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Volumn 10, Issue 2, 2011, Pages 239-250

The role of natural products in the discovery of new drug candidates for the treatment of neurodegenerative disorders i: Parkinson's disease

Author keywords

Alzheime sdisease; Biodiversity; Chemistry; Drugdiscovery; Medicinal; Naturalproducts; Neurodegenerative disorders; Parkinso sdisease

Indexed keywords

HERBACEOUS AGENT; NATURAL PRODUCT; PLANT EXTRACT;

EID: 79551664192     PISSN: 18715273     EISSN: None     Source Type: Journal    
DOI: 10.2174/187152711794480483     Document Type: Article
Times cited : (42)

References (146)
  • 1
    • 33645658773 scopus 로고    scopus 로고
    • The natural products and the modern medicinal chemistry
    • Viegas Jr., C.; Bolzani, V.S.; Barreiro, E.J. The natural products and the modern medicinal chemistry. Quim. Nova, 2006, 29, 326-337.
    • (2006) Quim. Nova , vol.29 , pp. 326-337
    • Viegas, C.1    Bolzani, V.S.2    Barreiro, E.J.3
  • 2
    • 0031028432 scopus 로고    scopus 로고
    • Natural products in drug discovery and development
    • Cragg, G.M.; Newmann, D.J.; Snader, K.M. Natural products in drug discovery and development. J. Nat. Prod., 1997, 60, 52-60.
    • (1997) J. Nat. Prod , vol.60 , pp. 52-60
    • Cragg, G.M.1    Newmann, D.J.2    Snader, K.M.3
  • 3
    • 0042844744 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the period 1981-2002
    • Cragg, G.M.; Newmann, D.J.; Snader, K.M. Natural products as sources of new drugs over the period 1981-2002. J. Nat. Prod., 2003, 66, 1022-1037.
    • (2003) J. Nat. Prod , vol.66 , pp. 1022-1037
    • Cragg, G.M.1    Newmann, D.J.2    Snader, K.M.3
  • 4
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newmann, D.J.; Cragg, G.M. Natural products as sources of new drugs over the last 25 years. J. Nat. Prod., 2007, 70, 461-477.
    • (2007) J. Nat. Prod , vol.70 , pp. 461-477
    • Newmann, D.J.1    Cragg, G.M.2
  • 5
    • 42949160050 scopus 로고    scopus 로고
    • Natural products as leads to Potential Drugs: An old process or the new hope for drug discovery?
    • Newmann, D.J. Natural products as leads to Potential Drugs: An old process or the new hope for drug discovery? J. Med. Chem., 2008, 51(9), 2589-2599.
    • (2008) J. Med. Chem , vol.51 , Issue.9 , pp. 2589-2599
    • Newmann, D.J.1
  • 6
    • 42949149681 scopus 로고    scopus 로고
    • Modern natural products chemistry and drug discovery
    • Ojima, I. Modern natural products chemistry and drug discovery. J. Med. Chem., 2008, 51(9), 2587-2588.
    • (2008) J. Med. Chem , vol.51 , Issue.9 , pp. 2587-2588
    • Ojima, I.1
  • 7
    • 79551660064 scopus 로고    scopus 로고
    • Drugs used to treat neuromuscular disorders: Antiparkinsonian and spasmolytic agents
    • Williams, D. A.; Lemke, T.L., Eds.; In, 5th ed., Lippincott Williams & Wilkins: United States
    • Booth, R.G.; Neumeyer, J.L. Drugs used to treat neuromuscular disorders: antiparkinsonian and spasmolytic agents. Williams, D. A.; Lemke, T.L., Eds.; In: Foyes Principles of Medicinal Chemistry. 5th ed., Lippincott Williams & Wilkins: United States, 2002, pp. 480-493.
    • (2002) Foyes Principles of Medicinal Chemistry , pp. 480-493
    • Booth, R.G.1    Neumeyer, J.L.2
  • 8
    • 15044356788 scopus 로고    scopus 로고
    • Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer
    • Bolzani V.S., Furlan M., Fraga C.A.M., Barreiro E.J. Produtos naturais como candidatos a fármacos úteis no tratamento do Mal de Alzheimer. Quím. Nova, 2004, 27(4), 655-660.
    • (2004) Quím. Nova , vol.27 , Issue.4 , pp. 655-660
  • 9
    • 24944466608 scopus 로고    scopus 로고
    • New anti-Alzheimer drugs from biodiversity: The role of the natural acetylcholinesterase inhibitors
    • Bolzani, V.S.; Barreiro, E.J.; Fraga, C.A.M. New anti-Alzheimer drugs from biodiversity: the role of the natural acetylcholinesterase inhibitors. Mini Rev. Med. Chem., 2005, 5, 915-926.
    • (2005) Mini. Rev. Med. Chem , vol.5 , pp. 915-926
  • 11
    • 0043199852 scopus 로고    scopus 로고
    • Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar top established mood stabilizers-a review
    • Carlini, E.A. Plants and the central nervous system. Pharmacol. Biochem. Behav., 2003, 75, 501-512. b) Grunze, H.; Langosch, J.; Schirrmacher, K.; Bingmann, D.; Von Wegerer, J.; Walden, J. Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar top established mood stabilizers-a review. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2001, 25, 1555-1570.
    • (2003) Pharmacol. Biochem. Behav , vol.75 , pp. 501-512
    • Carlini, E.A.1
  • 12
    • 0034765967 scopus 로고    scopus 로고
    • Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar top established mood stabilizers-a review
    • Grunze, H.; Langosch, J.; Schirrmacher, K.; Bingmann, D.; Von Wegerer, J.; Walden, J. Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar top established mood stabilizers-a review. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2001, 25, 1555-1570
    • (2001) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.25 , pp. 1555-1570
    • Grunze, H.1    Langosch, J.2    Schirrmacher, K.3    Bingmann, D.4    von Wegerer, J.5    Walden, J.6
  • 14
    • 0030483476 scopus 로고    scopus 로고
    • Sedative effects of crude extract of Passiflora incarnata after oral administration
    • Speroni, E.; Billi, R.; Mercati, V.; Boncompagni, E.; Toja, E. Sedative effects of crude extract of Passiflora incarnata after oral administration. Phytother. Res., 1996, 10, S92-S94
    • (1996) Phytother. Res , vol.10
    • Speroni, E.1    Billi, R.2    Mercati, V.3    Boncompagni, E.4    Toja, E.5
  • 15
    • 0030738463 scopus 로고    scopus 로고
    • Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse
    • Soulimani, R.; Younos, C.; Jarmouni, S.; Bousta, D.; Misslin, R.; Mortier, F. Behavioural effects of Passiflora incarnata L. and its indole alkaloid and flavonoid derivatives and maltol in the mouse. J. Ethnopharmacol., 1997, 57, 11-20.
