The prognostic effect of micrometastases in previously staged lymph node negative (N0) colorectal carcinoma: A meta-analysis

Annals of Surgical Oncology

Volumn 13, Issue 11, 2006, Pages 1386-1392

  Iddings, Douglas ^a   Ahmad, Aziz ^a   Elashoff, David ^a   Bilchik, Anton ^a  

^a JOHN WAYNE CANCER INSTITUTE   (United States)

Author keywords

Colorectal micrometastases; Meta analysis; Occult metastatic disease; Prognostic markers

Indexed keywords

ARTICLE; BINOMIAL DISTRIBUTION; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; DATA ANALYSIS; DISEASE FREE SURVIVAL; HUMAN; IMMUNOHISTOCHEMISTRY; LYMPH NODE; LYMPH NODE METASTASIS; MICROMETASTASIS; PROGNOSIS; PUBLICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICAL SIGNIFICANCE;

COLORECTAL NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINS; LYMPH NODES; LYMPHATIC METASTASIS; NEOPLASM STAGING; PROGNOSIS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL RATE;

EID: 33750970026     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-006-9120-y     Document Type: Article

References (46)

1. American Cancer Society. Cancer Facts and Figures 2006. Atlanta: American Cancer Society, 2006.
2. Jemal A, Murray T, Ward E, et al. Cancer statistics, 2005. CA Cancer J Clin 2005; 55:10-30.
3. Cohen AM, Kelsen D, Saltz L, et al. Adjuvant therapy for colorectal cancer. Curr Prob Cancer 1998; 22:5-65.
4. Adell G, Boeryd B, Franlund B, et al. Occurrence and prognostic importance of micrometastases in regional lymph nodes in Dukes' B colorectal carcinoma: An immunohistochemical study. Eur J Surg 1996; 162:637-42.
5. Broll R, Schauer V, Schimmelpenning H, et al. Prognostic relevance of occult tumor cells in lymph nodes of colorectal carcinomas: An immunohistochemical study. Dis Colon Rectum 1997; 40:1465-71.
6. Clarke G, Ryan E, O'Keane JC, Crowe J, MacMathuna P. The detection of cytokeratins in lymph nodes of Duke's B colorectal cancer subjects predicts a poor outcome. Eur J Gastroenterol Hepatol 2000; 12:549-52.
7. Cutait R, Alves VA, Lopes LC, et al. Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins. Dis Colon Rectum 1991; 34:917-20.
8. Davidson B, Sams R, Styles J, et al. Detection of occult nodal metastases in patients with colorectal carcinoma. Cancer 1990; 15;65:967-70.
9. Greenson JK, Isenhart CE, Rice R, et al. Identification of occult micrometastases in pericolic lymph nodes of Dukes' B colorectal cancer patients using monoclonal antibodies against cytokeratin and CC49: correlation with long-term survival. Cancer 1994; 73:563-9.
10. Haboubi N, Clark P, Kaftan S, et al. The importance of combining xylene clearance and immunohistochemistry in the accurate staging of colorectal cancer. J R Soc Med 1992; 85:386-8.
11. Hayashi N, Ito I, Yanagisawa A, et al. Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet 1995; 345:1257-9.
12. Isaka N, Nozue M, Doy M, et al. Prognostic significance of perirectal lymph node micrometastases in Dukes' B rectal carcinoma: an immunohistochemical study by CAM5.2. Clin Cancer Res 1999; 5:2065-8.
13. Jeffers MD, O'Dowd GM, Mulcahy H, et al. The prognostic significance of immunohistochemically detected lymph node micrometastases in colorectal carcinoma. J Pathol 1994; 172:183-7.
14. Makin C, Bobrow L, Nicholls J. Can immunohistology improve detection of lymph-node metastases in large-bowel cancer? Dis Colon Rectum 1989; 32:99-102.
15. Mori M, Mimori K, Inoue H, et al. Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res 1995; 55:3417-20.
16. Nakanishi Y, Atsushi O, Yamauchi Y, et al. Clinical implications of lymph node micrometastases in patients with colorectal cancers. Oncology 1999; 57:276-80.
17. Nakamori S, Kameyama M, Furukawa H, et al. Genetic detection of colorectal cancer cells in circulation and lymph nodes. Dis Colon Rectum 1997; 40(suppl 10):S29-36.
18. Nicholson AG, Marks CG, Cook MG. Effect on lymph node status of triple leveling and immunohistochemistry with CAM 5.2 on node negative colorectal carcinomas. Gut 1994; 35:1447-8.
19. Noura S, Yamamoto H, Miyake Y, et al. Immunohistochemical assessment of localization and frequency of micrometastasis in lymph nodes of colorectal cancer. Clin Cancer Res 2002; 8:759-67.
20. Oberg A, Stenling R, Tavelin B, et al. Are lymph node micrometastases of any clinical significance in Dukes stage A and B colorectal cancer? Dis Colon Rectum 1998; 41:1244-9.
