Atypical chemokine receptors

Experimental Cell Research

Volumn 317, Issue 5, 2011, Pages 556-568

  Ulvmar, Maria Helena ^a   Hub, Elin ^a   Rot, Antal ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

ACR; CCRL1; CCRL2; CXCR7; D6; DARC; Interceptor

Indexed keywords

ATYPICAL CHEMOKINE RECEPTOR; BLOOD GROUP ANTIGEN; CCL25 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCRL1; CHEMOKINE RECEPTOR CCRL2; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR7; CHEMOKINE RECEPTOR D6; CXCL11 CHEMOKINE; DARC ANTIGEN; G PROTEIN COUPLED RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; SECONDARY LYMPHOID TISSUE CHEMOKINE; UNCLASSIFIED DRUG;

ENDOTHELIUM CELL; ERYTHROCYTE; HOMEOSTASIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW;

EID: 79952107293     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.01.012     Document Type: Review

References (168)

1. Rot A., von Andrian U.H. Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. Annu. Rev. Immunol. 2004, 22:891-928.
2. Fernandez E.J., Lolis E. Structure, function, and inhibition of chemokines. Annu. Rev. Pharmacol. Toxicol. 2002, 42:469-499.
3. Colobran R., Pujol-Borrell R., Armengol M.P., Juan M. The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility. Clin. Exp. Immunol. 2007, 150:1-12.
4. Proost P., Struyf S., Van Damme J. Natural post-translational modifications of chemokines. Biochem. Soc. Trans. 2006, 34:997-1001.
5. Nibbs R., Graham G., Rot A. Chemokines on the move: control by the chemokine "interceptors" Duffy blood group antigen and D6. Semin. Immunol. 2003, 15:287-294.
6. Mantovani A., Bonecchi R., Locati M. Tuning inflammation and immunity by chemokine sequestration: decoys and more. Nat. Rev. Immunol. 2006, 6:907-918.
7. Brzostowski J.A., Kimmel A.R. Signaling at zero G: G-protein-independent functions for 7-TM receptors. Trends Biochem. Sci. 2001, 26:291-297.
8. Hall R.A., Premont R.T., Lefkowitz R.J. Heptahelical receptor signaling: beyond the G protein paradigm. J. Cell Biol. 1999, 145:927-932.
9. Sun Y.T., Huang J.Y., Xiang Y., Bastepe M., Juppner H., Kobilka B.K., Zhang J.J., Huang X.Y. Dosage-dependent switch from G protein-coupled to G protein-independent signaling by a GPCR. EMBO J. 2007, 26:53-64.
10. Colditz I.G., Schneider M.A., Pruenster M., Rot A. Chemokines at large: in-vivo mechanisms of their transport, presentation and clearance. Thromb. Haemost. 2007, 97:688-693.
11. Fra A.M., Locati M., Otero K., Sironi M., Signorelli P., Massardi M.L., Gobbi M., Vecchi A., Sozzani S., Mantovani A. Cutting edge: scavenging of inflammatory CC chemokines by the promiscuous putatively silent chemokine receptor D6. J. Immunol. 2003, 170:2279-2282.
12. Pruenster M., Mudde L., Bombosi P., Dimitrova S., Zsak M., Middleton J., Richmond A., Graham G.J., Segerer S., Nibbs R.J.B., Rot A. The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nat. Immunol. 2009, 10:101-108.
13. Rot A. Neutrophil attractant activation protein-1 (interleukin-8) induces invitro neutrophil migration by haptotactic mechanism. Eur. J. Immunol. 1993, 23:303-306.
14. Bamberg C.E., Mackay C.R., Lee H., Zahra D., Jackson J., Lim Y.S., Whitfeld P.L., Craig S., Corsini E., Lu B., Gerard C., Gerard N.P. The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction. J. Biol. Chem. 2010, 285:7633-7644.
15. D'Amico G., Frascaroli G., Bianchi G., Transidico P., Doni A., Vecchi A., Sozzani S., Allavena P., Mantovani A. Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat. Immunol. 2000, 1:387-391.
16. Ariel A., Fredman G., Sun Y.P., Kantarci A., Van Dyke T.E., Luster D., Serhan C.N. Apoptotic neutrophils and T cells sequester chemokines during immune response resolution through modulation of CCR5 expression. Nat. Immunol. 2006, 7:1209-1216.
17. Dar A., Goichberg P., Shinder V., Kalinkovich A., Kollet O., Netzer N., Margalit R., Zsak M., Nagler A., Hardan I., Resnick I., Rot A., Lapidot T. Chemokine receptor CXCR4-dependent internalization and resecretion of functional chemokine SDF-1 by bone marrow endothelial and stromal cells. Nat. Immunol. 2005, 6:1038-1046.
18. Sfriso P., Oliviero F., Calabrese F., Miorin M., Facco M., Contri A., Cabrelle A., Baesso I., Cozzi F., Andretta M., Cassatella M.A., Fiocco U., Todesco S., Konttinen Y.T., Punzi L., Agostini C. Epithelial CXCR3-B regulates chemokines bioavailability in normal, but not in Sjogren's syndrome, salivary glands. J. Immunol. 2006, 176:2581-2589.
19. Maus U.A., Wellmann S., Hampl C., Kuziel W.A., Srivastava M., Mack M., Everhart M.B., Blackwell T.S., Christman J.W., Schlondorff D., Bohle R.M., Seeger W., Lohmeyer J. CCR2-positive monocytes recruited to inflamed lungs downregulate local CCL2 chemokine levels. Am. J. Physiol. Lung Cell. Mol. Physiol. 2005, 288:L350-L358.
20. DeVries M.E., Kelvin A.A., Xu L., Ran L., Robinson J., Kelvin D.J. Defining the origins and evolution of the chemokine/chemokine receptor system. J. Immunol. 2006, 176:401-415.
