Detoxification of ammonia in mouse cortical GABAergic cell cultures increases neuronal oxidative metabolism and reveals an emerging role for release of glucose-derived alanine

Neurotoxicity Research

Volumn 19, Issue 3, 2011, Pages 496-510

  Leke, Renata ^a,b   Bak, Lasse K ^b   Anker, Malene ^b   Melø, Torun M ^c   Sørensen, Michael ^d   Keiding, Susanne ^d   Vilstrup, Hendrik ^d   Ott, Peter ^d   Portela, Luis V ^a   Sonnewald, Ursula ^c   Schousboe, Arne ^b   Waagepetersen, Helle S ^b  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^d AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Alanine; Ammonia; Energy; Glucose; Glutamine; Hepatic encephalopathy; Lactate

Indexed keywords

3 HYDROXYBUTYRIC ACID; 4 AMINOBUTYRIC ACID; ALANINE; AMMONIUM CHLORIDE; ASPARTIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; LACTIC ACID;

AEROBIC METABOLISM; AMINO ACID SYNTHESIS; ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN NERVE CELL; CITRIC ACID CYCLE; COCULTURE; CONTROLLED STUDY; DETOXIFICATION; DRUG EXPOSURE; ENERGY METABOLISM; GABAERGIC SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALANINE; AMMONIA; ANIMALS; CELLS, CULTURED; CEREBRAL CORTEX; COCULTURE TECHNIQUES; GAMMA-AMINOBUTYRIC ACID; GLUCOSE; MICE; NEURONS; OXIDATIVE STRESS;

EID: 79951948409     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12640-010-9198-7     Document Type: Article

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