Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties. J. Biol. Chem. 271:25657-25663.
366. Patel, R. C., and G. C. Sen. 1998. PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J. 17:4379-4390.
367. Pause, A., G. J. Belsham, A. C. Gingras, O. Donzé, T. A. Lin, J. C. Lawrence, and N. Sonenberg. 1994. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767.
368. Pavlakis, G. N., and B. K. Felber. 1990. Regulation of expression of human immunodeficiency virus. New Biol. 2:20-31.
369. Pavlovic, J., and P. Staehli. 1991. The antiviral potentials of Mx proteins. J. Interferon Res. 11:215-219.
370. Pelletier, J., and N. Sonenberg. 1988. Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA. Nature 334:320-325.
371. Pelletier, J., and N. Sonenberg. 1989. Internal binding of eukaryotic ribosomes on poliovirus RNA: translation in HeLa cell extracts. J. Virol. 63: 441-444.
372. Pestova, T. V., C. T. Hellen, and I. N. Shatsky. 1996. Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry. Mol. Cell Biol. 16:6859-6869.
373. Petryshyn, R. A., A. G. Ferrenz, and J. Li. 1997. Characterization and mapping of the double-stranded regions involved in activation of PKR within a cellular RNA from 3T3-F442A cells. Nucleic Acids Res. 25:2672-2678.
374. Petska, S., J. A. Langer, K. Zoon, and C. E. Samuel. 1987. Interferons and their actions. Annu. Rev. Biochem. 56:727-777.
375. Pietu, G., O. Alibert, V. Guichard, B. Lamy, F. Bois, E. Leroy, R. Mariage-Samson, R. Houlgatee, P. Soularue, and C. Auffray. 1996. Novel gene transcripts preferentially expressed in human muscles revealed by quantitative hybridization of a high density cDNA array. Genome Res. 6:492-503.
376. Piron, M., P. Vende, J. Cohen, and D. Poncet. 1998. Rotavirus RNA-binding protein NSP3 interacts with eIF4GI and evicts the poly(A) binding protein from eIF4F. EMBO J. 17:5811-5821.
377. Polyak, S. J., D. M. Paschal, S. Mcardle, M. J. Gale, Jr., D. Moradpour, and D. R. Gretch. 1999. Characterization of the effects of hepatitis C virus nonstructural 5A protein expression in human cell lines and on interferon-sensitive virus replication. Hepatology 29:1262-1271.
378. Polyak, S. J., N. Tang, M. Wambach, G. N. Barber, and M. G. Katze. 1996. The p58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity. J. Biol. Chem. 271:1702-1707.
379. Poon, A. W., and B. Roizman. 1997. Differentiation of the shutoff of protein synthesis by virion host shutoff and mutant gamma(1)34.5 genes of herpes simplex virus 1. Virology 229:98-105.
380. Poulin, F., A.-C. Gingras, H. Olsen, and N. Sonenberg. 1998. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. J. Biol. Chem. 273:14002-14007.
381. Pratt, G., A. R. Galpine, N. A. Sharp, S. Palmer, and M. J. Clemens. 1988. Regulation of in vitro translation by double-stranded RNA in mammalian cell mRNA preparations. Nucleic Acids Res. 16:3497-3510.
382. Proud, C. G. 1995. PKR: a new name and new roles. Trends Biochem. Sci. 20:241-246.
383. Pyronnet, S., H. Imataka, A.-C. Gingras, R. Fukunaga, T. Hunter, and N. Sonenberg. 1999. Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E. EMBO J. 18:270-279.
384. + mRNA binding protein which interacts with a conserved G-rich element. Nucleic Acids Res. 22: 2334-2343.
385. Qiu, Y., and R. M. Krug. 1994. The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A). J. Virol. 68:2425-2432.
386. Rajan, P., S. Swaminathan, J. Zhu, C. N. Cole, G. Barber, M. J. Tevethia, and B. Thimmapaya. 1995. A novel translational regulation function for the simian virus 40 large T-antigen gene. J. Virol. 69:785-795.
