Adiponectin and vulnerable atherosclerotic plaques

Journal of the American College of Cardiology

Volumn 57, Issue 7, 2011, Pages 761-770

  Barseghian, Ailin ^a   Gawande, Dipika ^b   Bajaj, Mandeep ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b A and M Consolidated High School   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

acute coronary syndrome; adventitia; atherosclerosis; biomarkers; intraplaque hemorrhage; necrotic core; plaque rupture; thin cap fibroatheroma; vasa vasorum

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; ANGIOTENSIN RECEPTOR ANTAGONIST; ANTIINFLAMMATORY AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FENOFIBRATE; FISH OIL; GLIMEPIRIDE; NEBIVOLOL; PIOGLITAZONE; RECOMBINANT ADIPONECTIN; RIMONABANT; SCAVENGER RECEPTOR; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ATHEROSCLEROTIC PLAQUE; CALORIC RESTRICTION; CARDIOVASCULAR RISK; CELL INFILTRATION; CORONARY ARTERY DISEASE; DISEASE COURSE; DRUG MECHANISM; DRUG TARGETING; EXERCISE; HISTOPATHOLOGY; HUMAN; LIFESTYLE MODIFICATION; MOLECULAR MECHANICS; MONOCYTE; NEOVASCULARIZATION (PATHOLOGY); NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; PROTEIN TARGETING; STOMACH BYPASS; THROMBOCYTE ACTIVATION; WEIGHT REDUCTION;

EID: 79851498098     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2010.11.011     Document Type: Review

References (142)

1. World Health Organization The top 10 causes of death. Fact Sheet No. 310. Updated October 2008 http://www.who.int/mediacentre/factsheets/fs310/en/index. html Accessed September 14, 2009
2. M.J. Davies Anatomic features in victims of sudden coronary death: coronary artery pathology (abstr) Circulation 85 1992 119 124
3. E. Falk, P.K. Shah, and V. Fuster Coronary plaque disruption Circulation 92 1995 657 671
4. R. Ross Atherosclerosisan inflammatory disease N Engl J Med 340 1999 115 126
5. J. Narula, P. Garg, and S. Achenbach Arithmetic of vulnerable plaques for noninvasive imaging Nat Clin Pract Cardiovasc Med 5 Suppl 2 2008 2 10
6. M. Bajaj, S. Suraamornkul, and P. Piper Decreased plasma adiponectin concentrations are closely related to hepatic fat content and hepatic insulin resistance in pioglitazone-treated type 2 diabetic patients J Clin Endocrinol Metab 89 2004 200 206 (Pubitemid 38183882)
7. M. Bajaj, S. Suraamornkul, and A. Romanelli Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients Diabetes 54 2005 3148 3153 (Pubitemid 43334368)
8. D.M. Putz, W.S. Goldner, and R.S. Bar Adiponectin and C-reactive protein in obesity, type 2 diabetes, and monodrug therapy Metabolism 53 2004 1454 1461 (Pubitemid 39410386)
9. N. Ouchi, S. Kihara, and T. Funahashi Reciprocal association of C-reactive protein with adiponectin in blood stream and adipose tissue Circulation 107 2003 671 674 (Pubitemid 36222590)
10. F. Otsuka, S. Sugiyama, and S. Kojima Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease J Am Coll Cardiol 48 2006 1155 1162 (Pubitemid 44345143)
11. R. Wolk, P. Berger, and R.J. Lennon Association between plasma adiponectin levels and unstable coronary syndromes Eur Heart J 28 2007 292 298
12. H. Otake, J. Shite, and T. Shinke Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome Am J Cardiol 101 2008 1 7 (Pubitemid 350297191)
13. C. Steppan, and M. Lazar Resistin and obesity-associated insulin resistance Trends Endocrinol Metab 13 2002 18 23 (Pubitemid 36734011)
14. M. Bajaj, and O. Ben-Yehuda A big fat wedding: association of adiponectin with coronary vascular lesions J Am Coll Cardiol 48 2006 1163 1165
15. P.E. Scherer, S. Williams, M. Fogliano, G. Baldini, and H.F. Lodish A novel serum protein similar to C1q, produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
16. E. Hu, P. Liang, and B.M. Spiegelman AdipoQ is a novel adipose-specific gene disregulated in obesity J Biol Chem 271 1996 10697 10703 (Pubitemid 26145805)
