Role of Glu312 in binding and positioning of the substrate for the hydride transfer reaction in choline oxidase

Biochemistry

Volumn 47, Issue 1, 2008, Pages 243-256

  Quaye, Osbourne ^a   Lountos, George T ^b,d   Fan, Fan ^a,e   Orville, Allen M ^b,c   Gadda, Giovanni ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c BROOKHAVEN NATIONAL LABORATORY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BACTERIA; BINDING SITES; CRYSTALLOGRAPHY; PATHOGENS; SYNCHROTRON RADIATION;

COVALENT LINKAGE; HYDRIDE TRANSFER; PATHOGENIC BACTERIA; POSITIONING; TEMPERATURE STRESSES;

ENZYME ACTIVITY;

ALANINE; ASPARTIC ACID; BETAINE; CHOLINE; CHOLINE OXIDASE; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HYDROGEN;

AMINO ACID SUBSTITUTION; ARTICLE; COVALENT BOND; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME LOCALIZATION; ENZYME MECHANISM; ENZYME SUBSTRATE; ISOTOPE LABELING; NONHUMAN; OSMOTIC STRESS; OXIDATION KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; REACTION ANALYSIS; SYNCHROTRON RADIATION; TEMPERATURE MEASUREMENT; WILD TYPE;

ALCOHOL OXIDOREDUCTASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; KINETICS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 37849031214     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi7017943     Document Type: Article

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