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Volumn 98, Issue 1, 2005, Pages 22-32

Intestinal metabolism of PAH: In vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium

Author keywords

Caco 2 cells; Intestinal transfer; Metabolism; PAH

Indexed keywords

BENZO[A]PYRENE; CARBON 14; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; PYRENE;

EID: 13844281744     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.envres.2004.10.010     Document Type: Article
Times cited : (54)

References (40)
  • 2
    • 0032826794 scopus 로고    scopus 로고
    • Use of Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics
    • E. Biganzoli, L.A. Cavenaghi, R. Rossi, M.C. Brunati, and M.L. Nolli Use of Caco-2 cell culture model for the characterization of intestinal absorption of antibiotics Il. Farmaco 54 1999 594 599
    • (1999) Il. Farmaco , vol.54 , pp. 594-599
    • Biganzoli, E.1    Cavenaghi, L.A.2    Rossi, R.3    Brunati, M.C.4    Nolli, M.L.5
  • 4
    • 0018728080 scopus 로고
    • Absorption and metabolism of naphthalene and benzo[a]pyrene in the rat jejunum in situ
    • K.W. Bock, U.C.V. Clausbruch, and D. Winne Absorption and metabolism of naphthalene and benzo[a]pyrene in the rat jejunum in situ Med. Biol. 57 1979 262 264
    • (1979) Med. Biol. , vol.57 , pp. 262-264
    • Bock, K.W.1    Clausbruch, U.C.V.2    Winne, D.3
  • 5
    • 0036395143 scopus 로고    scopus 로고
    • Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes
    • R. Buesen, M. Mock, A. Seidel, J. Jacob, and A. Lampen Interaction between metabolism and transport of benzo[a]pyrene and its metabolites in enterocytes Toxicol. Appl. Pharmacol. 183 2002 168 178
    • (2002) Toxicol. Appl. Pharmacol. , vol.183 , pp. 168-178
    • Buesen, R.1    Mock, M.2    Seidel, A.3    Jacob, J.4    Lampen, A.5
  • 6
    • 0037420963 scopus 로고    scopus 로고
    • Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites
    • R. Buesen, M. Mock, H. Nau, A. Seidel, J. Jacob, and A. Lampen Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites Chem. Biol. Interact. 142 2003 201 211
    • (2003) Chem. Biol. Interact. , vol.142 , pp. 201-211
    • Buesen, R.1    Mock, M.2    Nau, H.3    Seidel, A.4    Jacob, J.5    Lampen, A.6
  • 7
    • 0032189356 scopus 로고    scopus 로고
    • Decreased expression of γ-glutamyltranspeptidase in the intestinal cell line Caco-2 by inducers of cytochrome p450 1a1
    • V. Carriere, E. Dussaulx, M. Rousset, A. Zweibaum, and D. Cambier Decreased expression of γ-glutamyltranspeptidase in the intestinal cell line Caco-2 by inducers of cytochrome p450 1a1 Biochem. Pharmacol. 56 1998 817 823
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 817-823
    • Carriere, V.1    Dussaulx, E.2    Rousset, M.3    Zweibaum, A.4    Cambier, D.5
  • 9
    • 0029941483 scopus 로고    scopus 로고
    • Effect of fatty acids and the aqueous diffusion barrier on the uptake and transport of polychlorinated biphenyls in Caco-2 cells
    • W.J. Dulfer, H.A.J. Govers, and J.P. Groten Effect of fatty acids and the aqueous diffusion barrier on the uptake and transport of polychlorinated biphenyls in Caco-2 cells J. Lipid Res. 37 1996 950 961
    • (1996) J. Lipid Res. , vol.37 , pp. 950-961
    • Dulfer, W.J.1    Govers, H.A.J.2    Groten, J.P.3
  • 10
    • 0031887085 scopus 로고    scopus 로고
    • Kinetics and conductivity parameters of uptake and transport of polychlorinated biphenyls in the Caco-2 intestinal cell line model
    • W.J. Dulfer, H.A.J. Govers, and J.P. Groten Kinetics and conductivity parameters of uptake and transport of polychlorinated biphenyls in the Caco-2 intestinal cell line model Environ. Toxicol. Chem. 17 1998 493 501
    • (1998) Environ. Toxicol. Chem. , vol.17 , pp. 493-501
    • Dulfer, W.J.1    Govers, H.A.J.2    Groten, J.P.3
  • 11
    • 0034259499 scopus 로고    scopus 로고