17. K. Maeda, K. Okubo, and I. Shimomura cDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose Most abundant Gene transcript 1) Biochem Biophys Res Commun 221 1996 286 289 (Pubitemid 26136463)
18. Y. Nakano, T. Tobe, and N.H. Choi-Miura Isolation and characterization of GBP28, a novel gelatin binding protein purified from human plasma J Biochem (Tokyo) 120 1996 803 812 (Pubitemid 26385421)
19. R. Pineiro, M.J. Iglesias, and R. Gallego Adiponectin is synthesized and secreted by human and murine cardiomyocytes FEBS Lett 579 2005 5163 5169 (Pubitemid 41318086)
20. M. Takahashi, Y. Arita, and K. Yamagata Genomic structure and mutations in adipose-specific gene, adiponectin Int J Obes 24 2000 861 868 (Pubitemid 30449921)
21. M. Jogi, and M. Bajaj Adiponectin and cardiovascular disease V. Fonseca, Contemporary Endocrinology: Cardiovascular Endocrinology: Shared Pathways and Clinical Crossroads 2009 Humana Press New York, NY 171 184
22. P.E. Scherer, S. Williams, and M. Fogliano A novel serum protein similar to C1q produced exclusively in adipocytes J Biol Chem 270 1995 26746 26749
23. Y. Arita, S. Kihara, and N. Ouchi Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor induced common postreceptor signal in vascular smooth muscle cell Circulation 105 2002 2893 2898 (Pubitemid 34666104)
24. Y. Arita, S. Kihara, and N. Ouchi Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity Biochem Biophys Res Commun 257 1999 79 83 (Pubitemid 29299050)
25. U.B. Pajvani, X. Du, and T.P. Combs Structure-function studies of the adipocyte-secreted hormone Acrp3/adiponectin Implications for metabolic regulation and bioactivity J Biol Chem 278 2003 9073 9085 (Pubitemid 36800387)
26. H. Ebinuma, O. Miyazaki, and H. Yago A novel ELISA system for selective measurement of human adiponectin multimers by using proteases Clin Chim Acta 372 2006 47 53 (Pubitemid 44286756)
27. C. Lara-Castro, N. Luo, and P. Wallace Adiponectin multimeric complexes and the metabolic syndrome trait cluster Diabetes 55 2006 249 259 (Pubitemid 43343322)
28. H. Motoshima, X. Wu, and K. Mahadev Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL Biochem Biophys Res Commun 315 2004 264 271 (Pubitemid 38183103)
29. N. Ouchi, R. Shibata, and K. Walsh Cardioprotection by adiponectin Trends Cardiovasc Med 16 2006 141 146 (Pubitemid 43867326)
30. I. Kharroubi, J. Rasschaert, and D.L. Eizirik Expression of adiponectin receptors in pancreatic beta cells Biochem Biophys Res Commun 312 2003 1118 1122 (Pubitemid 37490931)
31. T. Yamauchi, J. Kamon, and Y. Ito Cloning of adiponectin receptors that mediate antidiabetic metabolic effects Nature 423 2003 762 769 (Pubitemid 36735700)
32. K.C. Tan, A. Xu, and W.S. Chow Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation J Clin Endocrinol Metab 89 2004 765 769 (Pubitemid 38269891)
33. G. Chinetti, C. Zawadski, and J.C. Fruchart Expression of adiponectin receptors in human macrophages and regulation by agonists of the nuclear receptors PPARalpha, PPARgamma, and LXR Biochem Biophys Res Commun 14 2004 151 158 (Pubitemid 38058382)
34. T. Kadowaki, T. Yamauchi, and N. Kubota Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome J Clin Invest 116 2006 1784 1792 (Pubitemid 44033298)
35. N. Ouchi, S. Kihara, and Y. Arita Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-κB signaling through a cAMP-dependent pathway Circulation 102 2000 1296 1301
36. M.P. de Winther, E. Kanters, and G. Kraal Nuclear factor kappaB signaling in atherogenesis Arterioscler Thromb Vasc Biol 25 2005 904 914 (Pubitemid 40627833)
37. R. Shibata, K. Sato, and D.R. Pimentel Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms Nat Med 11 2005 1048 1049
