메뉴 건너뛰기




Volumn 47, Issue 1-2 SPEC. ISS., 2005, Pages 39-50

Ammonia toxicity under hyponatremic conditions in astrocytes: De novo synthesis of amino acids for the osmoregulatory response

Author keywords

Alanine; Ammonia; Astrocytes; Cell swelling; Energy metabolism; Glutamine; Hyponatremia; Myo inositol; NMR spectroscopy

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALANINE; AMINO ACID; AMMONIA; CHOLINE; GLUCOSE; GLUTAMINE; GLUTATHIONE; HYPOTAURINE; INOSITOL;

EID: 20544474654     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2005.04.005     Document Type: Article
Times cited : (16)

References (77)
  • 2
    • 0041322883 scopus 로고    scopus 로고
    • Glucose-derived osmolytes and energy impairment in brain edema accompanying liver failure: The role of glutamine reevaluated
    • J. Albrecht Glucose-derived osmolytes and energy impairment in brain edema accompanying liver failure: the role of glutamine reevaluated Gastroenterology 125 2003 976 978
    • (2003) Gastroenterology , vol.125 , pp. 976-978
    • Albrecht, J.1
  • 5
    • 84989509425 scopus 로고
    • Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis
    • A.T. Blei, S. Olafsson, G. Therrien, and R.F. Butterworth Ammonia-induced brain edema and intracranial hypertension in rats after portacaval anastomosis Hepatology 19 1994 1437 1444
    • (1994) Hepatology , vol.19 , pp. 1437-1444
    • Blei, A.T.1    Olafsson, S.2    Therrien, G.3    Butterworth, R.F.4
  • 6
    • 0031595057 scopus 로고    scopus 로고
    • 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy
    • 31P magnetic resonance spectroscopy reveals osmotic and metabolic disturbances in human hepatic encephalopathy J. Neurochem. 71 1998 1564 1576
    • (1998) J. Neurochem. , vol.71 , pp. 1564-1576
    • Bluml, S.1    Zuckerman, E.2    Tan, J.3    Ross, B.D.4
  • 8
    • 0026615180 scopus 로고
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells
    • 13C NMR study on fluxes into the TCA cycle of neuronal and glial tumor cell lines and primary cells Biochimie 74 1992 941 948
    • (1992) Biochimie , vol.74 , pp. 941-948
    • Brand, A.1    Engelmann, J.2    Leibfritz, D.3
  • 9
    • 0027749707 scopus 로고
    • Multinuclear NMR studies on the energy metabolism of glial and neuronal cells
    • A. Brand, C. Richter-Landsberg, and D. Leibfritz Multinuclear NMR studies on the energy metabolism of glial and neuronal cells Dev. Neurosci. 15 1993 289 298
    • (1993) Dev. Neurosci. , vol.15 , pp. 289-298
    • Brand, A.1    Richter-Landsberg, C.2    Leibfritz, D.3
  • 11
    • 0036988606 scopus 로고    scopus 로고
    • Pathophysiology of hepatic encephalopathy: A new look at ammonia
    • R.F. Butterworth Pathophysiology of hepatic encephalopathy: a new look at ammonia Metab. Brain Dis. 17 2002 221 227
    • (2002) Metab. Brain Dis. , vol.17 , pp. 221-227
    • Butterworth, R.F.1
  • 14
  • 15
    • 0023277382 scopus 로고
    • Biochemistry and physiology of brain ammonia
    • A.J. Cooper, and F. Plum Biochemistry and physiology of brain ammonia Physiol. Rev. 67 1987 440 519
    • (1987) Physiol. Rev. , vol.67 , pp. 440-519
    • Cooper, A.J.1    Plum, F.2
  • 16
    • 0030460773 scopus 로고    scopus 로고
    • Brain edema and hepatic encephalopathy
    • J. Cordoba, and A.T. Blei Brain edema and hepatic encephalopathy Semin. Liver Dis. 16 1996 271 280
    • (1996) Semin. Liver Dis. , vol.16 , pp. 271-280