    • Le transfert des micropolluants organiques dans la chaîne alimentaire: Etats et perspectives de recherche
    • C. Feidt, N. Grova, C. Laurent, G. Rychen, and F. Laurent Le transfert des micropolluants organiques dans la chaîne alimentaire etats et perspectives de recherche Oléagineux, Corps gras, Lipides 7 2000 431 435
    • (2000) Oléagineux, Corps Gras, Lipides , vol.7 , pp. 431-435
    • Feidt, C.1    Grova, N.2    Laurent, C.3    Rychen, G.4    Laurent, F.5
  • 12
    • 0023832819 scopus 로고
    • Pharmacokinetics of low doses of benzo[a]pyrene in the rat
    • H. Foth, R. Kahl, and G.F. Kahl Pharmacokinetics of low doses of benzo[a]pyrene in the rat Chem. Toxicol. 26 1988 45 51
    • (1988) Chem. Toxicol. , vol.26 , pp. 45-51
    • Foth, H.1    Kahl, R.2    Kahl, G.F.3
  • 13
    • 0024236331 scopus 로고
    • The molecular biology of cytochrome P450s
    • F.J. Gonzalez The molecular biology of cytochrome P450s Pharmacol. Rev 40 1989 243 288
    • (1989) Pharmacol. Rev , vol.40 , pp. 243-288
    • Gonzalez, F.J.1
  • 14
    • 0031470901 scopus 로고    scopus 로고
    • Rate of pyrene metabolism in rat liver post-mitochondrial fractions
    • S. Haddad, R. Tardif, J. Whitey, and K. Krishnan Rate of pyrene metabolism in rat liver post-mitochondrial fractions Toxicol. Lett. 93 1997 177 184
    • (1997) Toxicol. Lett. , vol.93 , pp. 177-184
    • Haddad, S.1    Tardif, R.2    Whitey, J.3    Krishnan, K.4
  • 16
    • 0021007163 scopus 로고
    • Polynuclear aromatic compounds. Part 1: Chemical, environmental and experimental data
    • International Agency for Research on Cancer, Lyon.
    • IARC Working Group, 1983. Polynuclear aromatic compounds. Part 1: chemical, environmental and experimental data. In: Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans, vol. 32. International Agency for Research on Cancer, Lyon.
    • (1983) Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Humans , vol.32
  • 17
    • 0018353906 scopus 로고
    • Uptake and excretion of benzo[a]pyrene and its metabolites by the rat pancreas
    • Z.M. Iqbal, A. Yoshida, and S.S. Epstein Uptake and excretion of benzo[a]pyrene and its metabolites by the rat pancreas Drug Metab. Dispos. 7 1979 44 48
    • (1979) Drug Metab. Dispos. , vol.7 , pp. 44-48
    • Iqbal, Z.M.1    Yoshida, A.2    Epstein, S.S.3
  • 18
    • 0030321495 scopus 로고    scopus 로고
    • Metabolism and excretion of polycyclic aromatic hydrocarbons in rat and in human
    • J. Jacob, and G. Grimmer Metabolism and excretion of polycyclic aromatic hydrocarbons in rat and in human Cent. Eur. J. Public Health 4 1996 33 39
    • (1996) Cent. Eur. J. Public Health , vol.4 , pp. 33-39
    • Jacob, J.1    Grimmer, G.2
  • 19
    • 0031777216 scopus 로고    scopus 로고
    • Metabolism and activation of cyclopenta polycyclic aromatic hydrocarbons in liver tissue from rats and humans
    • N.M. Johnsen, S.H. Nyholm, K. Haug, T. Scholz, and J.A. Holme Metabolism and activation of cyclopenta polycyclic aromatic hydrocarbons in liver tissue from rats and humans Chem. Biol. Interact. 113 1998 217 231
    • (1998) Chem. Biol. Interact. , vol.113 , pp. 217-231
    • Johnsen, N.M.1    Nyholm, S.H.2    Haug, K.3    Scholz, T.4    Holme, J.A.5
  • 20
    • 0033987319 scopus 로고    scopus 로고
    • Metabolism of phenanthrene by house fly CYP6D1 and dog liver cytochrome P450
    • P.J. Korytko, F.W. Quimby, and J.G. Scott Metabolism of phenanthrene by house fly CYP6D1 and dog liver cytochrome P450 J. Biochem. Mol. Toxicol. 14 2000 20 25
    • (2000) J. Biochem. Mol. Toxicol. , vol.14 , pp. 20-25
    • Korytko, P.J.1    Quimby, F.W.2    Scott, J.G.3
  • 21
    • 0021729905 scopus 로고
    • Similar bioavailability and lymphatic transport of benzo[a]pyrene when administered to rats in different amounts of dietary fat
    • J.M. Laher, M.W. Rigler, R.D. Vetter, J.A. Barrowman, and J.S. Patton Similar bioavailability and lymphatic transport of benzo[a]pyrene when administered to rats in different amounts of dietary fat J. Lipid Res. 25 1984 1337 1342