38. K. Hotta, T. Funahashi, and Y. Arita Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients Arterioscler Thromb Vasc Biol 20 2000 1595 1599 (Pubitemid 30353893)
39. N. Ouchi, S. Kihara, and Y. Arita Novel modulator for endothelial adhesion molecules: adipocyte-derived plasma protein adiponectin Circulation 100 1999 2473 2476 (Pubitemid 30005109)
40. C. Zoccali, F. Mallamaci, and G. Tripepi Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease J Am Soc Nephrol 13 2002 134 141 (Pubitemid 34042020)
41. T. Pischon, C.J. Girman, and G.S. Hotamisligil Plasma adiponectin levels and risk of myocardial infarction in men JAMA 291 2004 1730 1737 (Pubitemid 38489895)
42. M.B. Schulze, I. Shai, and E.B. Rimm Adiponectin and future coronary heart disease events among men with type 2 diabetes Diabetes 54 2005 534 539
43. B. Becker, F. Kronenberg, and J.T. Kielstein Renal insulin resistance syndrome, adiponectin and cardiovascular events in patients with kidney disease: The mild and moderate kidney disease study J Am Soc Nephrol 16 2005 1091 1098 (Pubitemid 41710320)
44. Y. Iwashima, T. Horio, and M. Kumada Adiponectin and renal function, and implication as a risk of cardiovascular disease Am J Cardiol 98 2006 1603 1608 (Pubitemid 44827969)
45. T. Costacou, J.C. Zgibor, and R.W. Evans The prospective association between adiponectin and coronary artery disease among individuals with type 1 diabetes The Pittsburgh Epidemiology of Diabetes Complications Study Diabetologia 48 2005 41 48 (Pubitemid 40174655)
46. N. Sattar, G. Wannamethee, and N. Sarwar Adiponectin and coronary heart disease: a prospective study and meta-analysis Circulation 114 2006 623 629 (Pubitemid 44252303)
47. R.S. Lindsay, H.E. Resnick, and J. Zhu Adiponectin and coronary heart disease: the Strong Heart Study Arterioscler Thromb Vasc Biol 25 2005 e15 e16
48. D.A. Lawlor, G. Davey Smith, and S. Ebrahim Plasma adiponectin levels are associated with insulin resistance, but do not predict future risk of coronary heart disease in women J Clin Endocrinol Metab 90 2005 5677 5683 (Pubitemid 41415475)
49. G.A. Laughlin, E. Barrett-Connor, S. May, and C. Langenberg Association of adiponectin with coronary heart disease and mortality: the Rancho Bernardo Study Am J Epidemiol 165 2007 164 174 (Pubitemid 46096378)
50. M. Kumada, S. Kihara, and S. Sumitsuji Association of hypoadiponectinemia with coronary artery disease in men Arterioscler Thromb Vasc Biol 2 2003 85 89 (Pubitemid 36091630)
51. J. Frystyk, C. Berne, and L. Berglund Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow up study in elderly men J Clin Endocrinol Metab 92 2007 571 576
52. M. Cesari, A.C. Pessina, and M. Zanchetta Low plasma adiponectin is associated with coronary artery disease but not with hypertension in high-risk nondiabetic patients J Intern Med 260 2006 474 483 (Pubitemid 44571136)
53. K. Hara, T. Yamauchi, and Y. Imai Reduced adiponectin level is associated with severity of coronary artery disease Int Heart J 48 2007 149 153 (Pubitemid 46592753)
54. F. Otsuka, S. Sugiyama, and S. Kojima Plasma adiponectin levels are associated with coronary lesion complexity in men with coronary artery disease J Am Coll Cardiol 48 2006 1155 1162 (Pubitemid 44345143)
55. X.Y. Wang, Y.H. Guo, and L.J. Guo Association between plasma adiponectin levels and coronary lesion complexity Beijing Da Xue Xue Bao 39 2007 599 602
56. Y. Nakamura, K. Shimada, and D. Fukuda Implications of plasma concentrations of adiponectin in patients with coronary artery disease Heart 90 2004 528 533 (Pubitemid 38530170)
57. S. Kojima, T. Funahashi, and T. Sakamoto The variation of plasma concentrations of a novel, adipocyte derived protein, adiponectin, in patients with acute myocardial infarction Heart 89 2003 667 668 (Pubitemid 36606220)
