메뉴 건너뛰기




Volumn 29, Issue 3, 2011, Pages 187-195

Gene silencing by the polycomb group proteins and associations with cancer

Author keywords

Cancer; Epigenetics; Polycomb group proteins

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BETA CATENIN; BETA3 INTEGRIN; BMI1 PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; EMBRYONIC ECTODERM DEVELOPMENT PROTEIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; ONCOPROTEIN; POLYCOMB GROUP PROTEIN; POLYCOMB REPRESSIVE COMPLEX 1 PROTEIN; POLYCOMB REPRESSIVE COMPLEX 2 PROTEIN; PROTEIN CBX; PROTEIN HPC PCG; PROTEIN HPH; PROTEIN MEL18; PROTEIN RING1; PROTEIN RING1B; PROTEIN SUZ12; RETINOBLASTOMA BINDING PROTEIN 4; RETINOBLASTOMA BINDING PROTEIN 7; T CELL FACTOR PROTEIN; TRANSCRIPTION FACTOR EZH2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; UNTRANSLATED RNA; UVOMORULIN; WNT PROTEIN;

EID: 79951616712     PISSN: 07357907     EISSN: 15324192     Source Type: Journal    
DOI: 10.3109/07357907.2010.512605     Document Type: Article
Times cited : (18)

References (89)
  • 1
    • 67649397334 scopus 로고    scopus 로고
    • Epigenetic gene regulation in stem cells and correlation to cancer
    • Mathews LA, Crea F, Farrar WL. Epigenetic gene regulation in stem cells and correlation to cancer. Differentiation 2009;78(1):1-17.
    • (2009) Differentiation , vol.78 , Issue.1 , pp. 1-17
    • Mathews, L.A.1    Crea, F.2    Farrar, W.L.3
  • 3
    • 70349469565 scopus 로고    scopus 로고
    • Mechanisms of polycomb gene silencing: Knowns and unknowns
    • Simon JA, Kingston RE. Mechanisms of polycomb gene silencing: knowns and unknowns. Nat Rev Mol Cell Biol 2009;10(10):697-708.
    • (2009) Nat. Rev. Mol. Cell. Biol. , vol.10 , Issue.10 , pp. 697-708
    • Simon, J.A.1    Kingston, R.E.2
  • 4
    • 70349696541 scopus 로고    scopus 로고
    • Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer
    • Gieni RS, Hendzel MJ. Polycomb group protein gene silencing, non-coding RNA, stem cells, and cancer. Biochem Cell Biol 2009;87(5):711-746.
    • (2009) Biochem. Cell. Biol. , vol.87 , Issue.5 , pp. 711-746
    • Gieni, R.S.1    Hendzel, M.J.2
  • 6
    • 0033552813 scopus 로고    scopus 로고
    • The oncogene and Polycombgroup gene bmi-1 regulates cell proliferation and senescence through the ink4a locus
    • DOI 10.1038/16476
    • Jacobs JJ, Kieboom K, Marino S, DePinho RA, van Lohuizen M. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397(6715):164-168. (Pubitemid 29050921)
    • (1999) Nature , vol.397 , Issue.6715 , pp. 164-168
    • Jacobs, J.L.1    Kieboom, K.2    Marino, S.3    DePinho, R.A.4    Van Lohuizen, M.5
  • 7
    • 33846850149 scopus 로고    scopus 로고
    • Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins
    • DOI 10.1091/mbc.E06-05-0447
    • Guo WJ, Datta S, Band V, Dimri GP. Mel-18, a polycomb group protein, regulates cell proliferation and senescence via transcriptional repression of Bmi-1 and c-Myc oncoproteins. Mol Biol Cell 2007;18(2):536-546. (Pubitemid 46213222)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.2 , pp. 536-546
    • Guo, W.-J.1    Datta, S.2    Band, V.3    Dimri, G.P.4
  • 8
    • 2942618531 scopus 로고    scopus 로고
    • Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells
    • DOI 10.1016/j.exphem.2004.03.001, PII S0301472X04000876
    • Kajiume T, Ninomiya Y, Ishihara H, Kanno R, Kanno M. Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. Exp Hematol 2004;32(6):571-578. (Pubitemid 38739469)
    • (2004) Experimental Hematology , vol.32 , Issue.6 , pp. 571-578
    • Kajiume, T.1    Ninomiya, Y.2    Ishihara, H.3    Kanno, R.4    Kanno, M.5
  • 9
    • 0038349957 scopus 로고    scopus 로고
    • Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
    • DOI 10.1038/nature01587
    • Park IK, Qian D, Kiel M, Becker MW, Pihalja M, Weissman IL, Morrison SJ, Clarke MF. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423(6937):302-305. (Pubitemid 40852701)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 302-305
    • Park, I.-K.1    Qian, D.2    Kiel, M.3    Becker, M.W.4    Pihalja, M.5    Weissman, I.L.6    Morrison, S.J.7    Clarke, M.F.8
  • 10
    • 67049136167 scopus 로고    scopus 로고
    • Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells
    • Kajiume T, Ohno N, Sera Y, Kawahara Y, Yuge L, Kobayashi M. Reciprocal expression of Bmi1 and Mel-18 is associated with functioning of primitive hematopoietic cells. Exp Hematol 2009;37(7):857-866.