21. Cutbush M., Mollison P.L., Parkin D.M. A new human blood group. Nature 1950, 165:189.
22. Ikin E.W., Mourant A.E., Pettenkofer H.J., Blumenthal G. Discovery of the expected haemagglutinin. AntiFyb. Nat. 1951, 168:1077-1078.
23. Iwamoto S., Omi T., Kajii E., Ikemoto S. Genomic organization of the glycoprotein-D gene - Duffy blood-group Fy(A)/Fy(B) alloantigen system is associated with a polymorphism at the 44-amino acid residue. Blood 1995, 85:622-626.
24. Tournamille C., Colin Y., Cartron J.P., Levankim C. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene-expression in Duffy negative individuals. Nat. Gen. 1995, 10:224-228.
25. Peiper S.C., Wang Z.X., Neote K., Martin A.W., Showell H.J., Conklyn M.J., Ogborne K., Hadley T.J., Lu Z.H., Hesselgesser J., Horuk R. The Duffy antigen receptor for chemokines (DARC) is expressed in endothelial-cells of Duffy negative individuals who lack the erythrocyte receptor. J. Exp. Med. 1995, 181:1311-1317.
26. Horuk R., Martin A.W., Wang Z.X., Schweitzer L., Gerassimides A., Guo H.H., Lu Z.H., Hesselgesser J., Perez H.D., Kim J., Parker J., Hadley T.J., Peiper S.C. Expression of chemokine receptors by subsets of neurons in the central nervous system. J. Immunol. 1997, 158:2882-2890.
27. Chaudhuri A., Nielsen S., Elkjaer M.L., Zbrzezna V., Fang F., Pogo A.O. Detection of duffy antigen in the plasma membranes and caveolae of vascular endothelial and epithelial cells of nonerythroid organs. Blood 1997, 89:701-712.
28. Horuk R., Chitnis C.E., Darbonne W.C., Colby T.J., Rybicki A., Hadley T.J., Miller L.H. A receptor for the malarial parasite Plasmodium vivax - the erythrocyte chemokine receptor. Science 1993, 261:1182-1184.
29. Miller L.H., Mason S.J., Dvorak J.A., Mcginniss M.H., Rothman I.K. Erythrocyte receptors for (Plasmodium knowlesi) malaria - Duffy blood-group determinants. Science 1975, 189:561-563.
30. Menard D., Barnadas C., Bouchier C., Henry-Halldin C., Gray L.R., Ratsimbasoa A., Thonier V., Carod J.F., Domarle O., Colin Y., Bertrand O., Picot J., King C.L., Grimberg B.T., Mercereau-Puijalon O., Zimmerman P.A. Plasmodium vivax clinical malaria is commonly observed in Duffy-negative Malagasy people. Proc. Nat. Acad. Sci. U.S.A. 2010, 107:5967-5971.
31. Zimmerman P.A., Woolley I., Masinde G.L., Miller S.M., McNamara D.T., Hazlett F., Mgone C.S., Alpers M.P., Genton B., Boatin B.A., Kazura J.W. Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea. Proc. Nat. Acad. Sci. U.S.A. 1999, 96:13973-13977.
32. Tournamille C., van Kim C., Gane P., Le Pennec P.Y., Roubinet F., Babinet J., Cartron J.P., Colin Y. Arg89Cys substitution results ins very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. Blood 1998, 92:2147-2156.
33. Mallinson G., Soo K.S., Schall T.J., Pisacka M., Anstee D.J. Mutations in the erythrocyte chemokine receptor (Duffy) gene - the molecular-basis of the Fy(A)/Fy(B) antigens and identification of a deletion in the Duffy gene of an apparently healthy individual with the Fy(A-B-) phenotype. Br. J. Haematol. 1995, 90:823-829.
34. Parasol N., Reid M., Rios M., Castilho L., Harari I., Kosower N.S. A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype. Blood 1998, 92:2237-2243.
35. Rios M., Chaudhuri A., Mallinson G., Sausais L., Gomensoro-Garcia A.E., Hannon J., Rosenberger S., Poole J., Burgess G., Pogo O., Reid M. New genotypes in Fy(a-b-) individuals: nonsense mutations (Trp to stop) in the coding sequence of either FY A or FY B. Br. J. Haematol. 2000, 108:448-454.
36. He W.J., Neil S., Kulkarni H., Wright E., Agan B.K., Marconi V.C., Dolan M.J., Weiss R.A., Ahujal S.K. Duffy antigen receptor for chemokines mediates trans-infection of HIV-1 from red blood cells to target cells and affects HIV-AIDS susceptibility. Cell Host Microbe 2008, 4:52-62.
37. Lachgar A., Jaureguiberry G., Le Buenac H., Bizzini B., Zagury J.F., Rappaport J., Zagury D. Binding of HIV-1 to RBCs involves the Duffy antigen receptors for chemokines (DARC). Biomed. Pharmacother. 1998, 52:436-439.
38. Kulkarni H., Marconi V.C., He W., Landrum M.L., Okulicz J.F., Delmar J., Kazandjian D., Castiblanco J., Ahuja S.S., Wright E.J., Weiss R.A., Clark R.A., Dolan M.J., Ahuja S.K. The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry. Blood 2009, 114:2783-2792.
39. Horne K.C., Li X., Jacobson L.P., Palella F., Jamieson B.D., Margolick J.B., Martinson J., Turkozu V., Visvanathan K., Woolley I.J. Duffy antigen polymorphisms do not alter progression of HIV in African Americans in the MACS cohort. Cell Host Microbe 2009, 5:415-417.
40. Julg B., Reddy S., van der Stok M., Kulkarni S., Qi Y., Bass S., Gold B., Nalls M.A., Nelson G.W., Walker B.D., Carrington M., Ndung'u T. Lack of Duffy antigen receptor for chemokines: no influence on HIV disease progression in an African treatment-naive population. Cell Host Microbe 2009, 5:413-415.