    • (1984) J. Lipid Res. , vol.25 , pp. 1337-1342
    • Laher, J.M.1    Rigler, M.W.2    Vetter, R.D.3    Barrowman, J.A.4    Patton, J.S.5
  • 22
    • 0031810016 scopus 로고    scopus 로고
    • Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines
    • A. Lampen, A. Bader, T. Bestmann, M. Winklers, L. Witte, and J.T. Borlak Catalytic activities, protein- and mRNA-expression of cytochrome P450 isoenzymes in intestinal cell lines Xenobiotica 5 1998 429 441
    • (1998) Xenobiotica , vol.5 , pp. 429-441
    • Lampen, A.1    Bader, A.2    Bestmann, T.3    Winklers, M.4    Witte, L.5    Borlak, J.T.6
  • 23
    • 0033725067 scopus 로고    scopus 로고
    • Metabolism of vitamin a and its active metabolite all-trans-retinoic acid in small intestinal enterocytes
    • A. Lampen, S. Meyer, T. Arnhold, and H. Nau Metabolism of vitamin A and its active metabolite all-trans-retinoic acid in small intestinal enterocytes Pharmacol. Exp. Ther. 295 2000 979 985
    • (2000) Pharmacol. Exp. Ther. , vol.295 , pp. 979-985
    • Lampen, A.1    Meyer, S.2    Arnhold, T.3    Nau, H.4
  • 26
    • 0033165880 scopus 로고    scopus 로고
    • Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models
    • C. Meany, and C. O'Driscoll Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models Eur. J. Pharm. Sci. 8 1999 167 175
    • (1999) Eur. J. Pharm. Sci. , vol.8 , pp. 167-175
    • Meany, C.1    O'Driscoll, C.2
  • 27
    • 0019825888 scopus 로고
    • Cytotoxic effects and metabolism of benzo[a]pyrene and 7,12-diméthylbenz[a]anthracene in duodenal and ileal epithelial cell cultures
    • A. Quaroni, and K.J. Isselbacher Cytotoxic effects and metabolism of benzo[a]pyrene and 7,12-diméthylbenz[a]anthracene in duodenal and ileal epithelial cell cultures J. Natl. Cancer Inst. 67 1981 1353 1362
    • (1981) J. Natl. Cancer Inst. , vol.67 , pp. 1353-1362
    • Quaroni, A.1    Isselbacher, K.J.2
  • 28
    • 0023029866 scopus 로고
    • The influence of bile on the bioavailability of polycyclic aromatic hydrocarbons from the rat intestine
    • A. Rahman, J.A. Barrowman, and A. Rahimtula The influence of bile on the bioavailability of polycyclic aromatic hydrocarbons from the rat intestine Can. J. Physiol. Pharmacol. 64 1986 1214 1218
    • (1986) Can. J. Physiol. Pharmacol. , vol.64 , pp. 1214-1218
    • Rahman, A.1    Barrowman, J.A.2    Rahimtula, A.3
  • 29
    • 0027183516 scopus 로고
    • The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen
    • S.J. Roberts-Thomson, M.E. McManus, R.H. Tukey, F.J. Gonzalez, and J.M. Holder The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen Biochem. Biophys. Res. Commun. 192 1993 1729 1731
    • (1993) Biochem. Biophys. Res. Commun. , vol.192 , pp. 1729-1731
    • Roberts-Thomson, S.J.1    McManus, M.E.2    Tukey, R.H.3    Gonzalez, F.J.4    Holder, J.M.5
  • 30
    • 0036016868 scopus 로고    scopus 로고
    • Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic hydrocarbons
    • P.H. Roos Differential induction of CYP1A1 in duodenum, liver and kidney of rats after oral intake of soil containing polycyclic hydrocarbons Arch. Toxicol. 76 2002 326 334
    • (2002) Arch. Toxicol. , vol.76 , pp. 326-334
    • Roos, P.H.1
  • 32
    • 0025963631 scopus 로고
    • Fatty acid uptake and metabolism in a human intestinal cell line (Caco-2): Comparison of apical and basolateral incubation
    • P.J. Trotter, and J. Storch Fatty acid uptake and metabolism in a human intestinal cell line (Caco-2) comparison of apical and basolateral incubation J. Lipid Res. 32 1991 293 304
    • (1991) J. Lipid Res. , vol.32 , pp. 293-304
    • Trotter, P.J.1    Storch, J.2
  • 33
    • 0041328812 scopus 로고    scopus 로고
    • Constitutive CYP 1B1 mRNA expression in human blood mononuclear cells in relation to gender, genotype, and environmental factors
