The evolving field of imaging mass spectrometry and its impact on future biological research

Journal of Mass Spectrometry

Volumn 46, Issue 2, 2011, Pages 209-222

  Watrous, Jeramie D ^a   Alexandrov, Theodore ^b   Dorrestein, Pieter C ^a,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF BREMEN   (Germany)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

data mining; DESI; imaging mass spectrometry; IMS public database; informatics; MALDI; SIMS; spectral processing

Indexed keywords

DESI; IMAGING MASS SPECTROMETRY; IMS PUBLIC DATABASE; INFORMATICS; MALDI; SIMS; SPECTRAL PROCESSING;

BIOLOGY; DATA MINING; INFORMATION SCIENCE; RESEARCH; SECONDARY ION MASS SPECTROMETRY; SPECTROMETRY;

DATA HANDLING;

ARTICLE; ELECTROSPRAY MASS SPECTROMETRY; ENERGY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BACTERIOLOGICAL TECHNIQUES; BIOMEDICAL RESEARCH; HUMANS; MASS SPECTROMETRY; MEDICAL INFORMATICS; MICE; MOLECULAR IMAGING; RATS;

EID: 79951677254     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.1876     Document Type: Article

References (137)

1. H. Liebl,. Ion microprobe mass analyzer. J. Appl. Phys. 1967, 38, 5277.
2. R. M. Caprioli, T. B. Farmer, J. Gile,. Molecular imaging of biological samples: localization of peptides and proteins using MALDI-TOF MS. Anal. Chem. 1997, 69, 4751.
3. M. Schuerenberg, C. Luebbert, S.-O. Deininger, R. Ketterlinus, D. Suckau,. MALDI tissue imaging: mass spectrometric localization of biomarkers in tissue slices. Nat. Methods 2007, 4.
4. S. C. C. Wong, C. M. L. Chan, B. B. Y. Ma, M. Y. Y. Lam, G. C. G. Choi, T. C. C. Au, A. S. K. Chan, A. T. C. Chan,. Advanced proteomic technologies for cancer biomarker discovery. Exp. Rev. Prot. 2009, 6, 123.
5. Y. Sugiura, M. Setou,. Imaging mass spectrometry for visualization of drug and endogenous metabolite distribution: toward in situ pharmacometabolomes. J. Neuro. Pharm. 2010, 5, 31.
6. E. Solon, A. Schweitzer, M. Stoeckli, B. Prideaux,. Autoradiography, MALDI-MS, and SIMS-MS imaging in pharmaceutical discovery and development. AAPS J. 2010, 12, 11.
7. S. N. Jackson, H.-Y. J. Wang, A. S. Woods,. Direct profiling of lipid distribution in brain tissue using MALDI-TOF MS. Anal. Chem. 2005, 77, 4523.
8. K. Amaya, E. Monroe, J. Sweedler, D. Clayton,. Lipid imaging in the zebra finch brain with secondary ion mass spectrometry. Int. J. Mass Spectrom. 2007, 260, 121.
9. H. Tanaka, N. Zaima, N. Yamamoto, D. Sagara, M. Suzuki, M. Nishiyama, Y. Mano, M. Sano, T. Hayasaka, N. Goto-Inoue, T. Sasaki, H. Konno, N. Unno, M. Setou,. Imaging mass spectrometry reveals unique lipid distribution in primary varicose veins. Eur. J. Vasc. Endovasc. 2010, 40, 657.
10. A. Brunelle, O. Laprevote,. Lipid imaging with cluster time-of-flight secondary ion mass spectrometry. Anal. Bioanal. Chem. 2009, 393, 31.
11. L. A. McDonnell, G. L. Corthals, S. M. Willems, A. van Remoortere, R. J. M. van Zeijl, A. M. Deelder,. Peptide and protein imaging mass spectrometry in cancer research. J. Proteomics 2010, 73, 1921.
12. A. van Remoortere, R. J. M. van Zeijl, N. van den Oever, J. Franck, R. Longuespee, M. Wisztorski, M. Salzet, A. M. Deelder, I. Fournier, L. A. McDonnell,. MALDI imaging and profiling MS of higher mass proteins from tissue. J. Am. Soc. Mass Spectrom. 2010, 21, 1922.