    • (2009) Exp. Hematol. , vol.37 , Issue.7 , pp. 857-866
    • Kajiume, T.1    Ohno, N.2    Sera, Y.3    Kawahara, Y.4    Yuge, L.5    Kobayashi, M.6
  • 11
    • 33947576177 scopus 로고    scopus 로고
    • Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
    • DOI 10.1038/sj.emboj.7601632, PII 7601632
    • Dietrich N, Bracken AP, Trinh E, Schjerling CK, Koseki H, Rappsilber J, Helin K, Hansen KH. Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4AARF locus. EMBO J 2007;26(6):1637-1648. (Pubitemid 46480949)
    • (2007) EMBO Journal , vol.26 , Issue.6 , pp. 1637-1648
    • Dietrich, N.1    Bracken, A.P.2    Trinh, E.3    Schjerling, C.K.4    Koseki, H.5    Rappsilber, J.6    Helin, K.7    Hansen, K.H.8
  • 13
    • 1342332096 scopus 로고    scopus 로고
    • Polycomb CBX7 has a unifying role in cellular lifespan
    • DOI 10.1038/ncb1077
    • Gil J, Bernard D, Martinez D, Beach D. Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol 2004;6:67-72. (Pubitemid 38425732)
    • (2004) Nature Cell Biology , vol.6 , Issue.1 , pp. 67-72
    • Gil, J.1    Bernard, D.2    Martinez, D.3    Beach, D.4
  • 16
    • 29144487990 scopus 로고    scopus 로고
    • Role of Bmi-1 and Ring1A in H2A ubiquitylation and hox gene silencing
    • DOI 10.1016/j.molcel.2005.12.002, PII S1097276505018174
    • Cao R, Tsukada Y, Zhang Y. Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell 2005;20(6):845-854. (Pubitemid 41814874)
    • (2005) Molecular Cell , vol.20 , Issue.6 , pp. 845-854
    • Cao, R.1    Tsukada, Y.-I.2    Zhang, Y.3
  • 17
    • 33746008541 scopus 로고    scopus 로고
    • Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex
    • DOI 10.1074/jbc.M602461200
    • Li Z, Cao R, Wang M, Myers MP, Zhang Y, Xu RM. Structure of a Bmi-1-Ring1B polycomb group ubiquitin ligase complex. J Biol Chem 2006;281:20643-20649. (Pubitemid 44065835)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.29 , pp. 20643-20649
    • Li, Z.1    Cao, R.2    Wang, M.3    Myers, M.P.4    Zhang, Y.5    Xu, R.-M.6
  • 19
    • 30344442873 scopus 로고    scopus 로고
    • The many faces of SAM
    • Qiao F, Bowie JU. The many faces of SAM. Sci STKE 2005;2005(286): re7.