    • Cordoba, J.1    Blei, A.T.2
  • 17
    • 0029827933 scopus 로고    scopus 로고
    • Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: Implications for ammonia-induced brain edema
    • J. Cordoba, J. Gottstein, and A.T. Blei Glutamine, myo-inositol, and organic brain osmolytes after portocaval anastomosis in the rat: implications for ammonia-induced brain edema Hepatology 24 1996 919 923
    • (1996) Hepatology , vol.24 , pp. 919-923
    • Cordoba, J.1    Gottstein, J.2    Blei, A.T.3
  • 18
    • 0032190949 scopus 로고    scopus 로고
    • Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis
    • J. Cordoba, J. Gottstein, and A.T. Blei Chronic hyponatremia exacerbates ammonia-induced brain edema in rats after portacaval anastomosis J. Hepatol. 29 1998 589 594
    • (1998) J. Hepatol. , vol.29 , pp. 589-594
    • Cordoba, J.1    Gottstein, J.2    Blei, A.T.3
  • 19
    • 0033233212 scopus 로고    scopus 로고
    • 13C NMR studies of metabolic compartmentation in the adult mammalian brain
    • 13C NMR studies of metabolic compartmentation in the adult mammalian brain NMR Biomed. 12 1999 451 462
    • (1999) NMR Biomed. , vol.12 , pp. 451-462
    • Cruz, F.1    Cerdan, S.2
  • 20
    • 0038636003 scopus 로고    scopus 로고
    • Glutathione pathways in the brain
    • R. Dringen, and J. Hirrlinger Glutathione pathways in the brain Biol. Chem. 384 2003 505 516
    • (2003) Biol. Chem. , vol.384 , pp. 505-516
    • Dringen, R.1    Hirrlinger, J.2
  • 21
    • 0028343853 scopus 로고
    • Cerebral alanine transport and alanine aminotransferase reaction: Alanine as a source ofneuronal glutamate
    • M. Erecinska, D. Nelson, I. Nissim, Y. Daikhin, and M. Yudkoff Cerebral alanine transport and alanine aminotransferase reaction: alanine as a source ofneuronal glutamate J. Neurochem. 62 1994 1953 1964
    • (1994) J. Neurochem. , vol.62 , pp. 1953-1964
    • Erecinska, M.1    Nelson, D.2    Nissim, I.3    Daikhin, Y.4    Yudkoff, M.5
  • 22
    • 0029160798 scopus 로고
    • Changes in organic solutes, volume, energy state, and metabolism associated with osmotic stress in a glial cell line: A multinuclear NMR study
    • U. Flögel, T. Niendorf, N. Serkowa, A. Brand, J. Henke, and D. Leibfritz Changes in organic solutes, volume, energy state, and metabolism associated with osmotic stress in a glial cell line: a multinuclear NMR study Neurochem. Res. 20 1995 793 802
    • (1995) Neurochem. Res. , vol.20 , pp. 793-802
    • Flögel, U.1    Niendorf, T.2    Serkowa, N.3    Brand, A.4    Henke, J.5    Leibfritz, D.6
  • 25
    • 77049162117 scopus 로고
    • A micro biuret method for protein determination
    • J. Goa A micro biuret method for protein determination Scand. J. Clin. Lab. Invest. 5 1953 218 222
    • (1953) Scand. J. Clin. Lab. Invest. , vol.5 , pp. 218-222
    • Goa, J.1
  • 26
    • 2442655404 scopus 로고    scopus 로고
    • Management of hyponatremia
    • K.P. Goh Management of hyponatremia Am. Fam. Physician 69 2004 2387 2394
    • (2004) Am. Fam. Physician , vol.69 , pp. 2387-2394
    • Goh, K.P.1
  • 27
  • 28
  • 29
    • 1442289613 scopus 로고    scopus 로고
    • Magnetic resonance imaging and spectroscopy in hepatic encephalopathy
    • R.K. Gupta, and R.K. Dhiman Magnetic resonance imaging and spectroscopy in hepatic encephalopathy Indian J. Gastroenterol. 22 Suppl. 2 2003 45 S49
    • (2003) Indian J. Gastroenterol. , vol.22 , Issue.2 SUPPL.