13. P. Chaurand, S. A. Schwartz, R. M. Caprioli,. Assessing protein patterns in disease using imaging mass spectrometry. J. Proteome Res. 2004, 3, 245.
14. J. Franck, K. Arafah, M. Elayed, D. Bonnel, D. Vergara, A. Jacquet, D. Vinatier, M. Wisztorski, R. Day, I. Fournier, M. Salzet,. MALDI imaging mass spectrometry: state of the art technology in clinical proteomics. Mol. Cell. Proteomics 2009, 8, 2023.
15. S. Khatib-Shahidi, M. Andersson, J. L. Herman, T. A. Gillespie, R. M. Caprioli,. Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 2006, 78, 6448.
16. M. Stoeckli, D. Staab, A. Schweitzer,. Compound and metabolite distribution measured by MALDI mass spectrometric imaging in whole-body tissue sections. Int. J. Mass Spectrom. 2007, 260, 195.
17. J. Watrous, N. Hendricks, M. Meehan, P. C. Dorrestein,. Capturing bacterial metabolic exchange using thin film desorption electrospray ionization-imaging mass spectrometry. Anal. Chem. 2010, 82, 1598.
18. Y.-L. Yang, Y. Xu, P. Straight, P. C. Dorrestein,. Translating metabolic exchange with imaging mass spectrometry. Nat. Chem. Biol. 2009, 5, 885.
19. W.-T. Liu, Y.-L. Yang, Y. Xu, A. Lamsa, N. M. Haste, J. Y. Yang, J. Ng, D. Gonzalez, C. D. Ellermeier, P. D. Straight, P. A. Pevzner, J. Pogliano, V. Nizet, K. Pogliano, P. C. Dorrestein,. Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 2010, 107, 16286.
20. S. Cha, Z. Song, B. J. Nikolau, E. S. Yeung,. Direct profiling and imaging of epicuticular waxes on Arabidopsis thaliana by laser desorption/ionization mass spectrometry using silver colloid as a matrix. Anal. Chem. 2009, 81, 2991.
21. G. Hamm, V. Carre, A. Poutaraud, B. Maunit, G. Frache, D. Merdinoglu, J.-F. F. Muller,. Determination and imaging of metabolites from Vitis vinifera leaves by laser desorption/ionisation time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 2010, 24, 335.
22. D. M. Anderson, V. A. Carolan, S. Crosland, K. R. Sharples, M. R. Clench,. Examination of the distribution of nicosulfuron in sunflower plants by matrix-assisted laser desorption/ionisation mass spectrometry imaging. Rapid Commun. Mass Spectrom. 2009, 23, 1321.
23. F. J. M. Rutten, D. Briggs, J. Henderson, M. J. Roe,. The application of time-of-flight secondary ion mass spectrometry (TOF-SIMS) to the characterization of opaque ancient glasses. Archaeometry 2009, 51, 966.
24. K. Lehmann, A. Berger, T. Gotte, K. Ramseyer, M. Wiedenbeck,. Growth related zonations in authigenic and hydrothermal quartz characterized by SIMS-, EPMA-, SEM-CL- and SEM-CC-imaging. Mineral Mag. 2009, 73, 633.
25. M. V. Zoriy, D. Mayer, J. S. Becker,. Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range. J. Am. Soc. Mass Spectrom. 2009, 20, 883.
26. M. J. Bailey, B. N. Jones, S. Hinder, J. Watts, S. Bleay, R. P. Webb,. Depth profiling of fingerprint and ink signals by SIMS and MeV SIMS. Nucl. Instrum. Methods B 2010, 268, 1929.
27. D. R. Ifa, N. E. Manicke, A. L. Dill, R. G. Cooks,. Latent fingerprint chemical imaging by mass spectrometry. Science 2008, 321, 805.
28. H.-W. Tang, W. Lu, C.-M. Che, K.-M. Ng,. Gold nanoparticles and imaging mass spectrometry: double imaging of latent fingerprints. Anal. Chem. 2010, 82, 1589.
29. M. W. Duncan, R. Aebersold, R. M. Caprioli,. The pros and cons of peptide-centric proteomics. Nat. Biotechnol. 2010, 28, 659.
30. P. Mitchell,. Proteomics retrenches. Nat. Biotechnol. 2010, 28, 665.
31. B. P. Bowen, T. R. Northen,. Dealing with the unknown: metabolomics and metabolite atlases. J. Am. Soc. Mass Spectrom. 2010, 21, 1471.