387. Raught, B., and A.-C. Gingras. 1999. eIF4E activity is regulated at multiple levels. Int. J. Biochem. Cell Biol. 31:43-57.
388. Ray, B. K., T. G. Brendler, S. Adya, S. Daniels-McQueen, J. K. Miller, J. W. B. Hershey, J. A. Grifo, W. C. Merrick, and R. E. Thach. 1983. Role of mRNA competition in regulating translation: further characterization of mRNA discriminatory initiation factors. Proc. Natl. Acad. Sci. USA 80:663-667.
389. Read, G. S., B. M. Karr, and K. Knight. 1993. Isolation of a herpes simplex virus type 1 mutant with a deletion in the virion host shutoff gene and identification of multiple forms of the vhs (UL41) polypeptide. J. Virol. 67: 7149-7160.
390. Reed, K. E., and C. M. Rice. 2000. Overview of hepatitis C virus genome structure, polyprotein processing, and protein properties. Curr. Top. Microbiol. Immunol. 242:55-84.
391. Reynolds, J. E., A. Kaminski, A. R. Carroll, B. E. Clarke, D. J. Rowlands, and R. J. Jackson. 1996. Internal initiation of translation of hepatitis C virus RNA: the ribosome entry site is at the authentic initiation codon. RNA 2: 867-878.
392. Rhoads, R. E., S. Joshi-Barve, and C. Rinker-Schaeffer. 1993. Mechanism of action and regulation of protein synthesis initiation factor 4E: effects on mRNA discrimination, cellular growth rate, and oncogenesis. Prog. Nucleic Acid Res. 46:183-219.
393. Richter, J. D. 1996. Dynamics of poly(A) addition and removal during development, p. 481-504. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translation control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
394. Roberts, L. O., R. A. Seamons, and G. J. Belsham. 1998. Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. RNA 4:520-529.
395. Romano, P. R., S. R. Green, G. N. Barber, M. B. Mathews, and A. G. Hinnebusch. 1995. Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2α kinase DAI in Saccharomyces cerevisiae. Mol. Cell. Biol. 15:365-378.
396. Rouault, T. A., R. D. Klausner, and J. B. Harford. 1996. Translational control of ferritin, p. 335-362. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
397. Roy, S., M. G. Katze, N. T. Parkin, I. Edery, A. G. Hovanessian, and N. Sonenberg. 1990. Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product. Science 247:1216-1219.
398. Rueckert, R. R. 1996. Picornaviridae: the viruses and their replication, p. 609-654. In B. N. Fields, D. M. Knipe, R. M. Chanock, M. S. Hirsch, J. L. Melnick, T. P. Monath, and B. Roizman (ed.), Virology, 3rd ed. Raven Press, New York, N.Y.
399. Ryabova, L. A., A. F. Torgashov, O. V. Kurnasov, M. G. Bubunenko, and A. S. Spirin. 1993. The 3′-terminal intranslated region of alfalfa mosaic virus RNA 4 facilitates the RNA entry into translation in a cell-free system. FEBS Lett. 326:264-266.
400. Sabin, A., and L. Boulger. 1973. History of Sabin attenuated poliovirus oral live vaccine strains. J. Biol. Stand. 1:115-118.
401. Sachs, A. B., P. Sarnow, and M. W. Hentze. 1997. Starting at the beginning, middle, and end: translation initiation in eukaryotes. Cell 89:831-838,
402. Sakamoto, N., C.-H. Wu, and G.-Y. Wu. 1996. Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes. J. Clin. Investig. 98:2720-2728.
403. Samuel, C. E. 1991. Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 183:1-11.
404. Samuel, C. E. 1993. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268:7603-7606.
405. Sandri-Goldin, R. M. 1998. ICP27 mediates HSV RNA export by shuttling through a leucine-rich nuclear export signal and binding viral intronless RNAs through an RGG motif. Genes Dev. 12:868-879.