    • (1997) J. Ethnopharmacol , vol.57 , pp. 11-20
    • Soulimani, R.1    Younos, C.2    Jarmouni, S.3    Bousta, D.4    Misslin, R.5    Mortier, F.6
  • 16
    • 0034772832 scopus 로고    scopus 로고
    • Anti-anxiety studies on extracts of Passiflora incarnate Linneaus
    • Dhawan, K.; Kumar, S.; Sharma, A. Anti-anxiety studies on extracts of Passiflora incarnate Linneaus. J. Ethnopharmacol., 2001, 78, 165-170.
    • (2001) J. Ethnopharmacol , vol.78 , pp. 165-170
    • Dhawan, K.1    Kumar, S.2    Sharma, A.3
  • 17
    • 0042201867 scopus 로고    scopus 로고
    • Ginseng: Potential for the enhancement of cognitive performance and mood
    • Kennedy, D.O.; Scholey, A.B. Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol. Biochem. Behav., 2003, 75, 687-700.
    • (2003) Pharmacol. Biochem. Behav , vol.75 , pp. 687-700
    • Kennedy, D.O.1    Scholey, A.B.2
  • 18
    • 33645058893 scopus 로고    scopus 로고
    • Use of Ginseng in medicine with emphasis on neurodegenerative disorders
    • Radad, K.; Gille, G.; Liu, L.; Rausch, W.-D. Use of Ginseng in medicine with emphasis on neurodegenerative disorders. J. Pharmacol. Sci., 2006, 100, 175-186.
    • (2006) J. Pharmacol. Sci , vol.100 , pp. 175-186
    • Radad, K.1    Gille, G.2    Liu, L.3    Rausch, W.-D.4
  • 20
    • 0029655506 scopus 로고    scopus 로고
    • Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia
    • Wen, T-C.; Yoshimura, H.; Matsuda, S.; Lim, J.-H.; Sakanaka, M. Ginseng root prevents learning disability and neuronal loss in gerbils with 5-minute forebrain ischemia. Acta Neuropathol., 1996, 91, 15-22.
    • (1996) Acta Neuropathol , vol.91 , pp. 15-22
    • Wen, T.-C.1    Yoshimura, H.2    Matsuda, S.3    Lim, J.-H.4    Sakanaka, M.5
  • 21
    • 0029704284 scopus 로고    scopus 로고
    • Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats
    • Zhang, Y.G.; Liu, T.P. Influences of ginsenosides Rb1 and Rg1 on reversible focal brain ischemia in rats. Acta Pharmacol. Sin., 1996, 17(1), 44-48.
    • (1996) Acta Pharmacol. Sin , vol.17 , Issue.1 , pp. 44-48
    • Zhang, Y.G.1    Liu, T.P.2
  • 22
    • 0031596324 scopus 로고    scopus 로고
    • Rb1 and Rg3 protect cultured rat cortical cells from glutamateinduced neurodegeneration
    • Kim, Y.C.; Kim, S.R.; Markelonis, G.J.; Oh, T.H. Ginsenosides Rb1 and Rg3 protect cultured rat cortical cells from glutamateinduced neurodegeneration. J. Neurosci. Res., 1998, 4, 426-432.
    • (1998) J. Neurosci. Res , vol.4 , pp. 426-432
    • Kim, Y.C.1    Kim, S.R.2    Markelonis, G.J.3    Oh, T.H.4
  • 23
    • 0036180097 scopus 로고    scopus 로고
    • Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg3 on spinal cord neurons in vitro
    • Liao, B.; Newmark, H. Zhou, R. Neuroprotective effects of ginseng total saponin and ginsenosides Rb1 and Rg3 on spinal cord neurons in vitro. Exp. Neurol., 2002, 173, 224-234.
    • (2002) Exp. Neurol , vol.173 , pp. 224-234
    • Liao, B.1    Newmark, H.2    Zhou, R.3
  • 24
    • 0030799814 scopus 로고    scopus 로고
    • Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng
    • Byun, B.H.; Shin, I.; Yoon, Y.S.; Kim, S.I.; Joe, C.O. Modulation of protein kinase C activity in NIH 3T3 cells by plant glycosides from Panax ginseng. Planta Medica, 1997, 63, 389-392.
    • (1997) Planta Medica , vol.63 , pp. 389-392
    • Byun, B.H.1    Shin, I.2    Yoon, Y.S.3    Kim, S.I.4    Joe, C.O.5
  • 25
    • 0018132155 scopus 로고
    • Evaluation of commercial Ginseng products
    • Liberti, L.E.; Der Mardesian, A. Evaluation of commercial Ginseng products. J. Pharm. Sci., 1978, 10, 1487-1489.
    • (1978) J. Pharm. Sci , vol.10 , pp. 1487-1489
    • Liberti, L.E.1    der Mardesian, A.2
  • 26
    • 0007998448 scopus 로고
    • Ginseng-quality safety and efficacy
    • Phillipson, J.D.; Anderson, L.A. Ginseng-quality safety and efficacy? Pharm. J., 1984, 232, 161-165.
    • (1984) Pharm. J , vol.232 , pp. 161-165
    • Phillipson, J.D.1    Anderson, L.A.2
  • 27
    • 0019048612 scopus 로고
    • Separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations
    • Soldati, F.; Sticher, O. HPLC separation and quantitative determination of ginsenosides from Panax ginseng, Panax quinquefolium and from ginseng drug preparations. Planta Medica, 1980, 39(4), 348-357.
    • (1980) Planta Medica , vol.39 , Issue.4 , pp. 348-357
    • Soldati, F.1    Sticher, O.2
  • 28
    • 0033829312 scopus 로고    scopus 로고
    • The dose dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers
    • Kennedy, D.O.; Scholey, A.B.; Wesnes, K.A. The dose dependent cognitive effects of acute administration of Ginkgo biloba to healthy young volunteers. Psychopharmacology, 2000, 151, 416-423.
    • (2000) Psychopharmacology , vol.151 , pp. 416-423
    • Kennedy, D.O.1    Scholey, A.B.2    Wesnes, K.A.3
  • 29
    • 0035202967 scopus 로고    scopus 로고
    • Differential, dosedependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers
    • Kennedy, D.O.; Scholey, A.B.; Wesnes, K.A. Differential, dosedependent changes in cognitive performance and mood following acute administration of Ginseng to healthy young volunteers. Nutr. Neurosci., 2000, 4(4), 295-310.
    • (2000) Nutr. Neurosci , vol.4 , Issue.4 , pp. 295-310
    • Kennedy, D.O.1    Scholey, A.B.2    Wesnes, K.A.3
  • 30
    • 0035195054 scopus 로고    scopus 로고
    • Differential, dosedependent changes in cognitive performance following acute administration of ginkgo biloba/Panax ginseng combination to healthy young volunteers
    • Kennedy, D.O.; Scholey, A.B.; Wesnes, K.A. Differential, dosedependent changes in cognitive performance following acute administration of ginkgo biloba/Panax ginseng combination to healthy young volunteers. Nutr. Neurosci., 2001, 4(5), 399-412.