32. P. A. Pevzner, S. Kim, J. Ng,. Comment on 'protein sequences from mastodon and tyrannosaurus rex revealed by mass spectrometry'. Science 2008, 321, 1040.
33. A. W. Bell, E. W. Deutsch, C. E. Au, R. E. Kearney, R. Beavis, S. Sechi, T. Nilsson, J. J. M. Bergeron,. A HUPO test sample study reveals common problems in mass spectrometry based proteomics. Nat. Methods 2009, 6, 423.
34. S. D. Patterson,. Data analysis: the Achilles heel of proteomics. Nat. Biotechnol. 2003, 21, 221.
35. K. Aberg, E. Alm, R. Torgrip,. The correspondence problem for metabonomics datasets. Anal. Bioanal. Chem. 2009, 394, 151.
36. M. Arita,. What can metabolomics learn from genomics and proteomics? Curr. Opin. Biotechnol. 2009, 20, 610.
37. E. R. Amstalden van Hove, D. F. Smith, R. M. A. Heeren,. A concise review of mass spectrometry imaging. J. Chromatogr. A 2010, 1217, 3946.
38. S. Francese, F. R. Dani, P. Traldi, G. Mastrobuoni, G. Pieraccini, G. Moneti,. MALDI mass spectrometry imaging, from its origins up to today: the state of the art. Comb. Chem. High Throughput Screen 2009, 12, 156.
39. M. A. Heeren, D. F. Smith, J. Stauber, B. Kukrer-Kaletas, L. MacAleese,. Imaging mass spectrometry: hype or hope? J. Am. Soc. Mass Spectrom. 2009, 20, 1006.
40. N. Winograd, B. J. Garrison,. Biological cluster mass spectrometry. Annu. Rev. Phys. Chem. 2010, 61, 305.
41. K. Schwamborn, R. M. Caprioli,. Molecular imaging by mass spectrometry: looking beyond classical histology. Nat. Rev. Cancer 2010, 10, 639.
42. L. A. McDonnell, R. M. Heeren,. Imaging mass spectrometry. Mass Spectrom. Rev. 2007, 26, 606.
43. A. Svatos,. Mass spectrometric imaging of small molecules. Trends Biotechnol. 2010, 28, 425.
44. S. G. Boxer, M. L. Kraft, P. K. Weber,. Advances in imaging secondary ion mass spectrometry for biological samples. Annu. Rev. Biophys. 2009, 38, 53.
45. F. Kollmer,. Cluster primary ion bombardment of organic materials. Appl. Surf. Sci. 2004, 231-232, 153.
46. D. Touboul, F. Kollmer, E. Niehuis, A. Brunelle, O. Laprevote,. Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source. J. Am. Soc. Mass Spectrom. 2005, 16, 1608.
47. M. Benguerba, A. Brunelle, S. Dellanegra, J. Depauw, H. Joret, Y. Lebeyec, M. Blain, E. Schweikert, G. Assayag, P. Sudraud,. Impact of slow gold clusters on various solids: nonlinear effects in secondary ion emission. Nucl. Instrum. Methods B 1991, 62, 8.
48. A. Novikov, M. Caroff, S. Della-Negra, J. Depauw, M. Fallavier, Y. Le Beyec, M. Pautrat, J. A. Schultz, A. Tempez, A. S. Woods,. The Au(n) cluster probe in secondary ion mass spectrometry: influence of the projectile size and energy on the desorption/ionization rate from biomolecular solids. Rapid Commun. Mass Spectrom. 2005, 19, 1851.
49. D. Weibel, S. Wong, N. Lockyer, P. Blenkinsopp, R. Hill, J. C. Vickerman,. A C60 primary ion beam system for time of flight secondary ion mass spectrometry: its development and secondary ion yield characteristics. Anal. Chem. 2003, 75, 1754.
50. A. Benninghoven, B. Hagenhoff, E. Niehuis,. Surface MS: probing real-world samples. Anal. Chem. 1993, 65, 630.
51. C. Diehnelt, M. J. Van Stipdonka, E. A. Schweikert,. Effectiveness of atomic and polyatomic primary ions for organic secondary ion mass spectrometry. Int. J. Mass Spectrom. 2001, 207, 111.