41. Walley N.M., Julg B., Dickson S.P., Fellay J., Ge D., Walker B.D., Carrington M., Cohen M.S., de Bakker P.I.W., Goldstein D.B., Shianna K.V., Haynes B.F., Letvin N.L., McMichael A.J., Michael N.L., Weintrob A.C. The Duffy antigen receptor for chemokines null promoter variant does not influence HIV-1 acquisition or disease progression. Cell Host Microbe 2009, 5:408-410.
42. Winkler C.A., An P., Johnson R., Nelson G.W., Kirk G. Expression of Duffy antigen receptor for chemokines (DARC) has no effect on HIV-1 acquisition or progression to AIDS in African Americans. Cell Host Microbe 2009, 5:411-413.
43. He W.J., Marconi V.C., Castiblanco J., Kulkarni H., Clark R.A., Dolan M.J., Weiss R.A., Ahuja S.K. Response: association of Duffy antigen genotypes with HIV-AIDS susceptibility. Cell Host Microbe 2009, 5:418-419.
44. Darbonne W.C., Rice G.C., Mohler M.A., Apple T., Hebert C.A., Valente A.J., Baker J.B. Red-blood-cells are a sink for interleukin-8, a leukocyte chemotaxin. J. Clin. Invest. 1991, 88:1362-1369.
45. Neote K., Darbonne W., Ogez J., Horuk R., Schall T.J. Identification of a promiscuous inflammatory peptide receptor on the surface of red-blood-cells. J. Biol. Chem. 1993, 268:12247-12249.
46. Horuk R., Wang Z.X., Peiper S.C., Hesselgesser J. Identification and characterization of a promiscuous chemokine-binding protein in a human erythroleukemic cell-line. J. Biol. Chem. 1994, 269:17730-17733.
47. Gardner L., Patterson A.M., Ashton B.A., Stone M.A., Middleton J. The human Duffy antigen binds selected inflammatory but not homeostatic chemokines. Biochem. Biophys. Res. Commun. 2004, 321:306-312.
48. Szabo M.C., Soo K.S., Zlotnik A., Schall T.J. Chemokine class-differences in binding to the Duffy antigen-erythrocyte chemokine receptor. J. Biol. Chem. 1995, 270:25348-25351.
49. Chaudhuri A., Polyakova J., Zbrzezna V., Williams K., Gulati S., Pogo A.O. Cloning of glycoprotein-D cDNA. Which encodes the major subunit of the Duffy blood-group system and the receptor for the Plasmodium vivax malaria parasite. Proc. Natl. Acad. Sci. U.S.A. 1993, 90:10793-10797.
50. Neote K., Mak J.Y., Kolakowski L.J., Schall T.J. Functional and biochemical analysis of the cloned Duffy antigen: identity with the red blood cell chemokine receptor. Blood 1994, 84:44-52.
51. Schnabel R.B., Baumert J., Barbalic M., Dupuis J., Ellinor P.T., Durda P., Dehghan A., Bis J.C., Illig T., Morrison A.C., Jenny N.S., Keaney J.F., Gieger C., Tilley C., Yamamoto J.F., Khuseyinova N., Heiss G., Doyle M., Blankenberg S., Herder C., Walston J.D., Zhu Y.Y., Vasan R.S., Klopp N., Boerwinkle E., Larson M.G., Psaty B.M., Peters A., Ballantyne C.M., Witteman J.C.M., Hoogeveen R.C., Benjamin E.J., Koenig W., Tracy R.P. Duffy antigen receptor for chemokines (DARC) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators. Blood 2010, 115:5289-5299.
52. Galliera E., Jala V.R., Trent J.O., Bonecchi R., Signorelli P., Lefkowitz R.J., Mantovani A., Locati M., Haribabu B. Beta-arrestin-dependent constitutive internalization of the human chemokine decoy receptor D6. J. Biol. Chem. 2004, 279:25590-25597.
53. Weber M., Blair E., Simpson C.V., O'Hara M., Blackburn P.E., Rot A., Graham G.J., Nibbs R.J.B. The chemokine receptor D6 constitutively traffics to and from the cell surface to internalize and degrade chemokine. Mol. Biol. Cell 2004, 15:2492-2508.
54. Pruenster M., Rot A. Throwing light on DARC. Biochem. Soc. Trans. 2006, 34:1005-1008.
55. Comerford I., Milasta S., Morrow V., Milligan G., Nibbs R. The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro. Eur. J. Immunol. 2006, 36:1904-1916.
56. Naumann U., Cameroni E., Pruenster M., Mahabaleshwar H., Raz E., Zerwes H.G., Rot A., Thelen M. CXCR7 functions as a scavenger for CXCL12 and CXCL11. PLoS ONE 2010, 5:e9175.
57. Du J.G., Luan J., Liu H., Daniel T.O., Peiper S., Chen T.S., Yu Y.C., Horton L.W., Nanney L.B., Strieter R.M., Richmond A. Potential role for Duffy antigen chemokine-binding protein in angiogenesis and maintenance of homeostasis in response to stress. J. Leukoc. Biol. 2002, 71:141-153.
58. Horton L.W., Yu Y.C., Zaja-Milatovic S., Strieter R.M., Richmond A. Opposing roles of murine Duffy antigen receptor for chemokine and murine CXC chemokine receptor-2 receptors in murine melanoma tumor growth. Cancer Res. 2007, 67:9791-9799.
59. Addison C.L., Belperio J.A., Burdick M.D., Strieter R.M. Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis. BMC Cancer 2004, 4:28. 10.1186/1471-2407-4-28.
60. Shen H., Schuster R., Stringer K.F., Waltz S.E., Lentsch A.B. The Duffy antigen/receptor for chemokines (DARC) regulates prostate tumor growth. FASEB J. 2006, 20:59-64.
61. Chakera A., Seeber R.M., John A.E., Eidne K.A., Greaves D.R. The Duffy antigen/receptor for chemokines exists in an oligomeric form in living cells and functionally antagonizes CCR5 signaling through hetero-oligomerization. Mol. Pharmacol. 2008, 73:1362-1370.