    • (2005) Sci. STKE , vol.2005 , Issue.286
    • Qiao, F.1    Bowie, J.U.2
  • 20
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in polycomb-group silencing
    • DOI 10.1126/science.1076997
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, Jones RS, Zhang Y. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002;298(5595):1039-1043. (Pubitemid 35247314)
    • (2002) Science , vol.298 , Issue.5595 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6    Jones, R.S.7    Zhang, Y.8
  • 21
    • 0037131523 scopus 로고    scopus 로고
    • Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites
    • DOI 10.1016/S0092-8674(02)00975-3
    • Czermin B, Melfi R, McCabe D, Seitz V, Imhof A, Pirrotta V. Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell 2002;111(2):185-196. (Pubitemid 35292439)
    • (2002) Cell , vol.111 , Issue.2 , pp. 185-196
    • Czermin, B.1    Melfi, R.2    McCabe, D.3    Seitz, V.4    Imhof, A.5    Pirrotta, V.6
  • 22
    • 0043127085 scopus 로고    scopus 로고
    • Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by polycomb and HP1 chromodomains
    • DOI 10.1101/gad.1110503
    • Fischle W, Wang Y, Jacobs SA, Kim Y, Allis CD, Khorasanizadeh S. Molecular basis for the discrimination of repressive methyllysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 2003;17(15):1870-1881. (Pubitemid 36944564)
    • (2003) Genes and Development , vol.17 , Issue.15 , pp. 1870-1881
    • Fischle, W.1    Wang, Y.2    Jacobs, S.A.3    Kim, Y.4    Allis, C.D.5    Khorasanizadeh, S.6
  • 23
    • 1942502862 scopus 로고    scopus 로고
    • Different Ezh2-containing complexes target methylation of histone H1 or nucleosomal histone H3
    • DOI 10.1016/S1097-2765(04)00185-6, PII S1097276504001856
    • Kuzmichev A, Jenuwein T, Tempst P, Reinberg DE. Differentzh2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell 2004;14(2), 183-193. (Pubitemid 38515646)
    • (2004) Molecular Cell , vol.14 , Issue.2 , pp. 183-193
    • Kuzmichev, A.1    Jenuwein, T.2    Tempst, P.3    Reinberg, D.4
  • 25
    • 0032751323 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
    • van der Vlag J, Otte AP. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 1999;23(4):474-478.
    • (1999) Nat. Genet. , vol.23 , Issue.4 , pp. 474-478
    • Van Der Vlag, J.1    Otte, A.P.2
  • 26
    • 8144230178 scopus 로고    scopus 로고
    • Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
    • DOI 10.1038/sj.emboj.7600402
    • Pasini D, Bracken AP, Jensen MR, Lazzerini Denchi E, Helin K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity. EMBO J 2004;23(20):4061-4071. (Pubitemid 39472427)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4061-4071
    • Pasini, D.1    Bracken, A.P.2    Jensen, M.R.3    Denchi, E.L.4    Helin, K.5
  • 27
    • 0037111831 scopus 로고    scopus 로고
    • Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of zeste protein
    • DOI 10.1101/gad.1035902
    • Kuzmichev A, Nishioka K, Erdjument-Bromage H, Tempst P, Reinberg D. Histone methyltransferase activity associated with a human multiprotein complex containing the enhancer of Zeste protein. Genes Dev 2002;16(22):2893-2905. (Pubitemid 35334738)
    • (2002) Genes and Development , vol.16 , Issue.22 , pp. 2893-2905
    • Kuzmichev, A.1    Nishioka, K.2    Erdjument-Bromage, H.3    Tempst, P.4    Reinberg, D.5
  • 29
    • 43249116995 scopus 로고    scopus 로고
    • Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2
    • DOI 10.1101/gad.470008
    • Pasini D, Hansen KH, Christensen J, Agger K, Cloos PA, Helin K. Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-repressive complex 2. Genes Dev 2008;22(10):1345-1355. (Pubitemid 351717525)
    • (2008) Genes and Development , vol.22 , Issue.10 , pp. 1345-1355
    • Pasini, D.1    Hansen, K.H.2    Christensen, J.3    Agger, K.4    Cloos, P.A.C.5    Helin, K.6
  • 30
    • 0034785891 scopus 로고    scopus 로고