    • Gupta, R.K.1    Dhiman, R.K.2
  • 30
    • 0028037077 scopus 로고
    • Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy
    • D. Haussinger, J. Laubenberger, S. vom Dahl, T. Ernst, S. Bayer, M. Langer, W. Gerok, and J. Hennig Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy Gastroenterology 107 1994 1475 1480
    • (1994) Gastroenterology , vol.107 , pp. 1475-1480
    • Haussinger, D.1    Laubenberger, J.2    Vom Dahl, S.3    Ernst, T.4    Bayer, S.5    Langer, M.6    Gerok, W.7    Hennig, J.8
  • 31
    • 0027474144 scopus 로고
    • Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy
    • R.A. Hawkins, J. Jessy, A.M. Mans, and M.R. De Joseph Effect of reducing brain glutamine synthesis on metabolic symptoms of hepatic encephalopathy J. Neurochem. 60 1993 1000 1006
    • (1993) J. Neurochem. , vol.60 , pp. 1000-1006
    • Hawkins, R.A.1    Jessy, J.2    Mans, A.M.3    De Joseph, M.R.4
  • 33
    • 0015071855 scopus 로고
    • Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy
    • B.T. Hourani, E.M. Hamlin, and T.B. Reynolds Cerebrospinal fluid glutamine as a measure of hepatic encephalopathy Arch. Int. Med. 127 1971 1033 1036
    • (1971) Arch. Int. Med. , vol.127 , pp. 1033-1036
    • Hourani, B.T.1    Hamlin, E.M.2    Reynolds, T.B.3
  • 35
    • 0030882563 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy in the study of hyperammonemia and hepatic encephalopathy
    • K. Kanamori, S. Bluml, and B. Ross Magnetic resonance spectroscopy in the study of hyperammonemia and hepatic encephalopathy Adv. Exp. Med. Biol. 420 1997 185 194
    • (1997) Adv. Exp. Med. Biol. , vol.420 , pp. 185-194
    • Kanamori, K.1    Bluml, S.2    Ross, B.3
  • 36
    • 0026601109 scopus 로고
    • Carbon dioxide fixation in neuronal and astroglial cells in culture
    • E.E. Kaufmann, and B.F. Driscoll Carbon dioxide fixation in neuronal and astroglial cells in culture J. Neurochem. 58 1992 258 262
    • (1992) J. Neurochem. , vol.58 , pp. 258-262
    • Kaufmann, E.E.1    Driscoll, B.F.2
  • 37
    • 0026149236 scopus 로고
    • 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols
    • 1H NMR spectroscopy in patients with chronic hepatic encephalopathy. Analysis of changes in cerebral glutamine, choline and inositols NMR Biomed. 4 1991 109 116
    • (1991) NMR Biomed. , vol.4 , pp. 109-116
    • Kreis, R.1    Farrow, N.2    Ross, B.D.3
  • 39
    • 0031018960 scopus 로고    scopus 로고
    • 15N coupling patterns and isotopic shifts
    • 15N coupling patterns and isotopic shifts Eur. J. Biochem. 243 1997 597 604
    • (1997) Eur. J. Biochem. , vol.243 , pp. 597-604
    • Lapidot, A.1    Gopher, A.2
  • 40
    • 0035062328 scopus 로고    scopus 로고
    • Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema
    • F.S. Larsen, J. Gottstein, and A.T. Blei Cerebral hyperemia and nitric oxide synthase in rats with ammonia-induced brain edema J. Hepatol. 34 2001 548 554
    • (2001) J. Hepatol. , vol.34 , pp. 548-554
    • Larsen, F.S.1    Gottstein, J.2    Blei, A.T.3
  • 41
    • 0023515075 scopus 로고
    • Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy
    • J. Lavoie, J.F. Giguere, G.P. Layrargues, and R.F. Butterworth Activities of neuronal and astrocytic marker enzymes in autopsied brain tissue from patients with hepatic encephalopathy Metab. Brain Dis. 2 1987 283 290
    • (1987) Metab. Brain Dis. , vol.2 , pp. 283-290
    • Lavoie, J.1    Giguere, J.F.2    Layrargues, G.P.3    Butterworth, R.F.4
  • 42
    • 1542673293 scopus 로고    scopus 로고
    • Taurine counteracts cell swelling in rat cerebrocortical slices exposed to ammonia in vitro and in vivo
    • R.O. Law, M. Zielinska, and J. Albrecht Taurine counteracts cell swelling in rat cerebrocortical slices exposed to ammonia in vitro and in vivo Adv. Exp. Med. Biol. 526 2003 123 129
    • (2003) Adv. Exp. Med. Biol. , vol.526 , pp. 123-129
    • Law, R.O.1    Zielinska, M.2    Albrecht, J.3
  • 43
    • 0028020080 scopus 로고
    • Metabolic abnormalities and grade of encephalopathy in acute hepatic failure
    • A.M. Mans, M.R. De Joseph, and R.A. Hawkins Metabolic abnormalities and grade of encephalopathy in acute hepatic failure J. Neurochem. 63 1994 1829 1838
    • (1994) J. Neurochem. , vol.63 , pp. 1829-1838
    • Mans, A.M.1    De Joseph, M.R.2    Hawkins, R.A.3
  • 45
    • 0034257048 scopus 로고    scopus 로고
    • Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes
    • C.R. Murthy, A.S. Bender, R.S. Dombro, G. Bai, and M.D. Norenberg Elevation of glutathione levels by ammonium ions in primary cultures of rat astrocytes Neurochem. Int. 37 2000 255 268
    • (2000) Neurochem. Int. , vol.37 , pp. 255-268
    • Murthy, C.R.1    Bender, A.S.2    Dombro, R.S.3    Bai, G.4    Norenberg, M.D.5
  • 46
    • 0035888288 scopus 로고    scopus 로고
    • Ammonia-induced production of free radicals in primary cultures of rat astrocytes
    • C.-R. Murthy, K.-V. Rama Rao, G. Bai, and M.-D. Norenberg Ammonia-induced production of free radicals in primary cultures of rat astrocytes J. Neurosci. Res. 66 2001 282 288
    • (2001) J. Neurosci. Res. , vol.66 , pp. 282-288
    • Murthy, C.-R.1    Rama Rao, K.-V.2    Bai, G.3    Norenberg, M.-D.4
  • 47
    • 0027161389 scopus 로고
    • Neuronal-glial exchange of taurine during hypo-osmotic stress: A combined immunocytochemical and biochemical analysis in rat cerebellar cortex
    • E.A. Nagelhus, A. Lehmann, and O.P. Ottersen Neuronal-glial exchange of taurine during hypo-osmotic stress: a combined immunocytochemical and biochemical analysis in rat cerebellar cortex Neuroscience 54 1993 615 631
    • (1993) Neuroscience , vol.54 , pp. 615-631
    • Nagelhus, E.A.1    Lehmann, A.2    Ottersen, O.P.3
  • 49
    • 0018382256 scopus 로고
    • Fine structural localization of glutamine synthetase in astrocytes of rat brain
    • M.-D. Norenberg, and A. Martinez-Hernandez Fine structural localization of glutamine synthetase in astrocytes of rat brain Brain Res. 161 1979 303 310
    • (1979) Brain Res. , vol.161 , pp. 303-310
    • Norenberg, M.-D.1    Martinez-Hernandez, A.2
  • 51
    • 0028321104 scopus 로고
    • Astrocyte swelling in liver failure. Role of glutamine and benzodiazepines
    • M.D. Norenberg, and A.S. Bender Astrocyte swelling in liver failure. Role of glutamine and benzodiazepines Acta Neurochir 60 Suppl. 1994 24 27