    • (2001) Nutr. Neurosci , vol.4 , Issue.5 , pp. 399-412
    • Kennedy, D.O.1    Scholey, A.B.2    Wesnes, K.A.3
  • 31
    • 0037088968 scopus 로고    scopus 로고
    • Modulation of cognition and mood following administration of single doses of Ginkgo biloba, Ginseng and a Ginkgo/Ginseng combination to healthy young adults
    • Kennedy, D.O.; Scholey, A.B.; Wesnes, K.A. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, Ginseng and a Ginkgo/Ginseng combination to healthy young adults. Physiol. Behav., 2002, 75, 1-13.
    • (2002) Physiol. Behav , vol.75 , pp. 1-13
    • Kennedy, D.O.1    Scholey, A.B.2    Wesnes, K.A.3
  • 32
    • 0035991315 scopus 로고    scopus 로고
    • Modulation of mood and cognitiver performance following acute administration of single doses of Melissa officinalis (Lemon Balm)
    • Kennedy, D.O.; Scholey, A.B.; Tildesley, N.T.J.; Perry, E.K.; Wesnes, K.A. Modulation of mood and cognitiver performance following acute administration of single doses of Melissa officinalis (Lemon Balm). Pharmacol. Biochem. Behav., 2002, 72(4), 953-964.
    • (2002) Pharmacol. Biochem. Behav , vol.72 , Issue.4 , pp. 953-964
    • Kennedy, D.O.1    Scholey, A.B.2    Tildesley, N.T.J.3    Perry, E.K.4    Wesnes, K.A.5
  • 34
    • 0033662614 scopus 로고    scopus 로고
    • The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle aged volunteers
    • Wesnes, K.A.; Ward, T.; McGinty, A.; Petrini, O. The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle aged volunteers. Psychopharmacology, 2000, 152, 353-361.
    • (2000) Psychopharmacology , vol.152 , pp. 353-361
    • Wesnes, K.A.1    Ward, T.2    McGinty, A.3    Petrini, O.4
  • 35
    • 14944381228 scopus 로고    scopus 로고
    • The effect of acute administration of 400mg of Panax ginseng on cognitive performance and mood in healthy young volunteers
    • Sünram-Lea, S.I.; Birchall, R.J.; Wesnes, K.A.; Petrini, O. The effect of acute administration of 400mg of Panax ginseng on cognitive performance and mood in healthy young volunteers. Curr. Top. Nutraceutical Res., 2005, 3, 65-74.
    • (2005) Curr. Top. Nutraceutical Res , vol.3 , pp. 65-74
    • Sünram-Lea, S.I.1    Birchall, R.J.2    Wesnes, K.A.3    Petrini, O.4
  • 36
    • 0026525526 scopus 로고
    • Neuropathology of Parkinson's disease and related syndromes
    • Gibb, W.R. Neuropathology of Parkinson's disease and related syndromes. Neurol. Clin., 1992, 10, 361-376.
    • (1992) Neurol. Clin , vol.10 , pp. 361-376
    • Gibb, W.R.1
  • 37
    • 0014668762 scopus 로고
    • Brain lesions, obesity, and other disturbances in mice related with monosodium glutamate
    • Olney, J.W. Brain lesions, obesity, and other disturbances in mice related with monosodium glutamate. Science, 1969, 164, 719-721.
    • (1969) Science , vol.164 , pp. 719-721
    • Olney, J.W.1
  • 38
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton, S.A.; Rosenberg, P.A. Excitatory amino acids as a final common pathway for neurologic disorders. New Engl. J. Med., 1994, 330, 613-622.
    • (1994) New Engl. J. Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 39
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for aging and degenerative diseases?
    • Wallace D.C. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science, 1992, 256, 628-632.
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 41
    • 0001898787 scopus 로고    scopus 로고
    • Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th Ed.; McGraw Hill; New York
    • D.G.; Young, A.H. In: Treatment of Central Nervous System Degenerative Disorders. Goodman and Gilman's: The Pharmacological Basis of Therapeutics, 9th Ed.; McGraw Hill; New York, 1996, pp. 503-519.
    • (1996) In: Treatment of Central Nervous System Degenerative Disorders , pp. 503-519
  • 42
    • 0032770148 scopus 로고    scopus 로고
    • Quality of life and Parkinson's disease: Translation and validation of the US Parkinson's Disease Questionnaire (PDQ-39)
    • Qual. Life Res., 1999, 8, 345-350. b) Savitt, J.M.; Dawson, V.L.; Dawson, T.M. Diagnosis and treatment of Parkinson disease: molecules to medicine
    • Bushnell, D.M.; Martin, M.L. Quality of life and Parkinson's disease: Translation and validation of the US Parkinson's Disease Questionnaire (PDQ-39). Qual. Life Res., 1999, 8, 345-350. b) Savitt, J.M.; Dawson, V.L.; Dawson, T.M. Diagnosis and treatment of Parkinson disease: molecules to medicine. J. Clin. Invest., 2006, 116, 1744-1754.
    • (2006) J. Clin. Invest , vol.116 , pp. 1744-1754
    • Bushnell, D.M.1    Martin, M.L.2
  • 45
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson's disease
    • Miller, R.L.; James-Kracke, M.; Sun, G.Y.; Sun, A.Y. Oxidative and inflammatory pathways in Parkinson's disease. Neurochem. Res., 2009, 34, 55.
    • (2009) Neurochem. Res , vol.34 , pp. 55
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 46
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer, W.; Przedborski, S. Parkinson's disease: mechanisms and models. Neuron, 2003, 39, 889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 47
    • 2542596183 scopus 로고    scopus 로고
    • Parkinson's disease
    • Samii, A.; Nutt, J.G.; Ransom, B.R. Parkinson's disease. Lancet, 2004, 363, 1783-1793.
    • (2004) Lancet , vol.363 , pp. 1783-1793
    • Samii, A.1    Nutt, J.G.2    Ransom, B.R.3
  • 49
    • 0000188870 scopus 로고
    • Influence of the substantia nigra on the catecholamine content of the striatum
    • Poirier, L.J.; Sourkes, T.L. Influence of the substantia nigra on the catecholamine content of the striatum. Brain, 1965, 88, 181-192.
    • (1965) Brain , vol.88 , pp. 181-192
    • Poirier, L.J.1    Sourkes, T.L.2
  • 50
    • 10244246626 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment
    • Beal, M.F. Mitochondrial dysfunction and oxidative damage in Alzheimer's and Parkinson's diseases and coenzyme Q10 as a potential treatment. J. Bioenerg. Biomembr., 2004, 36, 381-386.
