Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 Message

Toxicological Sciences

Volumn 116, Issue 2, 2010, Pages 549-561

  Nguyen, Phuong Minh ^a   Park, Miki Susanto ^b   Chow, Marilynn ^b   Chang, Jae H ^c   Wrischnik, Lisa ^b   Chan, William K ^b  

^a VIETNAM MILITARY MEDICAL UNIVERSITY   (Viet Nam)

^b UNIVERSITY OF THE PACIFIC   (United States)

^c GENENTECH INC   (United States)

Author keywords

Benzo a pyrene; Gene regulation; Keap1; Nrf2; Suppressive subtractive hybridization

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; GLUTATHIONE TRANSFERASE P1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; CYTOCHROME P450 1A1; DIMETHYL SULFOXIDE; KEAP1 PROTEIN, HUMAN; NFE2L2 PROTEIN, HUMAN; NQO1 PROTEIN, HUMAN; SIGNAL PEPTIDE;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DNA LIBRARY; DOT HYBRIDIZATION; DOWN REGULATION; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; PROTEIN FOLDING; REAL TIME POLYMERASE CHAIN REACTION; SUBTRACTIVE HYBRIDIZATION; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GENETICS; JURKAT CELL LINE; METABOLISM; PHYSIOLOGY; TOXICITY;

BENZO(A)PYRENE; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; DIMETHYL SULFOXIDE; DOWN-REGULATION; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; JURKAT CELLS; NAD(P)H DEHYDROGENASE (QUINONE); NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; RECEPTORS, ARYL HYDROCARBON;

EID: 77955060225     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq150     Document Type: Article

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