62. Bandyopadhyay S., Zhan R., Chaudhuri A., Watabe M., Pai S.K., Hirota S., Hosobe S., Tsukada T., Miura K., Takano Y., Saito K., Pauza M.E., Hayashi S., Wang Y., Mohinta S., Mashimo T., Iiizumi M., Furuta E., Watabe K. Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat. Med. 2006, 12:933-938.
63. Dawson T.C., Lentsch A.B., Wang Z.X., Cowhig J.E., Rot A., Maeda N., Peiper S.C. Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC). Blood 2000, 96:1681-1684.
64. Green S.P., Chuntharapai A., Curnutte J.T. Interleukin-8 (IL-8), melanoma growth-stimulatory activity, and neutrophil-activating peptide selectively mediate priming of the neutrophil NADPH oxidase through the type A or type B IL-8 receptor. J. Biol. Chem. 1996, 271:25400-25405.
65. 2+], responses to IL-8 in human neutrophils. Shock 1999, 12:428-437.
66. Brandt E., Muller-Alouf H., Desreumaux P., Woerly G., Colombel J.F., Capron M. Circulating growth-regulated oncogene alpha contributes to neutrophil priming and interleukin-8-directed mucosal recruitment into chronic lesions of patients with Crohn's disease. Eur. Cytokine Netw. 1998, 9:647-653.
67. Luo H., Chaudhuri A., Zbrezezna V., He Y., Pogo A.O. Deletion of murine Duffy gene (Dfy) reveals that the Duffy receptor is functionally redundant. Mol. Cell. Biol. 2002, 20:3097-3101.
68. Mei J.J., Liu Y.H., Dai N., Favara M., Greene T., Jeyaseelan S., Poncz M., Lee J.S., Worthen G.S. CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection. Immunity 2010, 33:106-117.
69. Vielhauer V., Allam R., Lindenmeyer M.T., Cohen C.D., Draganovici D., Mandelbaum J., Eltrich N., Nelson P.J., Anders H.J., Pruenster M., Rot A., Schlodorff D., Segerer S. Efficient renal recruitment of macrophages and T cells in mice lacking the Duffy antigen/receptor for chemokines. Am. J. Pathol. 2009, 175:119-131.
70. Reutershan J., Harry B., Chang D., Bagby G.J., Ley K. DARC on RBC limits lung injury by balancing compartmental distribution of CXC chemokines. Eur. J. Immunol. 2009, 39:1597-1607.
71. Zarbock A., Bishop J., Muller H., Schmolke M., Buschmann K., Van Aken H., Singbartl K. Chemokine homeostasis vs. chemokine presentation during severe acute lung injury: the other side of the Duffy antigen receptor for chemokines. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, 298:L462-L471.
72. Jilma-Stohlawetz P., Homoncik M., Drucker C., Marsik C., Rot A., Mayr W.R., Seibold B., Jilma B. Fy phenotype and gender determine plasma levels of monocyte chemotactic protein. Transfusion 2001, 41:378-381.
73. Fukuma N., Akimitsu N., Hamamoto H., Kusuhara H., Sugiyama Y., Sekimizu K. A role of the Duffy antigen for the maintenance of plasma chemokine concentrations. Biochem. Biophys. Res. Commun. 2003, 303:137-139.
74. Reich D., Nalls M.A., Kao W.H.L., Akylbekova E.L., Tandon A., Patterson N., Mullikin J., Hsueh W.C., Cheng C.Y., Coresh J., Boerwinkle E., Li M., Waliszewska A., Neubauer J., Li R.L., Leak T.S., Ekunwe L., Files J.C., Hardy C.L., Zmuda J.M., Taylor H.A., Ziv E., Harris T.B., Wilson J.G. Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene. PLoS Genet. 2009, 5:e1000360.
75. Vergara C., Tsai Y.J., Grant A.V., Rafaels N., Gao L., Hand T., Stockton M., Campbell M., Mercado D., Faruque M., Dunston G., Beaty T.H., Oliveira R.R., Ponte E.V., Cruz A.A., Carvalho E., Araujo M.L., Watson H., Schleimer R.P., Caraballo L., Nickel R.G., Mathias R.A., Barnes K.C. Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations. Am. J. Res. Crit. Care Med. 2008, 178:1017-1022.
76. Rot A. Endothelial-cell binding of NAP-1/IL-8 - role in neutrophil emigration. Immunol. Today 1992, 13:291-294.
77. Handel T.M., Johnson Z., Crown S.E., Lau E.K., Sweeney M., Proudfoot A.E. Regulation of protein function by glycosaminoglycans - as exemplified by chemokines. Ann. Rev. Biochem. 2005, 74:385-410.
78. Webb L.M.C., Ehrengruber M.U., ClarkLewis I., Baggiolini M., Rot A. Binding to heparan-sulfate or heparin enhances neutrophil responses to interleukin-8. Proc. Nat. Acad. Sci. U.S.A. 1993, 90:7158-7162.
79. Middleton J., Neil S., Wintle J., ClarkLewis I., Moore H., Lam C., Auer M., Hub E., Rot A. Transcytosis and surface presentation of IL-8 ky venular endothelial cells. Cell 1997, 91:385-395.
80. Wang L.C., Fuster M., Sriramarao P., Esko J.D. Endothelial heparan sulfate deficiency impairs l-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responses. Nat. Immunol. 2005, 6:902-910.
81. Kashiwazaki M., Tanaka T., Kanda H., Ebisuno Y., Izawa D., Fukuma N., Akimitsu N., Sekimizu K., Monden M., Miyasaka M. A high endothelial venule-expressing promiscuous chemokine receptor DARC can bind inflammatory, but not lymphoid, chemokines and is dispensable for lymphocyte homing under physiological conditions. Int. Immunol. 2003, 15:1219-1227.
