Expression of L-CCR in HEK 293 cells reveals functional responses to CCL2, CCL5, CCL7, and CCL8

Journal of Leukocyte Biology

Volumn 74, Issue 2, 2003, Pages 243-251

  Biber, Knut ^a   Zuurman, Mike W ^a   Homan, Han ^a   Boddeke, Hendrikus W G M ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Calcium signals; Chemokine receptors; Chemotaxis; GPCR

Indexed keywords

CHEMOKINE; CHEMOKINE CCL8; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR L CCR; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 3; PERTUSSIS TOXIN; RANTES; UNCLASSIFIED DRUG; ACTIN; BETA CHEMOKINE; CALCIUM; CCRL2 PROTEIN, MOUSE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MESSENGER RNA; PHOTOPROTEIN;

ANIMAL CELL; ARTICLE; BIOTINYLATION; CELL LINE; CELL MEMBRANE; CHEMOTAXIS; CONTROLLED STUDY; EMBRYO; EMBRYO CELL; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOASSAY; ANIMAL; CELL CULTURE; CHO CELL; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; ISOLATION AND PURIFICATION; KIDNEY; METABOLISM; MOUSE; PHYSIOLOGY; PLASMID; TISSUE DISTRIBUTION;

ANIMALIA;

ACTINS; ANIMALS; BIOTINYLATION; CALCIUM; CELLS, CULTURED; CHEMOKINES, CC; CHEMOTAXIS; CHO CELLS; CRICETINAE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; KIDNEY; LUMINESCENT PROTEINS; MICE; PERTUSSIS TOXIN; PLASMIDS; RECEPTORS, CHEMOKINE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TISSUE DISTRIBUTION; TRANSFECTION;

EID: 0042351113     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.0802415     Document Type: Article

References (31)