    • Reconstitution of a functional core polycomb repressive complex
    • DOI 10.1016/S1097-2765(01)00316-1
    • Francis NJ, Saurin AJ, Shao Z, Kingston RE. Reconstitution of a functional core polycomb repressive complex. Mol Cell 2001;8(3):545-556. (Pubitemid 32946932)
    • (2001) Molecular Cell , vol.8 , Issue.3 , pp. 545-556
    • Francis, N.J.1    Saurin, A.J.2    Shao, Z.3    Kingston, R.E.4
  • 31
    • 0033538578 scopus 로고    scopus 로고
    • Stabilization of chromatin structure by PRC1, a polycomb complex
    • DOI 10.1016/S0092-8674(00)80604-2
    • Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu CT, Bender W, Kingston RE. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 1999;98(1), 37-46. (Pubitemid 29331194)
    • (1999) Cell , vol.98 , Issue.1 , pp. 37-46
    • Shao, Z.1    Raible, F.2    Mollaaghababa, R.3    Guyon, J.R.4    Wu, C.-T.5    Bender, W.6    Kingston, R.E.7
  • 32
    • 43249130490 scopus 로고    scopus 로고
    • SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
    • DOI 10.1128/MCB.02019-07
    • Kia SK, Gorski MM, Giannakopoulos S, Verrijzer CP. SWI/SNF mediates Polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol 2008;28(10):3457-3464. (Pubitemid 351657107)
    • (2008) Molecular and Cellular Biology , vol.28 , Issue.10 , pp. 3457-3464
    • Kia, S.K.1    Gorski, M.M.2    Giannakopoulos, S.3    Verrijzer, C.P.4
  • 34
    • 0035833726 scopus 로고    scopus 로고
    • General transcription factors bind promoters repressed by Polycomb group proteins
    • Breiling A, Turner BM, Bianchi ME, Orlando V. General transcription factors bind promoters repressed by Polycomb group proteins. Nature 2001;412(6847):651-655.
    • (2001) Nature , vol.412 , Issue.6847 , pp. 651-655
    • Breiling, A.1    Turner, B.M.2    Bianchi, M.E.3    Orlando, V.4
  • 35
    • 0037268947 scopus 로고    scopus 로고
    • The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing
    • DOI 10.1242/dev.00204
    • Brown JL, Fritsch C, Mueller J, Kassis JA. D. Therosophila pholike gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development 2003;130(2):285-294. (Pubitemid 36175927)
    • (2003) Development , vol.130 , Issue.2 , pp. 285-294
    • Brown, J.L.1    Fritsch, C.2    Mueller, J.3    Kassis, J.A.4
  • 37
    • 73149111929 scopus 로고    scopus 로고
    • A region of the human HOXD cluster that confers Polycomb-group responsiveness
    • Woo CJ, Kharchenko PV, Daheron L, Park PJ, Kingston RE. A region of the human HOXD cluster that confers Polycomb-group responsiveness. Cell 2010;140(1):99-110.
    • (2010) Cell. , vol.140 , Issue.1 , pp. 99-110
    • Woo, C.J.1    Kharchenko, P.V.2    Daheron, L.3    Park, P.J.4    Kingston, R.E.5
  • 39
    • 38149098408 scopus 로고    scopus 로고
    • H. Histone2 Amonoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation
    • Zhou W, Zhu P, Wang J, Pascual G, Ohgi KA, Lozach J, Glass CK, Rosenfeld MG. H. Histone2 Amonoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation. Mol Cell 2008;29(1):69-80.
    • (2008) Mol. Cell. , vol.29 , Issue.1 , pp. 69-80
    • Zhou, W.1    Zhu, P.2    Wang, J.3    Pascual, G.4    Ohgi, K.A.5    Lozach, J.6    Glass, C.K.7    Rosenfeld, M.G.8
  • 42
    • 33645751058 scopus 로고    scopus 로고
    • Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state
    • McGarvey KM, Fahrner JA, Greene E, Martens J, Jenuwein T, Baylin SB. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state. Cancer Res 2006;66:3541-3549.
    • (2006) Cancer Res. , vol.66 , pp. 3541-3549
    • McGarvey, K.M.1    Fahrner, J.A.2    Greene, E.3    Martens, J.4    Jenuwein, T.5    Baylin, S.B.6
  • 44
    • 73449144780 scopus 로고    scopus 로고
    • Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation
    • Rush M, Appanah R, Lee S, Lam LL, Goyal P, Lorincz MC. Targeting of EZH2 to a defined genomic site is sufficient for recruitment of Dnmt3a but not de novo DNA methylation. Epigenetics 2009;4(6):404-414.
