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Volumn 1681, Issue 1, 2004, Pages 38-46

Induction of gene expression of xenobiotic metabolism enzymes and ABC-transport proteins by PAH and a reconstituted PAH mixture in human Caco-2 cells

Author keywords

ABC transporter; Benzo a pyrene; Caco 2 cell; CYP1A1; CYP1B1

Indexed keywords

ABC TRANSPORTER; BENZO[K]FLUORANTHENE; CHRYSENE; CYTOCHROME P450; DIBENZO[A,L]PYRENE; EPOXIDE HYDROLASE; GLUCURONOSYLTRANSFERASE; MESSENGER RNA; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE; SULFOTRANSFERASE;

EID: 9244220651     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2004.09.010     Document Type: Article
Times cited : (56)

References (40)
  • 1
    • 0025311288 scopus 로고
    • Epithelial transport of drugs in cell culture: I. a model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells
    • P. Artursson Epithelial transport of drugs in cell culture: I. A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells J. Pharm. Sci. 79 1990 476 482
    • (1990) J. Pharm. Sci. , vol.79 , pp. 476-482
    • Artursson, P.1
  • 2
    • 0024593744 scopus 로고
    • Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability
    • I.J. Hidalgo, T.J. Raub, and R.T. Borchardt Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability Gastroenterology 96 1989 736 749
    • (1989) Gastroenterology , vol.96 , pp. 736-749
    • Hidalgo, I.J.1    Raub, T.J.2    Borchardt, R.T.3
  • 3
    • 0031810016 scopus 로고    scopus 로고
    • Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines
    • A. Lampen, A. Bader, T. Bestmann, M. Winkler, L. Witte, and J.T. Borlak Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines Xenobiotica 28 1998 429 441
    • (1998) Xenobiotica , vol.28 , pp. 429-441
    • Lampen, A.1    Bader, A.2    Bestmann, T.3    Winkler, M.4    Witte, L.5    Borlak, J.T.6
  • 4
    • 0031413702 scopus 로고    scopus 로고
    • Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond
    • P. Artursson, and R.T. Borchardt Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond Pharm. Res. 14 1997 1655 1658
    • (1997) Pharm. Res. , vol.14 , pp. 1655-1658
    • Artursson, P.1    Borchardt, R.T.2
  • 6
    • 0036395143 scopus 로고    scopus 로고
    • Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes
    • R. Buesen, M. Mock, A. Seidel, J. Jacob, and A. Lampen Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes Toxicol. Appl. Pharmacol. 183 2002 168 178
    • (2002) Toxicol. Appl. Pharmacol. , vol.183 , pp. 168-178
    • Buesen, R.1    Mock, M.2    Seidel, A.3    Jacob, J.4    Lampen, A.5
  • 7
    • 0035152853 scopus 로고    scopus 로고
    • CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies
    • H.A. Engman, H. Lennernas, J. Taipalensuu, C. Otter, B. Leidvik, and P. Artursson CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies J. Pharm. Sci. 90 2001 1736 1751
    • (2001) J. Pharm. Sci. , vol.90 , pp. 1736-1751
    • Engman, H.A.1    Lennernas, H.2    Taipalensuu, J.3    Otter, C.4    Leidvik, B.5    Artursson, P.6
  • 8
    • 0343249383 scopus 로고    scopus 로고
    • Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells
    • P.A. Münzel, S. Schmohl, H. Heel, K. Kalberer, B.S. Bock-Hennig, and K.W. Bock Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells Drug Metab. Dispos. 27 1999 569 573
    • (1999) Drug Metab. Dispos. , vol.27 , pp. 569-573
    • Münzel, P.A.1    Schmohl, S.2    Heel, H.3    Kalberer, K.4    Bock-Hennig, B.S.5    Bock, K.W.6
  • 9
    • 0025781413 scopus 로고
    • Substrate specificity and some properties of phenol sulfotransferase from human intestinal Caco-2 cells
    • A. Baranczyk-Kuzma, J.A. Garren, I.J. Hidalgo, and R.T. Borchardt Substrate specificity and some properties of phenol sulfotransferase from human intestinal Caco-2 cells Life Sci. 49 1991 1197 1206
    • (1991) Life Sci. , vol.49 , pp. 1197-1206
