6-Br-5methylindirubin-3′oxime (5-Me-6-BIO) targeting the leishmanial glycogen synthase kinase-3 (GSK-3) short form affects cell-cycle progression and induces apoptosis-like death: Exploitation of GSK-3 for treating leishmaniasis

International Journal for Parasitology

Volumn 39, Issue 12, 2009, Pages 1289-1303

  Xingi, Evangelia ^a   Smirlis, Despina ^a   Myrianthopoulos, Vassilios ^b   Magiatis, Prokopios ^b   Grant, Karen M ^c   Meijer, Laurent ^d   Mikros, Emmanuel ^b   Skaltsounis, Alexios Leandros ^b   Soteriadou, Ketty ^a  

^a HELLENIC PASTEUR INSTITUTE   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c LANCASTER UNIVERSITY   (United Kingdom)

^d STATION BIOLOGIQUE   (France)

Author keywords

5 Me 6 BIO; 6 BIO; Apoptosis like death; Drug target; Indirubins; Leishmania donovani glycogen synthase kinase 3 short

Indexed keywords

6 BROMO 5 METHYLINDIRUBIN 3' OXIME; 6 BROMO INDIRUBIN 3' ACETOXIME; 6 BROMO INDIRUBIN 3' OXIME; CYCLIN DEPENDENT KINASE; GLYCOGEN SYNTHASE KINASE 3; INDIRUBIN; UNCLASSIFIED DRUG;

CELL ORGANELLE; DRUG; INHIBITION; INHIBITOR; PARASITE; PHENOTYPE; SUBSTITUTION;

AMASTIGOTE; ANIMAL CELL; ANTIPROTOZOAL ACTIVITY; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL VIABILITY; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ASSAY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; GENE OVEREXPRESSION; IC 50; LEISHMANIA DONOVANI; LEISHMANIA INFANTUM; LEISHMANIASIS; MAMMAL; MOLECULAR DOCKING; MOUSE; NICK END LABELING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREDICTION; PROMASTIGOTE; TRYPANOSOMA BRUCEI;

ANIMALS; APOPTOSIS; CELL CYCLE; CELLS, CULTURED; CYCLIN-DEPENDENT KINASES; DRUG EVALUATION, PRECLINICAL; FLOW CYTOMETRY; FLUORESCENT DYES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOBLOTTING; INDOLES; LEISHMANIA DONOVANI; LEISHMANIASIS; OXIMES;

LEISHMANIA DONOVANI; MAMMALIA;

EID: 68249107643     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpara.2009.04.005     Document Type: Article

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