Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT

Cancer Science

Volumn 99, Issue 12, 2008, Pages 2518-2524

  Choi, Hyunsung ^a   Chun, Yang Sook ^a   Shin, Yong Jae ^a   Ye, Sang Kyu ^a   Kim, Myung Suk ^a   Park, Jong Wan ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CURCUMIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; ESTROGEN; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; CELL STRAIN HEK293; CELL STRAIN MCF 7; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOPLASM; EMBRYO; ENZYME INDUCTION; ENZYME SYNTHESIS; GENOTOXICITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; MALIGNANT TRANSFORMATION; MAMMAL CELL; OXIDATIVE STRESS; POLLUTION; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANTIGENS, POLYOMAVIRUS TRANSFORMING; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; BREAST NEOPLASMS; CARCINOMA, HEPATOCELLULAR; CELL LINE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL TRANSFORMATION, VIRAL; CURCUMIN; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; KIDNEY; LIVER NEOPLASMS; MALE; PROSTATIC NEOPLASMS; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TETRACHLORODIBENZODIOXIN;

EID: 57349185988     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2008.00984.x     Document Type: Article

References (36)

1. Bock KW, Köhle C. Ah receptor: Dioxin mediated toxic responses as hints to deregulated physiologic functions. Biochem Pharmacol 2006; 72: 393-404.
2. Huff J, Lucier G, Tritscher A. Carcinogenicity of TCDD: Experimental, mechanistic, and epidemiologic evidence. Annu Rev Pharmacol Toxicol 1994; 34: 343-72.
3. Burbach KM, Poland A, Bradfield CA. Cloning of the Ah receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 1992; 89: 8185-9.
4. Dolwick KM, Swanson HI, Bradfield CA. In vitro analysis of Ah receptor domains involved in ligand activated DNA recognition. Proc Natl Acad Sci USA 1993; 90: 8566-70.
5. Estabrook RW. The remarkable P450s: A historical overview of these versatile hemeprotein catalysts. Faseb J 1996; 10: 202-20.
6. Yager JD. Endogenous estrogens as carcinogens through metabolic activation. J Natl Cancer Inst Monogr 2000; 27: 67-73.
7. Zhu BT, Conney AH. Functional role of estrogen metabolism in target cells: Review and perspectives. Carcinogenesis 1998; 19: 1-27.
8. Cavalieri EL, Stack DE, Devanesan PD et al. Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. Proc Natl Acad Sci USA 1997; 94: 10937-42.
9. Hayes CL, Spink DC, Spink BC, Cao JQ, Walker NJ, Sutter TR. 17b-estradiol hydroxylation catalyzed by human cytochrome P4501B1. Proc Natl Acad Sci USA 1996; 93: 9776-81.
10. Kawamori T, Lubet R, Steele VE et al. Chemopreventive effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 1999; 59: 597-601.
11. Singh SV, Hu X, Srivastava SK et al. Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin. Carcinogenesis 1998; 19: 1357-60.
12. Limtrakul P, Lipigorngoson S, Namwong O, Apisariyakul A, Dunn FW. Inhibitory effect of dietary curcumin on skin carcinogenesis in mice. Cancer Lett 1997; 116: 197-203.
13. Meht RG, Moon RC. Characterization of effective chemopreventive agents in mammary gland in vitro using and initiation-promotion protocol. Anticancer Res 1991; 11: 593-6.
14. Soudamini NK, Kuttan R. Inhibition of chemical carcinogenesis by curcumin. J Ethnopharmacol 1989; 27: 227-33.
15. Choi H, Chun YS, Kim SW, Kim MS, Park JW. Curcumin inhibits hypoxia-induced factor-1 by degrading arylhydrocarbon receptor nuclear translocator: A mechanism of tumor growth inhibition. Mol Pharmacol 2006; 70: 1664-71.