    • (1994) Acta Neurochir , vol.60 , Issue.SUPPL. , pp. 24-27
    • Norenberg, M.D.1    Bender, A.S.2
  • 52
    • 0032427875 scopus 로고    scopus 로고
    • Astroglial dysfunction in hepatic encephalopathy
    • M.D. Norenberg Astroglial dysfunction in hepatic encephalopathy Metab. Brain Dis. 13 1998 319 335
    • (1998) Metab. Brain Dis. , vol.13 , pp. 319-335
    • Norenberg, M.D.1
  • 54
  • 56
    • 0038509984 scopus 로고    scopus 로고
    • Ammonia neurotoxicity: Role of the mitochondrial permeability transition
    • K.V. Rama Rao, A.R. Jayakumar, and M.D. Norenberg Ammonia neurotoxicity: role of the mitochondrial permeability transition Metab. Brain Dis. 18 2003 113 127
    • (2003) Metab. Brain Dis. , vol.18 , pp. 113-127
    • Rama Rao, K.V.1    Jayakumar, A.R.2    Norenberg, M.D.3
  • 57
    • 0034050921 scopus 로고    scopus 로고
    • Contribution of anion transporters to the acidosis-induced swelling and intracellular acidification of glial cells
    • F. Ringel, R.C.C. Chang, F. Staub, A. Baethamnn, and N. Plesnila Contribution of anion transporters to the acidosis-induced swelling and intracellular acidification of glial cells J. Neurochem. 75 2000 125 132
    • (2000) J. Neurochem. , vol.75 , pp. 125-132
    • Ringel, F.1    Chang, R.C.C.2    Staub, F.3    Baethamnn, A.4    Plesnila, N.5
  • 58
    • 0021988603 scopus 로고
    • Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools
    • R.P. Shank, G.-S. Bennett, S.O. Freytag, and G.L. Campbell Pyruvate carboxylase: An astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools Brain Res. 329 1986 364 367
    • (1986) Brain Res. , vol.329 , pp. 364-367
    • Shank, R.P.1    Bennett, G.-S.2    Freytag, S.O.3    Campbell, G.L.4
  • 60
    • 0026516232 scopus 로고
    • Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats
    • M. Swain, R.F. Butterworth, and A.T. Blei Ammonia and related amino acids in the pathogenesis of brain edema in acute ischemic liver failure in rats Hepatology 15 1992 449 453
    • (1992) Hepatology , vol.15 , pp. 449-453
    • Swain, M.1    Butterworth, R.F.2    Blei, A.T.3
  • 61
    • 0026004760 scopus 로고
    • Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats
    • H. Takahashi, R.C. Koehler, S.W. Brusilow, and R.J. Traystman Inhibition of brain glutamine accumulation prevents cerebral edema in hyperammonemic rats Am. J. Physiol. 261 1991 H825 H829
    • (1991) Am. J. Physiol. , vol.261
    • Takahashi, H.1    Koehler, R.C.2    Brusilow, S.W.3    Traystman, R.J.4
  • 62
    • 0032882570 scopus 로고    scopus 로고
    • Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy
    • S.D. Taylor-Robinson, C. Buckley, K.K. Changani, H.J. Hodgson, and J.D. Bell Cerebral proton and phosphorus-31 magnetic resonance spectroscopy in patients with subclinical hepatic encephalopathy Liver 19 1999 389 398
    • (1999) Liver , vol.19 , pp. 389-398
    • Taylor-Robinson, S.D.1    Buckley, C.2    Changani, K.K.3    Hodgson, H.J.4    Bell, J.D.5
  • 69
    • 0021037707 scopus 로고
    • Pyruvate carboxylase activity in primary cultures of astrocytes and neurons
