Genes involved with folate uptake and distribution and their association with colorectal cancer risk

Cancer Causes and Control

Volumn 21, Issue 4, 2010, Pages 597-608

  Figueiredo, Jane C ^a   Levine, A Joan ^a   Lee, Won H ^a   Conti, David V ^a   Poynter, Jenny N ^a,b   Campbell, Peter T ^c,g   Duggan, David ^d   Lewinger, Juan Pablo ^a   Martinez, Maria Elena ^e,f   Ulrich, Cornelia M ^g   Newcomb, Polly ^g   Potter, John ^g   Limburg, Paul J ^h   Hopper, John ⁱ   Jenkins, Mark A ⁱ   Le Marchand, Loic ^j   Baron, John A ^k   Haile, Robert W ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c AMERICAN CANCER SOCIETY   (United States)

^d TRANSLATIONAL GENOMICS RESEARCH INSTITUTE   (United States)

^e UNIVERSITY OF ARIZONA   (United States)

^f UNIVERSITY OF ARIZONA   (United States)

^g Fred Hutchinson Cancer Research Center   (United States)

^h MAYO CLINIC   (United States)

ⁱ UNIVERSITY OF MELBOURNE   (Australia)

^j UNIVERSITY OF HAWAII CANCER CENTER   (United States)

^k DARTMOUTH MEDICAL SCHOOL   (United States)

more..

Author keywords

Case control; Clinic based; Colorectal cancer; Folate; Folate receptor 1 (FOLR1); Folylpolyglutamate synthase (FPGS); Gamma glutamyl hydrolase (GGH) family based; Polymorphisms; Population based; Reduced folate carrier (RFC); Solute carrier family 19 (SLC19A1)

Indexed keywords

FOLATE RECEPTOR; FOLATE RECEPTOR 1; FOLIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; GAMMA GLUTAMYL HYDROLASE; REDUCED FOLATE CARRIER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CANCER REGISTRY; CANCER RISK; CARCINOGENESIS; CASE CONTROL STUDY; COLORECTAL CANCER; CONTROLLED STUDY; DIETARY INTAKE; FAMILY HISTORY; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HEALTH SURVEY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN INTAKE;

ADULT; AGED; CARRIER PROTEINS; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FAMILY HEALTH; FEMALE; FOLIC ACID; GAMMA-GLUTAMYL HYDROLASE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LOGISTIC MODELS; MALE; MEMBRANE TRANSPORT PROTEINS; MIDDLE AGED; PEPTIDE SYNTHASES; POLYMORPHISM, SINGLE NUCLEOTIDE; QUESTIONNAIRES; RECEPTORS, CELL SURFACE; REGISTRIES; RISK FACTORS;

EID: 77953293418     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-009-9489-6     Document Type: Article

References (52)