406. Sandri-Goldin, R. M., M. K. Hibbard, and M. A. Hardwicke. 1995. The C-terminal repressor region of herpes simplex virus type 1 ICP27 is required for the redistribution of small nuclear ribonucleoprotein particles and splicing factor SC35; however, these alterations are not sufficient to inhibit host cell splicing. J. Virol. 69:6063-6076.
407. Schena, M., R. A. Heller, T. P. Theriault, K. Konrad, E. Lachenmeier, and R. W. Davis. 1998. Microarrays: biotechnology's discovery platform for functional genomics. Trends Biotechnol. 16:301-306.
408. Schena, M., D. Shalon, R. W. Davis, and P. O. Brown. 1995. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270:467-470.
409. Schiff, L. A. 1998. Reovirus capsid proteins sigma 3 and μ1: interactions that influence viral entry, assembly, and translational control. Curr. Top. Microbiol. Immunol. 233:167-183.
410. Schmidt-Puchta, W., D. I. Dominguez, D. Lewetag, and T. Hohn. 1997. Plant ribosome shunting in vitro. Nucleic Acids Res. 25:2854-2860.
411. Schneider, R. J. 1996. Adenovirus and vaccinia virus translational control, p. 575-606. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
412. Schwartz, S., B. K. Felber, E.-M. Fenyo, and G. N. Pavlakis. 1990. Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAs. J. Virol. 64:5448-5456.
413. Schwartz, S., B. K. Felber, and G. N. Pavlakis. 1992. Mechanism of translation of monocistronic and human immunodeficiency virus type 1 mRNAs. Mol. Cell. Biol. 12:207-219.
414. Sen, G. C., and P. Lengyel. 1992. The interferon system: a bird's eye view of its biochemistry. J. Biol. Chem. 267:5017-5020.
415. Sen, G. C., and R. M. Ransohoff. 1993. Interferon-induced antiviral actions and their regulation. Adv. Virus Res. 42:57-102.
416. Seydoux, G. 1996. Mechanisms of translational control in early development. Curr. Opin. Genet. Dev. 6:555-561.
417. Sharpe, A. H., and B. N. Fields. 1982. Reovirus inhibition of cellular RNA and protein synthesis: role of the S4 gene. Virology 122:381-391.
418. Sheng, L. X., and I. Tinoco, Jr. 1995. The structure of an RNA pseudoknot that causes efficient frameshifting in mouse mammary tumor virus. J. Mol. Biol. 247:963-978.
419. Shi, Y., K. M. Vattem, R. Sood, J. An, L. Stramm, and R. C. Wek. 1998. Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control. Mol. Cell. Biol. 18:7499-7509.
420. Shors, S. T., E. Beattie, K. Paoletti, J. Tartaglia, and B. L. Jacobs. 1998. Role of the vaccinia virus E3L and K3L gene products in rescue of VSV and EMCV from the effects of IFN-alpha. J. Interferon Cytokine Res. 18:721-729.
421. Silverman, R. H. 1994. Fascination with 2-5A-dependent RNase: a unique enzyme that functions in interferon action. J. Interferon Res. 14:101-104.
422. Silverman, R. H., P. J. Cayley, M. Knight, C. S. Gilbert, and I. M. Kerr. 1982. Control of the ppp(A2′p)nA system in HeLa cells: effects of interferon and virus infection. Eur. J. Biochem. 124:131-138.
423. Silverman, R. H., and B. R. G. Williams. 1999. Translational control perks up. Nature 397:208-211.
424. Silverstein, S., and D. L. Engelhardt. 1979. Alterations in the protein synthetic apparatus in cells infected with herpes simplex virus. Virology 95: 334-342.
425. Simonin, D., J. J. Diaz, T. Masse, and J. J. Madjar. 1997. Persistence of ribosomal protein synthesis after infection of HeLa cells by herpes simplex virus type 1. J. Gen. Virol. 78:435-443.