52. K. J. Wu, R. W. Odom,. Matrix-enhanced secondary ion mass spectrometry: a method for molecular analysis of solid surfaces. Anal. Chem. 1996, 68, 873.
53. R. Heeren, L. McDonnell, E. Amstalden, S. Luxembourg, A. Altelaar, S. Piersma,. Why don't biologists use SIMS? A critical evaluation of imaging MS. Appl. Surf. Sci. 2006, 252, 6827.
54. W. Chang, L. Huang, Y. Wang, W. Peng, H. Chang, N. Hsu, W. Yang, C. Chen,. Matrix-assisted laser desorption/ionization (MALDI) mechanism revisited. Anal. Chim. Acta 2007, 582, 1.
55. M. Karas, R. Kruger,. Ion formation in MALDI: the cluster ionization mechanism. Chem. Rev. 2003, 103, 427.
56. R. Knochenmuss, A. Vertes,. Time-delayed 2-pulse studies of MALDI matrix ionization mechanisms. J. Phys. Chem. B 2000, 104, 5406.
57. R. Knochenmuss, R. Zenobi,. MALDI ionization: the role of in-plume processes. Chem. Rev. 2003, 103, 441.
58. R. Knochenmuss,. A bipolar rate equation model of MALDI primary and secondary ionization processes, with application to positive/negative analyte ion ratios and suppression effects. Int. J. Mass Spectrom. 2009, 285, 105.
59. S. H. Yoon, J. H. Moon, M. S. Kim,. A comparative study of in- and post-source decays of peptide and preformed ions in matrix-assisted laser desorption ionization time-of-flight mass spectrometry: effective temperature and matrix effect. J. Am. Soc. Mass Spectrom. 2010, 21, 1876.
60. K. Tanaka, H. Waki, Y. Ido, S. Akita, Y. Yoshida, T. Yoshida, T. Matsuo,. Protein and polymer analyses up to $\hbox{$m$/ $z$} 100 000 $ by laser ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1988, 2, 151.
61. M. Becker, S. O. Deininger, A. Holle, J. Hoehndorf, D. Suckau, M. Schrurenberg, C. Pineau,. High definition MALDI imaging: new capabilities for protein biomarker discovery from tissue. J. Biomol. Tech. 2010, 21, S33.
62. Z. Takats, J. M. Wiseman, B. Gologan, R. G. Cooks,. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science 2004, 306, 5695.
63. J. M. Wiseman, D. R. Ifa, Q. Song, R. G. Cooks,. Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry. Angew. Chem. Int. Ed. 2006, 45, 7188.
64. Z. Takats, J. M. Wiseman, R. G. Cooks,. Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J. Mass Spectrom. 2005, 40, 1261.
65. A. Venter, P. E. Sojka, R. G. Cooks,. Droplet dynamics and ionization mechanisms in desorption electrospray ionization mass spectrometry. Anal. Chem. 2006, 78, 8549.
66. A. B. Costa, R. Graham Cooks,. Simulated splashes: elucidating the mechanism of desorption electrospray ionization mass spectrometry. Chem. Phys. Lett. 2008, 464, 1.
67. N. Talaty, Z. Takats, R. G. Cooks,. Rapid in situ detection of alkaloids in plant tissue under ambient conditions using desorption electrospray ionization. Analyst 2005, 130, 1624.
68. A. L. Lane, L. Nyadong, A. S. Galhena, T. L. Shearer, E. P. Stout, R. M. Parry, M. Kwasnik, M. D. Wang, M. E. Hay, F. M. Fernandez, J. Kubanek,. Desorption electrospray ionization mass spectrometry reveals surface-mediated antifungal chemical defense of a tropical seaweed. Proc. Natl. Acad. Sci. USA 2009, 106, 7314.
69. C. Wu, D. R. Ifa, N. E. Manicke, R. G. Cooks,. Rapid, direct analysis of cholesterol by charge labeling in reactive desorption electrospray ionization. Anal. Chem. 2009, 81, 7618.
70. P. Nemes, A. Vertes,. Laser ablation electrospray ionization for atmospheric pressure, in vivo, and imaging mass spectrometry. Anal. Chem. 2007, 79, 8098.
71. J. S. Sampson, A. M. Hawkridge, D. C. Muddiman,. Generation and detection of multiply-charged peptides and proteins by matrix-assisted laser desorption electrospray ionization (MALDESI) Fourier transform ion cyclotron resonance mass spectrometry. J. Am. Soc. Mass Spectrom. 2006, 17, 1712.
