Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training

Diabetes Care

Volumn 30, Issue 12, 2007, Pages 3110-3115

  Blüher, Matthias ^a   Williams, Catherine J ^b   Klöting, Nora ^a   Hsi, Alex ^b   Ruschke, Karen ^a   Oberbach, Andreas ^a   Fasshauer, Mathias ^a   Berndt, Janin ^a   Schön, Michael R ^a   Wolk, Alicja ^c   Stumvoll, Michael ^a   Mantzoros, Christos S ^b,d  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d ST 816 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; HIGH DENSITY LIPOPROTEIN; MESSENGER RNA;

ARTICLE; CONTROLLED STUDY; EXERCISE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; LIPID STORAGE; MAJOR CLINICAL STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; REAL TIME POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TRAINING;

ABSORPTIOMETRY, PHOTON; ADIPOSE TISSUE; BARIATRIC SURGERY; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; EUROPEAN CONTINENTAL ANCESTRY GROUP; EXERCISE; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INSULIN RESISTANCE; MALE; OBESITY; RECEPTORS, ADIPONECTIN; RNA, MESSENGER;

EID: 37149051275     PISSN: 01495992     EISSN: 01495992     Source Type: Journal    
DOI: 10.2337/dc07-1257     Document Type: Article

References (25)

1. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE: Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46:459-469, 2003
2. Pajvani UB, Scherer PE: Adiponectin: systemic contributor to insulin sensitivity. Curr Diab Rep 3:207-213, 2003
3. Berg AH, Combs TP, Scherer PE: ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab 13:84-89, 2002
4. Wolf AM, Wolf D, Rumpold H, Enrich B, Tilg H: Adiponectin induces the anti-inflammatory cytokines IL-10 and IL-1RA in human leukocytes. Biochem Biophys Res Commun 323:630-635, 2004
5. Kobashi C, Urakaze M, Kishida M, Kibayashi E, Kobayashi H, Kihara S, Funahashi T, Takata M, Temaru R, Sato A, Yamazaki K, Nakamura N, Kobayashi M: Adiponectin inhibits endothelial synthesis of interleukin-8. Circ Res 97:1245-1252, 2005
6. Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 26:439-451, 2005
7. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T: Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769, 2003
8. Goldstein BJ, Scalia R: Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab 89:2563-2568, 2004
9. Yamauchi T, Nio Y, Maki T, Kobayashi M, Takazawa T, Iwabu M, Okada-Iwabu M, Kawamoto S, Kubota N, Kubota T, Ito Y, Kamon J, Tsuchida A, Kumagai K, Kozono H, Hada Y, Ogata H, Tokuyama K, Tsunoda M, Ide T, Murakami K, Awazawa M, Takamoto I, Froguel P, Hara K, Tobe K, Nagai R, Ueki K, Kadowaki T: Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 13:332-339, 2007
10. Kharroubi I, Rasschaert J, Eizirik DL, Cnop M: Expression of adiponectin receptors in pancreatic β cells. Biochem Biophys Res Commun 312:1118-1122, 2003
11. Tsuchida A, Yamauchi T, Ito Y, Hada Y, Maki T, Takekawa S, Kamon J, Kobayashi M, Suzuki R, Hara K, Kubota N, Terauchi Y, Froguel P, Nakae J, Kasuga M, Accili D, Tobe K, Ueki K, Nagai R, Kadowaki T: Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 279:30817-30822, 2004
12. Bullen JW Jr, Bluher S, Kelesidis T, Mantzoros CS: Regulation of adiponectin and its receptors in response to development of diet-induced obesity in mice. Am J Physiol 292:E1079-E1086, 2007
13. Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B: Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring) 14:28-35, 2006
14. Fasshauer M, Klein J, Kralisch S, Klier M, Lossner U, Bluher M, Paschke R: Growth hormone is a positive regulator of adiponectin receptor 2 in 3T3-L1 adipocytes. FEBS Lett 558:27-32, 2004
15. Li W, Tonelli J, Kishore P, Owen R, Goodman E, Scherer PE, Hawkins M: Insulin-sensitizing effects of thiazolidinediones are not linked to adiponectin receptor expression in human fat or muscle. Am J Physiol 292:E1301-E1307, 2007
16. Bluher M, Bullen JW, Jr, Lee JH, Kralisch S, Fasshauer M, Kloting N, Niebauer J, Schon MR, Williams CJ, Mantzoros CS: Circulating adiponectin and expression of adiponectin receptors in human skeletal muscle: associations with metabolic parameters and insulin resistance and regulation by physical training. J Clin Endocrinol Metab 91:2310-2316, 2006
17. Berndt J, Kloting N, Kralisch S, Kovacs P, Fasshauer M, Schon MR, Stumvoll M, Bluher M: Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes 54:2911-2916, 2005
18. Bluher M, Engeli S, Kloting N, Berndt J, Fasshauer M, Batkai S, Pacher P, Schon MR, Jordan J, Stumvoll M: Dysregulation of the peripheral and adipose tissue endocannabinoid system in human abdominal obesity. Diabetes 55:3053-3060, 2006
19. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S: Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36:54-59, 1987
20. DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 237:E214-E223, 1979
21. Mantzoros CS, Li T, Manson JE, Meigs JB, Hu FB: Circulating adiponectin levels are associated with better glycemic control, more favorable lipid profile, and reduced inflammation in women with type 2 diabetes. J Clin Endocrinol Metab 90:4542-4548, 2005
22. Wannamethee SG, Whincup PH, Lennon L, Sattar N: Circulating adiponectin levels and mortality in elderly men with and without cardiovascular disease and heart failure. Arch Intern Med 167:1510-1517, 2007
23. Morinigo R, Musri M, Vidal J, Casamitjana R, Delgado S, Lacy AM, Ayuso C, Gomis R, Corominola H: Intra-abdominal fat adiponectin receptors expression and cardiovascular metabolic risk factors in obesity and diabetes. Obes Surg 16:745-751, 2006
24. Bauche IB, it El MS, Rezsohazy R, Funahashi T, Maeda N, Miranda LM, Brichard SM: Adiponectin downregulates its own production and the expression of its AdipoR2 receptor in transgenic mice. Biochem Biophys Res Commun 345:1414-1424, 2006
25. Damcott CM, Ott SH, Pollin TI, Reinhart LJ, Wang J, O'Connell JR, Mitchell BD, Shuldiner AR: Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes 54:2245-2250, 2005