Replication of genetic variants from genome-wide association studies with metabolic traits in an island population of the Adriatic coast of Croatia

European Journal of Human Genetics

Volumn 19, Issue 3, 2011, Pages 341-346

  Karns, Rebekah ^a   Zhang, Ge ^a   Jeran, Nina ^b   Havas Augustin, Dubravka ^b   Missoni, Sasa ^b   Niu, Wen ^a   Indugula, Subba Rao ^a   Sun, Guangyun ^a   Durakovic, Zijad ^b   Narancic, Nina Smolej ^b   Rudan, Pavao ^b   Chakraborty, Ranajit ^c   Deka, Ranjan ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b INSTITUTE FOR ANTHROPOLOGICAL RESEARCH   (Croatia)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

FTO; genetic association; isolated population; obesity; TCF7L2; type 2 diabetes

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; FIBRINOGEN; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSCRIPTION FACTOR 7 LIKE 2;

ADULT; AGED; ARTICLE; BODY MASS; BODY WEIGHT; CROATIA; FEMALE; FIBRINOGEN BLOOD LEVEL; FTO GENE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HIP; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MC4R GENE; METABOLIC PARAMETERS; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ADULT; AGED; BODY MASS INDEX; BODY WEIGHT; CROATIA; DIABETES MELLITUS, TYPE 2; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GEOGRAPHY; HUMANS; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; POPULATION GROUPS; PROTEINS; TRANSCRIPTION FACTOR 7-LIKE 2 PROTEIN; WAIST CIRCUMFERENCE;

EID: 79951812460     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/ejhg.2010.178     Document Type: Article

References (34)

1. Sladek R, Rocheleau G, Rung J et al: A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445: 881-885.
2. Scott LJ, Mohlke KL, Bonnycastle LL et al: A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316: 1341-1345. (Pubitemid 46871655)
3. Diabetes Genetics Initiative of Broad Institute of Harvard and MIT, Lund University, and Novartis Institutes of BioMedical Research: Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316: 1331-1336.
4. Zeggini E, Weedon MN, Lindgren CM et al: Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316: 1336-1341. (Pubitemid 46871654)
5. Steinthorsdottir V, Thorleifsson G, Reynisdottir I et al: A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. Nat Genet 2007; 39: 770-775. (Pubitemid 46848592)
6. Gudmundsson J, Sulem P, Steinthorsdottir V et al: Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type-2 diabetes. Nat Genet 2007; 39: 977-983. (Pubitemid 47185170)
7. The Wellcome Trust Case Control Consortium: Genome-wide association study of 14 000 cases of seven common diseases and 3 000 shared controls. Nature 2007; 447: 661-678.
8. Herbert A, Gerry NP, McQueen MB et al: A common genetic variant is associated with adult and childhood obesity. Science 2006; 312: 279-283.
9. Frayling TM, Timpson NJ, Weedon MN et al: A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-894. (Pubitemid 46764279)
10. Dina C, Meyre D, Gallina S et al: Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 2007; 39: 724-726. (Pubitemid 46848595)
11. Hinney A, Nguyen TT, Scherag A et al: Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2007; 2: e1361.
12. Loos RJ, Lindgren CM, Li S et al: Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 2008; 40: 768-775. (Pubitemid 351748863)
13. Chambers JC, Elliott P, Zabaneh D et al: Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 2008; 40: 716-718. (Pubitemid 351748872)
14. Thorleifsson G, Walters GB, Gudbjartsson DF et al: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41: 18-24.
15. Frayling TM: Genome-wide association studies provide new insights into type 2 diabetes aetiology. Nat Rev Genet 2007; 8: 657-662. (Pubitemid 47281993)
16. Zeggini E, Scott LJ, Saxena R et al: Meta-analysis of genome-wide association data and large-scale replication idenitifies additional susceptibility loci for type 2 diabetes. Nat Genet 2008; 40: 638-645. (Pubitemid 351601209)
17. Rudan P, Roberts DF, Sujoldzic A et al: Strategy of anthropological research on the island of Hvar. Coll Anthropologicum 1982; 6: 39-46. (Pubitemid 12036528)
18. Rudan P, Sujoldzic, Simic D et al: Population structure in eastern Adriatic: the influence of historical processes, migration patterns, isolation and ecological pressures, and their interaction. in Roberts DF, Fujiki N, Torizuka K (eds): Isolation, Migration and Health. Cambridge University Press: Cambridge (SSHB), 1992, pp 204-218.
19. Smolej-Narancic N, Zagar I: Overweight and fatness in Dalmatia, Croatia: comparison with the US population reference. Coll Antropol 2000; 24: 411-421.
20. Rudan I, Rudan D, Campbell H et al: Inbreeding and risk of late onset complex disease. J Med Genet 2003; 40: 925-932. (Pubitemid 38117544)
21. Pucarin-Cvetkovic J, Mustajbegovic J, Jelinic JD et al: Body mass index and nutrition as determinants of health and disease in population of Croatian Adriatic islands. Croat Med J 2006; 47: 619-626. (Pubitemid 44285489)
22. Pal P, Xi H, Sun G et al: Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. Hum Genet 2007; 122: 251-259. (Pubitemid 47616533)
23. National Institutes of Health: Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Institutes of Health, NIH Publication No 01-3670, Bethesda, MD, 2001.
24. International Diabetes Federation: The IDF consensus worldwide definition of the metabolic syndrome. April 2005, http://www.idf.org/webdata/docs/ MetSyndrome- Final.pdf.
25. Scuteri A, Sanna S, Chen WM et al: Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 2007; 3: e115.
26. Grant SF, Li M, Bradfield JP et al: Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 2008; 3: e1746.
27. Price RA, Li W-D, Zhao H: FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. BMC Med Genet 2008; 9: 4.
28. Willer CJ, Speliotes EK, Loos RJ et al: Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
29. Zhang G, Karns R, Narancic NS et al: Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. PLoS One 2010; 5: e10375.
30. Grant SF, Thorleifsson G, Reynisdottir I et al: Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes. Nat Genet 2006; 38: 320-323.
31. Cauchi S, El Achhab Y, Choquet H et al: TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis. J Mol Med 2007; 85: 777-782. (Pubitemid 47063530)
32. Tong Y, Lin Y, Zhang Y et al: Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large human genome epidemiology (HuGE) review and meta-analysis. BMC Med Genet 2009; 10: 15.
33. Altshuler D, Hirschhorn JN, Klannemark M et al: The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 2000; 26: 76-80.
34. Lyon HN, Emilsson V, Hinney A et al: The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts. PLoS Genet 2007; 3: e61.