21. Palma RT, Waisberg J, Bromberg SH, et al. Micrometastasis in regional lymph nodes of extirpated colorectal carcinoma: immunohistochemical study using anti-cytokeratin antibodies AE1/AE3. Colorectal Dis 2003; 5:164-8.
22. Sasaki M, Watanabe H, Jass JR, et al. Occult lymph node metastases detected by cytokeratin immunohistochemistry predict recurrence in "node negative" colorectal cancer. J Gastroenterol 1997; 32:758-64.
23. Tschmelitsch J, Klimstra D, Cohen A. Lymph node micrometastases do not predict relapse in stage II colon cancer. Ann Surg Oncol 2000; 7:601-8.
24. Yasuda K, Adachi Y, Shiraishi N, et al. Pattern of lymph node micrometastases and prognosis of patients with colorectal cancer. Ann Surg Oncol 2001; 8:300-4.
25. Yamamoto H, Miyake Y, Noura S, et al. [Clinical significance of micrometastasis to lymph nodes in gastrointestinal tract cancers]. Gan To Kagaku Ryoho 2001; 28:776-83.
26. Noura S, Hirofumi Y, Ohnishi T, et al. Comparative detection of lymph node micrometastasis of stage II colorectal cancer by reverse transcriptase polymerase chain reaction and immunohistochemistery. J Clin Oncol 2002; 20:4232-41.
27. Liefers G, Cleton-James A, van de Velde C, et al. Micrometastasis and survival in stage II colorectal cancer. N Engl J Med 1998; 339:223-8.
28. Rosenberg R, Hoos R, Mueller J, et al. Prognostic significance of cytokeratin-20 reverse-transcriptase polymerase chain reaction in lymph nodes of node-negative colorectal cancer patients. J Clin Oncol 2002; 20:1049-55.
29. Benson AB, Schrag D, Somerfield M, et al. American Society of Clinical Oncology recommendations on adjuvant chemotherapy for stage II colon cancer. J Clin Oncol 2004; 22:3408-19.
30. Masuda N, Ohnishi T, Kawamoto S, et al. Analysis of chemical modification of RNA from formalin-fixed samples and optimization of molecular biology applications for such samples. Nucleic Acids Res 1999; 27:4436-43.
31. Masuda N, Tamaki Y, Sakita I, et al. Clinical significance of micrometastases in axillary lymph nodes assessed by reverse transcriptase- polymerase chain reaction in breast cancer patients. Clin Cancer Res 2000; 6:4176-85.
32. Gerhard M, Juhl H, Kalthoff H, et al. Specific detection of carcinoembryonic antigen-expressing tumor cells in bone marrow aspirates by polymerase chain reaction. J Clin Oncol 1994; 12:725-9.
33. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
34. Rosenberg R, Hoos A, Mueller J, et al. Impact of cytokeratin-20 and carcinoembryonic antigen mRNA detected by RT-PCR in regional lymph nodes of patients with colorectal cancer. Br J Cancer 2000; 83:1323-9.
35. Funaki NO, Tanaka J, Ohshio G, et al. Cytokeratin-20 mRNA in peripheral venous blood of colorectal carcinoma patients. Br J Cancer 1998; 77:1327-32.
36. Egger M, Smith GD, Sterne J. Uses and abuses of meta-analysis. Clin Med 2001; 1:478-84.
37. Law CHL, Wright FC, Rapanos T, et al. Impact of lymphnode retrieval and pathological ultra-staging on the prognosis of stage II colon cancer. J Surg Oncol 2003; 84:120-6.
38. Tempper JE, O'Connell MJ, Niedzwiecki D, et al. Impact of number of lymph nodes retriveved on outcome in patients with rectal cancer. J Clin Oncol 2001; 19:157-63.
39. Burdy G, Panis Y, Alves A, et al. Identifying patients with T3-T4 node-negative colon cancer at high risk or recurrence. Dis Colon Rectum 2001; 44:1682-8.
40. International Union Against Cancer (UICC). In: Sobin LH, Wittekind C, eds. TMN classification of malignant tumors, 6th ed. New York: Wiley, 2002.
41. Greene FL, Page DL, Fleming ID, et al. AJCC Cancer staging manual, 6th ed. New York: Springer, 2002; pp 5-226.
42. Bertagnolli M, Miedema B, Redson M, et al. Sentinel node staging of resectable colon cancer, results of a multicenter study. Ann Surg 2004; 240:624-30.
43. Redson M, Compton CC, Miedema B, et al. Analysis of micrometastatic disease in sentinel lymph nodes from resectable colon cancer: results of Cancer and Leukemia Group B Trial 80001. J Clin Oncol 2006; 24(6):878-83.
44. Saha S, Dan AG, Viehl CT, Zuber M, Wiese D. Sentinel lymph node mapping in colon and rectal cancer: its impact on staging, limitations, and pitfalls. Cancer Treat Res 2005; 127:105-22.
45. Turner RR, Nora DT, Trocha SD, Bilchik AJ. Colorectal carcinoma nodal staging. Frequency and nature of cytokeratin-positive cells in sentinel and nonsentinel lymph nodes. Arch Pathol Lab Med 2003; 127:673-9.
46. Saha S, Seghal R, Patel M, et al. A multicenter trial of sentinel lymph node mapping in colorectal cancer: prognostic implications for nodal staging and recurrence. Am J Surg 2006; 191:305-10.