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Volumn 36, Issue 2, 2011, Pages 91-97

IL-2: A two-faced master regulator of autoimmunity

Author keywords

Autoimmunity; IL 2; Inflammation; Regulatory T cells; Scurfy; Th cytokines; Trafficking

Indexed keywords

ANTIGEN; GLUTAMATE DECARBOXYLASE; INTERLEUKIN 2; PROINSULIN; RAPAMYCIN;

EID: 79951952929     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.01.001     Document Type: Review
Times cited : (39)

References (46)
  • 1
    • 33745288812 scopus 로고    scopus 로고
    • Emerging possibilities in the development and function of regulatory T cells
    • Wing K., Fehervari Z., Sakaguchi S. Emerging possibilities in the development and function of regulatory T cells. Int Immunol 2006, 18:991-1000.
    • (2006) Int Immunol , vol.18 , pp. 991-1000
    • Wing, K.1    Fehervari, Z.2    Sakaguchi, S.3
  • 2
    • 27144495833 scopus 로고    scopus 로고
    • + regulatory T cells control autoimmunity?
    • + regulatory T cells control autoimmunity?. Curr Opin Immunol 2005, 17:638-642.
    • (2005) Curr Opin Immunol , vol.17 , pp. 638-642
    • Bluestone, J.A.1    Tang, Q.2
  • 3
    • 1242295282 scopus 로고    scopus 로고
    • + immunoregulatory T cells: central players in the arena of peripheral tolerance
    • + immunoregulatory T cells: central players in the arena of peripheral tolerance. Semin Immunol 2004, 16:81-88.
    • (2004) Semin Immunol , vol.16 , pp. 81-88
    • Piccirillo, C.A.1    Shevach, E.M.2
  • 4
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • Sadlack B., Merz H., Schorle H., Schimpl A., Feller A.C., Horak I. Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene. Cell 1993, 75:253-261.
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 5
    • 4744357460 scopus 로고    scopus 로고
    • Overview of interleukin-2 function, production and clinical applications
    • Gaffen S.L., Liu K.D. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004, 28:109-123.
    • (2004) Cytokine , vol.28 , pp. 109-123
    • Gaffen, S.L.1    Liu, K.D.2
  • 6
    • 70249117182 scopus 로고    scopus 로고
    • + T cells in Scurfy mice that display both CD103-dependent and independent inflammation
    • + T cells in Scurfy mice that display both CD103-dependent and independent inflammation. J Immunol 2009, 183:1065-1073.
    • (2009) J Immunol , vol.183 , pp. 1065-1073
    • Sharma, R.1    Sung, S.S.2    Abaya, C.E.3    Ju, A.C.4    Fu, S.M.5    Ju, S.T.6
  • 7
    • 79251554090 scopus 로고    scopus 로고
    • IL-2-controlled expression of multiple T-cell trafficking genes and Th2 cytokines in the regulatory T-cell deficient Scurfy mice: Implication to multi-organ inflammation and control of skin and lung inflammation
    • Sharma R., Sharma P.R., Kim Y.-C., Leitinger N., Lee J.K., Fu S.M., et al. IL-2-controlled expression of multiple T-cell trafficking genes and Th2 cytokines in the regulatory T-cell deficient Scurfy mice: Implication to multi-organ inflammation and control of skin and lung inflammation. J Immunol 2011, 186:1268-1278.
    • (2011) J Immunol , vol.186 , pp. 1268-1278
    • Sharma, R.1    Sharma, P.R.2    Kim, Y.-C.3    Leitinger, N.4    Lee, J.K.5    Fu, S.M.6
  • 9
    • 27544446622 scopus 로고    scopus 로고
    • + regulatory T cells in the absence of interleukin 2 signaling
    • + regulatory T cells in the absence of interleukin 2 signaling. Nat Immunol 2005, 6:1152-1159.
    • (2005) Nat Immunol , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 10
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D., Rasmussen J.P., Gavin M., Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol 2005, 6:1142-1151.
    • (2005) Nat Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.3    Rudensky, A.Y.4
  • 12
    • 37849009964 scopus 로고    scopus 로고
    • A two-step process for thymic regulatory T cell development
    • Lio C.W., Hsueh C.S. A two-step process for thymic regulatory T cell development. Immunity 2008, 28:100-111.
    • (2008) Immunity , vol.28 , pp. 100-111
    • Lio, C.W.1    Hsueh, C.S.2
  • 13
    • 37849008688 scopus 로고    scopus 로고
    • Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire
    • Burchill M.A., Yang J., Vang K.B., Moon J.J., Chu H.H., Lio C.S., et al. Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity 2008, 28:112-121.
