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Volumn 2, Issue 8, 2010, Pages 2028-2054

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Author keywords

Biomarker; Colorectal cancer; Guanylin; Guanylyl cyclase C; Heat stable enterotoxins (STa); Hormone insufficiency; Hormone replacement therapy; Irritable bowel syndrome; Targeted delivery; Tumor vaccine; Uroguanylin

Indexed keywords

BACTERIAL HEAT STABLE ENTEROTOXIN; CANCER VACCINE; ELECTROLYTE; ENTEROTOXIN; GASTROINTESTINAL AGENT; GUANYLATE CYCLASE; GUANYLYL CYCLASE C; LINACLOTIDE; PIRNABIN; PLACEBO; PROKINETIC AGENT; SP 333; SPASMOLYTIC AGENT; UNCLASSIFIED DRUG;

EID: 79952080895     PISSN: None     EISSN: 20726651     Source Type: Journal    
DOI: 10.3390/toxins2082028     Document Type: Review
Times cited : (31)

References (170)
  • 1
    • 0018139654 scopus 로고
    • Biological evaluation of a methanol-soluble, heat-stable Escherichia coli enterotoxin in infant mice, pigs, rabbits, and calves
    • Burgess, M.N.; Bywater, R.J.; Cowley, C.M.; Mullan, N.A.; Newsome, P.M. Biological evaluation of a methanol-soluble, heat-stable Escherichia coli enterotoxin in infant mice, pigs, rabbits, and calves. Infect. Immun. 1978, 21, 526-531.
    • (1978) Infect. Immun , vol.21 , pp. 526-531
    • Burgess, M.N.1    Bywater, R.J.2    Cowley, C.M.3    Mullan, N.A.4    Newsome, P.M.5
  • 2
    • 0017946994 scopus 로고
    • Production of enterotoxin by Yersinia enterocolitica
    • Pai, C.H.; Mors, V. Production of enterotoxin by Yersinia enterocolitica. Infect. Immun. 1978, 19, 908-911.
    • (1978) Infect. Immun , vol.19 , pp. 908-911
    • Pai, C.H.1    Mors, V.2
  • 3
    • 0018921156 scopus 로고
    • Comparison of different assays for definition of heat-stable enterotoxigenicity of Escherichia coli porcine strains
    • Olsson, E.; Soderlind, O. Comparison of different assays for definition of heat-stable enterotoxigenicity of Escherichia coli porcine strains. J. Clin. Microbiol. 1980, 11, 6-15.
    • (1980) J. Clin. Microbiol , vol.11 , pp. 6-15
    • Olsson, E.1    Soderlind, O.2
  • 4
    • 0026102032 scopus 로고
    • Characterization of Escherichia coli strains producing heat-stable enterotoxin b (STb) isolated from humans with diarrhea
    • Lortie, L.A.; Dubreuil, J.D.; Harel, J. Characterization of Escherichia coli strains producing heat-stable enterotoxin b (STb) isolated from humans with diarrhea. J. Clin. Microbiol. 1991, 29, 656-659.
    • (1991) J. Clin. Microbiol , vol.29 , pp. 656-659
    • Lortie, L.A.1    Dubreuil, J.D.2    Harel, J.3
  • 6
    • 0025763676 scopus 로고
    • Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model
    • Savarino, S.J.; Fasano, A.; Robertson, D.C.; Levine, M.M. Enteroaggregative Escherichia coli elaborate a heat-stable enterotoxin demonstrable in an in vitro rabbit intestinal model. J. Clin. Invest. 1991, 87, 1450-1455.
    • (1991) J. Clin. Invest , vol.87 , pp. 1450-1455
    • Savarino, S.J.1    Fasano, A.2    Robertson, D.C.3    Levine, M.M.4
  • 9
    • 0023231218 scopus 로고
    • Production of Escherichia coli STa-like heat-stable enterotoxin by Citrobacter freundii isolated from humans
    • Guarino, A.; Capano, G.; Malamisura, B.; Alessio, M.; Guandalini, S.; Rubino, A. Production of Escherichia coli STa-like heat-stable enterotoxin by Citrobacter freundii isolated from humans. J. Clin. Microbiol. 1987, 25, 110-114.
    • (1987) J. Clin. Microbiol , vol.25 , pp. 110-114
    • Guarino, A.1    Capano, G.2    Malamisura, B.3    Alessio, M.4    Guandalini, S.5    Rubino, A.6
  • 10
    • 0021028674 scopus 로고
    • Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin
    • Klipstein, F.A.; Engert, R.F.; Houghten, R.A. Immunological properties of purified Klebsiella pneumoniae heat-stable enterotoxin. Infect. Immun. 1983, 42, 838-841.
    • (1983) Infect. Immun , vol.42 , pp. 838-841
    • Klipstein, F.A.1    Engert, R.F.2    Houghten, R.A.3
  • 11
    • 0029240559 scopus 로고
    • Escherichia coli heat-stable enterotoxins, guanylins, and their receptors: What are they and what do they do
    • Giannella, R.A. Escherichia coli heat-stable enterotoxins, guanylins, and their receptors: what are they and what do they do? J. Lab. Clin. Med. 1995, 125, 173-181.
    • (1995) J. Lab. Clin. Med , vol.125 , pp. 173-181
    • Giannella, R.A.1
  • 12
    • 0017758104 scopus 로고
    • Repression of heat-stable enterotoxin synthesis in enterotoxigenic Escherichia coli
    • Alderete, J.F.; Robertson, D.C. Repression of heat-stable enterotoxin synthesis in enterotoxigenic Escherichia coli. Infect. Immun. 1977, 17, 629-633.
    • (1977) Infect. Immun , vol.17 , pp. 629-633
    • Alderete, J.F.1    Robertson, D.C.2
  • 13
    • 0018193925 scopus 로고
    • Heat-stable enterotoxin from Escherichia coli: Factors involved in growth and toxin production
    • Johnson, W.M.; Lior, H.; Johnson, K.G. Heat-stable enterotoxin from Escherichia coli: factors involved in growth and toxin production. Infect. Immun. 1978, 20, 352-359.
    • (1978) Infect. Immun , vol.20 , pp. 352-359
    • Johnson, W.M.1    Lior, H.2    Johnson, K.G.3
  • 15
    • 14644392242 scopus 로고    scopus 로고
    • Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract
    • Birbe, R.; Palazzo, J.P.; Walters, R.; Weinberg, D.; Schulz, S.; Waldman, S.A. Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract. Hum. Pathol. 2005, 36, 170-179.
    • (2005) Hum. Pathol , vol.36 , pp. 170-179
    • Birbe, R.1    Palazzo, J.P.2    Walters, R.3    Weinberg, D.4    Schulz, S.5    Waldman, S.A.6
  • 16
    • 0025647794 scopus 로고
    • Guanylyl cyclase is a heat-stable enterotoxin receptor
    • Schulz, S.; Green, C.K.; Yuen, P.S.; Garbers, D.L. Guanylyl cyclase is a heat-stable enterotoxin receptor. Cell 1990, 63, 941-948.
    • (1990) Cell , vol.63 , pp. 941-948
    • Schulz, S.1    Green, C.K.2    Yuen, P.S.3    Garbers, D.L.4
  • 17
    • 0028240141 scopus 로고
    • Heat-stable enterotoxin receptor/guanylyl cyclase C is an oligomer consisting of functionally distinct subunits, which are non-covalently linked in the intestine
    • Vaandrager, A.B.; van der Wiel, E.; Hom, M.L.; Luthjens, L.H.; de Jonge, H.R. Heat-stable enterotoxin receptor/guanylyl cyclase C is an oligomer consisting of functionally distinct subunits, which are non-covalently linked in the intestine. J. Biol. Chem. 1994, 269, 16409-16415.