426. Siomi, H., and G. Dreyfuss. 1997. RNA-binding proteins as regulators of gene expression. Curr. Opin. Genet. Dev. 7:345-353.
427. Somogyi, P., A. J. Jenner, I. Brierley, and S. C. Inglis. 1999. Ribosomal pausing during translation of an RNA pseudoknot. Mol. Cell. Biol. 13: 6931-6940.
428. Sonenberg, N. 1990. Measures and countermeasures in the modulation of initiation factor activities by viruses. New Biol. 2:4022-4029.
429. Sonenberg, N. 1993. Translation factors as effectors of cell growth and tumorigenesis. Curr. Opin. Cell Biol. 5:955-960.
430. Sonenberg, N. 1994. mRNA translation: influence of the 5′ and 3′ untranslated regions. Curr. Opin. Genet. Dev. 4:310-315.
431. Sonenberg, N. 1994. Regulation of translation and cell growth by eIF-4E. Biochimie 76:839-846.
432. Sonenberg, N. 1996. mRNA 5′ cap-binding protein eIF4E and control of cell growth, p. 245-270. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
433. Sonenberg, N., and A. C. Gingras. 1998. The mRNA 5′ cap-binding protein eIF4E and control of cell growth. Curr. Opin. Cell Biol. 10:268-275.
434. Spellman, P. T., G. Sherlock, M. Q. Zhang, V. R. Iyer, K. Anders, M. B. Eisen, P. O. Brown, D. Botstein, and B. Futcher. 1998. Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization. Mol. Biol. Cell 9:3273-3297.
435. Srivastava, S. P., M. V. Davies, and R. J. Kaufman. 1995. Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis. J. Biol. Chem. 270:16619-16624.
436. Srivastava, S. P., K. U. Kumar, and R. J. Kaufman. 1998. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. J. Biol. Chem. 273:2416-2423.
437. Staehli, P. 1990. Interferon induced proteins and the antiviral state. Adv. Virus Res. 38:147-200.
438. Steffy, K., and F. Wong-Staal. 1991. Genetic regulation of human immunodeficiency virus. Microbiol. Rev. 55:193-205.
439. Suzuki, K., H. Shinzawa, M. Kuboki, M. Ishibashi, E. Yoshii, T. Saito, and T. Takahashi. 1998. Secondary structure of the hepatitis C virus 5′ untranslated region and efficacy of interferon therapy for chronic hepatitis C. Liver 18:331-336.
440. Svitkin, Y. V., A. Gradi, H. Imataka, S. Morina, and N. Sonenberg. 1999. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infectio. J. Virol. 73:3467-3472.
441. Svitkin, Y. V., H. Hahn, A. C. Gingras, A. C. Palmenberg, and N. Sonenberg. 1998. Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus. J. Virol. 72:5811-5819.
442. Svitkin, Y. V., L. P. Ovchinnikov, G. Dreyfuss, and N. Sonenberg. 1996. General RNA binding proteins render translation cap dependent. EMBO J. 15:7147-7155.
443. Svitkin, Y. V., A. Pause, and N. Sonenberg. 1994. La autoantigen alleviates translational repression by the 5′ leader sequence of the human immunodeficiency virus type 1 mRNA. J. Virol. 68:7001-7007.
444. Swaminathan, S., P. Rajan, O. Savinova, R. Jagus, and B. Thimmapaya. 1996. Simian virus 40 bypasses the translational block imposed by the phosphorylation of eIF-2α. Virology 219:321-323.
445. Takizawa, T. 1996. Mechanism of the induction of apoptosis by influenza virus infection. Nippon Rinsho 54:1836-1841.
446. Takizawa, T., S. Matsukawa, Y. Higuchi, S. Nakamura, Y. Nakanishi, and R. Fukuda. 1993. Induction of programmed cell death (apoptosis) by influenza virus infection in tissue culture cells. J. Gen. Virol. 74:2347-2355.