82. Hub E., Rot A. Binding of RANTES, MCP-1, MCP-3, and MIP-1 alpha to cells in human skin. Am. J. Pathol. 1998, 152:749-757.
83. Lee J.S., Frevert C.W., Wurfel M.M., Peiper S.C., Wong V.A., Ballman K.K., Ruzinski J.T., Rhim J.S., Martin T.R., Goodman R.B. Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo. J. Immunol. 2003, 170:5244-5251.
84. Bruhl H., Vielhauer V., Weiss M., Mack M., Schlondorff D., Segerer S. Expression of DARC, CXCR3 and CCR5 in giant cell arteritis. Rheumatology 2005, 44:309-313.
85. Gardner L., Wilson C., Patterson A.M., Bresnihan B., FitzGerald O., Stone M.A., Ashton B.A., Middleton J. Temporal expression pattern of Duffy antigen in rheumatoid arthritis: up-regulation in early disease. Arthritis Rheum. 2006, 54:2022-2026.
86. Geleff S., Draganovici D., Jaksch P., Segerer S. The role of chemokine receptors in acute lung allograft rejection. Eur. Respir. J. 2010, 35:167-175.
87. Lee J.S., Frevert C.W., Thorning D.R., Segerer S., Alpers C.E., Cartron J.P., Colin Y., Wong V.A., Martin T.R., Goodman R.B. Enhanced expression of Duffy antigen in the lungs during suppurative pneumonia. J. Histochem. Cytochem. 2003, 51:159-166.
88. Liu X.H., Hadley T.J., Xu L., Peiper S.C., Ray P.E. Up-regulation of Duffy antigen receptor expression in children with renal disease. Kidney Int. 1999, 55:1491-1500.
89. Patterson A.M., Siddall H., Chamberlain G., Gardner L., Middleton J. Expression of the Duffy antigen/receptor for chemokines (DARC) by the inflamed synovial endothelium. J. Pathol. 2002, 197:108-116.
90. Segerer S., Regele H., Mack M., Kain R., Cartron J.P., Colin Y., Kerjaschki D., Schlondorff D. The Duffy antigen receptor for chemokines is up-regulated during acute renal transplant rejection and crescentic glomerulonephritis. Kidney Int. 2000, 58:1546-1556.
91. Wick N., Haluza D., Gurnhofer E., Raab I., Kasimir M.T., Prinz M., Steiner C.W., Reinisch C., Howorka A., Giovanoli P., Buchsbaum S., Krieger S., Tschachler E., Petzelbauer P., Kerjaschki D. Lymphatic precollectors contain a novel, specialized subpopulation of podoplanin(low), CCL27-expressing lymphatic endothelial cells. Am. J. Pathol. 2008, 173:1202-1209.
92. Nibbs R.J.B., Wylie S.M., Yang J.Y., Landau N.R., Graham G.J. Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. J. Biol. Chem. 1997, 272:32078-32083.
93. Blackburn P.E., Simpson C.V., Nibbs R.J.B., O'Hara M., Booth R., Poulos J., Isaacs N.W., Graham G.J. Purification and biochemical characterization of the D6 chemokine receptor. Biochem. J. 2004, 379:263-272.
94. McCulloch C.V., Morrow V., Milasta S., Comerford I., Milligan G., Graham G.J., Isaacs N.W., Nibbs R.J.B. Multiple roles for the C-terminal tail of the chemokine scavenger D6. J. Biol. Chem. 2008, 283:7972-7982.
95. Schwarz M., Murphy P.M. Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor constitutively activates NF-{{kappa}}B and induces proinflammatory cytokine and chemokine production via a C-terminal signaling determinant. J. Immunol. 2001, 167:505-513.
96. Casarosa P., Bakker R.A., Verzijl D., Navis M., Timmerman H., Leurs R., Smit M.J. Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28. J. Biol. Chem. 2001, 276:1133-1137.
97. Bonecchi R., Borroni E.M., Anselmo A., Doni A., Savino B., Mirolo M., Fabbri M., Jala V.R., Haribabu B., Mantovani A., Locati M. Regulation of D6 chemokine scavenging activity by ligand- and Rab11-dependent surface up-regulation. Blood 2008, 112:493-503.
98. Nibbs R.J.B., Yang J.Y., Landau N.R., Mao J.H., Graham G.J. LD78 beta, a non-allelic variant of human MIP-1 alpha (LD78 alpha), has enhanced receptor interactions and potent HIV suppressive activity. J. Biol. Chem. 1999, 274:17478-17483.
99. Savino B., Borroni E.M., Torres N.M., Proost P., Struyf S., Mortier A., Mantovani A., Locati M., Bonecchi R. Recognition versus adaptive up-regulation and degradation of CC chemokines by the chemokine decoy receptor D6 are determined by their N-terminal sequence. J. Biol. Chem. 2009, 284:26207-26215.
100. Nibbs R.J.B., Wylie S.M., Pragnell I.B., Graham G.J. Cloning and characterization of a novel murine beta chemokine receptor, D6 - comparison to three other related macrophage inflammatory protein-1 alpha receptors, CCR-1, CCR-3, and CCR-5. J. Biol. Chem. 1997, 272:12495-12504.
101. Nibbs R.J.B., Kriehuber E., Ponath P.D., Parent D., Qin S.X., Campbell J.D.M., Henderson A., Kerjaschki D., Maurer D., Graham G.J., Rot A. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am. J. Pathol. 2001, 158:867-877.
102. Rot A. In situ binding assay for studying chemokine interactions with endothelial cells. J. Immunol. Meth. 2003, 273:63-71.
103. Stein J.V., Rot A., Luo Y., Narasimhaswamy M., Nakano H., Gunn M.D., Matsuzawa A., Quackenbush E.J., Dorf M.E., von Andrian U.H. The CC chemokine thymus-derived chemotactic agent 4 (TCA-4, secondary lymphoid tissue chemokine, 6Ckine, exodus-2) triggers lymphocyte function-associated antigen 1-mediated arrest of rolling T lymphocytes in peripheral lymph node high endothelial venules. J. Exp. Med. 2000, 191:61-75.