    • (1994) J. Biol. Chem , vol.269 , pp. 16409-16415
    • Vaandrager, A.B.1    van der Wiel, E.2    Hom, M.L.3    Luthjens, L.H.4    de Jonge, H.R.5
  • 18
    • 2242458562 scopus 로고    scopus 로고
    • Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution
    • Lauber, T.; Nourse, A.; Schulz, A.; Marx, U.C. Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution. Biochemistry 2002, 41, 14602-14612.
    • (2002) Biochemistry , vol.41 , pp. 14602-14612
    • Lauber, T.1    Nourse, A.2    Schulz, A.3    Marx, U.C.4
  • 23
    • 0033000111 scopus 로고    scopus 로고
    • Guanylin regulatory peptides: Structures, biological activities mediated by cyclic GMP and pathobiology
    • Forte, L.R. Guanylin regulatory peptides: structures, biological activities mediated by cyclic GMP and pathobiology. Regul. Pept. 1999, 81, 25-39.
    • (1999) Regul. Pept , vol.81 , pp. 25-39
    • Forte, L.R.1
  • 24
    • 0033303533 scopus 로고    scopus 로고
    • Regulated, side-directed secretion of proguanylin from isolated rat colonic mucosa
    • Martin, S.; Adermann, K.; Forssmann, W.G.; Kuhn, M. Regulated, side-directed secretion of proguanylin from isolated rat colonic mucosa. Endocrinology 1999, 140, 5022-5029.
    • (1999) Endocrinology , vol.140 , pp. 5022-5029
    • Martin, S.1    Adermann, K.2    Forssmann, W.G.3    Kuhn, M.4
  • 25
    • 50449088585 scopus 로고    scopus 로고
    • Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide
    • Moss, N.G.; Fellner, R.C.; Qian, X.; Yu, S.J.; Li, Z.; Nakazato, M.; Goy, M.F. Uroguanylin, an intestinal natriuretic peptide, is delivered to the kidney as an unprocessed propeptide. Endocrinology 2008, 149, 4486-4498.
    • (2008) Endocrinology , vol.149 , pp. 4486-4498
    • Moss, N.G.1    Fellner, R.C.2    Qian, X.3    Yu, S.J.4    Li, Z.5    Nakazato, M.6    Goy, M.F.7
  • 26
    • 0026722971 scopus 로고
    • Stimulation of intestinal Cl- transport by heat-stable enterotoxin: Activation of cAMP-dependent protein kinase by cGMP
    • Forte, L.R.; Thorne, P.K.; Eber, S.L.; Krause, W.J.; Freeman, R.H.; Francis, S.H.; Corbin, J.D. Stimulation of intestinal Cl- transport by heat-stable enterotoxin: activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol. 1992, 263, C607-C615.
    • (1992) Am. J. Physiol , vol.263
    • Forte, L.R.1    Thorne, P.K.2    Eber, S.L.3    Krause, W.J.4    Freeman, R.H.5    Francis, S.H.6    Corbin, J.D.7
  • 27
    • 4243138171 scopus 로고    scopus 로고
    • Cyclic GMP transporters
    • Sager, G. Cyclic GMP transporters. Neurochem. Int. 2004, 45, 865-873.
    • (2004) Neurochem. Int , vol.45 , pp. 865-873
    • Sager, G.1
  • 28
    • 0014940141 scopus 로고
    • Stimulation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases by some analogs of adenosine 3',5'-monophosphate
    • Kuo, J.F.; Greengard, P. Stimulation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases by some analogs of adenosine 3',5'-monophosphate. Biochem. Biophys. Res. Commun. 1970, 40, 1032-1038.
    • (1970) Biochem. Biophys. Res. Commun , vol.40 , pp. 1032-1038
    • Kuo, J.F.1    Greengard, P.2
  • 30
    • 0017833396 scopus 로고
    • Comparison of cAMP and cGMP-dependent protein kinases
    • Corbin, J.D.; Lincoln, T.M. Comparison of cAMP and cGMP-dependent protein kinases. Adv. Cyclic Nucleotide Res. 1978, 9, 159-170.
    • (1978) Adv. Cyclic Nucleotide Res , vol.9 , pp. 159-170
    • Corbin, J.D.1    Lincoln, T.M.2
  • 31
    • 0019443305 scopus 로고
    • Distribution of cyclic-GMP-dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay
    • U. Distribution of cyclic-GMP-dependent protein kinase in various rat tissues and cell lines determined by a sensitive and specific radioimmunoassay. Eur. J. Biochem. 1981, 118, 339-346.
    • (1981) Eur. J. Biochem , vol.118 , pp. 339-346
  • 32
    • 0020643213 scopus 로고
    • CGMP-dependent protein kinase
    • Lincoln, T.M. cGMP-dependent protein kinase. Methods Enzymol. 1983, 99, 62-71.
    • (1983) Methods Enzymol , vol.99 , pp. 62-71
    • Lincoln, T.M.1
  • 33
    • 0023723086 scopus 로고
    • Purification of cGMP-binding protein phosphodiesterase from rat lung
    • Francis, S.H.; Corbin, J.D. Purification of cGMP-binding protein phosphodiesterase from rat lung. Methods Enzymol. 1988, 159, 722-729.
    • (1988) Methods Enzymol , vol.159 , pp. 722-729
    • Francis, S.H.1    Corbin, J.D.2
  • 34
    • 0024297299 scopus 로고
    • Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta
    • Lincoln, T.M.; Thompson, M.; Cornwell, T.L. Purification and characterization of two forms of cyclic GMP-dependent protein kinase from bovine aorta. J. Biol. Chem. 1988, 263, 17632-17637.
    • (1988) J. Biol. Chem , vol.263 , pp. 17632-17637
    • Lincoln, T.M.1    Thompson, M.2    Cornwell, T.L.3
  • 35
    • 0029114468 scopus 로고
    • Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator
    • Markert, T.; Vaandrager, A.B.; Gambaryan, S.; Pohler, D.; Hausler, C.; Walter, U.; De Jonge, H.R.; Jarchau, T.; Lohmann, S.M. Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulator. J. Clin. Invest. 1995, 96, 822-830.
    • (1995) J. Clin. Invest , vol.96 , pp. 822-830
    • Markert, T.1    Vaandrager, A.B.2    Gambaryan, S.3    Pohler, D.4    Hausler, C.5    Walter, U.6    de Jonge, H.R.7    Jarchau, T.8    Lohmann, S.M.9
  • 36
    • 0024325064 scopus 로고
    • Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat
    • Sandberg, M.; Natarajan, V.; Ronander, I.; Kalderon, D.; Walter, U.; Lohmann, S.M.; Jahnsen, T. Molecular cloning and predicted full-length amino acid sequence of the type I beta isozyme of cGMP-dependent protein kinase from human placenta. Tissue distribution and developmental changes in rat. FEBS Lett. 1989, 255, 321-329.
