IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18276-18282

  Dunne, Aisling ^a   Carpenter, Susan ^a   Brikos, Constantinos ^a,e   Gray, Pearl ^a   Strelow, Astrid ^c   Wesche, Holger ^b   Morrice, Nick ^d   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b AMGEN INC   (United States)

^c CFD Therapeutics Inc   (United States)

^d UNIVERSITY OF DUNDEE   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL LYSATES; CO-EXPRESSION; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; TOLL-LIKE RECEPTOR 2; UBIQUITINATION;

PHOSPHORYLATION; SIGNAL TRANSDUCTION;

DEGRADATION;

ADAPTOR PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; MYELOID DIFFERENTIATION FACTOR 88 ADAPTOR LIKE PROTEIN; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; EMBRYO; ENZYME DEGRADATION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION;

CELL LINE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LIPOPOLYSACCHARIDES; MASS SPECTROMETRY; MEMBRANE TRANSPORT PROTEINS; MODELS, BIOLOGICAL; MYELIN PROTEINS; MYELOID DIFFERENTIATION FACTOR 88; PHOSPHORYLATION; PROTEOLIPIDS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; UBIQUITIN;

EID: 77953302679     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.098137     Document Type: Article

References (24)

1. Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., and Cao, Z. (1997) Immunity 7, 837-847
2. Fitzgerald, K. A., Palsson-McDermott, E. M., Bowie, A. G., Jefferies, C. A., Mansell, A. S., Brady, G., Brint, E., Dunne, A., Gray, P., Harte, M. T., McMurray, D., Smith, D. E., Sims, J. E., Bird, T. A., and O'Neill, L. A. (2001) Nature 413, 78-83
3. Horng, T., Barton, G. M., and Medzhitov, R. (2001) Nat. Immunol. 2, 835-841
4. Yamamoto, M., Sato, S., Mori, K., Hoshino, K., Takeuchi, O., Takeda, K., and Akira, S. (2002) J. Immunol. 169, 6668-6672
5. Oshiumi, H., Sasai, M., Shida, K., Fujita, T., Matsumoto, M., and Seya, T. (2003) J. Biol. Chem. 278, 49751-49762
6. Fitzgerald, K. A., Rowe, D. C., Barnes, B. J., Caffrey, D. R., Visintin, A., Latz, E., Monks, B., Pitha, P. M., and Golenbock, D. T. (2003) J. Exp. Med. 198, 1043-1055
7. Gottipati, S., Rao, N. L., and Fung-Leung, W. P. (2008) Cell. Signal. 20, 269-276
8. Meylan, E., and Tschopp, J. (2008) Nat. Immunol. 9, 581-582
9. Kobayashi, K., Hernandez, L. D., Galán, J. E., Janeway, C. A., Jr., Medzhitov, R., and Flavell, R. A. (2002) Cell 110, 191-202
10. Strelow, A., Kollewe, C., and Wesche, H. (2003) FEBS Lett. 547, 157-161
11. Huang, Y., Li, T., Sane, D. C., and Li, L. (2004) J. Biol. Chem. 279, 51697-51703
12. Liu, G., Park, Y. J., and Abraham, E. (2008) FASEB J. 22, 2285-2296
13. Uematsu, S., Sato, S., Yamamoto, M., Hirotani, T., Kato, H., Takeshita, F., Matsuda, M., Coban, C., Ishii, K. J., Kawai, T., Takeuchi, O., and Akira, S. (2005) J. Exp. Med. 201, 915-923
14. Butler, M. P., Hanly, J. A., and Moynagh, P. N. (2007) J. Biol. Chem. 282, 29729-29737
15. Dunne, A., Ejdeback, M., Ludidi, P. L., O'Neill, L. A., and Gay, N. J. (2003) J. Biol. Chem. 278, 41443-41451
16. Mansell, A., Smith, R., Doyle, S. L., Gray, P., Fenner, J. E., Crack, P. J., Nicholson, S. E., Hilton, D. J., O'Neill, L. A., and Hertzog, P. J. (2006) Nat. Immunol. 7, 148-155
17. Kollewe, C., Mackensen, A. C., Neumann, D., Knop, J., Cao, P., Li, S., Wesche, H., and Martin, M. U. (2004) J. Biol. Chem. 279, 5227-5236
18. Gray, P., Dunne, A., Brikos, C., Jefferies, C. A., Doyle, S. L., and O'Neill, L. A. (2006) J. Biol. Chem. 281, 10489-10495
19. Chuang, T. H., and Ulevitch, R. J. (2004) Nat. Immunol. 5, 495-502
20. Naiki, Y., Michelsen, K. S., Zhang, W., Chen, S., Doherty, T. M., and Arditi, M. (2005) J. Biol. Chem. 280, 5491-5495
21. Song, K. W., Talamas, F. X., Suttmann, R. T., Olson, P. S., Barnett, J. W., Lee, S. W., Thompson, K. D., Jin, S., Hekmat-Nejad, M., Cai, T. Z., Manning, A. M., Hill, R. J., and Wong, B. R. (2009) Mol. Immunol. 46, 1458-1466
22. Bhattacharyya, S., Borthakur, A., Pant, N., Dudeja, P. K., and Tobacman, J. K. (2007) Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429-G437
23. Butler, M. P., Hanly, J. A., and Moynagh, P. N. (2007) J. Biol. Chem. 282, 29729-29737
24. Kubo-Murai, M., Hazeki, K., Nigorikawa, K., Omoto, T., Inoue, N., and Hazeki, O. (2008) J. Biochem. 143, 295-302