    • (2009) Epigenetics , vol.4 , Issue.6 , pp. 404-414
    • Rush, M.1    Appanah, R.2    Lee, S.3    Lam, L.L.4    Goyal, P.5    Lorincz, M.C.6
  • 45
    • 34347233479 scopus 로고    scopus 로고
    • DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2
    • DOI 10.1158/0008-5472.CAN-06-2029
    • McGarvey KM, Greene E, Fahrner JA, Jenuwein T, Baylin SB. DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2. Cancer Res 2007;67(11):5097-5102. (Pubitemid 46997244)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5097-5102
    • McGarvey, K.M.1    Greene, E.2    Fahrner, J.A.3    Jenuwein, T.4    Baylin, S.B.5
  • 46
    • 13244279419 scopus 로고    scopus 로고
    • Role of polycomb group proteins in stem cell self-renewal and cancer
    • DOI 10.1089/dna.2005.24.117
    • Gil J, Bernard D, Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol 2005;24(2):117-125. (Pubitemid 40189747)
    • (2005) DNA and Cell Biology , vol.24 , Issue.2 , pp. 117-125
    • Gil, J.1    Bernard, D.2    Peters, G.3
  • 49
    • 17144412566 scopus 로고    scopus 로고
    • Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases
    • DOI 10.1016/j.ejso.2004.11.001, PII S0748798304003233
    • Mimori K., Ogawa K., OkamotoM., Sudo T., Inoue H., Mori M. Clinical significance of enhancer of zeste homolog 2 expression in colorectal cancer cases. Eur J Surg Oncol 2005;31(4):376-380. (Pubitemid 40521303)
    • (2005) European Journal of Surgical Oncology , vol.31 , Issue.4 , pp. 376-380
    • Mimori, K.1    Ogawa, K.2    Okamoto, M.3    Sudo, T.4    Inoue, H.5    Mori, M.6
  • 51
    • 34347233480 scopus 로고    scopus 로고
    • Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells
    • DOI 10.1158/0008-5472.CAN-06-4368
    • Guo WJ, Zeng MS, Yadav A, Song LB, Guo BH, Band V, Dimri GP. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res 2007;67(11):5083-5089. (Pubitemid 46997242)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5083-5089
    • Guo, W.-J.1    Zeng, M.-S.2    Yadav, A.3    Song, L.-B.4    Guo, B.-H.5    Band, V.6    Dimri, G.P.7
  • 53
    • 55149119362 scopus 로고    scopus 로고
    • Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance
    • Hinz S, Kempkensteffen C, Christoph F, Krause H, Schrader M, Schostak M, Miller K, Weikert S. Expression parameters of the polycomb group proteins BMI1, SUZ12, RING1 and CBX7 in urothelial carcinoma of the bladder and their prognostic relevance. Tumour Biol 2008;29(5):323-329.
    • (2008) Tumour Biol. , vol.29 , Issue.5 , pp. 323-329
    • Hinz, S.1    Kempkensteffen, C.2    Christoph, F.3    Krause, H.4    Schrader, M.5    Schostak, M.6    Miller, K.7    Weikert, S.8
  • 55
    • 0141576562 scopus 로고    scopus 로고
    • Identification of the polycomb group protein SU (Z) 12 as a potential molecular target for human cancer therapy
    • Kirmizis A, Bartley SM, Farnham PJ. Identification of the polycomb group protein SU (Z) 12 as a potential molecular target for human cancer therapy. Mol Cancer Ther 2003;2(1):113-121.
