Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: Identification of 3′ substituted indolones as a scaffold for the development of neuroprotective drugs

Journal of Neurochemistry

Volumn 93, Issue 3, 2005, Pages 538-548

  Johnson, Kyle ^a   Liu, Li ^a   Majdzadeh, Nazanin ^a   Chavez, Cindy ^a   Chin, Paul C ^a   Morrison, Brad ^a   Wang, Lulu ^a   Park, Jane ^a   Chugh, Priti ^a   Chen, Hsin Mei ^a   D'Mello, Santosh R ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

3 substituted indolones; Cerebellar granule neurons; Cyclin dependent kinases; Neurodegeneration; Neuronal apoptosis; Neuroprotection

Indexed keywords

2,3 DIHYDRO 2 OXO 3 (4,5,6,7 TETRAHYDRO 1H INDOL 2 YLMETHYLENE) 1H INDOLE 5 SULFONIC ACID DIMETHYLAMIDE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; CYCLIN DEPENDENT KINASE INHIBITOR; GW 5074; GW 8510; MITOGEN ACTIVATED PROTEIN KINASE; NEUROPROTECTIVE AGENT; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN C JUN; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VEGF RECEPTOR 2 KINASE INHIBITOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE; CHEMICAL ANALYSIS; MITOSIS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CELL LINE; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; NEURONS; NEUROPROTECTIVE AGENTS; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR;

EID: 20944431614     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.03004.x     Document Type: Article

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