    • (2008) Immunity , vol.28 , pp. 112-121
    • Burchill, M.A.1    Yang, J.2    Vang, K.B.3    Moon, J.J.4    Chu, H.H.5    Lio, C.S.6
  • 14
    • 25844504653 scopus 로고    scopus 로고
    • Developmental regulation of Foxp3 expression during ontogeny
    • Fontenot J.D., Dooley J.L., Farr A.G., Rudensky A.Y. Developmental regulation of Foxp3 expression during ontogeny. J Exp Med 2005, 202:901-906.
    • (2005) J Exp Med , vol.202 , pp. 901-906
    • Fontenot, J.D.1    Dooley, J.L.2    Farr, A.G.3    Rudensky, A.Y.4
  • 16
    • 65549123867 scopus 로고    scopus 로고
    • + regulatory T cells: more of the same or a division of labor?
    • + regulatory T cells: more of the same or a division of labor?. Immunity 2009, 30:626-635.
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto de Lafaille, M.A.1    Lafaille, J.J.2
  • 18
    • 0023663430 scopus 로고
    • T cell tolerance by clonal elimination in the thymus
    • Kappler J.W., Roehm N., Marrack P. T cell tolerance by clonal elimination in the thymus. Cell 1987, 49:273-280.
    • (1987) Cell , vol.49 , pp. 273-280
    • Kappler, J.W.1    Roehm, N.2    Marrack, P.3
  • 19
    • 0033025703 scopus 로고    scopus 로고
    • Thymic selection by single MHC-peptide ligand. Autoreactive T cells are low-affinity cells
    • Lee D.-S., Aim C., Ernst B., Sprent J., Surh C.D. Thymic selection by single MHC-peptide ligand. Autoreactive T cells are low-affinity cells. Immunity 1999, 10:83-92.
    • (1999) Immunity , vol.10 , pp. 83-92
    • Lee, D.-S.1    Aim, C.2    Ernst, B.3    Sprent, J.4    Surh, C.D.5
  • 21
    • 78149310029 scopus 로고    scopus 로고
    • A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota
    • Chinen T., Volchkov P.Y., Chervonsky A.V., Rudensky A.Y. A critical role for regulatory T cell-mediated control of inflammation in the absence of commensal microbiota. J Exp Med 2010, 207:2323-2330.
    • (2010) J Exp Med , vol.207 , pp. 2323-2330
    • Chinen, T.1    Volchkov, P.Y.2    Chervonsky, A.V.3    Rudensky, A.Y.4
  • 24
    • 34548680545 scopus 로고    scopus 로고
    • Nonself-antigens are the cognate specificities of Foxp3 regulatory T cells
    • Pacholczyk R., Kem J., Singh N., Iwashima M., Kraj P., Ignatowicz L. Nonself-antigens are the cognate specificities of Foxp3 regulatory T cells. Immunity 2007, 27:493-504.
    • (2007) Immunity , vol.27 , pp. 493-504
    • Pacholczyk, R.1    Kem, J.2    Singh, N.3    Iwashima, M.4    Kraj, P.5    Ignatowicz, L.6
  • 27
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • Malek T.R., Yu A., Vincek V., Scibelli P., Kong L. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2. Immunity 2002, 17:167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 28
    • 0348047537 scopus 로고    scopus 로고
    • The main function of IL-2 is to promote the development of T regulatory cells
    • Malek T.R. The main function of IL-2 is to promote the development of T regulatory cells. J Leuk Biol 2003, 74:961-965.
    • (2003) J Leuk Biol , vol.74 , pp. 961-965
    • Malek, T.R.1
  • 29
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • Malek T.R., Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 2004, 4:665-674.
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 30
    • 41949097030 scopus 로고    scopus 로고
    • The biology of IL-2
    • Malek T.R. The biology of IL-2. Annu Rev Immunol 2008, 26:453-479.
    • (2008) Annu Rev Immunol , vol.26 , pp. 453-479
    • Malek, T.R.1
  • 33
    • 40049092674 scopus 로고    scopus 로고
    • A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms
    • Zheng L., Sharma R., Gaskin F., Fu S.M., Ju S.T. A novel role of IL-2 in organ-specific autoimmune inflammation beyond regulatory T cell checkpoint: both IL-2 knockout and Fas mutation prolong lifespan of Scurfy mice but by different mechanisms. J Immunol 2007, 179:8035-8041.
    • (2007) J Immunol , vol.179 , pp. 8035-8041
    • Zheng, L.1    Sharma, R.2    Gaskin, F.3    Fu, S.M.4    Ju, S.T.5
  • 34
    • 42649137213 scopus 로고    scopus 로고
    • T cell trafficking in allergic asthma: the ins and outs
    • Medoff B.D., Thomas S.Y., Luster A.D. T cell trafficking in allergic asthma: the ins and outs. Annu Rev Immunol 2008, 26:205-232.