72. K. Hiraoka,. Laser spray: electric field-assisted matrix-assisted laser desorption/ionization. J. Mass Spectrom. 2004, 39, 341.
73. J. S. Becker,. Bioimaging of metals in brain tissue from micrometre to nanometre scale by laser ablation inductively coupled plasma mass spectrometry: state of the art and perspectives. Int. J. Mass. Spectrom. 2010, 289, 65.
74. W. Lewis,. Desorption/ionization on silicon (DIOS) mass spectrometry: background and applications. Int. J. Mass Spectrom. 2003, 226, 107.
75. T. R. Northen, O. Yanes, M. T. Northen, D. Marrinucci, W. Uritboonthai, J. Apon, S. L. Golledge, A. Nordstrom, G. Siuzdak,. Clathrate nanostructures for mass spectrometry. Nature 2007, 449, 1033.
76. J. A. McLean, W. B. Ridenour, R. M. Caprioli,. Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. J. Mass Spectrom. 2007, 42, 1099.
77. P. Chaurand, S. Schwartz, D. Billheimer, B. J. Xu, A. Crecelius, R. Caprioli,. Integrating histology and imaging mass spectrometry. Anal. Chem. 2004, 76, 1145.
78. C. A. Smith, E. J. Want, G. O'Maille, R. Abagyan, G. Siuzdak,. XCMS: processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification. Anal. Chem. 2006, 78, 779.
79. A. Broersen, R. van Liere, A. F. M. Altelaar, R. M. A. Heeren, L. A. McDonnell,. Automated, feature-based image alignment for high-resolution imaging mass spectrometry of large biological samples. J. Am. Soc. Mass Spectrom. 2008, 19, 823.
80. W. Yu, Z. He, J. Liu, H. Zhao,. Improving mass spectrometry peak detection using multiple peak alignment results. J. Proteome Res. 2008, 7, 123.
81. J. S. Morris, K. R. Coombes, J. Koomen, K. A. Baggerly, R. Kobayashi,. Feature extraction and quantification for mass spectrometry in biomedical applications using the mean spectrum. Bioinformatics 2005, 21, 2005.
82. E. J. Breen, F. G. Hopwood, K. L. Williams, M. R. Wilkins,. Automatic Poisson peak harvesting for high throughput protein identification. Electrophoresis 2000, 21, 2243.
83. D. Kwon, M. Vannucci, J. J. Song, J. Jeong, R. M. Pfeiffer,. A novel wavelet-based thresholding method for the pre-processing of mass spectrometry data that accounts for heterogeneous noise. Proteomics 2008, 8, 3019.
84. M. R. Groseclose, P. P. Massion, P. Chaurand, R. Caprioli,. High-throuput proteomic analysis of formalin-fixed paraffin-embedded tissue microarrays using MALDI imaging mass spectrometry. Proteomics 2008, 18, 3715.
85. S. Rauser, C. Marquardt, B. Balluff, S. O. Deininger, C. Albers, E. Belau, R. Hartmer, D. Suckau, K. Specht, M. P. Ebert, M. Schmitt, M. Aubele, H. Hofler, A. Walch,. Classification of HER2 receptor status in breast cancer tissues by MALDI imaging mass spectrometry. J. Proteome Res. 2010, 9, 1854.
86. L. H. Cazares, D. Troyer, S. Mendrinos, R. A. Lance, J. O. Nyalwidhe, H. A. Beydoun, M. A. Clements, R. R. Drake, O. J. Semmes,. Imaging mass spectrometry of a specific fragment mitogen-activated protein kinase/extracellular signal-regulated kinase kinase kinase 2 discriminates cancer from uninvolved prostate tissue. Clin. Cancer Res. 2009, 15, 5541.
87. S. M. Willems, A. van Remoortere, R. van Zeijl, A. M. Deedler, L. A. McDonnell, P. C. Hogendoorn,. Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumor type and grade and reveals biochemical intratumor heterogeneity. J. Pathol. 2010, 222, 400.
88. J. Zakrzewski, K. Didona,. Advances in hyperspectral imaging technologies for multichannel fiber sensing. SPIE 2009, 7316, 73.
