Redox-cycling of anthracyclines by thioredoxin system: Increased superoxide generation and DNA damage

Cancer Chemotherapy and Pharmacology

Volumn 54, Issue 5, 2004, Pages 449-458

  Ravi, Dashnamoorthy ^a   Das, Kumuda C ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Anthracyclines; DNA damage; Redox cycling; Thioredoxin

Indexed keywords

ANTHRACYCLINE DERIVATIVE; CYTOCHROME P450 REDUCTASE; DAUNORUBICIN; DOXORUBICIN; PLASMID DNA; SUPEROXIDE; THIOREDOXIN; THIOREDOXIN REDUCTASE;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ESCHERICHIA COLI; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; NICK END LABELING; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTHRACYCLINES; CELL LINE, TUMOR; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES C; DNA DAMAGE; ESCHERICHIA COLI; HUMANS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SUPEROXIDES; THIOREDOXIN;

EID: 7744224040     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-004-0833-y     Document Type: Article

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