    • (1989) FEBS Lett , vol.255 , pp. 321-329
    • Sandberg, M.1    Natarajan, V.2    Ronander, I.3    Kalderon, D.4    Walter, U.5    Lohmann, S.M.6    Jahnsen, T.7
  • 37
    • 0030217898 scopus 로고    scopus 로고
    • Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes
    • Tamura, N.; Ogawa, Y.; Yasoda, A.; Itoh, H.; Saito, Y.; Nakao, K. Two cardiac natriuretic peptide genes (atrial natriuretic peptide and brain natriuretic peptide) are organized in tandem in the mouse and human genomes. J. Mol. Cell. Cardiol. 1996, 28, 1811-1815.
    • (1996) J. Mol. Cell. Cardiol , vol.28 , pp. 1811-1815
    • Tamura, N.1    Ogawa, Y.2    Yasoda, A.3    Itoh, H.4    Saito, Y.5    Nakao, K.6
  • 38
    • 0024523027 scopus 로고
    • Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta
    • Wolfe, L.; Corbin, J.D.; Francis, S.H. Characterization of a novel isozyme of cGMP-dependent protein kinase from bovine aorta. J. Biol. Chem. 1989, 264, 7734-7741.
    • (1989) J. Biol. Chem , vol.264 , pp. 7734-7741
    • Wolfe, L.1    Corbin, J.D.2    Francis, S.H.3
  • 39
    • 0024361274 scopus 로고
    • The cDNA of the two isoforms of bovine cGMP-dependent protein kinase
    • Wernet, W.; Flockerzi, V.; Hofmann, F. The cDNA of the two isoforms of bovine cGMP-dependent protein kinase. FEBS Lett. 1989, 251, 191-196.
    • (1989) FEBS Lett , vol.251 , pp. 191-196
    • Wernet, W.1    Flockerzi, V.2    Hofmann, F.3
  • 40
    • 0032848914 scopus 로고    scopus 로고
    • Cyclic nucleotide-dependent protein kinases: Intracellular receptors for cAMP and cGMP action
    • Francis, S.H.; Corbin, J.D. Cyclic nucleotide-dependent protein kinases: intracellular receptors for cAMP and cGMP action. Crit. Rev. Clin. Lab. Sci. 1999, 36, 275-328.
    • (1999) Crit. Rev. Clin. Lab. Sci , vol.36 , pp. 275-328
    • Francis, S.H.1    Corbin, J.D.2
  • 41
    • 0018976238 scopus 로고
    • Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: Studies of tissue specificity, potential receptors, and intermediates
    • Guerrant, R.L.; Hughes, J.M.; Chang, B.; Robertson, D.C.; Murad, F. Activation of intestinal guanylate cyclase by heat-stable enterotoxin of Escherichia coli: studies of tissue specificity, potential receptors, and intermediates. J. Infect. Dis. 1980, 142, 220-228.
    • (1980) J. Infect. Dis , vol.142 , pp. 220-228
    • Guerrant, R.L.1    Hughes, J.M.2    Chang, B.3    Robertson, D.C.4    Murad, F.5
  • 44
    • 0034764410 scopus 로고    scopus 로고
    • Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent
    • Steinbrecher, K.A.; Mann, E.A.; Giannella, R.A.; Cohen, M.B. Increases in guanylin and uroguanylin in a mouse model of osmotic diarrhea are guanylate cyclase C-independent. Gastroenterology 2001, 121, 1191-1202.
    • (2001) Gastroenterology , vol.121 , pp. 1191-1202
    • Steinbrecher, K.A.1    Mann, E.A.2    Giannella, R.A.3    Cohen, M.B.4
  • 45
    • 0030779011 scopus 로고    scopus 로고
    • Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice
    • Schulz, S.; Lopez, M.J.; Kuhn, M.; Garbers, D.L. Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice. J. Clin. Invest. 1997, 100, 1590-1595.
    • (1997) J. Clin. Invest , vol.100 , pp. 1590-1595
    • Schulz, S.1    Lopez, M.J.2    Kuhn, M.3    Garbers, D.L.4
  • 46
    • 0017064520 scopus 로고
    • Intestinal myoelectric activity in response to live Vibrio cholerae and cholera enterotoxin
    • Mathias, J.R.; Carlson, G.M.; DiMarino, A.J. Intestinal myoelectric activity in response to live Vibrio cholerae and cholera enterotoxin. J. Clin. Invest. 1976, 58, 91-96.
    • (1976) J. Clin. Invest , vol.58 , pp. 91-96
    • Mathias, J.R.1    Carlson, G.M.2    Dimarino, A.J.3
  • 47
    • 0018017485 scopus 로고
    • Effect of toxigenic Escherichia coli on myoelectric activity of small intestine
    • Burns, T.W.; Mathias, J.R.; Carlson, G.M. Effect of toxigenic Escherichia coli on myoelectric activity of small intestine. Am. J. Physiol. Endocrinol. Metab. 1978, 235, E311-E315.
    • (1978) Am. J. Physiol. Endocrinol. Metab , vol.235
    • Burns, T.W.1    Mathias, J.R.2    Carlson, G.M.3
  • 50
    • 0026889511 scopus 로고
    • Myoelectric activity of the small intestine in enterotoxin-induced diarrhea of calves
    • Roussel, A.J.; Woode, G.N.; Waldron, R.C.; Sriranganathan, N.; Jones, M.K. Myoelectric activity of the small intestine in enterotoxin-induced diarrhea of calves. Am. J. Vet. Res. 1992, 53, 1145-1148.
    • (1992) Am. J. Vet. Res , vol.53 , pp. 1145-1148
    • Roussel, A.J.1    Woode, G.N.2    Waldron, R.C.3    Sriranganathan, N.4    Jones, M.K.5
  • 51
    • 0024580162 scopus 로고
    • Enteric nervous system. I. Physiology and pathophysiology of the intestinal tract
    • Lundgren, O.; Svanvik, J.; Jivegard, L. Enteric nervous system. I. Physiology and pathophysiology of the intestinal tract. Dig. Dis. Sci. 1989, 34, 264-283.
    • (1989) Dig. Dis. Sci , vol.34 , pp. 264-283
    • Lundgren, O.1    Svanvik, J.2    Jivegard, L.3
  • 52
    • 0020466302 scopus 로고
    • Effects of indomethacin, acetazolamide, ethacrynate sodium, and atropine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum
    • Ahrens, F.A.; Zhu, B. Effects of indomethacin, acetazolamide, ethacrynate sodium, and atropine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in pig jejunum. Can. J. Physiol. Pharmacol. 1982, 60, 1281-1286.
    • (1982) Can. J. Physiol. Pharmacol , vol.60 , pp. 1281-1286
    • Ahrens, F.A.1    Zhu, B.2
  • 53
    • 0026761864 scopus 로고
    • 5-HT receptor antagonists and heat-stable Escherichia coli enterotoxin-induced effects in the rat
    • Beubler, E.; Badhri, P.; Schirgi, D. 5-HT receptor antagonists and heat-stable Escherichia coli enterotoxin-induced effects in the rat. Eur. J. Pharmacol. 1992, 219, 445-450.
    • (1992) Eur. J. Pharmacol , vol.219 , pp. 445-450
    • Beubler, E.1    Badhri, P.2    Schirgi, D.3
  • 54
    • 0027293717 scopus 로고
    • Inhibition of 5-hydroxytryptamine- and enterotoxininduced fluid secretion by 5-HT receptor antagonists in the rat jejunum
    • Beubler, E.; Schirgi-Degen, A.; Gamse, R. Inhibition of 5-hydroxytryptamine- and enterotoxininduced fluid secretion by 5-HT receptor antagonists in the rat jejunum. Eur. J. Pharmacol. 1993, 248, 157-162.