89. R. Molina, J. Mateos,. Multichannel image restoration in astronomy. Vistas Astron. 1997, 41, 373.
90. A. F. H. Goetz, G. Vane, J. E. Solomon, B. N. Rock,. Imaging spectrometry for Earth remote sensing. Science 1985, 228, 1147.
91. N. M. Sijtsema, S. D. Wouters, C. J. Grauw, C. Otto, J. Greve,. Confocal direct imaging Raman microscope: design and applications in biology. Appl. Spectrosc. 1998, 52, 348.
92. J. L. Norris, D. S. Cornett, J. A. Mobley, M. Andersson, E. H. Seeley, P. Chaurand, R. M. Caprioli,. Processing MALDI mass spectra to improve mass spectral direct tissue analysis. Int. J. Mass Spectrom. 2007, 260, 212.
93. S. O. Deininger, M. Becker, E. Wolski, H. Kaminski, R. Paape, D. S. Cornett,. Practical considerations on normalization in MALDI imaging, Proceedings of the 58th ASMS Conference on Mass Spectrometry and Allied Topics, May 22-27, 2010.
94. M. Keenan,. Optimal scaling of TOF-SIMS spectrum-images prior to multivariate statistical analysis. Appl. Surf. Sci. 2004, 231-232, 240.
95. M. R. Keenan, P. G. Kotula,. Accounting for Poisson noise in the multivariate analysis of TOF-SIMS spectrum images. Surf. Interface Anal. 2004, 36, 203.
96. S. A. Schwartz, M. L. Reyzer, R. M. Caprioli,. Direct tissue analysis using matrix-assisted laser desorption/ionization mass spectrometry: practical aspects of sample preparation. J. Mass Spectrom. 2003, 38, 699.
97. A. J. Ibanez, A. Muck, A. Svatos,. Dissipation of charge on MALDI-TOF polymeric chips using an electron-acceptor: analysis of proteins. J. Mass Spectrom. 2007, 42, 634.
98. M. Wisztorski, J. Franck, M. Salzet, I. Fournier,. MALDI direct analysis and imaging of frozen versus FFPE tissues: what strategy for which sample? Method. Mol. Biol. 2010, 656, 303.
99. J. C. Russ, R. P. Woods,. The Image Processing Handbook, 2nd ed, J. Comp. Assist. Tom. 1995, 19, 979.
100. T. Alexandrov, M. Becker, S.-O. Deininger, G. Ernst, L. Wehder, M. Grasmair, F. von Eggeling, H. Thiele, P. Maass,. Spatial segmentation of imaging mass spectrometry data with edge-preserving image denoising and clustering. J. Proteome Res. 2010, 9, 6535-6546.
101. C. Mayrhofer, S. Krieger, E. Raptakis, G. Allmaier,. Comparison of vacuum matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI (AP-MALDI) tandem mass spectrometry of 2-dimensional separated and trypsin-digested glomerular proteins for database search derived identification. J. Proteome Res. 2006, 5, 1967.
102. S. Chandra,. Imaging ion and molecular transport at subcellular resolution by secondary ion mass spectrometry. Int. J. Mass Spectrom. 1995, 143, 161.
103. M. Wagner,. Single-cell ecophysiology of microbes as revealed by Raman microspectroscopy or secondary ion mass spectrometry imaging. Annu. Rev. Microbiol. 2009, 63, 411.
104. R. Levisetti, M. Lebeau,. Cytogenetic applications of high resolution secondary ion imaging microanalysis: detection and mapping of tracer isotopes in human chromosomes. Biol. Cell 1992, 74, 51.
105. V. W. Petit, M. Refregiers, C. Guettier, F. Jamme, K. Sebanayakam, A. Brunelle, O. Laprevote, P. Dumas, F. Le Naour,. Multimodal spectroscopy combining time-of-flight-secondary ion mass spectrometry, synchrotron-FT-IR, and synchrotron-UV microspectroscopies on the same tissue section. Anal. Chem. 2010, 82, 3963.
106. S.-T. T. Tsai, C. W. W. Chen, L. C. C. Lora, M.-C. C. Huang, C.-H. H. Chen, Y.-S. S. Wang,. Simultaneous mass analysis of positive and negative ions using a dual-polarity time-of-flight mass spectrometer. Anal. Chem. 2006, 78, 7729.