    • (2003) Mol. Cancer Ther. , vol.2 , Issue.1 , pp. 113-121
    • Kirmizis, A.1    Bartley, S.M.2    Farnham, P.J.3
  • 56
    • 0842311697 scopus 로고    scopus 로고
    • Inducible Expression of RbAp46 Activates c-Jun NH2-terminal Kinase-dependent Apoptosis and Suppresses Progressive Growth of Tumor Xenografts in Nude Mice
    • Zhang TF, Yu SQ, Loggie BW, Wang ZY. Inducible expression of RbAp46 activates c-N. H. Jun2-terminal kinase-dependent apoptosis and suppresses progressive growth of tumor xenografts in nude mice. Anticancer Res 2003;23(6C): 4621-4627. (Pubitemid 38173876)
    • (2003) Anticancer Research , vol.23 , Issue.6 C , pp. 4621-4627
    • Zhang, T.-F.1    Yu, S.-Q.2    Loggie, B.W.3    Wang, Z.-Y.4
  • 57
    • 35348959966 scopus 로고    scopus 로고
    • RbAp46 inhibits estrogen-stimulated progression of neoplastigenic breast epithelial cells
    • Zhang TF, Yu SQ, Wang ZY. RbAp46 inhibits estrogen-stimulated progression of neoplastigenic breast epithelial cells. Anticancer Res 2007;27(5 A): 3205-3209.
    • (2007) Anticancer Res. , vol.27 , Issue.5 A , pp. 3205-3209
    • Zhang, T.F.1    Yu, S.Q.2    Wang, Z.Y.3
  • 59
    • 48749104292 scopus 로고    scopus 로고
    • The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma
    • Sasaki M, Ikeda H, Itatsu K, Yamaguchi J, Sawada S, Minato H, Ohta T, Nakanuma Y. The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma. Lab Invest 2008;88(8):873-882.
    • (2008) Lab. Invest. , vol.88 , Issue.8 , pp. 873-882
    • Sasaki, M.1    Ikeda, H.2    Itatsu, K.3    Yamaguchi, J.4    Sawada, S.5    Minato, H.6    Ohta, T.7    Nakanuma, Y.8
  • 60
    • 77951205862 scopus 로고    scopus 로고
    • Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features
    • Epub ahead of print
    • Wang W, Lin T, Huang J, Hu W, Xu K, Liu J. Analysis of Mel-18 expression in prostate cancer tissues and correlation with clinicopathologic features. Urol Oncol 2009; (Epub ahead of print).
    • (2009) Urol. Oncol.
    • Wang, W.1    Lin, T.2    Huang, J.3    Hu, W.4    Xu, K.5    Liu, J.6
  • 61
    • 33646870495 scopus 로고    scopus 로고
    • Genomewide mapping of Polycomb target genes unravels their roles in cell fate transitions
    • Bracken AP, Dietrich N, Pasini D, Hansen KH, Helin K. Genomewide mapping of Polycomb target genes unravels their roles in cell fate transitions. Genes Dev 2006;20(9):1123-1136.
    • (2006) Genes Dev. , vol.20 , Issue.9 , pp. 1123-1136
    • Bracken, A.P.1    Dietrich, N.2    Pasini, D.3    Hansen, K.H.4    Helin, K.5
  • 63
    • 33747587608 scopus 로고    scopus 로고
    • Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
    • DOI 10.1038/nrm1987, PII NRM1987
    • Gil J, Peters G. Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all. Nat Rev Mol Cell Biol 2006;7(9):667-677. (Pubitemid 44268212)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.9 , pp. 667-677
    • Gil, J.1    Peters, G.2
  • 64
    • 0033569429 scopus 로고    scopus 로고
    • Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc- induced apoptosis via INK4a/ARF
    • DOI 10.1101/gad.13.20.2678
    • Jacobs JJ, Scheijen B, Voncken JW, Kieboom K, Berns A, van Lohuizen M. Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARGenes, F. Genes Dev 1999;13(20):2678-2690. (Pubitemid 29508555)
    • (1999) Genes and Development , vol.13 , Issue.20 , pp. 2678-2690
    • Jacobs, J.J.L.1    Scheijen, B.2    Voncken, J.-W.3    Kieboom, K.4    Berns, A.5    Van Lohuizen, M.6
  • 66
    • 20444370974 scopus 로고    scopus 로고
    • What has senescence got to do with cancer?
    • DOI 10.1016/j.ccr.2005.05.025, PII S1535610805001662
    • Dimri GP. What has senescence got to do with cancer? Cancer Cell 2005;7(6):505-512. (Pubitemid 40799244)
    • (2005) Cancer Cell , vol.7 , Issue.6 , pp. 505-512
    • Dimri, G.P.1
  • 67
    • 34248333318 scopus 로고    scopus 로고
    • Cancer regression by senescence
    • Serrano M. Cancer regression by senescence. N Engl J Med 2007;356(19):1996-1997.