104. Palframan R.T., Jung S., Cheng C.Y., Weninger W., Luo Y., Dorf M., Littman D.R., Rollins B.J., Zweerink H., Rot A., von Andrian U.H. Inflammatory chemokine transport and presentation in HEV: a remote control mechanism for monocyte recruitment to lymph nodes in inflamed tissues. J. Exp. Med. 2001, 194:1361-1373.
105. McKimmie C.S., Fraser A.R., Hansell C., Gutierrez L., Philipsen S., Connell L., Rot A., Kurowska-Stolarska M., Carreno P., Pruenster M., Chu C.C., Lombardi G., Halsey C., McInnes I.B., Liew F.Y., Nibbs R.J., Graham G.J. Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1 (vol 181, pg 3353, 2008). J. Immunol. 2008, 181:8170-8181.
106. Graham G.J., McKimmie C.S. Chemokine scavenging by D6: a movable feast?. Trends Immunol. 2006, 27:381-386.
107. Bradford L., Marshall H., Robertson H., Kirby J.A., Graham G., Ali S., O'Boyle G. Cardiac allograft rejection: examination of the expression and function of the decoy chemokine receptor D6. Transplantation 2010, 89:1411-1416.
108. Sierro F., Biben C., Martinez-Munoz L., Mellado M., Ransohoff R.M., Li M., Woehl B., Leung H., Groom J., Batten M., Harvey R.P., Martinez A., Mackay C.R., Mackay F. Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7. Proc. Nat. Acad. Sci. U.S.A. 2007, 104:14759-14764.
109. Jamieson T., Cook D.N., Nibbs R.J.B., Rot A., Nixon C., Mclean P., Alcami A., Lira S.A., Wiekowski M., Graham G.J. The chemokine receptor D6 limits the inflammatory response in vivo. Nat. Immunol. 2005, 6:403-411.
110. de la Torre Y.M., Locati M., Buracchi C., Dupor J., Cook D.N., Bonecchi R., Nebuloni M., Rukavina D., Vago L., Vecchi A., Lira S.A., Mantovani A. Increased inflammation in mice deficient for the chemokine decoy receptor D6. Eur. J. Immunol. 2005, 35:1342-1346.
111. Nibbs R.J.B., Gilchrist D.S., King V., Ferra A., Forrow S., Hunter K.D., Graham G.J. The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. J. Clin. Invest. 2007, 117:1884-1892.
112. Di Liberto D., Locati M., Caccamo N., Vecchi A., Meraviglia S., Salerno A., Sireci G., Nebuloni M., Caceres N., Cardona P.J., Dieli F., Mantovani A. Role of the chemokine decoy receptor D6 in balancing inflammation, immune activation, and antimicrobial resistance in Mycobacterium tuberculosis infection. J. Exp. Med. 2008, 205:2075-2084.
113. Berres M.L., Trautwein C., Zaldivar M.M., Schmitz P., Pauels K., Lira S.A., Tacke F., Wasmuth H.E. The chemokine scavenging receptor D6 limits acute toxic liver injury in vivo. Biol. Chem. 2009, 390:1039-1045.
114. de la Torre Y.M., Buracchi C., Borroni E.M., Dupor J., Bonecchi R., Nebuloni M., Pasqualini F., Doni A., Lauri E., Agostinis C., Bulla R., Cook D.N., Haribabu B., Meroni P.L., Rukavina D., Vago L., Tedesco F., Vecchi A., Lira S.A., Locati M., Mantovani A. Protection against inflammation- and antiphospholipid antibody-caused fetal loss by the chemokine decoy receptor D6. Proc. Natl Acad. Sci. USA 2007, 104:2319-2324.
115. Madigan J., Freeman D.J., Menzies F., Forrow S., Nelson S.M., Young A., Sharkey A., Moffet A., Graham G.J., Greer I.A., Rot A., Nibbs R.J.B. Chemokine scavenger D6 is expressed by trophoblasts and aids the survival of mouse embryos transferred into allogeneic recipients. J. Immunol. 2010, 184:3202-3212.
116. Neil S.J.D., Aasa-Chapman M.M.I., Clapham P.R., Nibbs R.J., McKnight A., Weiss R.A. The promiscuous CC chemokine receptor D6 is a functional coreceptor for primary isolates of human immunodeficiency virus type 1 (HIV-1) and HIV-2 on astrocytes. J. Virol. 2005, 79:9618-9624.
117. Liu L.P., Graham G.J., Damodaran A., Hu T.F., Lira S.A., Sasse M., Canasto-Chibuque C., Cook D.N., Ransohoff R.M. Cutting edge: The silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis. J. Immunol. 2006, 177:17-21.
118. Bordon Y., Hansell C.A.H., Sester D.P., Clarke M., Mowat A.M., Nibbs R.J.B. The atypical chemokine receptor D6 contributes to the development of experimental colitis. J. Immunol. 2009, 182:5032-5040.
119. Vetrano S., Borroni E., Bonecchi R., Correale C., Arena V., Fantini M.C., Malesci A., Vecchi A., Mantovani A., Locati M., Danese S. The atypical chemokine receptor D6 controls intestinal inflammation and inflammation-associated colon cancer. Gut 2010, 59:197-206.
120. Whitehead G.S., Wang T., DeGraff L.M., Card J.W., Lira S.A., Graham G.J., Cook D.N. The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity. Am. J. Res. Crit. Care Med. 2007, 175:243-249.
121. Wu F.Y., Ou Z.L., Feng L.Y., Luo J.M., Wang L.P., Shen Z.Z., Shao Z.M. Chemokine decoy receptor D6 plays a negative role in human breast cancer. Mol. Cancer Res. 2008, 6:1276-1288.