    • (2004) J. Bioenerg. Biomembr , vol.36 , pp. 381-386
    • Beal, M.F.1
  • 51
    • 0030748461 scopus 로고    scopus 로고
    • Effect of NO synthesis inhibition on striatal dopamine release and stereotyped behaviour induced by a single administration of methamphetamine
    • Abekawa, T.; Ohmori, T.; koyama, T. Effect of NO synthesis inhibition on striatal dopamine release and stereotyped behaviour induced by a single administration of methamphetamine. Progress Neuro-Psychopharmacol. Biol. Psychiatry, 1997, 21, 831-838.
    • (1997) Progress Neuro-Psychopharmacol. Biol. Psychiatry , vol.21 , pp. 831-838
    • Abekawa, T.1    Ohmori, T.2    Koyama, T.3
  • 52
    • 3242855995 scopus 로고    scopus 로고
    • Histochemical and immunohistochemical detection of neurons that produce nitric oxide: Effect of different fixative parameters and immunoreactivity against non-neuronal NOS antisera
    • Gonzales-Hernandez, T.; Perez de la Cruz, M.A.; Mantolan-Sarmiento, B. Histochemical and immunohistochemical detection of neurons that produce nitric oxide: effect of different fixative parameters and immunoreactivity against non-neuronal NOS antisera. J. Histochem. Cytochem., 1996, 44, 1399-1413.
    • (1996) J. Histochem. Cytochem , vol.44 , pp. 1399-1413
    • Gonzales-Hernandez, T.1    Dela, C.P.M.A.2    Mantolan-sarmiento, B.3
  • 53
    • 0037443073 scopus 로고    scopus 로고
    • Synergisitc dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: Relevance to the etiology of Parkinson's disease
    • Gao, H.M.; Hong, J.S.; Zhang, W.; Liu, B. Synergisitc dopaminergic neurotoxicity of the pesticide rotenone and inflammogen lipopolysaccharide: relevance to the etiology of Parkinson's disease. J. Neurosci., 2003, 23, 1228-1236.
    • (2003) J. Neurosci , vol.23 , pp. 1228-1236
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 54
    • 84863116750 scopus 로고    scopus 로고
    • Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's diseasae
    • Gao, H.M.; Liu, B.; Zhang, W.; Hong, J.S. Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's diseasae. FASEB J. 2003, 17, 1954-1956.
    • (2003) FASEB J , vol.17 , pp. 1954-1956
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 55
    • 30744455267 scopus 로고    scopus 로고
    • Microglia proliferation in regulated by hydrogen peroxide from NADPH oxidase
    • Mander, P.K.; Jekabsone, A.; Brown, G.C. Microglia proliferation in regulated by hydrogen peroxide from NADPH oxidase. J. Immunol., 2006, 176, 1046-1052.
    • (2006) J. Immunol , vol.176 , pp. 1046-1052
    • Mander, P.K.1    Jekabsone, A.2    Brown, G.C.3
  • 57
    • 0030878320 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
    • Liou, H.H.; Tsai, M.C.; Chen, C.J.; Jeng, J.S.; Chang, Y.C.; Chen, S.Y.; Chen, R.C. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology, 1997, 48(6), 1583-1588.
    • (1997) Neurology , vol.48 , Issue.6 , pp. 1583-1588
    • Liou, H.H.1    Tsai, M.C.2    Chen, C.J.3    Jeng, J.S.4    Chang, Y.C.5    Chen, S.Y.6    Chen, R.C.7
  • 58
    • 0031772384 scopus 로고    scopus 로고
    • Paraquat-induced cell death in PC12 cells. Neurochem
    • Yang, W.L.; Sun, A.Y. Paraquat-induced cell death in PC12 cells. Neurochem. Res., 1998, 23, 1387-1394.
    • (1998) Res , vol.23 , pp. 1387-1394
    • Yang, W.L.1    Sun, A.Y.2
  • 59
    • 0030726396 scopus 로고    scopus 로고
    • Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system
    • Koshimura, I.; Imai, H.; Hidano, T.; Endo, K.; Mochizuki, H.; Kondo, T.; Mizuno, Y. Dimethoxyphenylethylamine and tetrahydropapaverine are toxic to the nigrostriatal system. Brain Res., 1997, 773, 108-116.
    • (1997) Brain Res , vol.773 , pp. 108-116
    • Koshimura, I.1    Imai, H.2    Hidano, T.3    Endo, K.4    Mochizuki, H.5    Kondo, T.6    Mizuno, Y.7
  • 60
    • 70350639468 scopus 로고    scopus 로고
    • Manganese-induced dopaminergic neurodegeneration: Insights into mechanisms and genetics shared with Parkinson's disease
    • Benedetto, A.; Au, C.; Aschner, M. Manganese-induced dopaminergic neurodegeneration: insights into mechanisms and genetics shared with Parkinson's disease. Chem. Rev., 2009, 109, 4862-4884.
    • (2009) Chem. Rev , vol.109 , pp. 4862-4884
    • Benedetto, A.1    Au, C.2    Aschner, M.3
  • 61
    • 0032983552 scopus 로고    scopus 로고
    • Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells
    • Li, X.; Sun, A.Y. Paraquat induced activation of transcription factor AP-1 and apoptosis in PC12 cells. J. Neur. Trans., 1999, 106, 1-21.
    • (1999) J. Neur. Trans , vol.106 , pp. 1-21
    • Li, X.1    Sun, A.Y.2
  • 62
    • 0031943867 scopus 로고    scopus 로고
    • Paraquat-induced free radical reaction in mouse brain microsomes
    • Yang, W.; Sun, A.Y. Paraquat-induced free radical reaction in mouse brain microsomes. Neurochem. Res., 1998, 23, 47-53.
    • (1998) Neurochem. Res , vol.23 , pp. 47-53
    • Yang, W.1    Sun, A.Y.2
  • 63
    • 5544229693 scopus 로고    scopus 로고
    • Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP
    • Schober, A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res., 2004, 318, 215-224.
    • (2004) Cell Tissue Res , vol.318 , pp. 215-224
    • Schober, A.1
  • 64
    • 34247645457 scopus 로고    scopus 로고
    • Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons
    • Lim, M.L.; Mercer, L.D.; Nagley, P.; Beart, P.M. Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons. Neuroreport, 2007, 18, 307-312.
    • (2007) Neuroreport , vol.18 , pp. 307-312
    • Lim, M.L.1    Mercer, L.D.2    Nagley, P.3    Beart, P.M.4
  • 65
    • 0000412998 scopus 로고
    • Cohort analysis of Parkinson's síndrome: Evidence for a single etiology related to subclinical infection about 1920
    • Poskanzer, D.C.; Schwab, R.S. Cohort analysis of Parkinson's síndrome: evidence for a single etiology related to subclinical infection about 1920. J. Chronic Dis., 1963, 16, 961-973.