1. Kim YI (2003) Role of folate in colon cancer development and progression. J Nutr 133:3731S-3739S
2. Choi SW, Mason JB (2002) Folate status: effects on pathways of colorectal carcinogenesis. J Nutr 132: 2413S-2418S
3. Giovannucci E (2002) Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr 132: 2350S-2355S
4. Kim YI (2004) Will mandatory folic acid fortification prevent or promote cancer? Am J Clin Nutr 80: 1123-1128
5. Cole BF, Baron JA, Sandler RS, Haile RW, Ahnen DJ, Bresalier RS, McKeown-Eyssen G, Summers RW, Rothstein RI, Burke CA, Snover DC, Church TR, Allen JI, Robertson DJ, Beck GJ, Bond JH, Byers T, Mandel JS, Mott LA, Pearson LH, Barry EL, Rees JR, Marcon N, Saibil F, Ueland PM, Greenberg ER (2007) Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. Jama 297: 2351-2359
6. Mason JB, Dickstein A, Jacques PF, Haggarty P, Selhub J, Dallal G, Rosenberg IH (2007) A temporal association between folic acid fortification and an increase in colorectal cancer rates may be illuminating important biological principles: a hypothesis. Cancer Epidemiol Biomark Prev 16: 1325-1329 (Pubitemid 47076861)
7. Ulrich CM, Potter JD (2006) Folate supplementation: too much of a good thing? Cancer Epidemiol Biomark Prev 15: 189-193
8. Ulrich CM, Potter JD (2007) Folate and cancer-timing is everything. Jama 297: 2408-2409
9. Ulrich CM (2007) Folate and cancer prevention: a closer look at a complex picture. Am J Clin Nutr 86: 271-273
10. Kim YI (2006) Folate: a magic bullet or a double edged sword for colorectal cancer prevention? Gut 55: 1387-1389
11. Figueiredo JC, Levine AJ, Grau MV, Barry EL, Ueland PM, Ahnen DJ, Byers T, Bresalier RS, Summers RW, Bond J, McKeown-Eyssen GE, Sandler RS, Haile RW, Baron JA (2008) Colorectal adenomas in a randomized folate trial: the role of baseline dietary and circulating folate levels. Cancer Epidemiol Biomark Prev 17: 2625-2631
12. Reed MC, Nijhout HF, Neuhouser ML, Gregory JF III, Shane B, James SJ, Boynton A, Ulrich CM (2006) A mathematical model gives insights into nutritional and genetic aspects of folatemediated one-carbon metabolism. J Nutr 136: 2653-2661 (Pubitemid 44521628)
13. Galivan J, Ryan TJ, Chave K, Rhee M, Yao R, Yin D (2000) Glutamyl hydrolase, pharmacological role and enzymatic characterization. Pharmacol Ther 85: 207-215 (Pubitemid 30160790)
14. Sierra EE, Goldman ID (1999) Recent advances in the understanding of the mechanism of membrane transport of folates and antifolates. Semin Oncol 26: 11-23 (Pubitemid 29218023)
15. Spiegelstein O, Eudy JD, Finnell RH (2000) Identification of two putative novel folate receptor genes in humans and mouse. Gene 258: 117-125
16. Matherly LH (2001) Molecular and cellular biology of the human reduced folate carrier. Prog Nucleic Acid Res Mol Biol 67: 131-162 (Pubitemid 33804643)
17. Wang X, Shen F, Freisheim JH, Gentry LE, Ratnam M (1992) Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates. Biochem Pharmacol 44: 1898-1901
18. Lowe KE, Osborne CB, Lin BF, Kim JS, Hsu JC, Shane B (1993) Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpolygamma-glutamate specificity of metabolic cycles of one-carbon metabolism. J Biol Chem 268: 21665-21673
19. Newcomb PA, Baron J, Cotterchio M, Gallinger S, Grove J, Haile R, Hall D, Hopper JL, Jass J, Le Marchand L, Limburg P, Lindor N, Potter JD, Templeton AS, Thibodeau S, Seminara D (2007) Colon cancer family registry: an international resource for studies of the genetic epidemiology of colon cancer. Cancer Epidemiol Biomark Prev 16: 2331-2343