    • Baranczyk-Kuzma, A.1    Garren, J.A.2    Hidalgo, I.J.3    Borchardt, R.T.4
  • 10
    • 0032031001 scopus 로고    scopus 로고
    • Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin
    • P.O. Beaumont, M.J. Moore, K. Ahmad, M.M. Payne, C. Lee, and D.S. Riddick Role of glutathione S-transferases in the resistance of human colon cancer cell lines to doxorubicin Cancer Res. 58 1998 947 955
    • (1998) Cancer Res. , vol.58 , pp. 947-955
    • Beaumont, P.O.1    Moore, M.J.2    Ahmad, K.3    Payne, M.M.4    Lee, C.5    Riddick, D.S.6
  • 11
    • 0033739725 scopus 로고    scopus 로고
    • Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine
    • H. Suzuki, and Y. Sugiyama Role of metabolic enzymes and efflux transporters in the absorption of drugs from the small intestine Eur. J. Pharm. Sci. 12 2000 3 12
    • (2000) Eur. J. Pharm. Sci. , vol.12 , pp. 3-12
    • Suzuki, H.1    Sugiyama, Y.2
  • 12
    • 0033985306 scopus 로고    scopus 로고
    • Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2)
    • T. Hirohashi, H. Suzuki, X.Y. Chu, I. Tamai, A. Tsuji, and Y. Sugiyama Function and expression of multidrug resistance-associated protein family in human colon adenocarcinoma cells (Caco-2) J. Pharmacol. Exp. Ther. 292 2000 265 270
    • (2000) J. Pharmacol. Exp. Ther. , vol.292 , pp. 265-270
    • Hirohashi, T.1    Suzuki, H.2    Chu, X.Y.3    Tamai, I.4    Tsuji, A.5    Sugiyama, Y.6
  • 13
    • 0031719032 scopus 로고    scopus 로고
    • Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells
    • V.D. Makhey, A. Guo, D.A. Norris, P. Hu, J. Yan, and P.J. Sinko Characterization of the regional intestinal kinetics of drug efflux in rat and human intestine and in Caco-2 cells Pharm. Res. 15 1998 1160 1167
    • (1998) Pharm. Res. , vol.15 , pp. 1160-1167
    • Makhey, V.D.1    Guo, A.2    Norris, D.A.3    Hu, P.4    Yan, J.5    Sinko, P.J.6
  • 14
    • 0037420963 scopus 로고    scopus 로고
    • Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites
    • R. Buesen, M. Mock, H. Nau, A. Seidel, J. Jacob, and A. Lampen Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites Chem. Biol. Interact. 142 2003 201 221
    • (2003) Chem. Biol. Interact. , vol.142 , pp. 201-221
    • Buesen, R.1    Mock, M.2    Nau, H.3    Seidel, A.4    Jacob, J.5    Lampen, A.6
  • 15
    • 0030321495 scopus 로고    scopus 로고
    • Metabolism and excretion of polycyclic aromatic hydrocarbons in rat and in human
    • J. Jacob, and G. Grimmer Metabolism and excretion of polycyclic aromatic hydrocarbons in rat and in human Cent. Eur. J. Public Health 4 1996 33 39
    • (1996) Cent. Eur. J. Public Health , vol.4 , pp. 33-39
    • Jacob, J.1    Grimmer, G.2
  • 16
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • P. Chomczynski, and N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal. Biochem. 162 1987 156 159
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 18
    • 0025875527 scopus 로고
    • The Ah receptor and the mechanism of dioxin toxicity
    • J.P. Landers, and N.J. Bunce The Ah receptor and the mechanism of dioxin toxicity Biochem. J. 276 1991 273 287
    • (1991) Biochem. J. , vol.276 , pp. 273-287
    • Landers, J.P.1    Bunce, N.J.2
  • 19
    • 0037440941 scopus 로고    scopus 로고
    • Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene
    • T. Shimada, A. Sugie, M. Shindo, T. Nakajima, E. Azuma, M. Hashimoto, and K. Inoue Tissue-specific induction of cytochromes P450 1A1 and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in engineered C57BL/6J mice of arylhydrocarbon receptor gene Toxicol. Appl. Pharmacol. 187 2003 1 10
    • (2003) Toxicol. Appl. Pharmacol. , vol.187 , pp. 1-10
    • Shimada, T.1    Sugie, A.2    Shindo, M.3    Nakajima, T.4    Azuma, E.5    Hashimoto, M.6    Inoue, K.7
  • 21
    • 0021037060 scopus 로고
    • Bone marrow toxicity induced by oral benzo[a]pyrene: Protection resides at the level of the intestine and liver
