Imaging mass spectrometry of intraspecies metabolic exchange revealed the cannibalistic factors of Bacillus subtilis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 37, 2010, Pages 16286-16290

  Liu, Wei Ting ^a   Yang, Yu Liang ^b   Xu, Yuquan ^a   Lamsa, Anne ^c   Haste, Nina M ^b,d   Yang, Jane Y ^a   Ng, Julio ^e   Gonzalez, David ^a   Ellermeier, Craig D ^f   Straight, Paul D ^g   Pevzner, Pavel A ^a,e   Pogliano, Joe ^c   Nizet, Victor ^b,d,h   Pogliano, Kit ^c   Dorrestein, Pieter C ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF IOWA   (United States)

^g TEXAS A AND M UNIVERSITY   (United States)

^h UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Bacterial communication; Cannibalism; Natural product; Posttranslational modifications; Thioether

Indexed keywords

CYCLOPEPTIDE; SPORULATION DELAYING PROTEIN; SPORULATION KILLING FACTOR; UNCLASSIFIED DRUG; VANCOMYCIN; BACTERIAL PROTEIN;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; CANNIBALISM; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOLYSIS; FLUORESCENCE MICROSCOPY; GENE SEQUENCE; IC 50; LIQUID CULTURE; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SPOROGENESIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; BACTERIAL SPORE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; PROCEDURES;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BACILLUS SUBTILIS; BACTERIAL PROTEINS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; SPORES, BACTERIAL;

EID: 77957977117     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1008368107     Document Type: Article

References (20)

1. Shank EA, Kolter R (2009) New developments in microbial interspecies signaling. Curr Opin Microbiol 12:205-214.
2. Tam NKM, et al. (2006) The intestinal life cycle of Bacillus subtilis and close relatives. J Bacteriol 188:2692-2700.
3. Aguilar C, Vlamakis H, Losick R, Kolter R (2007) Thinking about Bacillus subtilis as a multicellular organism. Curr Opin Microbiol 10:638-643.
4. Earl AM, Losick R, Kolter R (2008) Ecology and genomics of Bacillus subtilis. Trends Microbiol 16:269-275.
5. Kunst F, et al. (1997) The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature 390:249-256.
6. González-Pastor JE, Hobbs EC, Losick R (2003) Cannibalism by sporulating bacteria. Science 301:510-513.
7. Ellermeier CD, Hobbs EC, Gonzalez-Pastor JE, Losick R (2006) A three-protein signaling pathway governing immunity to a bacterial cannibalism toxin. Cell 124:549-559.
8. Engelberg-Kulka H, Amitai S, Kolodkin-Gal I, Hazan R (2006) Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet 2:e135.
9. Claverys JP, Håvarstein LS (2007) Cannibalism and fratricide: Mechanisms and raisons d'être. Nat Rev Microbiol 5:219-229.
10. López D, Vlamakis H, Losick R, Kolter R (2009) Cannibalism enhances biofilm development in Bacillus subtilis. Mol Microbiol 74:609-618.
11. Burbulys D, Trach KA, Hoch JA (1991) Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 64:545-552.
12. Fawcett P, Eichenberger P, Losick R, Youngman P (2000) The transcriptional profile of early to middle sporulation in Bacillus subtilis. Proc Natl Acad Sci USA 97:8063-8068.
13. Molle V, et al. (2003) The Spo0A regulon of Bacillus subtilis. Mol Microbiol 50:1683-1701.
14. Lin D, Qu LJ, Gu H, Chen ZA (2001) A 3.1-kb genomic fragment of Bacillus subtilis encodes the protein inhibiting growth of Xanthomonas oryzae pv. oryzae. J Appl Microbiol 91:1044-1050.
15. Nandy SK, Bapat PM, Venkatesh KV (2007) Sporulating bacteria prefers predation to cannibalism in mixed cultures. FEBS Lett 581:151-156.
16. Cornett DS, Reyzer ML, Chaurand P, Caprioli RM (2007) MALDI imaging mass spectrometry: Molecular snapshots of biochemical systems. Nat Methods 4:828-833.
17. Seeley EH, Caprioli RM (2008) Molecular imaging of proteins in tissues by mass spectrometry. Proc Natl Acad Sci USA 105:18126-18131.
18. Yang YL, Xu Y, Straight P, Dorrestein PC (2009) Translating metabolic exchange with imaging mass spectrometry. Nat Chem Biol 5:885-887.
19. Zeigler DR, et al. (2008) The origins of 168, W23, and other Bacillus subtilis legacy strains. J Bacteriol 190:6983-6995.
20. Li JW, Vederas JC (2009) Drug discovery and natural products: End of an era or an endless frontier? Science 325:161-165.