    • R. Tuominen, M. Warholm, L. Möller, and A. Rannug Constitutive CYP 1B1 mRNA expression in human blood mononuclear cells in relation to gender, genotype, and environmental factors Environ. Res. 93 2003 138 148
    • (2003) Environ. Res. , vol.93 , pp. 138-148
    • Tuominen, R.1    Warholm, M.2    Möller, L.3    Rannug, A.4
  • 34
    • 0026457126 scopus 로고
    • Influence of long-term ethanol treatment on in vitro biotransformation of benzo(a)pyrene in microsomes of the liver, lung and small intestine from male and female rats
    • J.A.G. Van de Wiel, M. Meuwissen, H. Kooy, P.H. Fijneman, J. Noordhoek, and R.P. Bos Influence of long-term ethanol treatment on in vitro biotransformation of benzo(a)pyrene in microsomes of the liver, lung and small intestine from male and female rats Biochem. Pharmacol. 44 1992 1977 1984
    • (1992) Biochem. Pharmacol. , vol.44 , pp. 1977-1984
    • Van De Wiel, J.A.G.1    Meuwissen, M.2    Kooy, H.3    Fijneman, P.H.4    Noordhoek, J.5    Bos, R.P.6
  • 35
    • 0030685054 scopus 로고    scopus 로고
    • Determination of polycyclic aromatic hydrocarbons (PAH) and their metabolites in blood, feces, and urine of rats orally exposed to PAH contaminated soils
    • F.J. Van Schooten, E.J.C. Moonen, L. van der Wal, P. Levels, and J.C.S. Kleinjans Determination of polycyclic aromatic hydrocarbons (PAH) and their metabolites in blood, feces, and urine of rats orally exposed to PAH contaminated soils Arch. Environ. Contam. Toxicol. 33 1997 317 322
    • (1997) Arch. Environ. Contam. Toxicol. , vol.33 , pp. 317-322
    • Van Schooten, F.J.1    Moonen, E.J.C.2    Van Der Wal, L.3    Levels, P.4    Kleinjans, J.C.S.5
  • 36
    • 0023860970 scopus 로고
    • Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of Toadfish (Opsanus tau): In vivo studies using portal vein-catheterized fish
    • P.A. Van Veld, J.S. Patton, and R.F. Lee Effect of preexposure to dietary benzo[a]pyrene (BP) on the first-pass metabolism of BP by the intestine of Toadfish (Opsanus tau) in vivo studies using portal vein-catheterized fish Toxicol. Appl. Pharmacol. 92 1988 255 265
    • (1988) Toxicol. Appl. Pharmacol. , vol.92 , pp. 255-265
    • Van Veld, P.A.1    Patton, J.S.2    Lee, R.F.3
  • 37
    • 0021905619 scopus 로고
    • Coassimilation of dietary fat and benzo[a]pyrene in the small intestine: An absorption model using the killifish
    • R.D. Vetter, M.C. Caray, and J.S. Patton Coassimilation of dietary fat and benzo[a]pyrene in the small intestine an absorption model using the killifish J. Lipid Res. 26 1985 428 434
    • (1985) J. Lipid Res. , vol.26 , pp. 428-434
    • Vetter, R.D.1    Caray, M.C.2    Patton, J.S.3
  • 38
    • 0037026984 scopus 로고    scopus 로고
    • Is 1-hydroxypyrene a reliable bioindicator of measured dietary polycyclic aromatic hydrocarbon under normal conditions?
    • C. Viau, A. Diakite, A. Ruzgyte, B. Tuchweber, C. Blais, M. Bouchard, and A. Vyscocil Is 1-hydroxypyrene a reliable bioindicator of measured dietary polycyclic aromatic hydrocarbon under normal conditions? J. Chromatogr. 778 2002 165 177
    • (2002) J. Chromatogr. , vol.778 , pp. 165-177
    • Viau, C.1    Diakite, A.2    Ruzgyte, A.3    Tuchweber, B.4    Blais, C.5    Bouchard, M.6    Vyscocil, A.7
  • 39
    • 0026135090 scopus 로고
    • Analysis of human exposure to benzo(a)pyrene via inhalation and food ingestion in the total human environmental exposure study [Thesis]
    • J.M. Waldman, P.J. Lioy, A. Greenberg, and J.P. Butler Analysis of human exposure to benzo(a)pyrene via inhalation and food ingestion in the total human environmental exposure study [Thesis] J. Expo. Anal. Environ. Epidemiol. 1 1991 193 225
    • (1991) J. Expo. Anal. Environ. Epidemiol. , vol.1 , pp. 193-225
    • Waldman, J.M.1    Lioy, P.J.2    Greenberg, A.3    Butler, J.P.4


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