58. M.A. Mendall, P. Patel, and L. Ballam C reactive protein and its relation to cardiovascular risk factors: A population based cross sectional study BMJ 312 1996 1061 1065 (Pubitemid 26125131)
59. T. Nakamura, M. Nishida, and M. Kumada Reciprocal association of c-reactive protein with adiponectin in blood stream and adipose tissue Circulation 107 2003 671 674 (Pubitemid 36222590)
60. G. Liuzzo, L.M. Biasucci, and J.R. Gallimore The prognostic value of c-reactive protein and serum amyloid a protein in severe unstable angina N Engl J Med 331 1994 417 424 (Pubitemid 24247397)
61. L. Lindahl, H. Toss, and A. Siegbahn Markers of myocardial damage and inflammation in relation to long-term mortality in unstable coronary artery disease N Engl J Med 343 2000 1139 1147
62. S. Verma, C.-H. Wang, and S.-H. Li A self-fulfilling prophecy: C-reactive protein attenuates nitric oxide production and inhibits angiogenesis Circulation 106 2002 913 919 (Pubitemid 34925323)
63. P.E. Szmitko, C.H. Wang, and R.D. Weisel New markers of inflammation and endothelial cell activation Circulation 108 2003 1917 1923 (Pubitemid 37296533)
64. D. Behrendt, and P. Ganz Endothelial function: from vascular biology to clinical applications Am J Cardiol 90 2002 40L 48L (Pubitemid 35379905)
65. N. Ouchi, and K. Walsh Adiponectin as an anti-inflammatory factor Clinica Chimica Acta 380 2007 24 30 (Pubitemid 46498041)
66. F.D. Kolodgie, R. Virmani, and A.P. Burke Pathologic assessment of the vulnerable human coronary plaque Heart 90 2004 1385 1391 (Pubitemid 39626306)
67. A. Burke, A. Farb, and G. Malcom Coronary risk factors and plaque morphology in men with coronary artery disease who died suddenly N Engl J Med 336 1997 1276 1282 (Pubitemid 27187780)
68. R. Virmani, A.P. Burke, and A. Farb Pathology of the vulnerable plaque J Am Coll Cardiol 47 2006 C13 C18
69. R. Virmani, F.D. Kolodgie, and A.P. Burke Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage Arterioscler Thromb Vasc Biol 25 2005 2054 2061 (Pubitemid 41416300)
70. M. Naghavi, P. Libby, and E. Falk From vulnerable plaque to vulnerable patient: A call for new definitions and risk assessment strategies: Part I Circulation 108 2003 1664 1672 (Pubitemid 37243650)
71. A.M. Varnava, P.G. Mills, and M.J. Davies Relationship between coronary artery remodeling and plaque vulnerability Circulation 105 2002 939 943 (Pubitemid 34184571)
72. A.P. Burke, A. Farb, and G.T. Malcolm Plaque rupture and sudden death related to exertion in men with coronary artery disease JAMA 281 1999 921 926 (Pubitemid 29124636)
73. T. Sawada, J. Shite, and T. Shinke Low plasma adiponectin levels are associated with presence of thin-cap fibroatheroma in men with stable coronary artery disease Int J Cardiol 142 2010 250 256
74. T. Yasu Low adiponectin level causes vascular remodeling? A perspective through intravascular ultrasound Hypertens Res 31 2008 2099 2101
75. S.P. Marso, S.K. Mehta, and A. Frutkin Low adiponectin levels are associated with atherogenic dyslipidemia and lipid-rich plaque in non-diabetic coronary arteries Diabetes Care 31 2008 989 994
76. D. Ribatti, F. Levi-Schaffer, and P.T. Kovanen Inflammatory angiogenesis in atherogenesisa double-edged sword Ann Med 40 2008 606 621
77. J. Narula, and H.W. Strauss The popcorn plaques Nat Med 13 2007 634 641
78. R. Di Stefano, F. Felice, and A. Balbarini Angiogenesis as risk factor for plaque vulnerability Curr Pharm Des 15 2009 1095 1106
79. R. Shibata, N. Ouchi, and S. Kihara Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of AMP-activated protein kinase signaling J Biol Chem 279 2004 28670 28674 (Pubitemid 38900150)
80. C. Kalka, H. Masuda, and T. Takahashi Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization Proc Natl Acad Sci U S A 97 2000 3422 3427 (Pubitemid 30183318)
81. N. Nakamura, K. Naruse, and T. Matsuki Adiponectin promotes migration activities of endothelial progenitor cells via Cdc42/Rac1 FEBS Lett 583 2009 2457 2463