    • (1963) J. Chronic Dis , vol.16 , pp. 961-973
    • Poskanzer, D.C.1    Schwab, R.S.2
  • 66
    • 0034938031 scopus 로고    scopus 로고
    • Experimenting on the past: The enigma of von Economo's encephalitis lethargica
    • Reid, A.H.; McCall, S.; Henry, J.M.; Taubenberger, J.K. Experimenting on the past: the enigma of von Economo's encephalitis lethargica. J. Neuropathol. Exp. Neurol., 2001, 60, 663-670.
    • (2001) J. Neuropathol. Exp. Neurol , vol.60 , pp. 663-670
    • Reid, A.H.1    McCall, S.2    Henry, J.M.3    Taubenberger, J.K.4
  • 68
    • 0027256104 scopus 로고
    • Parkinson's disease: A test of the multifactorial etiologic hypothesis
    • Semchuk, K.M.; Love, E.J.; Lee, R.G. Parkinson's disease: A test of the multifactorial etiologic hypothesis. Neurology, 1993, 43, 1173-1180.
    • (1993) Neurology , vol.43 , pp. 1173-1180
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.G.3
  • 69
    • 0031943867 scopus 로고    scopus 로고
    • Paraquat-induced free radical reaction in mouce brain microsomes. Neurochem
    • Yang, W-L.; Sun, A.Y. Paraquat-induced free radical reaction in mouce brain microsomes. Neurochem. Res., 1998, 23, 47-53.
    • (1998) Res , vol.23 , pp. 47-53
    • Yang, W.-L.1    Sun, A.Y.2
  • 70
    • 0030878320 scopus 로고    scopus 로고
    • Environmetnal risk factors and Parkinson's disease: A case-control study in Taiwan
    • Liou, H.H.; Tsai, M.C.; Chen, C.J.; Jeng, J.S.; Chang, Y.C.; Chen, S.Y.; Chen, R.C. Environmetnal risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology, 1997, 48, 1583-1588.
    • (1997) Neurology , vol.48 , pp. 1583-1588
    • Liou, H.H.1    Tsai, M.C.2    Chen, C.J.3    Jeng, J.S.4    Chang, Y.C.5    Chen, S.Y.6    Chen, R.C.7
  • 71
    • 24044447603 scopus 로고    scopus 로고
    • Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro
    • Jakel, R.J.; Kern, J.T.; Johnson, D.A.; Johnson, J.A. Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro. Toxicol. Sci., 2005, 87, 176-186.
    • (2005) Toxicol. Sci , vol.87 , pp. 176-186
    • Jakel, R.J.1    Kern, J.T.2    Johnson, D.A.3    Johnson, J.A.4
  • 72
    • 5544229693 scopus 로고    scopus 로고
    • Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP
    • Schober, A. Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res., 2004, 318, 215-224.
    • (2004) Cell Tissue Res , vol.318 , pp. 215-224
    • Schober, A.1
  • 73
  • 74
    • 5444255433 scopus 로고    scopus 로고
    • Neurotoxicant-induced animal models of Parkinson's disease: Understanding the role of rotenone, maneb and paraquat in neurodegeneration
    • Uversky, V.N. Neurotoxicant-induced animal models of Parkinson's disease: understanding the role of rotenone, maneb and paraquat in neurodegeneration. Cell Tissue Res., 2004, 318, 225-241.
    • (2004) Cell Tissue Res , vol.318 , pp. 225-241
    • Uversky, V.N.1
  • 75
    • 0034671469 scopus 로고    scopus 로고
    • The Nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's Disease
    • Thiruchelvam, M.; Richfield, E.K.; Baggs, R.B.; Tank, A.W.; Cory-Slechta, D.A. The Nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's Disease. J. Neurosci. Res., 2000, 20, 9207-9214.
    • (2000) J. Neurosci. Res , vol.20 , pp. 9207-9214
    • Thiruchelvam, M.1    Richfield, E.K.2    Baggs, R.B.3    Tank, A.W.4    Cory-Slechta, D.A.5
  • 77
    • 0031772384 scopus 로고    scopus 로고
    • Paraquat-induced cell death in PC12 cells
    • Yang, W-L.; Sun, A.Y. Paraquat-induced cell death in PC12 cells. Neurochem. Res., 1998, 23, 1387-1394.
    • (1998) Neurochem. Res , vol.23 , pp. 1387-1394
    • Yang, W.-L.1    Sun, A.Y.2
  • 78
    • 0037490957 scopus 로고    scopus 로고
    • Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture
    • Shimizu, K.; Matsubara, K.; Ohtaki, K.; Shiono, H. Paraquat leads to dopaminergic neural vulnerability in organotypic midbrain culture. Neurosci. Res., 2003, 46, 523-532.
    • (2003) Neurosci. Res , vol.46 , pp. 523-532
    • Shimizu, K.1    Matsubara, K.2    Ohtaki, K.3    Shiono, H.4
  • 79
    • 0030912325 scopus 로고    scopus 로고
    • Changes of energy metabolism induced by 1-methyl-4-phenylpyridinium (MPP+)-related compounds in rat pheochromocytoma PC12 cells
    • Kang, D.; Miyako, K.; Kuribayashi, F.; Hasegawa, E. Changes of energy metabolism induced by 1-methyl-4-phenylpyridinium (MPP+)-related compounds in rat pheochromocytoma PC12 cells. Arch. Biochem. Biophys., 1997, 337, 75-80.
    • (1997) Arch. Biochem. Biophys , vol.337 , pp. 75-80
    • Kang, D.1    Miyako, K.2    Kuribayashi, F.3    Hasegawa, E.4
  • 80
    • 0035116226 scopus 로고    scopus 로고
    • Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism
    • Chun, H.S.; Gibson, G.E.; DeGiorgio, L.A.; Zhang, H.; Kidd, V.J.; Son, J.H. Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J. Neurochem., 2001, 76, 1010-1021.
    • (2001) J. Neurochem , vol.76 , pp. 1010-1021
    • Chun, H.S.1    Gibson, G.E.2    Degiorgio, L.A.3    Zhang, H.4    Kidd, V.J.5    Son, J.H.6
  • 81
    • 23844483173 scopus 로고    scopus 로고
    • Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: Implications for Parkinson's disease
    • Peng, J.; Stevenson, F.F.; Doctrow, S.R.; Anderson, J.K. Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson's disease. J. Biol. Chem., 2005, 280, 29194-29198.
