Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia

PLoS ONE

Volumn 5, Issue 4, 2010, Pages

  Zhang, Ge ^a   Karns, Rebekah ^a   Narancic, Nina Smolej ^b   Sun, Guangyun ^a   Cheng, Hong ^a   Missoni, Sasa ^b   Durakovic, Zijad ^b   Rudan, Pavao ^b   Chakraborty, Ranajit ^c   Deka, Ranjan ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b INSTITUTE FOR ANTHROPOLOGICAL RESEARCH   (Croatia)

^c UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ANTHROPOMETRIC PARAMETERS; ARM CIRCUMFERENCE; ARTICLE; BODY FAT; BODY HEIGHT; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; CROATIA; FEMALE; FTO GENE; GENE; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; ISLAND (GEOLOGICAL); MALE; MUSCLE MASS; OBESITY; PLEIOTROPY; SINGLE NUCLEOTIDE POLYMORPHISM; SKINFOLD THICKNESS; STATISTICAL SIGNIFICANCE; WAIST CIRCUMFERENCE; WAIST HIP RATIO; ANTHROPOMETRY; BODY COMPOSITION; BODY SIZE; GENETICS; GEOGRAPHY;

FTO PROTEIN, HUMAN; PROTEIN;

ANTHROPOMETRY; BODY COMPOSITION; BODY SIZE; CROATIA; GEOGRAPHY; HUMANS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEINS;

EID: 77956419938     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0010375     Document Type: Article

References (52)

