2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosylcytosine: A novel anticancer nucleoside analog that causes both DNA strand breaks and G2 arrest

Molecular Pharmacology

Volumn 59, Issue 4, 2001, Pages 725-731

  Azuma, Atsushi ^a   Huang, Peng ^a   Matsuda, Akira ^b   Plunkett, William ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2' C CYANO 2' DEOXY 1 BETA DEXTRO ARABINOPENTOFURANOSYLCYTOSINE; CELL DNA; CYTOSINE DERIVATIVE; DEOXYCYTIDINE; GEMCITABINE; NUCLEOSIDE ANALOG; UNCLASSIFIED DRUG; 2' CYANO 2' DEOXYARABINOFURANOSYLCYTOSINE; 2'-CYANO-2'-DEOXYARABINOFURANOSYLCYTOSINE; ANTINEOPLASTIC AGENT; CYCLIN B; CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYTARABINE; DNA; DRUG DERIVATIVE; RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; DNA REPLICATION; DNA STRAND; DNA STRAND BREAKAGE; HYDROLYSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; ACUTE GRANULOCYTIC LEUKEMIA; CELL CULTURE; CHROMOSOME BREAKAGE; CYTOLOGY; DRUG EFFECT; GENETICS; HUMAN; LYMPHOCYTE; METABOLISM; PHOSPHORYLATION;

ANTINEOPLASTIC AGENTS; CDC2 PROTEIN KINASE; CHROMOSOME BREAKAGE; CYCLIN B; CYTARABINE; DEOXYCYTIDINE; DNA, NEOPLASM; G2 PHASE; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; LYMPHOCYTES; PHOSPHORYLATION; RNA; TUMOR CELLS, CULTURED;

EID: 0034744725     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.4.725     Document Type: Article

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