    • (2005) J. Biol. Chem , vol.280 , pp. 29194-29198
    • Peng, J.1    Stevenson, F.F.2    Doctrow, S.R.3    Anderson, J.K.4
  • 82
    • 28844448703 scopus 로고    scopus 로고
    • The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: Relevance to the dopaminergic pathogenesis
    • Yang, W.; Tiffany-Castiglioni, E. The bipyridyl herbicide paraquat produces oxidative stress-mediated toxicity in human neuroblastoma SH-SY5Y cells: relevance to the dopaminergic pathogenesis. J. Toxicol. Environ. Health Part A, 2005, 68, 1939-1961.
    • (2005) J. Toxicol. Environ. Health Part A , vol.68 , pp. 1939-1961
    • Yang, W.1    Tiffany-Castiglioni, E.2
  • 83
    • 20444471551 scopus 로고    scopus 로고
    • Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype
    • Thiruchelvam, M.; Prokopenko, O.; Cory-Slechta, D.; Richfield, E.; Buckley, B.; Mirochnitchenko, O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J. Biol. Chem., 2005, 280, 22530-22539.
    • (2005) J. Biol. Chem , vol.280 , pp. 22530-22539
    • Thiruchelvam, M.1    Prokopenko, O.2    Cory-Slechta, D.3    Richfield, E.4    Buckley, B.5    Mirochnitchenko, O.6
  • 84
    • 0037847451 scopus 로고    scopus 로고
    • Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats
    • Shimizu, K.; Matsubara, K.; Ohtaki, K.; Fujimaru, S.; Saito, O.; Shiono, H. Paraquat induces long-lasting dopamine overflow through the excitotoxic pathway in the striatum of freely moving rats. Brain Res., 2003, 976, 243-252.
    • (2003) Brain Res , vol.976 , pp. 243-252
    • Shimizu, K.1    Matsubara, K.2    Ohtaki, K.3    Fujimaru, S.4    Saito, O.5    Shiono, H.6
  • 85
    • 15744405993 scopus 로고    scopus 로고
    • Synuclein, dopamine and oxidative stress: Co-conspirators in Parkinson's disease? Brain Res
    • Maguire-Zeiss, K.A.; Short, D.W.; Federoff, H.J. Synuclein, dopamine and oxidative stress: co-conspirators in Parkinson's disease? Brain Res. Mol. Brain Res., 2005, 134, 18-23.
    • (2005) Mol. Brain Res , vol.134 , pp. 18-23
    • Maguire-Zeiss, K.A.1    Short, D.W.2    Federoff, H.J.3
  • 86
    • 0344824689 scopus 로고    scopus 로고
    • MPP+ analogs acting on mitochondria and inducing neuro-degeneration
    • Kotake, Y.; Ohta, S. MPP+ analogs acting on mitochondria and inducing neuro-degeneration. Curr. Med. Chem., 2003, 10, 2507-2516.
    • (2003) Curr. Med. Chem , vol.10 , pp. 2507-2516
    • Kotake, Y.1    Ohta, S.2
  • 87
    • 30744455267 scopus 로고    scopus 로고
    • Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase
    • Mander, P.K.; Jekabsone, A.; Brown, G.C. Microglia proliferation is regulated by hydrogen peroxide from NADPH oxidase. J. Immunol., 2006, 176, 1046-1052.
    • (2006) J. Immunol , vol.176 , pp. 1046-1052
    • Mander, P.K.1    Jekabsone, A.2    Brown, G.C.3
  • 88
    • 24144473653 scopus 로고    scopus 로고
    • Oxidative and antioxidative potential of brain microglial cells
    • Dringen, R. Oxidative and antioxidative potential of brain microglial cells. Antioxid. Redox Signal., 2005, 7, 1223-1233.
    • (2005) Antioxid. Redox Signal , vol.7 , pp. 1223-1233
    • Dringen, R.1
  • 90
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston, J.W.; Forno, L.S.; Tetrud, J.; Reeves, A.G.; Kaplan, J.A.; Karluk, D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol., 1999, 46, 598-605.
    • (1999) Ann. Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 91
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao, H.M.; Hong, J.S.; Zhang, W.; Liu, B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J. Neurosci., 2002, 22, 782-790.
    • (2002) J. Neurosci , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 93
    • 33747792064 scopus 로고    scopus 로고
    • MAPK signaling: ERK5 versus ERK1/2
    • Nishimoto, S.; Nishida, E. MAPK signaling: ERK5 versus ERK1/2. EMBO Rep., 2006, 7, 782-786.
    • (2006) EMBO Rep , vol.7 , pp. 782-786
    • Nishimoto, S.1    Nishida, E.2
  • 94
    • 33751261134 scopus 로고    scopus 로고
    • Mechanisms of MAPK signalling specificity Biochem
    • L. Mechanisms of MAPK signalling specificity Biochem. Soc. Trans. 2006, 34, 837-841.
    • (2006) Soc. Trans , vol.34 , pp. 837-841
  • 95
    • 28944450314 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase (MAPK)
    • Cushieri, J.; Maier, R.V. Mitogen-activated protein kinase (MAPK). Crit. Care Med., 2005, 33, S417-S419.
    • (2005) Crit. Care Med , vol.33
    • Cushieri, J.1    Maier, R.V.2
  • 96
    • 29144511607 scopus 로고    scopus 로고
    • MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits
    • Kaminska, B. MAPK signalling pathways as molecular targets for anti-inflammatory therapy-from molecular mechanisms to therapeutic benefits. Biochim. Biophys. Acta, 2005, 1754, 253-262.
    • (2005) Biochim. Biophys. Acta , vol.1754 , pp. 253-262
    • Kaminska, B.1
  • 98
    • 0034889654 scopus 로고    scopus 로고
    • Modulation of NMDA-mediated excitotoxicity by protein kinase C
    • Wagey, R.; Hu, J.; Pelech, S.L.; Raymond, L.A.; Krieger, C. Modulation of NMDA-mediated excitotoxicity by protein kinase C. J. Neurochem., 2001, 78, 715-726.
    • (2001) J. Neurochem , vol.78 , pp. 715-726
    • Wagey, R.1    Hu, J.2    Pelech, S.L.3    Raymond, L.A.4    Krieger, C.5
  • 99
    • 0038333243 scopus 로고    scopus 로고
    • Structural and dynamic characterization of a neuron-specific protein kinase C substrate, neurogranin
    • Ran, X.; Miao, H-H.; Sheu, F-S.; Yan, D. Structural and dynamic characterization of a neuron-specific protein kinase C substrate, neurogranin. Biochemistry, 2003, 42, 5143-5150.
    • (2003) Biochemistry , vol.42 , pp. 5143-5150
    • Ran, X.1    Miao, H.-H.2    Sheu, F.-S.3    Yan, D.4
  • 100
    • 0030748106 scopus 로고    scopus 로고
    • Requirement for tyrosine phosphatase during serotonergic neuromodulation by protein kinase C
    • Catarsi, S.; Drapeau, P.J. Requirement for tyrosine phosphatase during serotonergic neuromodulation by protein kinase C. Neurosci. Res., 1997, 17, 5792-5797.