82. H.M. Kwon, G. Sangiorgi, and E.L. Ritman Enhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia J Clin Invest 101 1998 1551 1556 (Pubitemid 28198482)
83. P. Libby Molecular bases of the acute coronary syndromes Circulation 91 1995 2844 2850
84. J. Polowinczak-Przybylek, and G. Melen-Mucha The inhibitory influence of adiponectin on the growth of the murine endothelial cell line HECa 10 in vitro Endokrynol Pol 60 2009 166 171
85. E. Brakenhielm, N. Veitonmaki, and R. Cao Adiponectin induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis Proc Natl Acad Sci U S A 101 2004 2476 2481 (Pubitemid 38269336)
86. P.W. Holm, R.H. Slart, and C.J. Zeebregts Atherosclerotic plaque development and instability: a dual role for VEGF Ann Med 41 2009 257 264
87. K. Mahadev, X. Wu, and S. Donnelly Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells Cardiovasc Res 78 2008 376 378
88. M. Cheng, S. Hashmi, and X. Mao Relationships of adiponectin and matrix metalloproteinase- to tissue inhibitor of metalloproteinase-1 ratio with coronary plaque morphology in patients with acute coronary syndrome Can J Cardiol 24 2008 385 390 (Pubitemid 351877358)
89. Z.S. Galis, M. Muszynski, and G.K. Sukhova Enhanced expression of vascular matrix metalloproteinases induced in vitro by cytokines and in regions of human atherosclerotic lesions Ann N Y Acad Sci 748 1995 501 507
90. K.K. Griendling, and G.A. FitzGerald Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS Circulation 108 2003 1912 1916 (Pubitemid 37296532)
91. K.K. Griendling, and G.A. FitzGerald Oxidative stress and cardiovascular injury: part II: animal and human studies Circulation 108 2003 2034 2040 (Pubitemid 37337574)
92. M. Kumada, S. Kihara, and N. Ouchi Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages Circulation 109 2004 2046 2049 (Pubitemid 38620209)
93. P.K. Shah, E. Falk, and J.J. Badimon Human monocyte-derived macrophages induce collagen breakdown in fibrous caps of atherosclerotic plaques Potential role of matrix-degrading metalloproteinases and implications for plaque rupture Circulation 92 1995 1565 1569
94. A. Iwata, S. Miura, and K. Mori Associations between metabolic factors and coronary plaque growth or arterial remodeling as assessed by intravascular ultrasound in patients with stable angina Hypertens Res 31 2008 1879 1886
95. M. Matsuda, I. Shimomura, and M. Sata Role of adiponectin in preventing vascular stenosis The missing link of adipo-vascular axis J Biol Chem 277 2002 37487 37491
96. N. Kubota, Y. Terauchi, and T. Yamauchi Disruption of adiponectin causes insulin resistance and neointimal formation J Biol Chem 277 2002 25863 25866 (Pubitemid 34967064)
97. P.E. Szmitko, H. Teoh, and D.J. Stewart Adiponectin and cardiovascular disease: state of the art? Am J Physiol Heart Circ Physiol 292 2007 H1655 H1663
98. P.H. Park, M.R. McMullen, and H. Huang Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-a (TNF-a) expression via ERK1/2 activation and Egr-1 expression: role of TNF-a in adiponectin stimulated interleukin-10 production J Biol Chem 282 2007 21695 21703 (Pubitemid 47195777)
99. N. Ouchi, S. Kihara, and Y. Arita Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages Circulation 103 2001 1057 1063 (Pubitemid 32200177)
100. Y. Okamoto, S. Kihara, and N. Ouchi Adiponectin reduces atherosclerosis in apolipoprotein E-deficient mice Circulation 106 2002 2767 2770 (Pubitemid 35396973)
101. H. Kato, H. Kashiwagi, and M. Shiraga Adiponectin acts as an endogenous antithrombotic factor Arterioscler Thromb Vasc Biol 26 2006 224 230 (Pubitemid 43732254)
102. Y. Cao, L. Tao, and Y. Yuan Endothelial dysfunction in adiponectin deficiency and its mechanisms involved J Mol Cell Cardiol 46 2009 413 419