1. Rollins, B. J. (1997) Chemokines. Blood 90, 909-928.
2. Baggiolini, M. (1998) Chemokines and leukocyte traffic. Nature 392, 565-568.
3. Murphy, P. M., Baggiolini, M., Charo, I. F., Hebert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., Power, C. A. (2000) International Union of Pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52, 145-176.
4. Mackay, C. R. (2001) Chemokines: immunology's high impact factors. Nat. Immunol. 2, 95-101.
5. Gerard, C., Rollins, B. J. (2001) Chemokines and disease. Nat. Immunol. 2, 108-115.
6. Proutfoot, A. E. I., Shaw, J. P., Power, C. A., Wells, T. N. C. (2002) Chemokines. In Universes in Delicate Balance: Chemokines and the Nervous System (R. M. Ransohoff, K. Suzuki, A. E. I. Proudfoot, W. F. Hickey, J. K. Harrison, eds.), Amsterdam, Elsevier, 65-87.
7. Slattery, D. M., Gerard, N. P., Gerard, C. (2002) Chemokine receptors. In Universes in Delicate Balance: Chemokines and the Nervous System (R. M. Ransohoff, K. Suzuki, A. E. I. Proudfoot, W. F. Hickey, J. K. Harrison, eds.), Amsterdam, Elsevier, 87-99.
8. Devalaraja, M. N., Richmond, A. (1999) Multiple chemotactic factors: fine control or redundancy? Trends Pharmacol. Sci. 20, 151-156.
9. Mantovani, A. (1999) The chemokine system: redundancy for robust outputs. Immunol. Today 20, 254-257.
10. Shimada, T., Matsumoto, M., Tatsumi, Y., Kanamaru, A., Akira, S. (1998) A novel lipopolysaccharide inducible C-C chemokine receptor related gene in murine macrophages. FEBS Lett. 425, 490-494.
11. Zuurman, M. W., Heeroma, J., Brouwer, N., Boddeke, H. W. G. M., Biber, K. (2003) LPS induced expression of a novel chemokine receptor (L-CCR) in mouse glial cells in vitro and in vivo. Glia 41, 327-336.
12. Chomczynski, P., Sacchi, N. (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
13. Biber, K., Klotz, K.-N., Berger, M., Gebicke-Haerter, P. J., van Calker, D. (1997) Adenosine Al receptor-mediated activation of phospholipase C in cultured astrocytes depends on the level of receptor expression. J. Neurosci. 17, 4956-4964.
14. Preobrazhensky, A. A., Dragan, S., Kawano, T., Gavrilin, M. A., Gulina, I. V., Chakravarty, L., Kolattukudy, P. E. (2000) Monocyte chemotactic protein-1 receptor CCR2b is a glycoprotein that has tyrosine sulfation in a conserved extracellular N-terminal region. J. Immunol. 165, 5295-5303.
15. Andjelkovic, A. V., Kerkovich, D., Shanley, J., Pulliam, L., Pachter, J. S. (1999a) Expression of binding sites for beta chemokines on human astrocytes. Glia 28, 225-235.
16. Andjelkovic, A. V., Spencer, D. D., Pachter, J. S. (1999b) Visualization of chemokine binding sites on human brain microvessels. J. Cell Biol. 145, 403-412.
17. Bennett, T. A., Maestas, D. C., Prossnitz, E. R. (2000) Arrestin binding to the G protein-coupled N-formyl peptide receptor is regulated by the conserved "DRY" sequence. J. Biol. Chem. 275, 24590-24594.
18. 2 cannabinoid receptor. FEBS Lett. 466, 300-304.
19. 2 receptor. Mol. Pharmacol. 57, 890-898.
20. Giles, H., Lansdell, S. J., Bolofo, M.-L., Wilson, H. L., Martin, G. R. (1996) Characterization of a 5-HTIB receptor on CHO cells: functional responses in the absence of radioligand binding. Br. J. Pharmacol. 117, 1119-1126.
21. Christopoulos, A., Kenakin, T. (2002) G protein-coupled receptor allosterism and complexing. Pharmacol. Rev. 54, 323-374.
22. Leurs, R., Smit, M. J., Alewijnse, A. E., Timmerman, H. (1998) Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends Biochem. Sci. 23, 418-422.
23. Alewijnse, A. E., Smit, M. J., Hoffmann, M., Verzijl, D., Timmerman, H., Leurs, R. (1998) Constitutive activity and structural instability of the wild-type human H2 receptor. J. Neurochem. 71, 799-807.
24. Heesen, M., Tanabe, S., Berman, M. A., Yoshizawa, I., Luo, Y., Kim, R. J., Post, T. W., Gerard, C., Dorf, M. E. (1996) Mouse astrocytes respond to the chemokines MCP-1 and KC, but reverse transcriptase-polymerase chain reaction does not detect mRNA for the KC or new MCP-1 receptor. J. Neurosci. Res. 45, 382-391.
25. MacLean, J. A., De Sanctis, G. T., Ackerman, K. G., Drazen, J. M., Sauty, A., DeHaan, E., Green, F. H. Y., Charo, I. F., Luster, A. D. (2000) CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J. Immunol. 165, 6568-6575.
26. Schweickart, V. L., Epp, A., Raport, C. J., Gray, P. W. (2000) CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J. Biol. Chem. 275, 9550-9556.
27. Nibbs, R. J. B., Wylie, S. M., Pragnell, I. B., Graham, G. J. (1997) Cloning and characterization of a novel promiscuous human beta-chemokine receptor D6. J. Biol. Chem. 272, 12495-12504.
28. Nibbs, R. J., Yang, J., Landau, N. R., Mao, J. H., Graham, G. J. (1999) LD78beta, a non-allelic variant of human MIP-lalpha (LD78alpha), has enhanced receptor interactions and potent HIV suppressive activity. J. Biol. Chem. 274, 17478-17483.
29. Gosling, J., Dairaghi, D. J., Wang, Y., Hanley, M., Talbot, D., Miao, Z., Schall, T. J. (2000) Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK. J. Immunol. 164, 2851-2856.
30. Schweickart, V. L., Epp, A., Raport, C. J., Gray, P. W. (2001) CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. J. Biol. Chem. 276, 856.
31. Murphy, P. M. (2002) International Union of Pharmacology. XXX. Update on chemokine receptor nomenclature. Pharmacol. Rev. 54, 227-229.