    • (1997) Neurosci. Res , vol.17 , pp. 5792-5797
    • Catarsi, S.1    Drapeau, P.J.2
  • 101
    • 0036323292 scopus 로고    scopus 로고
    • Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C
    • Ahlemeyer, B.; Kolker, S.; Zhu, Y.; Hoffmann, G.F.; Krieglstein, J. Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C. J. Neurochem., 2002, 82, 504-515.
    • (2002) J. Neurochem , vol.82 , pp. 504-515
    • Ahlemeyer, B.1    Kolker, S.2    Zhu, Y.3    Hoffmann, G.F.4    Krieglstein, J.5
  • 102
    • 0035204621 scopus 로고    scopus 로고
    • Protein kinase C isoforms as therapeutic targets in nervous system disease states
    • Battaini, F. Protein kinase C isoforms as therapeutic targets in nervous system disease states. Pharmacol. Res., 2001, 44, 353-361.
    • (2001) Pharmacol. Res , vol.44 , pp. 353-361
    • Battaini, F.1
  • 103
    • 0035050814 scopus 로고    scopus 로고
    • Delta regulates neural cell adhesion molecule polysialylation state in the rat brain
    • Gallagher, H.C.; Murphy, K.J.; Foley, A.G.; Regan, C.M. Protein kinase C delta regulates neural cell adhesion molecule polysialylation state in the rat brain. J. Neurochem., 2001, 77, 425-434.
    • (2001) J. Neurochem , vol.77 , pp. 425-434
    • Gallagher, H.C.1    Murphy, K.J.2    Foley, A.G.3    Regan, C.M.4
  • 104
    • 0037110732 scopus 로고    scopus 로고
    • Nuclear import of PKC is required for apoptosis: Identification of a novel nuclear import sequence
    • DeVries, T.A.; Neville, M.C.; Reyland, M.E. Nuclear import of PKC is required for apoptosis: identification of a novel nuclear import sequence. EMBO J., 2002, 21, 6050-6060.
    • (2002) EMBO J , vol.21 , pp. 6050-6060
    • Devries, T.A.1    Neville, M.C.2    Reyland, M.E.3
  • 105
    • 0037115731 scopus 로고    scopus 로고
    • Positive feedback of protein kinase C proteolytic activation during apoptosis
    • Leverrier, S.; Vallentin, A.; Joubert, D. Positive feedback of protein kinase C proteolytic activation during apoptosis. Biochem. J., 2002, 368, 905-913.
    • (2002) Biochem. J , vol.368 , pp. 905-913
    • Leverrier, S.1    Vallentin, A.2    Joubert, D.3
  • 106
    • 0036523088 scopus 로고    scopus 로고
    • Caspase-3-dependent proteolytic cleavage of protein kinase C is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
    • Anantharam, V.; Kitazawa, M.; Wagner, J.; Kaul, S.; Kanthasamy, A.G. Caspase-3-dependent proteolytic cleavage of protein kinase C is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl. J. Neurosci. Res., 2002, 22, 1738-1751.
    • (2002) J. Neurosci. Res , vol.22 , pp. 1738-1751
    • Anantharam, V.1    Kitazawa, M.2    Wagner, J.3    Kaul, S.4    Kanthasamy, A.G.5
  • 108
    • 10344246590 scopus 로고    scopus 로고
    • Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells
    • He, R.; Nanamor, M.; Sang, H.; Yin, H.; Dinauer, M.C.; Ye, R.D. Reconstitution of chemotactic peptide-induced nicotinamide adenine dinucleotide phosphate (reduced) oxidase activation in transgenic COS-phox cells. J. Immunol., 2004, 173, 7462-7470.
    • (2004) J. Immunol , vol.173 , pp. 7462-7470
    • He, R.1    Nanamor, M.2    Sang, H.3    Yin, H.4    Dinauer, M.C.5    Ye, R.D.6
  • 110
    • 0029789321 scopus 로고    scopus 로고
    • Characterization of hepatic nitric oxide synthase: Identification as the cytokine-inducible form primarily regulated by oxidants
    • Duval, D.L.; Miller, D.R.; Collier, J.; Billings, R.E. Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Mol. Pharmacol., 1996, 50, 277-284.
    • (1996) Mol. Pharmacol , vol.50 , pp. 277-284
    • Duval, D.L.1    Miller, D.R.2    Collier, J.3    Billings, R.E.4
  • 111
  • 112
    • 0035282654 scopus 로고    scopus 로고
    • Inhibitory effect of ��-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages
    • Guo, Q.; Tirosh, O.; Packer, L. Inhibitory effect of ��-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages. Biochem. Pharmacol., 2001, 61, 547-554.
    • (2001) Biochem. Pharmacol , vol.61 , pp. 547-554
    • Guo, Q.1    Tirosh, O.2    Packer, L.3
  • 114
    • 15444369648 scopus 로고    scopus 로고
    • Pro-inflammatory role for eNOS-derived NO in vivo
    • Connely, L.; Madhani, M.; Hobbs, A.J. A pro-inflammatory role for eNOS-derived NO in vivo. J. Biol. Chem., 2005, 280, 10040-10046.
    • (2005) J. Biol. Chem , vol.280 , pp. 10040-10046
    • Connely, L.1    Madhani, M.2    Hobbs, A.J.A.3
  • 115
    • 0032905887 scopus 로고    scopus 로고
    • Chronic ethanol and iron administration on iron content, neuronal nitric oxide synthase, and superoxide dismutase in rat cerebellum
    • Xia, J.; Simonyi, A.S.; Sun, G.Y. Chronic ethanol and iron administration on iron content, neuronal nitric oxide synthase, and superoxide dismutase in rat cerebellum. Alcohol Clin. Exp. Res., 1999, 23, 702-707.
    • (1999) Alcohol Clin. Exp. Res , vol.23 , pp. 702-707
    • Xia, J.1    Simonyi, A.S.2    Sun, G.Y.3
  • 116
    • 0030885658 scopus 로고    scopus 로고
    • Nitric oxide-and superoxide-mediated toxicity in cerebral endothelial cells
    • Gobbel, G.T.; Chan, TY-Y.; Chan, P.H. Nitric oxide-and superoxide-mediated toxicity in cerebral endothelial cells. J. Pharmacol. Exp. Ther., 1997, 282, 1600-1607.
    • (1997) J. Pharmacol. Exp. Ther , vol.282 , pp. 1600-1607
    • Gobbel, G.T.1    Chan, T-Y.2    Chan, P.H.3
  • 117
    • 0035072892 scopus 로고    scopus 로고
    • The role of nitric oxide in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line
    • Tomita, M.; Okuyama, T.; Ishikawa, T.; Hidaka, K.; Nohno, T. The role of nitric oxide in paraquat-induced cytotoxicity in the human A549 lung carcinoma cell line. Free Radic. Res., 2001, 34, 193-202.
