Proanthocyanidins produce significant attenuation of doxorubicin-induced mutagenicity via suppression of oxidative stress

Oxidative Medicine and Cellular Longevity

Volumn 3, Issue 6, 2010, Pages

  Attia, Sabry M ^a   Bakheet, Saleh A ^a   Al Rasheed, Nouf M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Chemoprotection; Doxorubicin; Mutagenesis; Oxidative stress; Proanthocyanidins

Indexed keywords

BONE; CELL PROLIFERATION; MAMMALS; MUTAGENESIS; OXIDATIVE STRESS; PATIENT TREATMENT;

CHEMOPREVENTIVE AGENTS; CHEMOPROTECTION; CHROMOSOMAL ABERRATION; DNA STRAND BREAK; DOXORUBICIN; LIPID PEROXIDATION; POTENTIAL MECHANISM; PROANTHOCYANIDINS;

FLAVONOIDS;

DOXORUBICIN; PROANTHOCYANIDIN DERIVATIVE; THIOL DERIVATIVE; ANTINEOPLASTIC ANTIBIOTIC; MUTAGENIC AGENT; PROANTHOCYANIDIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW SUPPRESSION; CELL PROLIFERATION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG MECHANISM; GERM CELL; LIPID PEROXIDATION; MALE; MOUSE; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; SECOND CANCER; SPERMATOCYTE; SPERMATOGONIUM; SPERMATOZOON ABNORMALITY; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; TREATMENT DURATION; ANIMAL; BONE MARROW CELL; COMET ASSAY; CONGENITAL MALFORMATION; CYTOLOGY; DOUBLE STRANDED DNA BREAK; DRUG EFFECT; ERYTHROCYTE; METABOLISM; METAPHASE; MUTATION; ORAL DRUG ADMINISTRATION; SPERMATOZOON;

MUS;

ADMINISTRATION, ORAL; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BONE MARROW CELLS; CELL PROLIFERATION; CHROMOSOME ABERRATIONS; COMET ASSAY; DNA BREAKS, DOUBLE-STRANDED; DOXORUBICIN; ERYTHROCYTES; LIPID PEROXIDATION; MALE; METAPHASE; MICE; MUTAGENS; MUTATION; OXIDATIVE STRESS; PROANTHOCYANIDINS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA;

EID: 79951538779     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.3.6.14418     Document Type: Article

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