103. M. Mossalam, J.H. Jeong, and E.D. Abel Reversal of oxidative stress in endothelial cells by controlled release of adiponectin J Control Release 130 2008 234 237
104. R. Li, W.Q. Wang, and H. Zhang Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity Am J Physiol Endocrinol Metab 293 2007 E1703 E1708
105. T. Yamauchi, J. Kamon, and Minokoshi Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase Nat Med 8 2002 1288 1295 (Pubitemid 35373562)
106. J.F. Ndisang, and A. Jadhav Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats Endocrinology 150 2009 2627 2636
107. R. Ouedraogo, Y. Gong, and B. Berzins Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo J Clin Invest 117 2007 1718 1726 (Pubitemid 46871356)
108. T. Murakami, C. Mataki, and C. Nagao The gene expression profile of human umbilical vein endothelial cells stimulated by tumor necrosis factor alpha using DNA microarray analysis (abstr) J Atheroscler Thromb 7 2000 39 44
109. C.G. Kevil, R.P. Patel, and D.C. Bullard Essential role of ICAM-1 in mediating monocyte adhesion to aortic endothelial cells Am J Physiol Cell Physiol 281 2001 C1442 C1447
110. M. Karaduman, A. Sengult, and C. Oktenli Tissue levels of adiponectin, tumour necrosis factor-alpha, soluble intercellular adhesion molecule-1 and heart-type fatty acid-binding protein in human coronary atherosclerotic plaques Clin Endocrinol (Oxf) 64 2006 196 202
111. M.J. Davies, J.L. Gordon, and A.J. Gearing The expression of the adhesion molecules ICAM-1, VCAM-1, PECAM, and E-selectin in human atherosclerosis J Pathol 171 1993 223 229 (Pubitemid 23345967)
112. C.J. Li, H.W. Sun, and F.L. Zhu Local adiponectin treatment reduces atherosclerotic plaque size in rabbits J Endocrinol 193 2007 137 145
113. X.J. Cai, L. Chen, and L. Li Adiponectin inhibits lipopolysaccharide- induced adventitial fibroblast migration and transition to myofibroblasts via AdipoR1-AMPK-iNOS pathway Mol Endocrinol 24 2010 218 228
114. Y. Okamoto, Y. Arita, and M. Nishida An adipocyte derived plasma protein, adiponectin, adheres to injured vascular walls Horm Metab Res 32 2000 47 50 (Pubitemid 30143606)
115. P. Restituto, I. Colina, and J.J. Varo Adiponectin diminishes platelet aggregation and sCD40L release Potential role in the metabolic syndrome Am J Physiol Endocrinol Metab 298 2010 e1072 e1077
116. N. Sogo, K.S. Magid, and C.A. Shaw Inhibition of human platelet aggregation by nitric oxide donor drugs: relative contribution of cGMP-independent mechanisms Biochem Biophys Res Commun 279 2000 412 419 (Pubitemid 32036706)
117. F.D. Kolodgie, J. Narula, and A.P. Burke Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death Am J Pathol 157 2000 1259 1268
118. H. Kobayashi, N. Ouchi, and S. Kihara Selective suppression of endothelial cell apoptosis by the high molecular weight form of adiponectin Circ Res 94 2004 e27 e31
119. Y. Takemura, N. Ouchi, and R. Shibata Adiponectin modulates inflammatory reactions via calreticulin receptor dependent clearance of early apoptotic bodies J Clin Invest 117 2007 375 386 (Pubitemid 46203966)
120. T. Yamauchi, J. Kamon, and H. Waki Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis J Biol Chem 278 2003 2461 2468 (Pubitemid 36801322)
121. T.S. Hermann, W. Li, and H. Dominguez Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes J Clin Endocrinol Metab 91 2006 1001 1008 (Pubitemid 43357772)
122. R. Krysiak, M. Sierant, and B. Marek The effect of angiotensin-converting enzyme inhibitors on plasma adipokine levels in normotensive patients with coronary artery disease Endokrynol Pol 61 2010 280 287
123. S. Makita, A. Abiko, and Y. Naganuma Effects of telmisartan on adiponectin levels and body weight in hypertensive patients with glucose intolerance Metabolism 57 2008 1473 1478