107. L. Nyadong, G. A. Harris, S. Balayssac, A. S. Galhena, M. Malet-Martino, R. Martino, R. M. Parry, M. D. Wang, F. M. Fernandez, V. Gilard,. Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuticals. Anal. Chem. 2009, 81, 4803.
108. J. A. Bradshaw, O. S. Ovchinnikova, K. A. Meyer, D. E. Goeringer,. Combined chemical and topographic imaging at atmospheric pressure via microprobe laser desorption/ionization mass spectrometry-atomic force microscopy. Rapid Commun. Mass Spectrom. 2009, 23, 3781.
109. T. K. Sinha, S. Khatib-Shahidi, T. E. Yankeelov, K. Mapara, M. Ehtesham, D. S. Cornett, B. M. Dawant, R. M. Caprioli, J. C. Gore,. Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging. Nat. Methods 2007, 5, 57.
110. G. B. Eijkel, B. Kukrer Kaletas, I. M. van der Wiel, J. M. Kros, T. M. Luider, R. M. A. Heeren,. Correlating MALDI and SIMS imaging mass spectrometric datasets of biological tissue surfaces. Surf. Interface Anal. 2009, 41, 675.
111. D. S. Gholap, A. Izmer, B. De Samber, J. T. van Elteren, V. S. Selih, R. Evens, K. De Schamphelaere, C. Janssen, L. Balcaen, I. Lindemann, L. Vincze, F. Vanhaecke,. Comparison of laser ablation-inductively coupled plasma-mass spectrometry and micro-X-ray fluorescence spectrometry for elemental imaging in Daphnia magna. Anal. Chim. Acta 2010, 664, 19.
112. A. Carado, M. K. Passarelli, J. Kozole, J. E. Wingate, N. Winograd, A. V. Loboda,. C60 secondary ion mass spectrometry with a hybrid-quadrupole orthogonal time-of-flight mass spectrometer. Anal. Chem. 2008, 80, 7921.
113. D. L. Baluya, T. J. Garrett, R. A. Yost,. Automated MALDI matrix deposition method with inkjet printing for imaging mass spectrometry. Anal. Chem. 2007, 79, 6862.
114. S.-E. Ong, B. Blagoev, I. Kratchmarova, D. B. Kristensen, H. Steen, A. Pandey, M. Mann,. Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol. Cell. Proteome 2002, 1, 376.
115. R. D. Unwin, A. Pierce, R. B. Watson, D. W. Sternberg, A. D. Whetton,. Quantitative proteomic analysis using isobaric protein tags enables rapid comparison of changes in transcript and protein levels in transformed cells. Mol. Cell. Proteome 2005, 4, 924.
116. H. Keshishian, T. Addona, M. Burgess, E. Kuhn, S. A. Carr,. Quantitative, multiplexed assays for low abundance proteins in plasma by targeted mass spectrometry and stable isotope dilution. Mol. Cell. Proteome 2007, 6, 2212.
117. G. McMahon, B. Glassner, C. Lechene,. Quantitative imaging of cells with multi-isotope imaging mass spectrometry (MIMS): nanoautography with stable isotope tracers. Appl. Surf. Sci. 2006, 252, 6895.
118. C. Lechene, F. Hillion, G. McMahon, D. Benson, A. M. Kleinfeld, J. P. Kampf, D. Distel, Y. Luyten, J. Bonventre, D. Hentschel, K. M. M. Park, S. Ito, M. Schwartz, G. Benichou, G. Slodzian,. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry. J. Biol. 2006, 5, 20.
119. J. S. Becker, A. Matusch, C. Depboylu, J. Dobrowolska, M. V. Zoriy,. Quantitative imaging of selenium, copper, and zinc in thin sections of biological tissues (slugs-genus arion) measured by laser ablation inductively coupled plasma mass spectrometry. Anal. Chem. 2007, 79, 6074.
120. M. S. Wagner, M. Shen, T. A. Horbett, D. G. Castner,. Quantitative analysis of binary adsorbed protein films by time of flight secondary ion mass spectrometry. J. Biomed. Mater. Res. 2003, 64, 1.
121. J. E. Elsila, N. P. de Leon, R. N. Zare,. Factors affecting quantitative analysis in laser desorption/laser ionization mass spectrometry. Anal. Chem. 2004, 76, 2430.