    • C. Legraverend, D.E. Harrison, F.W. Ruscetti, and D.W. Nebert Bone marrow toxicity induced by oral benzo[a]pyrene: protection resides at the level of the intestine and liver Toxicol. Appl. Pharmacol. 70 1983 390 401
    • (1983) Toxicol. Appl. Pharmacol. , vol.70 , pp. 390-401
    • Legraverend, C.1    Harrison, D.E.2    Ruscetti, F.W.3    Nebert, D.W.4
  • 22
    • 0029559174 scopus 로고
    • Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies
    • S. Ikushiro, Y. Emi, and T. Iyanagi Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies Arch. Biochem. Biophys. 324 1995 267 272
    • (1995) Arch. Biochem. Biophys. , vol.324 , pp. 267-272
    • Ikushiro, S.1    Emi, Y.2    Iyanagi, T.3
  • 23
    • 0033560067 scopus 로고    scopus 로고
    • Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7
    • K.W. Bock, F.T. Raschko, H. Gschaidmeier, A. Seidel, F. Oesch, A.D. Grove, and J.K. Ritter Mono- and diglucuronide formation from benzo[a]pyrene and chrysene diphenols by AHH-1 cell-expressed UDP-glucuronosyltransferase UGT1A7 Biochem. Pharmacol. 57 1999 653 656
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 653-656
    • Bock, K.W.1    Raschko, F.T.2    Gschaidmeier, H.3    Seidel, A.4    Oesch, F.5    Grove, A.D.6    Ritter, J.K.7
  • 25
    • 0036101804 scopus 로고    scopus 로고
    • Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer
    • C.P. Strassburg, A. Vogel, S. Kneip, R.H. Tukey, and M.P. Manns Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer Gut 50 2002 851 856
    • (2002) Gut , vol.50 , pp. 851-856
    • Strassburg, C.P.1    Vogel, A.2    Kneip, S.3    Tukey, R.H.4    Manns, M.P.5
  • 26
  • 27
    • 0031850954 scopus 로고    scopus 로고
    • Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene
    • E.G. Schuetz, K. Yasuda, K. Arimori, and J.D. Schuetz Human MDR1 and mouse mdr1a P-glycoprotein alter the cellular retention and disposition of erythromycin, but not of retinoic acid or benzo(a)pyrene Arch. Biochem. Biophys. 350 1998 340 347
    • (1998) Arch. Biochem. Biophys. , vol.350 , pp. 340-347
    • Schuetz, E.G.1    Yasuda, K.2    Arimori, K.3    Schuetz, J.D.4
  • 28
    • 0030051562 scopus 로고    scopus 로고
    • P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment
    • O. Fardel, V. Lecureur, A. Corlu, and A. Guillouzo P-glycoprotein induction in rat liver epithelial cells in response to acute 3-methylcholanthrene treatment Biochem. Pharmacol. 51 1996 1427 1436
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 1427-1436
    • Fardel, O.1    Lecureur, V.2    Corlu, A.3    Guillouzo, A.4
  • 29
    • 0037430811 scopus 로고    scopus 로고
    • Differential modulation of cytochrome P-450 1A and P-glycoprotein expression by aryl hydrocarbon receptor agonists and thyroid hormone in Xenopus laevis liver and intestine
    • A. Colombo, P. Bonfanti, F. Orsi, and M. Camatini Differential modulation of cytochrome P-450 1A and P-glycoprotein expression by aryl hydrocarbon receptor agonists and thyroid hormone in Xenopus laevis liver and intestine Aquat. Toxicol. 63 2003 173 186
    • (2003) Aquat. Toxicol. , vol.63 , pp. 173-186
    • Colombo, A.1    Bonfanti, P.2    Orsi, F.3    Camatini, M.4
  • 30
    • 0018537749 scopus 로고
    • [Profiles of polycyclic aromatic hydrocarbon metabolites after treatment with various inducers of microsomal rat liver monoxygenases (author's transl)]
    • J. Jacob, G. Grimmer, and A. Schmoldt [Profiles of polycyclic aromatic hydrocarbon metabolites after treatment with various inducers of microsomal rat liver monoxygenases (author's transl)] Hoppe-Seyler's Z. Physiol. Chem. 360 1979 1525 1534
    • (1979) Hoppe-Seyler's Z. Physiol. Chem. , vol.360 , pp. 1525-1534
    • Jacob, J.1    Grimmer, G.2    Schmoldt, A.3
  • 31
    • 0019834760 scopus 로고
