Role of asparagine 510 in the relative timing of substrate bond cleavages in the reaction catalyzed by choline oxidase

Biochemistry

Volumn 49, Issue 11, 2010, Pages 2483-2490

  Rungsrisuriyachai, Kunchala ^a   Gadda, Giovanni ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ASPARAGINE RESIDUE; ASPARTATES; BOND CLEAVAGES; C-H BOND; CHOLINE OXIDASE; CONCERTED MECHANISM; ELECTRON ACCEPTOR; ENZYME SUPERFAMILIES; GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE; GLYCINE BETAINE; HALF-REACTIONS; KINETIC ISOTOPE EFFECTS; MECHANISTIC PROPERTIES; MUTANT ENZYMES; REACTION CATALYZED; RELATIVE TIMING; SITE DIRECTED MUTAGENESIS; SUBSTRATE BINDING; TRANSIENT FORMATION; WILD TYPES;

ALDEHYDES; AMINO ACIDS; GLUCOSE; ISOTOPES; METHANOL; MOLECULAR OXYGEN; PHOSPHATASES; REACTION INTERMEDIATES;

ENZYMES;

ALANINE; ASPARAGINE; ASPARTIC ACID; BETAINE; CHOLINE OXIDASE; GLUCOSE; HISTIDINE; ISOTOPE; LEUCINE; METHANOL; OXIDOREDUCTASE; QUERCETIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYST; CHEMICAL REACTION; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HYDROGEN BOND; KINETICS; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEADY STATE; WILD TYPE;

ALCOHOL OXIDOREDUCTASES; ANIMALS; ASPARAGINE; BIOCATALYSIS; CATALYTIC DOMAIN; CATTLE; FLAVINS; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; OXIDATION-REDUCTION; SPECTRUM ANALYSIS;

EID: 77949505450     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901796a     Document Type: Article

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