20. Witte JS, Gauderman WJ, Thomas DC (1999) Asymptotic bias and efficiency in case-control studies of candidate genes and gene-environment interactions: basic family designs. Am J Epidemiol 149: 693-705
21. Stram DO, Hankin JH, Wilkens LR, Pike MC, Monroe KR, Park S, Henderson BE, Nomura AM, Earle ME, Nagamine FS, Kolonel LN (2000) Calibration of the dietary questionnaire for a multiethnic cohort in Hawaii and Los Angeles. Am J Epidemiol 151: 358-370 (Pubitemid 30463613)
22. Lindor NM, Rabe K, Petersen GM, Haile R, Casey G, Baron J, Gallinger S, Bapat B, Aronson M, Hopper J, Jass J, LeMarchand L, Grove J, Potter J, Newcomb P, Terdiman JP, Conrad P, Moslein G, Goldberg R, Ziogas A, Anton-Culver H, de Andrade M, Siegmund K, Thibodeau SN, Boardman LA, Seminara D (2005) Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X. Jama 293: 1979-1985
23. World Health Organization (2000) International classification of diseases for oncology. WHO, Geneva
24. Edlund CK, Lee WH, Li D, Van Den Berg DJ, Conti DV (2008) Snagger: a user-friendly program for incorporating additional information for tagSNP selection. BMC Bioinformatics 9:174
25. Siegmund KD, Langholz B, Kraft P, Thomas DC (2000) Testing linkage disequilibrium in sibships. Am J Hum Genet 67: 244-248
26. Chatzikyriakidou A, Vakalis KV, Kolaitis N, Kolios G, Naka KK, Michalis LK, Georgiou I (2008) Distinct association of SLC19A1 polymorphism -43T > C with red cell folate levels and of MTHFR polymorphism 677C > T with plasma folate levels. Clin Biochem 41: 174-176
27. Conneely KN, Boehnke M (2007) So many correlated tests, so little time! Rapid adjustment of P values for multiple correlated tests. Am J Hum Genet 81(6): 1158-1168
28. Conti DV, Lee W, Li D, Liu J, Van Den Berg D, Thomas PD, Bergen AW, Swan GE, Tyndale RF, Benowitz NL, Lerman C (2008) Nicotinic acetylcholine receptor beta2 subunit gene implicated in a systems-based candidate gene study of smoking cessation. Hum Mol Genet 17: 2834-2848
29. Odin E, Wettergren Y, Nilsson S, Willen R, Carlsson G, Spears CP, Larsson L, Gustavsson B (2003) Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. Clin Cancer Res 9: 6012-6019 (Pubitemid 38018088)
30. Moscow JA (1998) Methotrexate transport and resistance. Leuk Lymphoma 30: 215-224
31. Chango A, Emery-Fillon N, de Courcy GP, Lambert D, Pfister M, Rosenblatt DS, Nicolas JP (2000) A polymorphism (80G- > A) in the reduced folate carrier gene and its associations with folate status and homocysteinemia. Mol Genet Metab 70: 310-315
32. Devlin AM, Clarke R, Birks J, Evans JG, Halsted CH (2006) Interactions among polymorphisms in folate-metabolizing genes and serum total homocysteine concentrations in a healthy elderly population. Am J Clin Nutr 83: 708-713 (Pubitemid 44699220)
33. Winkelmayer WC, Eberle C, Sunder-Plassmann G, Fodinger M (2003) Effects of the glutamate carboxypeptidase II (GCP2 1561C > T) and reduced folate carrier (RFC1 80G > A) allelic variants on folate and total homocysteine levels in kidney transplant patients. Kidney Int 63: 2280-2285 (Pubitemid 36605843)
34. Fredriksen A, Meyer K, Ueland PM, Vollset SE, Grotmol T, Schneede J (2007) Large-scale population-based metabolic phenotyping of thirteen genetic polymorphisms related to one-carbon metabolism. Hum Mutat 28: 856-865 (Pubitemid 47579935)
35. Lissowska J, Gaudet MM, Brinton LA, Chanock SJ, Peplonska B, Welch R, Zatonski W, Szeszenia-Dabrowska N, Park S, Sherman M, Garcia-Closas M (2007) Genetic polymorphisms in the onecarbon metabolism pathway and breast cancer risk: a populationbased case-control study and meta-analyses. Int J Cancer 120: 2696-2703