447. IPK inhibitor. Mol. Cell. Biol. 18:2431-2443.
448. Tan, S.-L., and M. G. Katze. 1998. Biochemical and genetic evidence for complex formation between the influenza A virus NS1 protein and the interferon-induced PKR protein kinase. J. Interferon Cytokine Res. 18: 757-766.
449. Reference deleted.
450. Tan, S.-L., and M. G. Katze. 1999. The emerging role of the interferon-induced PKR protein kinase as an apoptotic effector: a new face of death? J. Interferon Cytokine Res. 19:543-554.
451. Tanaka, H., and C. E. Samuel. 1994. Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase. Proc. Natl. Acad. Sci. USA 91:7995-7999.
452. Tarun, S. Z. J., and A. B. Sachs. 1996. Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G. EMBO J. 15: 7168-7177.
453. Taylor, D. R., S. B. Lee, P. R. Romano, D. R. Marshak, A. G. Hinnebusch, M. Esteban, and M. B. Mathews. 1996. Autophosphorylation sites participate in the activation of the double-stranded-RNA-activated protein kinase PKR. Mol. Cell. Biol. 16:6295-6302.
454. Taylor, S. S., D. R. Knighton, J. Zheng, J. M. Sowadski, C. S. Gibbs, and M. J. Zoller. 1993. A template for the protein kinase family. Trends Biochem. Sci. 18:84-89.
455. Teodoro, J. G., and P. E. Branton. 1997. Regulation of apoptosis by viral gene products. J. Virol. 71:1739-1746.
456. Terada, N., H. R. Patel, K. Takase, K. Kohno, A. C. Nairn, and E. W. Gelfand. 1994. Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc. Natl. Acad. Sci. USA 91:11477-11481.
457. Thach, R. E. 1992. Cap recap: the involvement of eIF-4F in regulating gene expression. Cell 68:177-180.
458. Thimmappaya, B., C. Weinberger, R. J. Schneider, and T. Shenk. 1982. Adenovirus VA1 RNA is required for efficient translation of viral mRNAs at late times after infection. Cell 31:543-551.
459. Thomis, D. C., J. P. Doohan, and C. E. Samuel. 1992. Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells. Virology 188:33-46.
460. Thomis, D. C., and C. E. Samuel. 1995. Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase. J. Virol. 69:5195-5198.
461. Torrence, P. F., R. K. Miatra, K. Lesiak, S. Khamnei, A. Zhou, and R. H. Silverrnan. 1993. Targeting RNA for degradation with a (2′-5′)oligoadenylate antisense chimera. Proc. Natl. Acad. Sci. USA 90:1300-1304.
462. Trachsel, H. 1996. Binding of initiator methionyl-tRNA to ribosomes, p. 113-138. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
463. Trepo, C., P. Berthillon, and L. Vitvitski. 1998. HCV and lymphoproliferative diseases. Ann. Oncol. 9:469-470.
464. Tsuchihara, K., T. Tanaka, M. Hijikata, S. Kuge, H. Toyoda, A. Nomoto, N. Yamamoto, and K. Shimotohno. 1997. Specific interaction of polypyrimidine tract-binding protein with the extreme 3′-terminal structure of the hepatitis C virus genome, the 3′X. J. Virol. 71:6720-6726.
465. Tsuchihashi, Z. 1991. Translational frameshifting in the Escherichia coli dnaX gene in vitro. Nucleic Acids Res. 19:2457-2462.
466. Vakalopoulou, E., J. Schaack, and T. Shenk. 1991. A 32-kilodalton protein binds to AU-rich domains in the 3′ untranslated regions of rapidly degraded mRNAs. Mol. Cell. Biol. 11:3355-3364.
467. Venkatesan, A., S. Das, and A. Dasgupta. 1999. Structure and function of a small RNA that selectively inhibits internal ribosome entry site-mediated translation. Nucleic Acids Res. 27:562-572.