122. M. Bantscheff, M. Schirle, G. Sweetman, J. Rick, B. Kuster,. Quantitative mass spectrometry in proteomics: a critical review. Anal. Bioanal. Chem. 2007, 389, 1017.
123. R. Van de Plas, B. De Moor, E. Waelkens, (2007). Imaging Mass Spectrometry Based Exploration of Biochemical Tissue Composition using Peak Intensity Weighted PCA. Proc. of the Third IEEE/NIH BISTI Life Science Systems and Applications Workshop 2007 (LISSA 2007), Bethesda, Maryland USA, 2007, 209-212.
124. L. Klerk, A. Broersen, I. Fletcher, R. Vanliere, R. Heeren,. Extended data analysis strategies for high resolution imaging MS: new methods to deal with extremely large image hyperspectral datasets. Int. J. Mass Spectrom. 2007, 260, 222.
125. M. R. Keenan,. Exploiting spatial-domain simplicity in spectral image analysis. Surf. Interface Anal. 2009, 41, 79.
126. M. Hanselmann, M. Kirchner, B. Y. Renard, E. R. Amstalden, K. Glunde, R. M. A. Heeren, F. A. Hamprecht,. Concise representation of mass spectrometry images by probabilistic latent semantic analysis. Anal. Chem. 2008, 80, 9649.
127. S.-O. Deininger, M. P. Ebert, A. Futterer, M. Gerhard, C. Rocken,. MALDI imaging combined with hierarchical clustering as a new tool for the interpretation of complex human cancers. J. Proteome Res. 2008, 7, 5230.
128. G. McCombie, D. Staab, M. Stoeckli, R. Knochenmuss,. Spatial and spectral correlations in MALDI mass spectrometry images by clustering and multivariate analysis. Anal. Chem. 2005, 77, 6118.
129. A. Walch, S. Rauser, S.-O. Deininger, H. Hoer,. MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology. Histochem. Cell Biol. 2008, 130, 421.
130. T. Alexandrov, J. Decker, B. Mertens, A. M. Deelder, R. A. E. M. Tollenaar, P. Maass, H. Thiele,. Biomarker discovery in MALDI-TOF serum protein profiles using discrete wavelet transformation. Bioinformatics 2009, 25, 643.
131. G. A. Valaskovic, G. H. Morrison,. Quantitative imaging ion microscopy: a short review. Scan. Microsc. 1992, 6, 305.
132. R. Pang, P. Johnson, C. Chan, E. Kong, A. Chan, J. Sung, T. Poon,. Technical evaluation of MALDI-TOF mass spectrometry for quantitative proteomic profiling; matrix formulation and application. Clin. Proteomics 2004, 1, 259.
133. R. P. Joosten, J. Salzemann, V. Bloch, H. Stockinger, A. C. Berglund, C. Blanchet, E. B. Rudlolf, C. Combet, A. L. Da Costa, G. Deleage, M. Diarena, R. Fabbretti, G. Fettahi, V. Flegel, A. Gisel, V. Kasam, T. Kervinen, E. Korpelainen, K. Mattila, M. Pagni, M. Reichstadt, V. Breton, I. J. Tickle, G. Vriend,. PDB REDO: automated re-refinement of X-ray structure models in the PDB. J. Appl. Crystallogr. 2009, 42, 376.
134. T. Lutteke, C.-W. Von Der Lieth,. The protein data bank (PDB) as a versatile resource for glycobiology and glycomics. Biocatal. Biotransfor. 2006, 24, 147.
135. T. J. Oldfield,. Creating structure features by data mining the PDB to use as molecular-replacement models. Acta Crystallogr. D 2001, 57, 1421.
136. J. Balog, T. Szaniszlo, K.-C. Schaefer, J. Denes, A. Lopata, L. Godorhazy, D. Szalay, L. Balogh, L. Sasi-Szabo, M. Toth, Z. Takats,. Identification of biological tissues by rapid evaporative ionization mass spectrometry. Anal. Chem. 2010, 82, 7343.
137. L. C. Chen, K. Yoshimura, Z. Yu, R. Iwata, H. Ito, H. Suzuki, K. Mori, O. Ariyada, S. Takeda, T. Kubota, K. Hiraoka,. Ambient imaging mass spectrometry by electrospray ionization using solid needle as sampling probe. J. Mass Spectrom. 2009, 44, 1469.