124. Y. Mori, Y. Itoh, and N. Tajima Telmisartan improves lipid metabolism and adiponectin production but does not affect glycemic control in hypertensive patients with type 2 diabetes Adv Ther 24 2007 146 153 (Pubitemid 46700873)
125. T. Araki, M. Emoto, and T. Konishi Glimepiride increases high-density lipoprotein cholesterol via increasing adiponectin levels in type 2 diabetes mellitus Metabolism 58 2009 143 148
126. T. Celik, A. Iyisoy, and H. Kursaklioglu Comparative effects of nebivolol and metoprolol on oxidative stress, insulin resistance, plasma adiponectin and soluble P-selectin levels in hypertensive patients J Hypertens 24 2006 591 596 (Pubitemid 43261924)
127. M. Bensaid, M. Gary-Bobo, and A. Esclangon The cannabinoid CB1 receptor antagonist SR141716 increases Acrp30 mRNA expression in adipose tissue of obese fa/fa rats and in cultured adipocyte cells Mol Pharmacol 63 2003 908 914 (Pubitemid 36368998)
128. M. Itoh, T. Suganami, and N. Satoh Increased adiponectin secretion by highly purified eicosapentaenoic acid in rodent models of obesity and human obese subjects Arterioscler Thromb Vasc Biol 27 2007 1918 1925 (Pubitemid 47315642)
129. K. Shimada, T. Kawarabayashi, and A. Tanak Oolong tea increases plasma adiponectin levels and low-density lipoprotein particle size in patients with coronary artery disease Diabetes Res Clin Pract 65 2004 227 234 (Pubitemid 39141178)
130. M.M. Joosten, J.W. Beulens, and S. Kersten Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial Diabetologia 51 2008 1375 1381
131. M.L. Narasimhan, M.A. Coca, and J. Jin Osmotin is a homolog of mammalian adiponectin and controls apoptosis in yeast through a homolog of mammalian adiponectin receptor Mol Cell 17 2005 171 180 (Pubitemid 40138613)
132. K.K. Koh, S.H. Han, and M.J. Quon Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia Diabetes Care 28 2005 1419 1424 (Pubitemid 40756707)
133. N. Riera-Guardia, and D. Rothenbacher The effect of thiazolidinediones on adiponectin serum level: a meta-analysis Diabetes Obes Metab 10 2008 367 375 (Pubitemid 351524284)
134. D. Ogasawara, J. Shite, and T. Shinke Pioglitazone reduces the necrotic-core component in coronary plaque in association with enhanced plasma adiponectin in patients with type 2 diabetes mellitus Circ J 73 2009 343 351
135. W.S. Yang, W.J. Lee, and T. Funahashi Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin J Clin Endocrinol Metab 86 2001 3815 3819 (Pubitemid 32755982)
136. K. Esposito, A. Pontillo, and C. Di Palo Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: a randomized trial JAMA 289 2003 1799 1804 (Pubitemid 37430249)
137. H.P. Kopp, K. Krzyzanowska, and M. Mohlig Effects of marked weight loss on plasma levels of adiponectin, markers of chronic subclinical inflammation and insulin resistance in morbidly obese women Int J Obes Relat Metab Disord 29 2005 766 771 (Pubitemid 40897012)
138. M. Bluher, C.J. Williams, and N. Kloting Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training Diabetes Care 30 2007 3110 3115 (Pubitemid 350255258)
139. A.R. Nawrocki, S.M. Hofmann, and D. Teupser Lack of Association Between Adiponectin Levels and Atherosclerosis in Mice Arterioscler Thromb Vasc Biol 30 2010 1159 1165
140. S. Holewijn, M. den Heijer, and L.J. van Tits Impact of waist circumference versus adiponectin level on subclinical atherosclerosis: A cross-sectional analysis in a sample from the general population J Intern Med 267 2010 588 598
141. M. von Eynatten, A. Hamann, and D. Twardella Atherogenic dyslipidaemia but not total- and high-molecular weight adiponectin are associated with the prognostic outcome in patients with coronary heart disease Eur Heart J 29 2008 1307 1315 (Pubitemid 351768129)
142. Y. Aso, R. Yamamoto, and S. Wakabayashi Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin Diabetes 55 2006 1954 1960 (Pubitemid 44509967)