Importance of a serine proximal to the C(4a) and N(5) flavin atoms for hydride transfer in choline oxidase

Biochemistry

Volumn 50, Issue 5, 2011, Pages 770-779

  Yuan, Hongling ^a   Gadda, Giovanni ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ALKOXIDES; ANAEROBIC REDUCTION; BIPHASIC; CHOLINE OXIDASE; FLAVIN-DEPENDENT; GLYCINE BETAINE; HYDRIDE TRANSFERS; HYDRIDE-TRANSFER REACTION; KINETIC ISOTOPE EFFECTS; OXIDATION REACTIONS; PROTON ABSTRACTION; SERINE RESIDUES; SIDE CHAINS; SOLVENT KINETIC ISOTOPE EFFECTS; STOPPED FLOW; WILD-TYPE ENZYMES;

ABSTRACTING; ALDEHYDES; ATOMS; CARRIER MOBILITY; CATALYSIS; ENZYMES; ISOTOPES; OXIDATION; PROTONS; RATE CONSTANTS; REACTION INTERMEDIATES;

AMINO ACIDS;

ALANINE; ALDEHYDE; BETAINE; CARBON; CHOLINE; CHOLINE OXIDASE; CYSTEINE; HYDROGEN; NITROGEN; OXIDE; QUERCETIN; SERINE; THREONINE; VALINE;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTON TRANSPORT; REDUCTION; SITE DIRECTED MUTAGENESIS; SPECTROPHOTOMETRY; WILD TYPE;

ALCOHOL OXIDOREDUCTASES; ARTHROBACTER; BACTERIAL PROTEINS; BETAINE; CATALYSIS; CATALYTIC DOMAIN; CHOLINE; CRYSTALLOGRAPHY, X-RAY; ENERGY TRANSFER; FLAVINS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, MOLECULAR; OXIDATION-REDUCTION; PROTEIN BINDING; SERINE;

EID: 79952094721     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101837u     Document Type: Article

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