122. Wiederholt T., von Westernhagen M., Zaldivar M.M., Berres M.L., Schmitz P., Hellerbrand C., Muller T., Berg T., Trautwein C., Wasmuth H.E. Genetic variations of the chemokine scavenger receptor D6 are associated with liver inflammation in chronic hepatitis C. Hum. Immunol. 2008, 69:861-866.
123. Libert F., Parmentier M., Lefort A., Dinsart C., Vansande J., Maenhaut C., Simons M.J., Dumont J.E., Vassart G. Selective amplification and cloning of 4 new members of the G-protein coupled receptor family. Science 1989, 244:569-572.
124. Heesen M., Berman M.A., Charest A., Housman D., Gerard C., Dorf M.E. Cloning and chromosomal mapping of an orphan chemokine receptor: mouse RDC1. Immunogenetics 1998, 47:364-370.
125. Balabanian K., Lagane B., Infantino S., Chow K.Y.C., Harriague J., Moepps B., Arenzana-Seisdedos F., Thelen M., Bachelerie F. The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J. Biol. Chem. 2005, 280:35760-35766.
126. Burns J.M., Summers B.C., Wang Y., Melikian A., Berahovich R., Miao Z.H., Penfold M.E.T., Sunshine M.J., Littman D.R., Kuo C.J., Wei K., McMaster B.E., Wright K., Howard M.C., Schall T.J. A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development. J. Exp. Med. 2006, 203:2201-2213.
127. Boldajipour B., Mahabaleshwar H., Kardash E., Reichman-Fried M., Blaser H., Minina S., Wilson D., Xu Q.L., Raz E. Control of chemokine-guided cell migration by ligand sequestration. Cell 2008, 132:463-473.
128. Levoye A., Balabanian K., Baleux F., Bachelerie F., Lagane B. CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling. Blood 2009, 113:6085-6093.
129. Zabel B.A., Wang Y., Lewen S., Berahovich R.D., Penfold M.E.T., Zhang P.L., Powers J., Summers B.C., Miao Z.H., Zhao B., Jalili A., Janowska-Wieczorek A., Jaen J.C., Schall T.J. Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands. J. Immunol. 2009, 183:3204-3211.
130. Jin Z., Nagakubo D., Shirakawa A.K., Nakayama T., Shigeta A., Hieshima K., Yamada Y., Yoshie O. CXCR7 is inducible by HTLV-1 tax and promotes growth and survival of HTLV-1-infected T cells. Int. J. Cancer 2009, 125:2229-2235.
131. Miao Z., Luker K.E., Summers B.C., Berahovich R., Bhojani M.S., Rehemtulla A., Kleer C.G., Essner J.J., Nasevicius A., Luker G.D., Howard M.C., Schall T.J. CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature. Proc. Nat. Acad. Sci. U.S.A. 2007, 104:15735-15740.
132. Wang J.H., Shiozawa Y.S., Wang J.C., Wang Y., Jung Y.H., Pienta K.J., Mehra R., Loberg R., Taichman R.S. The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer. J. Biol. Chem. 2008, 283:4283-4294.
133. Rajagopal S., Kim J., Ahn S., Craig S., Lam C.M., Gerard N.P., Gerard C., Lefkowitz R.J. beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. Proc. Nat. Acad. Sci. U.S.A. 2010, 107:628-632.
134. Kalatskaya I., Berchiche Y.A., Gravel S., Limberg B.J., Rosenbaum J.S., Heveker N. AMD3100 is a CXCR7 ligand with allosteric agonist properties. Mol. Pharmacol. 2009, 75:1240-1247.
135. Luker K.E., Gupta M., Luker G.D. Imaging chemokine receptor dimerization with firefly luciferase complementation. FASEB J. 2009, 23:823-834.
136. Dambly-Chaudiere C., Cubedo N., Ghysen A. Control of cell migration in the development of the posterior lateral line: antagonistic interactions between the chemokine receptors CXCR4 and CXCR7/RDC1. BMC Dev. Biol. 2007, 7:23. 10.1186/1471-213X-7-23.
137. Valentin G., Haas P., Gilmour D. The chemokine SDF1a coordinates tissue migration through the spatially restricted activation of Cxcr7 and Cxcr4b. Curr. Biol. 2007, 17:1026-1031.
138. Gerrits H., Schenau D.S.V.I., Bakker N.E.C., van Disseldorp A.J.M., Strik A., Hermens L.S., Koenen T.B., Krajnc-Franken M.A.M., Gossen J.A. Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice. Genesis 2008, 46:235-245.
139. Luker K.E., Steele J.M., Mihalko L.A., Ray P., Luker G.D. Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands. Oncogene 2010, 29:4599-4610.
140. Infantino S., Moepps B., Thelen M. Expression and regulation of the orphan receptor RDC1 and its putative ligand in human dendritic and B cells. J. Immunol. 2006, 176:2197-2207.
141. Hartmann T.N., Grabovsky V., Pasvolsky R., Shulman Z., Buss E.C., Spiegel A., Nagler A., Lapidot T., Thelen M., Alon R. A crosstalk between intracellular CXCR7 and CXCR4 involved in rapid CXCL12-triggered integrin activation but not in chemokine-triggered motility of human T lymphocytes and CD34+ cells. J. Leukoc. Biol. 2008, 84:1130-1140.
142. Berahovich R.D., Zabel B.A., Penfold M.E.T., Lewen S., Wang Y., Miao Z., Gan L., Pereda J., Dias J., Slukvin I.I., McGrath K.E., Jaen J.C., Schall T.J. CXCR7 protein is not expressed on human or mouse leukocytes. J. Immunol. 2010, 185:5130-5139.
143. Tarnowski M., Liu R., Wysoczynski M., Ratajczak J., Kucia M., Ratajczak M.Z. CXCR7: a new SDF-1-binding receptor in contrast to normal CD34+ progenitors is functional and is expressed at higher level in human malignant hematopoietic cells. Eur. J. Haematol. 2010, 85:472-483.