    • The influence of polycyclic aromatic hydrocarbons as inducers of monooxygenases on the metabolite profile of benz[a]anthracene in rat liver microsomes
    • J. Jacob, G. Grimmer, and A. Schmoldt The influence of polycyclic aromatic hydrocarbons as inducers of monooxygenases on the metabolite profile of benz[a]anthracene in rat liver microsomes Cancer Lett. 14 1981 175 185
    • (1981) Cancer Lett. , vol.14 , pp. 175-185
    • Jacob, J.1    Grimmer, G.2    Schmoldt, A.3
  • 32
    • 0019720990 scopus 로고
    • Dose-dependent induction of rat liver microsomal aryl hydrocarbon monooxygenase by benzo[k]fluoranthene
    • A. Schmoldt, J. Jacob, and G. Grimmer Dose-dependent induction of rat liver microsomal aryl hydrocarbon monooxygenase by benzo[k]fluoranthene Cancer Lett. 13 1981 249 257
    • (1981) Cancer Lett. , vol.13 , pp. 249-257
    • Schmoldt, A.1    Jacob, J.2    Grimmer, G.3
  • 34
    • 0029035324 scopus 로고
    • Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice
    • K. Chaloupka, M. Steinberg, M. Santostefano, L.V. Rodriguez, L. Goldstein, and S. Safe Induction of Cyp1a-1 and Cyp1a-2 gene expression by a reconstituted mixture of polynuclear aromatic hydrocarbons in B6C3F1 mice Chem. Biol. Interact. 96 1995 207 221
    • (1995) Chem. Biol. Interact. , vol.96 , pp. 207-221
    • Chaloupka, K.1    Steinberg, M.2    Santostefano, M.3    Rodriguez, L.V.4    Goldstein, L.5    Safe, S.6
  • 35
    • 0020417059 scopus 로고
    • Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats
    • P.I. Mackenzie, M. Vaisanen, and O. Hanninen Differential induction of UDP glucuronosyltransferase activities towards various substrates after polycyclic aromatic hydrocarbon administration to rats O. Toxicol. Lett. 12 1982 259 263
    • (1982) O. Toxicol. Lett. , vol.12 , pp. 259-263
    • MacKenzie, P.I.1    Vaisanen, M.2    Hanninen, O.3
  • 36
    • 0036771751 scopus 로고    scopus 로고
    • In vitro EROD induction equivalency factors for the 10 PAHs generally monitored in risk assessment studies in the Netherlands
    • A.T. Bosveld, P.A. de Bie, N.W. van den Brink, H. Jongepier, and A.V. Klomp In vitro EROD induction equivalency factors for the 10 PAHs generally monitored in risk assessment studies in The Netherlands Chemosphere 49 2002 75 83
    • (2002) Chemosphere , vol.49 , pp. 75-83
    • Bosveld, A.T.1    De Bie, P.A.2    Van Den Brink, N.W.3    Jongepier, H.4    Klomp, A.V.5
  • 38
    • 4844220809 scopus 로고    scopus 로고
    • Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with MW 302 in environmental samples
    • A. Seidel, H. Frank, A. Behnke, D. Schneider, and J. Jacob Determination of dibenzo[a,l]pyrene and other fjord-region PAH isomers with MW 302 in environmental samples Polycycl. Aromat. Compd. 24 2004 759 771
    • (2004) Polycycl. Aromat. Compd. , vol.24 , pp. 759-771
    • Seidel, A.1    Frank, H.2    Behnke, A.3    Schneider, D.4    Jacob, J.5
  • 39
    • 0141890076 scopus 로고    scopus 로고
    • Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice
    • T. Shimada, A. Sugie, T. Yamada, H. Kawazoe, M. Hashimoto, E. Azuma, T. Nakajima, K. Inoue, and Y. Oda Dose-response studies on the induction of liver cytochromes P4501A1 and 1B1 by polycyclic aromatic hydrocarbons in arylhydrocarbon-responsive C57BL/6J mice Xenobiotica 33 2003 957 971
    • (2003) Xenobiotica , vol.33 , pp. 957-971
    • Shimada, T.1    Sugie, A.2    Yamada, T.3    Kawazoe, H.4    Hashimoto, M.5    Azuma, E.6    Nakajima, T.7    Inoue, K.8    Oda, Y.9
  • 40
    • 0141884785 scopus 로고    scopus 로고
    • Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells
    • J. Borlak, and C. Zwadlo Expression of drug-metabolizing enzymes, nuclear transcription factors and ABC transporters in Caco-2 cells Xenobiotica 3 2003 927 943
    • (2003) Xenobiotica , vol.3 , pp. 927-943
    • Borlak, J.1    Zwadlo, C.2


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