468. Ventoso, I., S. E. MacMillan, J. W. Hershey, and L. Carrasco. 1998. Poliovirus 2A proteinase cleaves directly the eIF-4G subunit of eIF-4F complex. FEBS Lett. 435:79-83.
469. s6k pathway and is MAP kinase-independent. Proc. Natl. Acad. Sci. USA 93:4076-4080.
470. Voorma, H. O. 1996. Control of translation initiation in prokaryotes, p. 759-779. In J. W. B. Hershey, M. B. Mathews, and N. Sonenberg (ed.), Translational control. Cold Spring Harbor Laboratory Press, Plainview, N.Y.
471. Walden, W. E., T. Godefroy-Colburn, and R. E. Thach. 1981. The role of mRNA competition in regulating translation. I. Demonstration of competition in vivo. J. Biol. Chem. 256:11739-11746.
472. Wang, X., A. Frynn, A. J. Waskiewicz, B. L. Webb, R. G. Vries, I. A. Baines, and J. A. Cooper. 1998. The phosphorylation of eukaryotic initiation factor 4E in response to phorbol esters, cell stresses, and cytokines is mediated by distinct MAP kinase pathways. J. Biol. Chem. 273:9373-9377.
473. Waskiewicz, A. J., A. Flynn, C. G. Pround, and J. A. Cooper. 1997. Mitogenactivated protein kinases activate the serine/threonine kinases MNK1 and MNK2. EMBO J. 16:1909-1920.
474. Waskiewicz, A. J., J. C. Johnson, B. Penn, M. Mahalingam, S. R. Kimbal, and J. A. Cooper. 1999. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol. Cell. Biol. 19:1871-1880.
475. Watson, J. C., H.-W. Chang, and B. L. Jacobs. 1991. Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded RNA-dependent protein kinase. Virology 185:206-216.
476. Wei, C. C., M. L. Balasta, J. Ren, and D. J. Goss. 1998. Wheat germ poly(A) binding protein enhances the binding affinity of eukaryotic initiation factor 4F and (iso)4F for cap analogue. Biochemistry 37:1910-1916.
477. Wek, R. C. 1994. eIF-2 kinases: regulators of general and gene-specific translation initiation. Trends Biochem. Sci. 19:491-496.
478. Welch, P. J., S. P. Yei, and J. R. Barber. 1998. Ribozyme gene therapy for hepatitis C virus infection. Clin. Diagn. Virol. 10:163-171.
479. Wells, S. E., P. E. Hillner, R. D. Vale, and A. B. Sachs. 1998. Circularization of mRNA by eukaryotic translation initiation factors. Mol. Cell 2:135-140.
480. Wickner, R. B. 1996. Double-stranded RNA viruses of Saccharomyces cerevisiae. Microbiol. Rev. 60:250-265.
481. Williams, B. R. G. 1995. The role of the dsRNA-activated kinase, PKR, in signal transduction. Semin. Virol. 6:191-202.
482. Wills, N. M., R. F. Gesteland, and J. F. Atkins. 1991. Evidence that a downstream pseudoknot is required for translational read-through of the Moloney murine leukemia virus gag stop codon. Proc. Natl. Acad. Sci. USA 88:6991-6995.
483. Wimmer, E., C. U. T. Hellen, and X. Cao. 1993. Genetics of poliovirus. Annu. Rev. Genet. 27:353-436.
484. Woodson, S. A. 1998. Ironing out the kinks: splicing and translation in bacteria. Genes Dev. 12:1243-1247.
485. Xiao, H., C. Neuveut, M. Benkirane, and K. T. Jeang. 1998. Interaction of the second coding exon of Tat with human EF-1 delta delineates a mechanism for HIV-1-mediated shut-off of host mRNA translation. Biochem. Biophys. Res. Commun. 244:384-389.
486. Yamanaka, K., A. Ishihama, and K. Nagata. 1988. Translational regulation of influenza virus mRNAs. Virus Gene 1:19-30.
487. Yamanaka, K., K. Nagata, and A. Ishihama. 1991. Temporal control for translation of influenza virus mRNAs. Arch. Virol. 120:33-42.