    • (1993) Eur. J. Pharmacol , vol.248 , pp. 157-162
    • Beubler, E.1    Schirgi-Degen, A.2    Gamse, R.3
  • 55
    • 0028210509 scopus 로고
    • Enterotoxin Escherichia coli STa activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum
    • Rolfe, V.; Levin, R.J. Enterotoxin Escherichia coli STa activates a nitric oxide-dependent myenteric plexus secretory reflex in the rat ileum. J. Physiol. 1994, 475, 531-537.
    • (1994) J. Physiol , vol.475 , pp. 531-537
    • Rolfe, V.1    Levin, R.J.2
  • 56
    • 0030077534 scopus 로고    scopus 로고
    • Role of prostaglandins and enteric nerves in Escherichia coli heat-stable enterotoxin (STa)-induced intestinal secretion in pigs
    • Hayden, U.L.; Greenberg, R.N.; Carey, H.V. Role of prostaglandins and enteric nerves in Escherichia coli heat-stable enterotoxin (STa)-induced intestinal secretion in pigs. Am. J. Vet. Res. 1996, 57, 211-215.
    • (1996) Am. J. Vet. Res , vol.57 , pp. 211-215
    • Hayden, U.L.1    Greenberg, R.N.2    Carey, H.V.3
  • 57
    • 0032966487 scopus 로고    scopus 로고
    • Vagotomy inhibits the jejunal fluid secretion activated by luminal ileal Escherichia coli STa in the rat in vivo
    • Rolfe, V.E.; Levin, R.J. Vagotomy inhibits the jejunal fluid secretion activated by luminal ileal Escherichia coli STa in the rat in vivo. Gut 1999, 44, 615-619.
    • (1999) Gut , vol.44 , pp. 615-619
    • Rolfe, V.E.1    Levin, R.J.2
  • 58
    • 0021961284 scopus 로고
    • The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats
    • Eklund, S.; Jodal, M.; Lundgren, O. The enteric nervous system participates in the secretory response to the heat stable enterotoxins of Escherichia coli in rats and cats. Neuroscience 1985, 14, 673-681.
    • (1985) Neuroscience , vol.14 , pp. 673-681
    • Eklund, S.1    Jodal, M.2    Lundgren, O.3
  • 59
    • 7044269199 scopus 로고    scopus 로고
    • Uroguanylin and guanylin peptides: Pharmacology and experimental therapeutics
    • Forte, L.R., Jr. Uroguanylin and guanylin peptides: pharmacology and experimental therapeutics. Pharmacol. Ther. 2004, 104, 137-162.
    • (2004) Pharmacol. Ther , vol.104 , pp. 137-162
    • Forte Jr., L.R.1
  • 60
    • 77950142037 scopus 로고    scopus 로고
    • Irritable bowel syndrome: Epidemiology, diagnosis and treatment: An update for health-care practitioners
    • Grundmann, O.; Yoon, S.L. Irritable bowel syndrome: Epidemiology, diagnosis and treatment: An update for health-care practitioners. Clin. Gastroenterol. Hepatol. 2010, 25, 691-699.
    • (2010) Clin. Gastroenterol. Hepatol , vol.25 , pp. 691-699
    • Grundmann, O.1    Yoon, S.L.2
  • 61
  • 62
    • 0036678922 scopus 로고    scopus 로고
    • The epidemiology of irritable bowel syndrome in North America: A systematic review
    • Saito, Y.A.; Schoenfeld, P.; Locke, G.R., III. The epidemiology of irritable bowel syndrome in North America: A systematic review. Am. J. Gastroenterol. 2002, 97, 1910-1915.
    • (2002) Am. J. Gastroenterol , vol.97 , pp. 1910-1915
    • Saito, Y.A.1    Schoenfeld, P.2    Locke III, G.R.3
  • 65
    • 20444464327 scopus 로고    scopus 로고
    • Irritable bowel syndrome in the United States: Prevalence, symptom patterns and impact
    • Hungin, A.P.S.; Chang, L.; Locke, G.R.; Dennis, E.H.; Barghout, V. Irritable bowel syndrome in the United States: Prevalence, symptom patterns and impact. Aliment. Pharmacol. Ther. 2005, 21, 1365-1375.
    • (2005) Aliment. Pharmacol. Ther , vol.21 , pp. 1365-1375
    • Hungin, A.P.S.1    Chang, L.2    Locke, G.R.3    Dennis, E.H.4    Barghout, V.5
  • 66
    • 2442629629 scopus 로고    scopus 로고
    • Epidemiology of constipation in North America: A systematic review
    • Higgins, P.D.; Johanson, J.F. Epidemiology of constipation in North America: a systematic review. Am. J. Gastroenterol. 2004, 99, 750-759.
    • (2004) Am. J. Gastroenterol , vol.99 , pp. 750-759
    • Higgins, P.D.1    Johanson, J.F.2
  • 67
    • 1542314722 scopus 로고    scopus 로고
    • Impact of anal incontinence and chronic constipation on quality of life
    • Damon, H.; Dumas, P.; Mion, F. Impact of anal incontinence and chronic constipation on quality of life. Gastroenterol. Clin. Biol. 2004, 28, 16-20.
    • (2004) Gastroenterol. Clin. Biol , vol.28 , pp. 16-20
    • Damon, H.1    Dumas, P.2    Mion, F.3
  • 70
    • 0034012726 scopus 로고    scopus 로고
    • Economic burden of irritable bowel syndrome: Proposed strategies to control expenditures
    • Camilleri, M.; Williams, D.E. Economic burden of irritable bowel syndrome: Proposed strategies to control expenditures. Pharmacoeconomics 2000, 17, 331-338.
    • (2000) Pharmacoeconomics , vol.17 , pp. 331-338
    • Camilleri, M.1    Williams, D.E.2
  • 74
    • 0035213537 scopus 로고    scopus 로고
    • Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome
    • Wahnschaffe, U.; Ullrich, R.; Riecken, E.O.; Schulzke, J.D. Celiac disease-like abnormalities in a subgroup of patients with irritable bowel syndrome. Gastroenterology 2001, 121, 1329-1338.
    • (2001) Gastroenterology , vol.121 , pp. 1329-1338
    • Wahnschaffe, U.1    Ullrich, R.2    Riecken, E.O.3    Schulzke, J.D.4
  • 75
    • 67649387888 scopus 로고    scopus 로고
    • MD-1100, a therapeutic agent in development for the treatment of IBS-C, enhances intestinal secretion and transit, decreases visceral pain and is minimally absorbed in rats
    • Bryant, A.P.; Busby, R.W.; Cordero, E.A. MD-1100, a therapeutic agent in development for the treatment of IBS-C, enhances intestinal secretion and transit, decreases visceral pain and is minimally absorbed in rats. Gastroenterology 2005, 128, 464.
    • (2005) Gastroenterology , vol.128 , pp. 464
    • Bryant, A.P.1    Busby, R.W.2    Cordero, E.A.3
  • 77
    • 33746879328 scopus 로고    scopus 로고
    • Effects of multidose administration of MD-1100 on safety, tolerability, exposure, and pharmacodynamics in healthy subjects
    • Kurtz, C.B.; Fitch, D.; Busby, R.W.; Fretzen, A.; Geis, S.; Currie, M.G. Effects of multidose administration of MD-1100 on safety, tolerability, exposure, and pharmacodynamics in healthy subjects. Gastroenterology 2006, 130, A26.