    • (2008) Annu Rev Immunol , vol.26 , pp. 205-232
    • Medoff, B.D.1    Thomas, S.Y.2    Luster, A.D.3
  • 35
    • 67650469526 scopus 로고    scopus 로고
    • Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mice
    • Kamanaka M., Rainbow D., Schuster-Gossler K., Eynon E.E., Chervonsky A.V., Wicker L.S., et al. Amino acid polymorphisms altering the glycosylation of IL-2 do not protect from type 1 diabetes in the NOD mice. Proc Nat Acad Sci USA 2009, 106:11236-11240.
    • (2009) Proc Nat Acad Sci USA , vol.106 , pp. 11236-11240
    • Kamanaka, M.1    Rainbow, D.2    Schuster-Gossler, K.3    Eynon, E.E.4    Chervonsky, A.V.5    Wicker, L.S.6
  • 36
    • 2442496304 scopus 로고    scopus 로고
    • An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T-cells
    • Vijayakrishnan L., Slavik J.M., Illes Z., Greenwald R.J., Rainbow D., Greve B., et al. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T-cells. Immunity 2004, 20:563-575.
    • (2004) Immunity , vol.20 , pp. 563-575
    • Vijayakrishnan, L.1    Slavik, J.M.2    Illes, Z.3    Greenwald, R.J.4    Rainbow, D.5    Greve, B.6
  • 38
    • 0024795364 scopus 로고
    • Immunostimulation circumvents diabetes in NOD/Lt mice
    • Serreze D.V., Hamaguchi K., Leiter E.H. Immunostimulation circumvents diabetes in NOD/Lt mice. J Autoimm 1989, 2:759-776.
    • (1989) J Autoimm , vol.2 , pp. 759-776
    • Serreze, D.V.1    Hamaguchi, K.2    Leiter, E.H.3
  • 39
    • 77956257716 scopus 로고    scopus 로고
    • IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells
    • Grinberg-Bleyer Y., Baeyens A., You S., Elhage R., Fourcade G., Gregoire S., et al. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. J Exp Med 2010, 207:1871-1878.
    • (2010) J Exp Med , vol.207 , pp. 1871-1878
    • Grinberg-Bleyer, Y.1    Baeyens, A.2    You, S.3    Elhage, R.4    Fourcade, G.5    Gregoire, S.6
  • 40
    • 26844450449 scopus 로고    scopus 로고
    • How defects in central tolerance impinge on a deficiency in regulatory T cells
    • Chen Z., Benoist C., Mathis D. How defects in central tolerance impinge on a deficiency in regulatory T cells. Proc Nat Acad Sci USA 2005, 102:14735-14740.
    • (2005) Proc Nat Acad Sci USA , vol.102 , pp. 14735-14740
    • Chen, Z.1    Benoist, C.2    Mathis, D.3
  • 42
    • 77954310457 scopus 로고    scopus 로고
    • Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice
    • Sharma R., Ju S.T. Genetic control of the inflammatory T-cell response in regulatory T-cell deficient scurfy mice. Clin Immunol 2010, 136:162-169.
    • (2010) Clin Immunol , vol.136 , pp. 162-169
    • Sharma, R.1    Ju, S.T.2
  • 43
    • 34249933446 scopus 로고    scopus 로고
    • Tracing the action of IL-2 in tolerance to islet-specific antigen
    • Liston A., Siggs O.M., Goodnow C.C. Tracing the action of IL-2 in tolerance to islet-specific antigen. Immunol Cell Biol 2007, 85:338-342.
    • (2007) Immunol Cell Biol , vol.85 , pp. 338-342
    • Liston, A.1    Siggs, O.M.2    Goodnow, C.C.3
  • 44
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q., Henriksen K.J., Bi M., Finger E.B., Szot G., Ye J., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 2004, 199:1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6
  • 45
    • 79951946676 scopus 로고    scopus 로고
    • A phase I trial of Proleukin and Rapamune in recent-onset type 1 diabetes mellitus. ClinicalTrials.gov (received 9/4/2007, updated on 12/10/2010, accessed on 1/19/2011).
    • Greenbaum C. A phase I trial of Proleukin and Rapamune in recent-onset type 1 diabetes mellitus. ClinicalTrials.gov (received 9/4/2007, updated on 12/10/2010, accessed on 1/19/2011).
    • Greenbaum, C.1
  • 46
    • 79151474882 scopus 로고    scopus 로고
    • Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens
    • Dromey J.A., Lee B.H., Yu H., Young H.E., Thearle D.J., Jensen K.P., et al. Generation and expansion of regulatory human CD4(+) T-cell clones specific for pancreatic islet autoantigens. J Autoimm 2011, 36:47-55.
    • (2011) J Autoimm , vol.36 , pp. 47-55
    • Dromey, J.A.1    Lee, B.H.2    Yu, H.3    Young, H.E.4    Thearle, D.J.5    Jensen, K.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.