    • A.C. Yu, J. Drejer, L. Hertz, and A. Schousboe Pyruvate carboxylase activity in primary cultures of astrocytes and neurons J. Neurochem. 41 1983 1484 1487
    • (1983) J. Neurochem. , vol.41 , pp. 1484-1487
    • Yu, A.C.1    Drejer, J.2    Hertz, L.3    Schousboe, A.4
  • 70
    • 0345355142 scopus 로고    scopus 로고
    • Effects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical minislices: Influence of inhibitors of volume-sensitive amino acid transport
    • M. Zielinska, W. Hilgier, R.O. Law, P. Gorynski, and J. Albrecht Effects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical minislices: influence of inhibitors of volume-sensitive amino acid transport Neuroscience 91 1999 631 638
    • (1999) Neuroscience , vol.91 , pp. 631-638
    • Zielinska, M.1    Hilgier, W.2    Law, R.O.3    Gorynski, P.4    Albrecht, J.5
  • 71
  • 72
    • 0033672168 scopus 로고    scopus 로고
    • Effects of ammonia exposition on glioma cells: Changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy
    • C. Zwingmann, U. Flogel, J. Pfeuffer, and D. Leibfritz Effects of ammonia exposition on glioma cells: changes in cell volume and organic osmolytes studied by diffusion-weighted and high-resolution NMR spectroscopy Dev. Neurosci. 22 2000 463 471
    • (2000) Dev. Neurosci. , vol.22 , pp. 463-471
    • Zwingmann, C.1    Flogel, U.2    Pfeuffer, J.3    Leibfritz, D.4
  • 73
    • 0033673044 scopus 로고    scopus 로고
    • NMR spectroscopic study on the metabolic fate of [3-(13)C]alanine in astrocytes, neurons, and cocultures: Implications for glia-neuron interactions in neurotransmitter metabolism
    • C. Zwingmann, C. Richter-Landsberg, A. Brand, and D. Leibfritz NMR spectroscopic study on the metabolic fate of [3-(13)C]alanine in astrocytes, neurons, and cocultures: implications for glia-neuron interactions in neurotransmitter metabolism Glia 32 2000 286 303
    • (2000) Glia , vol.32 , pp. 286-303
    • Zwingmann, C.1    Richter-Landsberg, C.2    Brand, A.3    Leibfritz, D.4
  • 75
    • 0038457946 scopus 로고    scopus 로고
    • Energy metabolism in astrocytes and neurons treated with manganese: Relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis
    • C. Zwingmann, D. Leibfritz, and A.S. Hazell Energy metabolism in astrocytes and neurons treated with manganese: relation among cell-specific energy failure, glucose metabolism, and intercellular trafficking using multinuclear NMR-spectroscopic analysis J. Cereb. Blood Flow Metab. 23 2003 756 771
    • (2003) J. Cereb. Blood Flow Metab. , vol.23 , pp. 756-771
    • Zwingmann, C.1    Leibfritz, D.2    Hazell, A.S.3
  • 77
    • 1642513500 scopus 로고    scopus 로고
    • Selective alterations of brain osmolytes in acute liver failure: Protective effect of mild hypothermia
    • C. Zwingmann, N. Chatauret, C. Rose, D. Leibfritz, and R.F. Butterworth Selective alterations of brain osmolytes in acute liver failure: protective effect of mild hypothermia Brain Res. 999 2004 118 123
    • (2004) Brain Res. , vol.999 , pp. 118-123
    • Zwingmann, C.1    Chatauret, N.2    Rose, C.3    Leibfritz, D.4    Butterworth, R.F.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.