16. Shin DH, Li SH, Chun YS, Huang LE, Kim MS, Park JW. CITED2 mediates the paradoxical responses of HIF-1a to proteasome inhibition. Oncogene 2008; 20: 1939-44.
17. Fernandez-Salguero PM, Hilbert DM, Rudikoff S, Ward JM, Gonzalez FJ. Aryl-hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin induced toxicity. Toxicol Appl Pharmacol 1996; 1: 173-9.
18. Yoon CY, Park M, Kim BH et al. Gene expression profile by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the liver of wild-type (AhR+/+) and aryl hydrocarbon receptor-deficient (AhR-/-) mice. J Vet Medical Sci 2006; 7: 663-8.
19. Yang JH, Vogel C, Abel J. A malignant transformation of human cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits altered expressions of growth regulatory factors. Carcinogenesis 1999; 20: 13-18.
20. Wölfle D, Marotzki S, Dartsch D, Schäfer W, Marquardt H. Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Carcinogenesis 2000; 21: 15-21.
21. Puga A, Nebert DW, Carrier F. Dioxin induces expression of c-fos and c-jun proto-oncogenes and a large increase in transcription factor AP-1. DNA Cell Biol 1992; 11: 269-81.
22. Weiss C, Faust D, Schreck I et al. TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A. Oncogene 2008; 27: 2198-207.
23. Nebert DW, Dalton TP. The role of cytochrome P450 enzymes in endogenous signalling pathways and environmental carcinogenesis. Nat Rev Cancer 2006; 6: 947-60.
24. Park JY, Shigenaga MK, Ames BN. Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo (3,2-b) carbazole is associated with oxidative DNA damage. Proc Natl Acad Sci USA 1996; 93: 2322-7.
25. Murray GI, Melvin WT, Greenlee WF, Burke MD. Regulation, function, and tissue-specific expression of cytochrome P450 CYP1B1. Annu Rev Pharmacol Toxicol 2001; 41: 297-316.
26. Sasaki M, Tanaka Y, Okino ST et al. Polymorphisms of the CYP1B1 gene as risk factors for human renal cell cancer. Clin Cancer Res 2004; 10: 2015-9.
27. McFadyen MC, Melvin WT, Murray GI. Cytochrome P450 CYP1B1 activity in renal cell carcinoma. Br J Cancer 2004; 91: 966-71.
28. Tokizane T, Shiina H, Igawa M et al. Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer. Clin Cancer Res 2005; 11: 5793-801.
29. Thapliyal R, Maru GB. Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food Chem Toxicol 2001; 39: 541-7.
30. Ciolino HP, Daschner PJ, Wang TT, Yeh GC. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem Pharmacol 1998; 56: 197-206.
31. Rinaldi AL, Morse MA, Fields HW et al. Curcumin activates the aryl hydrocarbon receptor yet significantly inhibits(-)-benzo(a) pyrene-7R-trans-7,8-dihydrodiol bioactivation in oral squamous cell carcinoma cells and oral mucosa. Cancer Res 2002; 62: 5451-6.
32. Nishiumi S, Yoshida K, Ashida H. Curcumin suppresses the transformation of an aryl hydrocarbon receptor through its phosphorylation. Arch Biochem Biophys 2007; 466: 267-73.
33. Davarinos NA, Pollenz RS. Aryl hydrocarbon receptor imported into the nucleus following ligand binding is rapidly degraded via the cytosplasmic proteasome following nuclear export. J Biol Chem 1999; 274: 28708-15.
34. Ma Q, Baldwin KT. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced degradation of ArylHydrocarbon Receptor (AhR) by the ubiquitin-proteasome pathway. J Biol Chem 2000; 275: 8432-8.
35. Ito S, Chen C, Satoh J, Yim S, Gonzalez FJ. Dietary phytochemicals regulate whole-body CYP1A1 expression through an arylhydrocarbon receptor nuclear translocator-dependent system in gut. J Clin Invest 2007; 117: 1940-50.
36. Kang HJ, Kim HJ, Kim SK et al. BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. J Biol Chem 2006; 281: 14654-62.