    • (2006) Gastroenterology , vol.130
    • Kurtz, C.B.1    Fitch, D.2    Busby, R.W.3    Fretzen, A.4    Geis, S.5    Currie, M.G.6
  • 78
    • 33745396435 scopus 로고    scopus 로고
    • Effects of single dose administration of MD-1100 on safety, tolerability, exposure, and stool consistency in healthy subjects
    • Currie, M.G.; Kurtz, C.B.; Mahajan-Miklos, S.; Busby, R.; Fretzen, A.; Geis, S. Effects of single dose administration of MD-1100 on safety, tolerability, exposure, and stool consistency in healthy subjects. Am. J. Gastroenterol. 2005, 100, S328.
    • (2005) Am. J. Gastroenterol , vol.100
    • Currie, M.G.1    Kurtz, C.B.2    Mahajan-Miklos, S.3    Busby, R.4    Fretzen, A.5    Geis, S.6
  • 82
    • 84856084614 scopus 로고    scopus 로고
    • Synergy Pharmaceuticals pipeline: Basic science-GC-C agonists. Available online, Accessed on 3 August
    • Synergy Pharmaceuticals pipeline: Basic science-GC-C agonists. Available online: http://www.synergybio.net/basic_science.htm (Accessed on 3 August 2010).
    • (2010)
  • 83
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • Kubes, P.; Suzuki, M.; Granger, D.N. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. USA 1991, 88, 4651-4655.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 84
    • 34250750653 scopus 로고    scopus 로고
    • Beneficial Effect of Phosphodiesterase-5 Inhibitor in Experimental Inflammatory Bowel Disease; Molecular Evidence for Involvement of Oxidative Stress
    • Khoshakhlagh, P.; Bahrololoumi-Shapourabadi, M.; Mohammadirad, A.; Ashtaral-Nakhai, L.; Minaie, B.; Abdollahi, M. Beneficial Effect of Phosphodiesterase-5 Inhibitor in Experimental Inflammatory Bowel Disease; Molecular Evidence for Involvement of Oxidative Stress. Toxicol. Mech. Methods 2007, 17, 281-288.
    • (2007) Toxicol. Mech. Methods , vol.17 , pp. 281-288
    • Khoshakhlagh, P.1    Bahrololoumi-Shapourabadi, M.2    Mohammadirad, A.3    Ashtaral-Nakhai, L.4    Minaie, B.5    Abdollahi, M.6
  • 85
    • 34548587662 scopus 로고    scopus 로고
    • Phosphodiesterase 4 inhibitors and inflammatory bowel disease: Emerging therapies in inflammatory bowel disease
    • Keshavarzian, A.; Mutlu, E.; Guzman, J.P.; Forsyth, C.; Banan, A. Phosphodiesterase 4 inhibitors and inflammatory bowel disease: Emerging therapies in inflammatory bowel disease. Expert Opin. Investig. Drugs 2007, 16, 1489-1506.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , pp. 1489-1506
    • Keshavarzian, A.1    Mutlu, E.2    Guzman, J.P.3    Forsyth, C.4    Banan, A.5
  • 86
    • 0032545491 scopus 로고    scopus 로고
    • Differential Regulation of Phospholipase A2(PLA2)-dependent Ca2+ Signaling in Smooth Muscle by cAMP- and cGMP-dependent Protein Kinases
    • Murthy, K.S.; Makhlouf, G.M. Differential Regulation of Phospholipase A2(PLA2)-dependent Ca2+ Signaling in Smooth Muscle by cAMP- and cGMP-dependent Protein Kinases. J. Biol. Chem. 1998, 273, 34519-34526.
    • (1998) J. Biol. Chem , vol.273 , pp. 34519-34526
    • Murthy, K.S.1    Makhlouf, G.M.2
  • 91
    • 44349126693 scopus 로고    scopus 로고
    • Colonic crypt organization and tumorigenesis
    • Humphries, A.; Wright, N.A. Colonic crypt organization and tumorigenesis. Nat. Rev. Cancer 2008, 8, 415-424.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 415-424
    • Humphries, A.1    Wright, N.A.2
  • 92
    • 33846833986 scopus 로고    scopus 로고
    • The morphogenetic code and colon cancer development
    • van den Brink, G.R.; Offerhaus, G.J. The morphogenetic code and colon cancer development. Cancer Cell 2007, 11, 109-117.
    • (2007) Cancer Cell , vol.11 , pp. 109-117
    • van den Brink, G.R.1    Offerhaus, G.J.2
  • 94
    • 33845875966 scopus 로고    scopus 로고
    • Gut hormones and the regulation of energy homeostasis
    • Murphy, K.G.; Bloom, S.R. Gut hormones and the regulation of energy homeostasis. Nature 2006, 444, 854-859.
    • (2006) Nature , vol.444 , pp. 854-859
    • Murphy, K.G.1    Bloom, S.R.2
  • 95
    • 59649090737 scopus 로고    scopus 로고
    • Breaking into bone biology: Serotonin's secrets
    • Rosen, C.J. Breaking into bone biology: serotonin's secrets. Nat. Med. 2009, 15, 145-146.
    • (2009) Nat. Med , vol.15 , pp. 145-146
    • Rosen, C.J.1
  • 98
    • 0033986128 scopus 로고    scopus 로고
    • Getting to the guts of enteroendocrine differentiation
    • Skipper, M.; Lewis, J. Getting to the guts of enteroendocrine differentiation. Nat. Genet. 2000, 24, 3-4.
    • (2000) Nat. Genet , vol.24 , pp. 3-4
    • Skipper, M.1    Lewis, J.2
  • 102
    • 0028864164 scopus 로고
    • Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine
    • Li, Z.; Taylor-Blake, B.; Light, A.R.; Goy, M.F. Guanylin, an endogenous ligand for C-type guanylate cyclase, is produced by goblet cells in the rat intestine. Gastroenterology 1995, 109, 1863-1875.
    • (1995) Gastroenterology , vol.109 , pp. 1863-1875
    • Li, Z.1    Taylor-Blake, B.2    Light, A.R.3    Goy, M.F.4
  • 103
    • 0029052539 scopus 로고
    • Immunohistochemical localization of guanylin in the rat small intestine and colon
    • Cohen, M.B.; Witte, D.P.; Hawkins, J.A.; Currie, M.G. Immunohistochemical localization of guanylin in the rat small intestine and colon. Biochem. Biophys. Res. Commun. 1995, 209, 803-808.
    • (1995) Biochem. Biophys. Res. Commun , vol.209 , pp. 803-808
    • Cohen, M.B.1    Witte, D.P.2    Hawkins, J.A.3    Currie, M.G.4
  • 104
    • 0030823669 scopus 로고    scopus 로고
    • Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract
    • Perkins, A.; Goy, M.F.; Li, Z. Uroguanylin is expressed by enterochromaffin cells in the rat gastrointestinal tract. Gastroenterology 1997, 113, 1007-1014.
    • (1997) Gastroenterology , vol.113 , pp. 1007-1014
    • Perkins, A.1    Goy, M.F.2    Li, Z.3
  • 107
    • 0031906877 scopus 로고    scopus 로고
    • Guanylin mRNA expression in human intestine and colorectal adenocarcinoma
    • Cohen, M.B.; Hawkins, J.A.; Witte, D.P. Guanylin mRNA expression in human intestine and colorectal adenocarcinoma. Lab. Invest. 1998, 78, 101-108.