1. Hill JO, Peters JC (1998) Environmental contributions to the obesity epidemic. Science 280: 1371-1374.
2. Popkin BM, Gordon-Larsen P (2004) The nutrition transition: worldwide obesity dynamics and their determinants. Int J Obes Relat Metab Disord 28 Suppl 3: S2-S9.
3. Stunkard AJ, Foch TT, Hrubec Z (1986) A twin study of human obesity. JAMA 256: 51-54.
4. Stunkard AJ, Sorensen TI, Hanis C, Teasdale TW, Chakraborty R, et al. (1986) An adoption study of human obesity. N Engl J Med 314: 193-198.
5. Stunkard AJ, Harris JR, Pedersen NL, McClearn GE (1990) The body-mass index of twins who have been reared apart. N Engl J Med 322: 1483-1487.
6. Clement K, Sorensen TIA (2008) Obesity: Genomics and Postgenomics. New York: Informa Healthcare.
7. Bell CG, Walley AJ, Froguel P (2005) The genetics of human obesity. Nat Rev Genet 6: 221-234.
8. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, et al. (2006) The human obesity gene map: the 2005 update. Obesity (Silver Spring) 14: 529-644.
9. Mutch DM, Clement K (2006) Unraveling the genetics of human obesity. PLoS Genet 2: e188.
10. Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, et al. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312: 279-283.
11. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
12. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-775.
13. Chambers JC, Elliott P, Zabaneh D, Zhang W, Li Y, et al. (2008) Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat Genet 40: 716-718.
14. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
15. Dina C, Meyre D, Gallina S, Durand E, Korner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724-726.
16. Scuteri A, Sanna S, Chen WM, Uda M, Albai G, et al. (2007) Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet 3: e115.
17. Grant SF, Li M, Bradfield JP, Kim CE, Annaiah K, et al. (2008) Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One 3: e1746.
18. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
19. Kring SI, Holst C, Zimmermann E, Jess T, Berentzen T, et al. (2008) FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness. PLoS One 3: e2958.
20. Rudan P, Sujoldzic A, Simic D, Bennett LA, Roberts DF (1992) Population structure in the eastern Adriatic: the influence of historical processes, migration patterns, isolation and ecological pressures, and their interaction. In: Roberts DF, Fujiki N, Torizuka K, eds. Isolation, Migration and Health. Cambridge England: Cambridge University Press. pp 204-218.
21. Rudan P, Janicijevic B, Jovanovic V, Milicic J, Narancic NS, et al. (2004) Holistic anthropological research of Hvar Islanders, Croatia-from parish registries to DNA studies in 33 years. Coll Antropol 28 Suppl 2: 321-343.
22. Weiner JS, Lourie JA (1981) Practical human biology. London: Academic Press.
23. Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, et al. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 74: 106-120.
24. Pal P, Xi H, Sun G, Kaushal R, Meeks JJ, et al. (2007) Tagging SNPs in the kallikrein genes 3 and 2 on 19q13 and their associations with prostate cancer in men of European origin. Hum Genet 122: 251-259.
25. Aulchenko YS, Ripke S, Isaacs A, van Duijn CM (2007) GenABEL: an R library for genome-wide association analysis. Bioinformatics 23: 1294-1296.
26. Barrett JC, Fry B, Maller J, Daly MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
27. Wigginton JE, Cutler DJ, Abecasis GR (2005) A note on exact tests of Hardy- Weinberg equilibrium. Am J Hum Genet 76: 887-893.
28. Clayton D, Chapman J, Cooper J (2004) Use of unphased multilocus genotype data in indirect association studies. Genet Epidemiol 27: 415-428.
29. Flegal KM, Shepherd JA, Looker AC, Graubard BI, Borrud LG, et al. (2009) Comparisons of percentage body fat, body mass index, waist circumference, and waist-stature ratio in adults. Am J Clin Nutr 89: 500-508.
30. Heymsfield SB, McManus C, Smith J, Stevens V, Nixon DW (1982) Anthropometric measurement of muscle mass: revised equations for calculating bone-free arm muscle area. Am J Clin Nutr 36: 680-690.
31. James WP, Mascie-Taylor GC, Norgan NG, Bistrian BR, Shetty PS, et al. (1994) The value of arm circumference measurements in assessing chronic energy deficiency in Third World adults. Eur J Clin Nutr 48: 883-894.
32. Timpson NJ, Lindgren CM, Weedon MN, Randall J, Ouwehand WH, et al. (2009) Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes 58: 505-510.
33. Rudan I, Rudan D, Campbell H, Carothers A, Wright A, et al. (2003) Inbreeding and risk of late onset complex disease. J Med Genet 40: 925-932.
34. Pritchard JK, Stephens M, Donnelly P (2000) Inference of population structure using multilocus genotype data. Genetics 155: 945-959.
35. Falush D, Stephens M, Pritchard JK (2003) Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics 164: 1567-1587.
36. Meyre D, Delplanque J, Chevre JC, Lecoeur C, Lobbens S, et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41: 157-159.
37. Hinney A, Nguyen TT, Scherag A, Friedel S, Bronner G, et al. (2007) Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. PLoS One 2: e1361.
38. Hubacek JA, Bohuslavova R, Kuthanova L, Kubinova R, Peasey A, et al. (2008) The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. Obesity (Silver Spring) 16: 2764-2766.
39. Zeggini E, Weedon MN, Lindgren CM, Frayling TM, Elliott KS, et al. (2007) Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 316: 1336-1341.
40. Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, et al. (2008) Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet 40: 638-645.
41. Scott LJ, Mohlke KL, Bonnycastle LL, Willer CJ, Li Y, et al. (2007) A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316: 1341-1345.
42. Wellcome Trust Case Control Consortium (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447: 661-678.
43. Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, et al. (2009) A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 41: 527-534.
44. Cotsapas C, Speliotes EK, Hatoum IJ, Greenawalt DM, Dobrin R, et al. (2009) Common BMI-associated variants confer risk of extreme obesity. Hum Mol Genet.
45. Frisancho AR (1984) New standards of weight and body composition by frame size and height for assessment of nutritional status of adults and the elderly. Am J Clin Nutr 40: 808-819.
46. Frisancho AR, Flegel PN (1983) Elbow breadth as a measure of frame size for US males and females. Am J Clin Nutr 37: 311-314.
47. Chumlea WC, Wisemandle W, Guo SS, Siervogel RM (2002) Relations between frame size and body composition and bone mineral status. Am J Clin Nutr 75: 1012-1016.
48. Jess T, Zimmermann E, Kring SI, Berentzen T, Holst C, et al. (2008) Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. Int J Obes (Lond) 32: 1388-1394.
49. Do R, Bailey SD, Desbiens K, Belisle A, Montpetit A, et al. (2008) Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes 57: 1147-1150.
50. Fischer J, Koch L, Emmerling C, Vierkotten J, Peters T, et al. (2009) Inactivation of the Fto gene protects from obesity. Nature 458: 894-898.
51. Church C, Lee S, Bagg EA, McTaggart JS, Deacon R, et al. (2009) A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene. PLoS Genet 5: e1000599.
52. Plomin R, Haworth CM, Davis OS (2009) Common disorders are quantitative traits. Nat Rev Genet 10: 872-878.