144. Khoja H., Wang G.L., Ng C.T.L., Tucker J., Brown T., Shyamala V. Cloning of CCRL1, an orphan seven transmembrane receptor related to chemokine receptors, expressed abundantly in the heart. Gene 2000, 246:229-238.
145. Gosling J., Dairaghi D.J., Wang Y., Hanley M., Talbot D., Miao Z.H., Schall T.J. Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 2000, 164:2851-2856.
146. Schweickart V.L., Epp A., Raport C.J., Gray P.W. CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J. Biol. Chem. 2000, 275:9550-9556.
147. Townson J.R., Nibbs R.J.B. Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3 beta/mCCL19: comparison to human CCX-CKR. Eur. J. Immunol. 2002, 32:1230-1241.
148. Krueger A., Willenzon S., Lyszkiewicz M., Kremmer E., Forster R. CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood 2010, 115:1906-1912.
149. Zlotoff D.A., Sambandam A., Logan T.D., Bell J.J., Schwarz B.A., Bhandoola A. CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood 2010, 115:1897-1905.
150. Forster R., Davalos-Misslitz A.C., Rot A. CCR7 and its ligands: balancing immunity and tolerance. Nat. Rev. Immunol. 2008, 8:362-371.
151. Haraldsen G., Rot A. Commentary: Coy decoy with a new ploy: interceptor controls the levels of homeostatic chemokines. Eur. J. Immunol. 2006, 36:1659-1661.
152. Baekkevold E.S., Yamanaka T., Palframan R.T., Carlsen H.S., Reinholt F.P., von Andrian U.H., Brandtzaeg P., Haraldsen G. The CCR7 ligand ELC (CCL19) is transcytosed in high endothelial venules and mediates T cell recruitment. J. Exp. Med. 2001, 193:1105-1111.
153. Comerford I., Nibbs R.J., Litchfield W., Bunting M., Harata-Lee Y., Haylock-Jacobs S., Forrow S., Korner H., McColl S.R. The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses. Blood 2010, 116:4130-4140.
154. Heinzel K., Benz C., Bleul C.C. A silent chemokine receptor regulates steady-state leukocyte homing in vivo. Proc. Nat. Acad. Sci. U.S.A. 2007, 104:8421-8426.
155. Kriegova E., Tsyrulnyk A., Arakelyan A., Mrazek F., Ordeltova M., Petzmann S., Zatloukal J., Kolek V., du Bois R.M., Popper H., Petrek M. Expression of CCX CKR in pulmonary sarcoidosis. Inflammat. Res. 2006, 55:441-445.
156. Dorf M.E., Berman M.A., Tanabe S., Heesen M., Luo Y. Astrocytes express functional chemokine receptors. J. Neuroimmunol. 2000, 111:109-121.
157. Zuurman M.W., Heeroma J., Brouwer N., Boddeke H.W.G.M., Biber K. LPS-induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Glia 2003, 41:327-336.
158. Brouwer N., Zuurman M.W., Wei T., Ransohoff R.M., Boddeke H.W.G.M., Biber K. Induction of glial L-CCR mRNA expression in spinal cord and brain in experimental autoimmune encephalomyelitis. Glia 2004, 46:84-94.
159. Leick M., Catusse J., Follo M., Nibbs R.J., Hartmann T.N., Veelken H., Burger M. CCL19 is a specific ligand of the constitutively recycling atypical human chemokine receptor CRAM-B. Immunology 2010, 129:536-546.
160. Shimada T., Matsumoto M., Tatsumi Y., Kanamaru A., Akira S. A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. FEBSLett. 1998, 425:490-494.
161. Fan P., Kyaw H., Su K., Zeng Z.Z., Augustus M., Carter K.C., Li Y. Cloning and characterization of a novel human chemokine receptor. Biochem. Biophys. Res. Comm. 1998, 243:264-268.
162. Galligan C.L., Matsuyama W., Matsukawa A., Mizuta H., Hodge D.R., Howard O.M.Z., Yoshimura T. Up-regulated expression and activation of the. orphan chemokine receptor, CCRL2, in rheumatoid arthritis. Arthritis Rheum. 2004, 50:1806-1814.
163. Zabel B.A., Nakae S., Zuniga L., Kim J.Y., Ohyama T., Alt C., Pan J., Suto H., Soler D., Allen S.J., Handel T.M., Song C.H., Galli S.J., Butcher E.C. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J. Exp. Med. 2008, 205:2207-2220.
164. Biber K., Zuurman M.W., Homan H., Boddeke H.W.G.M. Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8. J. Leukoc. Biol. 2003, 74:243-251.
165. Hartmann T.N., Leick M., Ewers S., Diefenbacher A., Schraufstatter I., Honczarenko M., Burger M. Human B cells express the orphan chemokine receptor CRAM-A/B in a maturation-stage-dependent and CCL5-modulated manner. Immunology 2008, 125:252-262.
166. Oostendorp J., Hylkema M.N., Luinge M., Geerlings M., Meurs H., Timens W., Zaagsma J., Postma D.S., Boddeke H.W., Biber K. Localization and enhanced mRNA expression of the orphan chemokine receptor L-CCR in the lung in a murine model of ovalbumin-induced airway inflammation. J. Histochem. Cytochem. 2004, 52:401-410.
167. Migeotte I., Franssen J.D., Goriely S., Willems F., Parmentier M. Distribution and regulation of expression of the putative human chemokine receptor HCR in leukocyte populations. Eur. J. Immunol. 2002, 32:494-501.
168. Otero K., Vecchi A., Hirsch E., Kearley J., Vermi W., Del Prete A., Gonzalvo-Feo S., Garlanda C., Azzolino O., Salogni L., Lloyd C.M., Facchetti F., Mantovani A., Sozzani S. Nonredundant role of CCRL2 in lung dendritic cell trafficking. Blood 2010, 116:2942-2949.