    • (1998) Lab. Invest , vol.78 , pp. 101-108
    • Cohen, M.B.1    Hawkins, J.A.2    Witte, D.P.3
  • 108
    • 0035300437 scopus 로고    scopus 로고
    • Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays
    • Notterman, D.A.; Alon, U.; Sierk, A.J.; Levine, A.J. Transcriptional gene expression profiles of colorectal adenoma, adenocarcinoma, and normal tissue examined by oligonucleotide arrays. Cancer Res. 2001, 61, 3124-3130.
    • (2001) Cancer Res , vol.61 , pp. 3124-3130
    • Notterman, D.A.1    Alon, U.2    Sierk, A.J.3    Levine, A.J.4
  • 109
    • 0036898023 scopus 로고    scopus 로고
    • Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation
    • Steinbrecher, K.A.; Wowk, S.A.; Rudolph, J.A.; Witte, D.P.; Cohen, M.B. Targeted inactivation of the mouse guanylin gene results in altered dynamics of colonic epithelial proliferation. Am. J. Pathol. 2002, 161, 2169-2178.
    • (2002) Am. J. Pathol , vol.161 , pp. 2169-2178
    • Steinbrecher, K.A.1    Wowk, S.A.2    Rudolph, J.A.3    Witte, D.P.4    Cohen, M.B.5
  • 111
    • 38349041719 scopus 로고    scopus 로고
    • Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine
    • Li, P.; Lin, J.E.; Chervoneva, I.; Schulz, S.; Waldman, S.A.; Pitari, G.M. Homeostatic control of the crypt-villus axis by the bacterial enterotoxin receptor guanylyl cyclase C restricts the proliferating compartment in intestine. Am. J. Pathol. 2007, 171, 1847-1858.
    • (2007) Am. J. Pathol , vol.171 , pp. 1847-1858
    • Li, P.1    Lin, J.E.2    Chervoneva, I.3    Schulz, S.4    Waldman, S.A.5    Pitari, G.M.6
  • 112
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • Yang, Q.; Bermingham, N.A.; Finegold, M.J.; Zoghbi, H.Y. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 2001, 294, 2155-2158.
    • (2001) Science , vol.294 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3    Zoghbi, H.Y.4
  • 113
    • 0344826531 scopus 로고    scopus 로고
    • Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/-compound mutant mice
    • Aoki, K.; Tamai, Y.; Horiike, S.; Oshima, M.; Taketo, M.M. Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/-compound mutant mice. Nat. Genet. 2003, 35, 323-330.
    • (2003) Nat. Genet , vol.35 , pp. 323-330
    • Aoki, K.1    Tamai, Y.2    Horiike, S.3    Oshima, M.4    Taketo, M.M.5
  • 114
    • 0033575920 scopus 로고    scopus 로고
    • Deregulated cyclin E induces chromosome instability
    • Spruck, C.H.; Won, K.A.; Reed, S.I. Deregulated cyclin E induces chromosome instability. Nature 1999, 401, 297-300.
    • (1999) Nature , vol.401 , pp. 297-300
    • Spruck, C.H.1    Won, K.A.2    Reed, S.I.3
  • 116
    • 28244432560 scopus 로고    scopus 로고
    • Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins
    • Pitari, G.M.; Baksh, R.I.; Harris, D.M.; Li, P.; Kazerounian, S.; Waldman, S.A. Interruption of homologous desensitization in cyclic guanosine 3',5'-monophosphate signaling restores colon cancer cytostasis by bacterial enterotoxins. Cancer Res. 2005, 65, 11129-11135.
    • (2005) Cancer Res , vol.65 , pp. 11129-11135
    • Pitari, G.M.1    Baksh, R.I.2    Harris, D.M.3    Li, P.4    Kazerounian, S.5    Waldman, S.A.6
  • 117
    • 0034933794 scopus 로고    scopus 로고
    • Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
    • Pitari, G.M.; Di Guglielmo, M.D.; Park, J.; Schulz, S.; Waldman, S.A. Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells. Proc. Natl. Acad. Sci. USA 2001, 98, 7846-7851.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 7846-7851
    • Pitari, G.M.1    di Guglielmo, M.D.2    Park, J.3    Schulz, S.4    Waldman, S.A.5
  • 118
    • 67651227644 scopus 로고    scopus 로고
    • Guanylyl cyclase C in colorectal cancer: Susceptibility gene and potential therapeutic target
    • Lin, J.E.; Li, P.; Pitari, G.M.; Schulz, S.; Waldman, S.A. Guanylyl cyclase C in colorectal cancer: susceptibility gene and potential therapeutic target. Future Oncol. 2009, 5, 509-522.
    • (2009) Future Oncol , vol.5 , pp. 509-522
    • Lin, J.E.1    Li, P.2    Pitari, G.M.3    Schulz, S.4    Waldman, S.A.5
  • 119
    • 0028865420 scopus 로고
    • Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption
    • Shen, W.; Hintze, T.H.; Wolin, M.S. Nitric oxide. An important signaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption. Circulation 1995, 92, 3505-3512.
    • (1995) Circulation , vol.92 , pp. 3505-3512
    • Shen, W.1    Hintze, T.H.2    Wolin, M.S.3
  • 121
    • 66649132533 scopus 로고    scopus 로고
    • Upregulating the heme oxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in rats
    • Ndisang, J.F.; Jadhav, A. Upregulating the heme oxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in rats. Endocrinology 2009, 150, 2627-2636.
    • (2009) Endocrinology , vol.150 , pp. 2627-2636
    • Ndisang, J.F.1    Jadhav, A.2
  • 125
    • 22144458670 scopus 로고    scopus 로고
    • Guanylyl cyclase C as a reliable immunohistochemical marker and its ligand Escherichia coli heat-stable enterotoxin as a potential protein-delivering vehicle for colorectal cancer cells
    • Buc, E.; Vartanian, M.D.; Darcha, C.; Dechelotte, P.; Pezet, D. Guanylyl cyclase C as a reliable immunohistochemical marker and its ligand Escherichia coli heat-stable enterotoxin as a potential protein-delivering vehicle for colorectal cancer cells. Eur. J. Cancer. 2005, 41, 1618-1627.
    • (2005) Eur. J. Cancer , vol.41 , pp. 1618-1627
    • Buc, E.1    Vartanian, M.D.2    Darcha, C.3    Dechelotte, P.4    Pezet, D.5
  • 126
    • 76549177140 scopus 로고
    • Demonstration of Tumor-Specific Antigens in Human Colonic Carcinomata by Immunological Tolerance and Absorption Techniques
    • Gold, P.; Freedman, S.O. Demonstration of Tumor-Specific Antigens in Human Colonic Carcinomata by Immunological Tolerance and Absorption Techniques. J. Exp. Med. 1965, 121, 439-462.
    • (1965) J. Exp. Med , vol.121 , pp. 439-462
    • Gold, P.1    Freedman, S.O.2
  • 127
    • 0036875381 scopus 로고    scopus 로고
    • Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity
    • Arakawa, F.; Shibaguchi, H.; Xu, Z.; Kuroki, M. Targeting of T cells to CEA-expressing tumor cells by chimeric immune receptors with a highly specific single-chain anti-CEA activity. Anticancer Res. 2002, 22, 4285-4289.