    • (2007) N. Engl. J. Med. , vol.356 , Issue.19 , pp. 1996-1997
    • Serrano, M.1
  • 68
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 1997;88(5), 593-602. (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 70
    • 34447508334 scopus 로고    scopus 로고
    • A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos
    • Petruk S, Sedkov Y, Brock HW, Mazo A. A model for initiation of mosaic HOX gene expression patterns by non-coding RNAs in early embryos. RNA Biol 2007;4(1):1-6. (Pubitemid 47328286)
    • (2007) RNA Biology , vol.4 , Issue.1 , pp. 1-6
    • Petruk, S.1    Sedkov, Y.2    Brock, H.W.3    Mazo, A.4
  • 71
    • 66349089138 scopus 로고    scopus 로고
    • Non-coding RNAs in polycomb/trithorax regulation
    • Hekimoglu B, Ringrose L R N A. Non-coding RNAs in polycomb/trithorax regulation. RNA Biol 2009;6(2):129-137.
    • (2009) RNA Biol. , vol.6 , Issue.2 , pp. 129-137
    • Hekimoglu, B.1    Ringrose, L.R.N.A.2
  • 75
    • 0035499267 scopus 로고    scopus 로고
    • Stem cells, cancer, and cancer stem cells
    • DOI 10.1038/35102167
    • Reya T, Morrison SJ, Clarke MF, Weissman IL. Stem cells, cancer, and cancer stem cells. Nature 2001;414(6859):105-111. (Pubitemid 33041634)
    • (2001) Nature , vol.414 , Issue.6859 , pp. 105-111
    • Reya, T.1    Morrison, S.J.2    Clarke, M.F.3    Weissman, I.L.4
  • 77
    • 0037673984 scopus 로고    scopus 로고
    • Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells
    • DOI 10.1038/nature01572
    • Lessard J, Sauvageau G. Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 2003;423(6937):255-260. (Pubitemid 40852690)
    • (2003) Nature , vol.423 , Issue.6937 , pp. 255-260
    • Lessard, J.1    Sauvageau, G.2
  • 79
    • 42349104332 scopus 로고    scopus 로고
    • Brain tumor stem cells and the tumor microenvironment
    • Jandial R U H, Levy ML, Snyder EY. Brain tumor stem cells and the tumor microenvironment. Neurosurg Focus 2008;24(3-4): E27b.
    • (2008) Neurosurg. Focus , vol.24 , Issue.3-4
    • Jandial, R.U.H.1    Levy, M.L.2    Snyder, E.Y.3
  • 82
    • 50149092414 scopus 로고    scopus 로고
    • Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion
    • Dovey JS, Zacharek SJ, Kim CF, Lees JA. Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci U S A 2008;105(33):11857-11862.
    • (2008) Proc. Natl. Acad. Sci. U S A , vol.105 , Issue.33 , pp. 11857-11862
    • Dovey, J.S.1    Zacharek, S.J.2    Kim, C.F.3    Lees, J.A.4
  • 85
    • 42549100819 scopus 로고    scopus 로고
    • Loss of BMI-1 expression is associated with clinical progress of malignant melanoma
    • DOI 10.1038/modpathol.2008.17, PII MODPATHOL200817
    • Bachmann IM, Puntervoll HE, Otte AP, Akslen LA. Loss of BMI-1 expression is associated with clinical progress of malignant melanoma. Mod Pathol 2008;21(5):583-590. (Pubitemid 351589652)
    • (2008) Modern Pathology , vol.21 , Issue.5 , pp. 583-590
    • Bachmann, I.M.1    Puntervoll, H.E.2    Otte, A.P.3    Akslen, L.A.4
  • 87
    • 27744555810 scopus 로고    scopus 로고
    • Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs
    • DOI 10.1038/nature04120, PII N04120
    • Lee N, Maurange C, Ringrose L, Paro R. Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature 2005;438(7065), 234-237. (Pubitemid 41599876)
    • (2005) Nature , vol.438 , Issue.7065 , pp. 234-237
    • Lee, N.1    Maurange, C.2    Ringrose, L.3    Paro, R.4
  • 89


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.