36. Ulrich CM, Curtin K, Potter JD, Bigler J, Caan B, Slattery ML (2005) Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol Biomark Prev 14: 2509-2516 (Pubitemid 41752708)
37. Moore LE, Malats N, Rothman N, Real FX, Kogevinas M, Karami S, Garcia-Closas R, Silverman D, Chanock S, Welch R, Tardon A, Serra C, Carrato A, Dosemeci M, Garcia-Closas M (2007) Polymorphisms in one-carbon metabolism and transsulfuration pathway genes and susceptibility to bladder cancer. Int J Cancer 120: 2452-2458 (Pubitemid 46642134)
38. Wang L, Chen W, Wang J, Tan Y, Zhou Y, Ding W, Hua Z, Shen J, Xu Y, Shen H (2006) Reduced folate carrier gene G80A polymorphism is associated with an increased risk of gastroesophageal cancers in a Chinese population. Eur J Cancer 42: 3206-3211 (Pubitemid 44854505)
39. Curtin K, Slattery ML, Ulrich CM, Bigler J, Levin TR, Wolff RK, Albertsen H, Potter JD, Samowitz WS (2007) Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet. Carcinogenesis 28(8): 1672-1679 (Pubitemid 47303944)
40. Iwakiri S, Sonobe M, Nagai S, Hirata T, Wada H, Miyahara R (2008) Expression status of folate receptor alpha is significantly correlated with prognosis in non-small-cell lung cancers. Ann Surg Oncol 15: 889-899
41. Allard JE, Risinger JI, Morrison C, Young G, Rose GS, Fowler J, Berchuck A, Maxwell GL (2007) Overexpression of folate binding protein is associated with shortened progression-free survival in uterine adenocarcinomas. Gynecol Oncol 107: 52-57 (Pubitemid 47464540)
42. Ma DW, Finnell RH, Davidson LA, Callaway ES, Spiegelstein O, Piedrahita JA, Salbaum JM, Kappen C, Weeks BR, James J, Bozinov D, Lupton JR, Chapkin RS (2005) Folate transport gene inactivation in mice increases sensitivity to colon carcinogenesis. Cancer Res 65: 887-897 (Pubitemid 40216448)
43. Kelemen LE (2006) The role of folate receptor alpha in cancer development, progression and treatment: cause, consequence or innocent bystander? Int J Cancer 119: 243-250
44. Borjel AK, Yngve A, Sjostrom M, Nilsson TK (2006) Novel mutations in the 5'-UTR of the FOLR1 gene. Clin Chem Lab Med 44: 161-167 (Pubitemid 43237958)
45. Kamen BA, Wang MT, Streckfuss AJ, Peryea X, Anderson RG (1988) Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. J Biol Chem 263: 13602-13609
46. Chave KJ, Ryan TJ, Chmura SE, Galivan J (2003) Identification of single nucleotide polymorphisms in the human gamma-glutamyl hydrolase gene and characterization of promoter polymorphisms. Gene 319:167-175
47. DeVos L, Chanson A, Liu Z, Ciappio ED, Parnell LD, Mason JB, Tucker KL, Crott JW (2008) Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. Am J Clin Nutr 88: 1149-1158
48. Leil TA, Endo C, Adjei AA, Dy GK, Salavaggione OE, Reid JR, Ames MM (2007) Identification and characterization of genetic variation in the folylpolyglutamate synthase gene. Cancer Res 67: 8772-8782 (Pubitemid 47437453)
49. Lee KM, Lan Q, Kricker A, Purdue MP, Grulich AE, Vajdic CM, Turner J, Whitby D, Kang D, Chanock S, Rothman N, Armstrong BK (2007) One-carbon metabolism gene polymorphisms and risk of non-Hodgkin lymphoma in Australia. Hum Genet 122:525-533 (Pubitemid 350148964)
50. Lim U, Wang SS, Hartge P, Cozen W, Kelemen LE, Chanock S, Davis S, Blair A, Schenk M, Rothman N, Lan Q (2007) Genenutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCISEER case-control study. Blood 109:3050-3059 (Pubitemid 46482106)
51. Imai K, Yamamoto H (2008) Carcinogenesis and microsatellite instability: the interrelationship between genetics and epigenetics. Carcinogenesis 29: 673-680 (Pubitemid 351494153)
52. Liu K (1988) Measurement error and its impact on partial correlation and multiple linear regression analyses. Am J Epidemiol 127: 864-874