    • (2002) Anticancer Res , vol.22 , pp. 4285-4289
    • Arakawa, F.1    Shibaguchi, H.2    Xu, Z.3    Kuroki, M.4
  • 129
    • 33750970026 scopus 로고    scopus 로고
    • The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: A meta-analysis
    • Iddings, D.; Ahmad, A.; Elashoff, D.; Bilchik, A. The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: a meta-analysis. Ann. Surg. Oncol. 2006, 13, 1386-1392.
    • (2006) Ann. Surg. Oncol , vol.13 , pp. 1386-1392
    • Iddings, D.1    Ahmad, A.2    Elashoff, D.3    Bilchik, A.4
  • 130
    • 36348943451 scopus 로고    scopus 로고
    • Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature
    • Nicastri, D.G.; Doucette, J.T.; Godfrey, T.E.; Hughes, S.J. Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. J. Mol. Diagn. 2007, 9, 563-571.
    • (2007) J. Mol. Diagn , vol.9 , pp. 563-571
    • Nicastri, D.G.1    Doucette, J.T.2    Godfrey, T.E.3    Hughes, S.J.4
  • 131
    • 11344286311 scopus 로고    scopus 로고
    • The staging of colorectal cancer: 2004 and beyond
    • Compton, C.C.; Greene, F.L. The staging of colorectal cancer: 2004 and beyond. CA Cancer J. Clin. 2004, 54, 295-308.
    • (2004) CA Cancer J. Clin , vol.54 , pp. 295-308
    • Compton, C.C.1    Greene, F.L.2
  • 133
    • 0032949446 scopus 로고    scopus 로고
    • Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
    • Mamounas, E.; Wieand, S.; Wolmark, N.; Bear, H.D.; Atkins, J.N.; Song, K.; Jones, J.; Rockette, H. Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J. Clin. Oncol. 1999, 17, 1349-1355.
    • (1999) J. Clin. Oncol , vol.17 , pp. 1349-1355
    • Mamounas, E.1    Wieand, S.2    Wolmark, N.3    Bear, H.D.4    Atkins, J.N.5    Song, K.6    Jones, J.7    Rockette, H.8
  • 134
    • 13744251436 scopus 로고    scopus 로고
    • Systemic therapy for colorectal cancer
    • Meyerhardt, J.A.; Mayer, R.J. Systemic therapy for colorectal cancer. N. Engl. J. Med. 2005, 352, 476-487.
    • (2005) N. Engl. J. Med , vol.352 , pp. 476-487
    • Meyerhardt, J.A.1    Mayer, R.J.2
  • 135
    • 36849064682 scopus 로고    scopus 로고
    • Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study
    • Quasar Collaborative, G.; Gray, R.; Barnwell, J.; McConkey, C.; Hills, R.K.; Williams, N.S.; Kerr, D.J. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet 2007, 370, 2020-2029.
    • (2007) Lancet , vol.370 , pp. 2020-2029
    • Quasar, C.G.1    Gray, R.2    Barnwell, J.3    McConkey, C.4    Hills, R.K.5    Williams, N.S.6    Kerr, D.J.7
  • 139
    • 79952074827 scopus 로고    scopus 로고
    • References
    • 7th ed.; Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., Trotti, A., Eds.; Springer: New York, NY, USA
    • Greene, F. References. In AJCC Cancer Staging Handbook: From the AJCC Cancer Staging Manual, 7th ed.; Edge, S.B., Byrd, D.R., Compton, C.C., Fritz, A.G., Greene, F.L., Trotti, A., Eds.; Springer: New York, NY, USA, 2002; Volume 6, pp. 27-38, 153-218.
    • (2002) AJCC Cancer Staging Handbook: From the AJCC Cancer Staging Manual , vol.6 , pp. 27-38
    • Greene, F.1
  • 140
    • 33748070507 scopus 로고    scopus 로고
    • A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer
    • Schulz, S.; Hyslop, T.; Haaf, J.; Bonaccorso, C.; Nielsen, K.; Witek, M.E.; Birbe, R.; Palazzo, J.; Weinberg, D.; Waldman, S.A. A validated quantitative assay to detect occult micrometastases by reverse transcriptase-polymerase chain reaction of guanylyl cyclase C in patients with colorectal cancer. Clin. Cancer Res. 2006, 12, 4545-4552.
    • (2006) Clin. Cancer Res , vol.12 , pp. 4545-4552
    • Schulz, S.1    Hyslop, T.2    Haaf, J.3    Bonaccorso, C.4    Nielsen, K.5    Witek, M.E.6    Birbe, R.7    Palazzo, J.8    Weinberg, D.9    Waldman, S.A.10
  • 142
    • 60749102639 scopus 로고    scopus 로고
    • Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer
    • Waldman, S.A.; Hyslop, T.; Schulz, S.; Barkun, A.; Nielsen, K.; Haaf, J.; Bonaccorso, C.; Li, Y.; Weinberg, D.S. Association of GUCY2C expression in lymph nodes with time to recurrence and disease-free survival in pN0 colorectal cancer. JAMA 2009, 301, 745-752.
    • (2009) JAMA , vol.301 , pp. 745-752
    • Waldman, S.A.1    Hyslop, T.2    Schulz, S.3    Barkun, A.4    Nielsen, K.5    Haaf, J.6    Bonaccorso, C.7    Li, Y.8    Weinberg, D.S.9
  • 143
    • 84856109707 scopus 로고    scopus 로고
    • SEER Stat Fact Sheets: Colon and Rectum. Available online:, Accessed on 3 August 2010
    • SEER Stat Fact Sheets: Colon and Rectum. Available online: http://seer.cancer.gov/statfacts/html/colorect.html (Accessed on 3 August 2010).
  • 144
    • 0036717382 scopus 로고    scopus 로고
    • Molecular imaging of cancer with positron emission tomography
    • S.S. Molecular imaging of cancer with positron emission tomography. Nat. Rev. Cancer 2002, 2, 683-693.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 683-693
  • 145
    • 33744487875 scopus 로고    scopus 로고
    • Molecular imaging in cancer
    • Weissleder, R. Molecular imaging in cancer. Science 2006, 312, 1168-1171.
    • (2006) Science , vol.312 , pp. 1168-1171
    • Weissleder, R.1
  • 147
    • 0035149532 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of an 111In-labeled ST-peptide enterotoxin (ST) analogue for specific targeting of guanylin receptors on human colonic cancers
    • Gali, H.; Sieckman, G.L.; Hoffman, T.J.; Kiefer, G.E.; Chin, D.T.; Forte, L.R.; Volkert, W.A. Synthesis and in vitro evaluation of an 111In-labeled ST-peptide enterotoxin (ST) analogue for specific targeting of guanylin receptors on human colonic cancers. Anticancer Res. 2001, 21, 2785-2792.
    • (2001) Anticancer Res , vol.21 , pp. 2785-2792
    • Gali, H.1    Sieckman, G.L.2    Hoffman, T.J.3    Kiefer, G.E.4    Chin, D.T.5    Forte, L.R.6    Volkert, W.A.7
  • 148
    • 0036009631 scopus 로고    scopus 로고
    • Chemical synthesis of Escherichia coli ST(h) analogues by regioselective disulfide bondformation: Biological evaluation of an (111)In- DOTA-Phe(19)-ST(h) analogue for specific targeting of human colon cancers
    • Gali, H.; Sieckman, G.L.; Hoffman, T.J.; Owen, N.K.; Mazuru, D.G.; Forte, L.R.; Volkert, W.A. Chemical synthesis of Escherichia coli ST(h) analogues by regioselective disulfide bondformation: biological evaluation of an (111)In- DOTA-Phe(19)-ST(h) analogue for specific targeting of human colon cancers. Bioconjug. Chem. 2002, 13, 224-231.