488. Yang, Y.-L., L. F. L. Reis, J. Pavlovic, A. Aguzzi, R. Schäfer, A. Kumar, B. R. G. Williams, M. Aguet, and C. Weissmann. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14:6095-6106.
489. Yeung, M. C., D. L. Chang, R. E. Camantigue, and A. S. Lau. 1999. Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells. Proc. Natl. Acad. Sci. USA 96:11860-11865.
490. Yeung, M. C., J. Liu, and A. S. Lau. 1996. An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells. Proc. Natl. Acad. Sci. USA 93:12451-12455.
491. Yoshinaka, Y., I. Katoh, T. D. Copeland, and S. Oroszlan. 1985. Murine leukemia virus protease is encoded by the gag-pol gene and is synthesized through suppression of an amber termination codon. Proc. Natl. Acad. Sci. USA 82:1618-1622.
492. You, Y., C. Y. Chen, and A. B. Shyu. 1992. U-rich sequence-binding proteins (URBPs) interacting with a 20-nucleotide U-rich sequence in the 3′ untranslated region of c-fos mRNA may be involved in the first step of c-fos mRNA degradation. Mol. Cell. Biol. 12:2931-2940.
493. Yue, Z., and A. J. Shatkin. 1997. Double-stranded RNA-dependent protein kinase (PKR) is regulated by reovirus structural proteins. Virology 234: 364-371.
494. Yueh, A., and R. J. Schneider. 1996. Selective translation initiation by ribosome jumping in adenovirus-infected and heat-shocked cells. Genes Dev. 10:1557-1567.
495. Zamanian-Daryoush, M., S. D. Der, and B. R. G. Williams. 1998. Cell cycle regulation of the double stranded RNA activated protein kinase, PKR. Oncogene 17:315-326.
496. Zehenko, V. V., L. A. Ryabova, D. R. Gallie, and A. S. Spirin. 1994. Enhancing effect of the 3′-untranslated region of tobacco mosaic virus RNA on protein synthesis. FEBS Lett. 254:271-273.
497. Zelus, B. D., R. S. Stewart, and J. Ross. 1996. The virion host shutoff protein of herpes simplex virus type 1: messenger ribonucleolytic activity in vitro. J. Virol. 70:2411-2419.
498. Zhang, H., R. Hanecak, D. V. Brown, R. Azad, B. Conklin, M. C. Fox, and K. P. Anderson. 1999. Antisense oligonucleotide inhibition of hepatitis C virus (HCV) gene expression in livers of mice infected with an HCV-vaccinia virus recombinant. Antimicrob. Agents Chemother. 43:347-353.
499. Zhang, Y., D. Feigenblum, and R. J. Schneider. 1994. A late adenovirus factor induces eIF-4E dephosphorylation and inhibition of cell protein synthesis. J. Virol. 68:7040-7050.
500. Zhou, A., B. A. Hassel, and R. H. Silverman. 1993. Expression cloning of 2′-5′ A-dependent RNase: a uniquely regulated mediator of interferon action. Cell 72:753-765.
501. Zhouravleva, G., L. Frolova, G. X. Le, G. R. Le, V. S. Inge, L. Kisselev, and M. Philippe. 1995. Termination of translation in eukaryotes is governed by two interacting polypeptide chain release factors, eRF1 and eRF3. EMBO J. 14:4065-4072.
502. Zhu, H., J.-P. Cong, G. Mamtora, T. Gingeras, and T. Shenk. 1998. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc. Natl. Acad. Sci. USA 95:14470-14475.
503. Zhu, S., P. R. Romano, and R. C. Wek. 1997. Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2. J. Biol. Chem. 272: 14434-14441.
504. Zong, Q., M. Schummer, L. Hood, and D. R. Morris. 1999. Messenger RNA translation state: the second dimension of high-throughput expression screening. Proc. Natl. Acad. Sci. USA 96:10636.