    • (2002) Bioconjug. Chem , vol.13 , pp. 224-231
    • Gali, H.1    Sieckman, G.L.2    Hoffman, T.J.3    Owen, N.K.4    Mazuru, D.G.5    Forte, L.R.6    Volkert, W.A.7
  • 149
    • 3242802916 scopus 로고    scopus 로고
    • In vitro and in vivo comparison of human Escherichia coli heat-stable peptide analogues incorporating the 111In-DOTA group and distinct linker moieties
    • Giblin, M.F.; Gali, H.; Sieckman, G.L.; Owen, N.K.; Hoffman, T.J.; Forte, L.R.; Volkert, W.A. In vitro and in vivo comparison of human Escherichia coli heat-stable peptide analogues incorporating the 111In-DOTA group and distinct linker moieties. Bioconjug. Chem. 2004, 15, 872-880.
    • (2004) Bioconjug. Chem , vol.15 , pp. 872-880
    • Giblin, M.F.1    Gali, H.2    Sieckman, G.L.3    Owen, N.K.4    Hoffman, T.J.5    Forte, L.R.6    Volkert, W.A.7
  • 150
    • 33646566467 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers
    • Giblin, M.F.; Sieckman, G.L.; Shelton, T.D.; Hoffman, T.J.; Forte, L.R.; Volkert, W.A. In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers. Nucl. Med. Biol. 2006, 33, 481-488.
    • (2006) Nucl. Med. Biol , vol.33 , pp. 481-488
    • Giblin, M.F.1    Sieckman, G.L.2    Shelton, T.D.3    Hoffman, T.J.4    Forte, L.R.5    Volkert, W.A.6
  • 153
    • 0029083540 scopus 로고
    • Internalization of E. coli ST mediated by guanylyl cyclase C in T84 human colon carcinoma cells
    • Urbanski, R.; Carrithers, S.L.; Waldman, S.A. Internalization of E. coli ST mediated by guanylyl cyclase C in T84 human colon carcinoma cells. Biochim. Biophys. Acta 1995, 1245, 29-36.
    • (1995) Biochim. Biophys. Acta , vol.1245 , pp. 29-36
    • Urbanski, R.1    Carrithers, S.L.2    Waldman, S.A.3
  • 155
    • 0036360019 scopus 로고    scopus 로고
    • The enemy within: Keeping self-reactive T cells at bay in the periphery
    • Walker, L.S.; Abbas, A.K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol. 2002, 2, 11-19.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 11-19
    • Walker, L.S.1    Abbas, A.K.2
  • 160
    • 0037966117 scopus 로고    scopus 로고
    • Immunization of colorectal carcinoma patients with a recombinantcanarypox virus expressing the tumor antigen Ep-CAM/KSA (ALVAC-KSA) and granulocytemacrophage colony- stimulating factor induced a tumor-specific cellular immune response
    • Ullenhag, G.J.; Frodin, J.E.; Mosolits, S.; Kiaii, S.; Hassan, M.; Bonnet, M.C.; Moingeon, P.; Mellstedt, H.; Rabbani, H. Immunization of colorectal carcinoma patients with a recombinantcanarypox virus expressing the tumor antigen Ep-CAM/KSA (ALVAC-KSA) and granulocytemacrophage colony- stimulating factor induced a tumor-specific cellular immune response. Clin. Cancer Res. 2003, 9, 2447-2456.
    • (2003) Clin. Cancer Res , vol.9 , pp. 2447-2456
    • Ullenhag, G.J.1    Frodin, J.E.2    Mosolits, S.3    Kiaii, S.4    Hassan, M.5    Bonnet, M.C.6    Moingeon, P.7    Mellstedt, H.8    Rabbani, H.9
  • 161
    • 67649340803 scopus 로고    scopus 로고
    • Harnessing the unique local immunostimulatory properties of modified vaccinia Ankara (MVA) virus to generate superior tumor-specific immune responses and antitumor activity in a diversified prime and boost vaccine regimen
    • Hodge, J.W.; Higgins, J.; Schlom, J. Harnessing the unique local immunostimulatory properties of modified vaccinia Ankara (MVA) virus to generate superior tumor-specific immune responses and antitumor activity in a diversified prime and boost vaccine regimen. Vaccine 2009, 27, 4475-4482.
    • (2009) Vaccine , vol.27 , pp. 4475-4482
    • Hodge, J.W.1    Higgins, J.2    Schlom, J.3
  • 163
    • 1642381854 scopus 로고    scopus 로고
    • Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines
    • Belyakov, I.M.; Berzofsky, J.A. Immunobiology of mucosal HIV infection and the basis for development of a new generation of mucosal AIDS vaccines. Immunity 2004, 20, 247-253.
    • (2004) Immunity , vol.20 , pp. 247-253
    • Belyakov, I.M.1    Berzofsky, J.A.2
  • 164
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • Mowat, A.M.; Viney, J.L. The anatomical basis of intestinal immunity. Immunol. Rev. 1997, 156, 145-166.
    • (1997) Immunol. Rev , vol.156 , pp. 145-166
    • Mowat, A.M.1    Viney, J.L.2
  • 165
    • 13244275187 scopus 로고    scopus 로고
    • Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues
    • Mora, J.R.; Cheng, G.; Picarella, D.; Briskin, M.; Buchanan, N.; von Andrian, U.H. Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut-associated lymphoid tissues. J. Exp. Med. 2005, 201, 303-316.
    • (2005) J. Exp. Med , vol.201 , pp. 303-316
    • Mora, J.R.1    Cheng, G.2    Picarella, D.3    Briskin, M.4    Buchanan, N.5    von Andrian, U.H.6
  • 166
    • 34548677817 scopus 로고    scopus 로고
    • Mucosally Restricted Antigens as Novel Immunological Targets for Antitumor Therapy
    • Snook, A.E.; Stafford, B.J.; Eisenlohr, L.C.; Rothstein, J.L.; Waldman, S.A. Mucosally Restricted Antigens as Novel Immunological Targets for Antitumor Therapy. Biomark. Med. 2007, 1, 187-202.
    • (2007) Biomark. Med , vol.1 , pp. 187-202
    • Snook, A.E.1    Stafford, B.J.2    Eisenlohr, L.C.3    Rothstein, J.L.4    Waldman, S.A.5
  • 167
    • 36148966955 scopus 로고    scopus 로고
    • Cancer mucosa antigens as a novel immunotherapeutic class of tumor-associated antigen
    • Snook, A.E.; Eisenlohr, L.C.; Rothstein, J.L.; Waldman, S.A. Cancer mucosa antigens as a novel immunotherapeutic class of tumor-associated antigen. Clin. Pharmacol. Ther. 2007, 82, 734-739.
    • (2007) Clin. Pharmacol. Ther , vol.82 , pp. 734-739
    • Snook, A.E.1    Eisenlohr, L.C.2    Rothstein, J.L.3    Waldman, S.A.4
  • 170
    • 73349104433 scopus 로고    scopus 로고
    • What role does the route of immunization play in the generation of protective immunity against mucosal pathogens
    • Belyakov, I.M.; Ahlers, J.D. What role does the route of immunization play in the generation of protective immunity against mucosal pathogens? J. Immunol. 2009, 183, 6883-6892
    • (2009) J. Immunol , vol.183 , pp. 6883-6892
    • Belyakov, I.M.1    Ahlers, J.D.2


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