    • (2001) Free Radic. Res , vol.34 , pp. 193-202
    • Tomita, M.1    Okuyama, T.2    Ishikawa, T.3    Hidaka, K.4    Nohno, T.5
  • 118
    • 0035924367 scopus 로고    scopus 로고
    • Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose
    • Shin, C.Y.; Choi, J-W.; Jang, E.S.; Ju, C.; Kim, W-K.; Kim, H-C; Choi, C-R.; Ko, K.H. Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose. Brain Res., 2001, 922, 267-275.
    • (2001) Brain Res , vol.922 , pp. 267-275
    • Shin, C.Y.1    Choi, J.-W.2    Jang, E.S.3    Ju, C.4    Kim, W.-K.5    Kim, H.-C.6    Choi, C.-R.7    Ko, K.H.8
  • 120
    • 1942504005 scopus 로고    scopus 로고
    • Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats
    • Goralski, K.B.; Renton, K.W. Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats. Toxicol. Appl. Pharmacol., 2004, 196, 381-389.
    • (2004) Toxicol. Appl. Pharmacol , vol.196 , pp. 381-389
    • Goralski, K.B.1    Renton, K.W.2
  • 121
    • 33747346235 scopus 로고    scopus 로고
    • Signal integration between IF γ and TLR signalling pathways in macrophages
    • Schroeder, K.; Sweet, M.J.; Hume, D.A. Signal integration between IF γ and TLR signalling pathways in macrophages. Immunobiology, 2006, 211, 511-524.
    • (2006) Immunobiology , vol.211 , pp. 511-524
    • Schroeder, K.1    Sweet, M.J.2    Hume, D.A.3
  • 124
    • 0032525741 scopus 로고    scopus 로고
    • In vivo inhibition of nitric oxide synthase gene expression by curcumin in gene expression by curcumin, and cancer prevention natural product with anti-inflammatory properties
    • Chan, M.M.Y.; Huang, H.I.; Fenton, M.R.; Fong, D. In vivo inhibition of nitric oxide synthase gene expression by curcumin in gene expression by curcumin, and cancer prevention natural product with anti-inflammatory properties. Biochem. Pharmacol., 1998, 55, 1955.
    • (1998) Biochem. Pharmacol , vol.55 , pp. 1955
    • Chan, M.M.Y.1    Huang, H.I.2    Fenton, M.R.3    Fong, D.4
  • 125
    • 1542364225 scopus 로고    scopus 로고
    • Curcumin has potent antiamyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
    • Hasegawa, K.; Naiki, M.; Yamada, J. Curcumin has potent antiamyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Neuroscience, 2004, 75, 742-750.
    • (2004) Neuroscience , vol.75 , pp. 742-750
    • Hasegawa, K.1    Naiki, M.2    Yamada, J.3
  • 126
    • 42049109707 scopus 로고    scopus 로고
    • Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice
    • Rajeswari A.; Sabesan, M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology, 2008, 16, 96-99.
    • (2008) Inflammopharmacology , vol.16 , pp. 96-99
    • Rajeswari, A.1    Sabesan, M.2
  • 127
    • 49749083488 scopus 로고    scopus 로고
    • Resveratrol: A natural compound with pharmacological potential in neurodegenerative diseases
    • Rocha-González, H.I.; Ambriz-Tututi, M.; Granados-Soto, V. Resveratrol: a natural compound with pharmacological potential in neurodegenerative diseases. CNS Neurosci. Ther., 2008, 14, 234-247.
    • (2008) CNS Neurosci. Ther , vol.14 , pp. 234-247
    • Rocha-González, H.I.1    Ambriz-Tututi, M.2    Granados-Soto, V.3
  • 128
    • 0000934306 scopus 로고
    • Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-jokon (Polygonum cuspidatum Sieb. Et Zucc.)
    • Nonomura, S.; Kanagawa, H.; Makimoto, A. Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-jokon (Polygonum cuspidatum Sieb. Et Zucc.). Yakugaku Zasshi, 1963, 83, 983-988.
    • (1963) Yakugaku Zasshi , vol.83 , pp. 983-988
    • Nonomura, S.1    Kanagawa, H.2    Makimoto, A.3
  • 129
    • 21644451021 scopus 로고    scopus 로고
    • Determination of the phytoalexin resveratrol (3,5,4'-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (CGMS)
    • Tokusoglu, O.; Unal, M.K.; Yemis, F. Determination of the phytoalexin resveratrol (3,5,4'-trihydroxystilbene) in peanuts and pistachios by high-performance liquid chromatographic diode array (HPLC-DAD) and gas chromatography-mass spectrometry (CGMS). J. Agric. Food Chem., 2005, 53, 5003-5009.
    • (2005) J. Agric. Food Chem , vol.53 , pp. 5003-5009
    • Tokusoglu, O.1    Unal, M.K.2    Yemis, F.3
  • 130
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur, J.A.; Sinclair, D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov., 2006, 5, 493-506.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 132
    • 0034645693 scopus 로고    scopus 로고
    • Biological effects of resveratrol
    • Frémont, L. Biological effects of resveratrol. Life Sci., 2000, 66, 663-673.
    • (2000) Life Sci , vol.66 , pp. 663-673
    • Frémont, L.1
  • 133
    • 0141616557 scopus 로고    scopus 로고
    • Pleiotropic effects of resveratrol
    • Granados-Soto, V. Pleiotropic effects of resveratrol. Drug News Perspect., 2003, 16, 299-307.
    • (2003) Drug News Perspect , vol.16 , pp. 299-307
    • Granados-Soto, V.1
  • 134
    • 33747286388 scopus 로고    scopus 로고
    • Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets
    • Ramassamy, C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: A review of their intracellular targets. Eur. J. Pharmacol., 2006, 545, 51-64.
    • (2006) Eur. J. Pharmacol , vol.545 , pp. 51-64
    • Ramassamy, C.1
  • 135
    • 33847105184 scopus 로고    scopus 로고
    • Advances in the treatment of Parkinson's disease
    • Singh, N.; Pillay, V.; Choonara, Y.E. Advances in the treatment of Parkinson's disease. Prog. Neurobiol., 2007, 81, 29-44.
    • (2007) Prog. Neurobiol , vol.81 , pp. 29-44
    • Singh, N.1    Pillay, V.2    Choonara, Y.E.3
  • 137
    • 34447136104 scopus 로고    scopus 로고
    • Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine
    • Lee, M.K.; Kang, S.J.; Poncz, M.; Song, K.J.; Park, K.S. Resveratrol protects SH-SY5Y neuroblastoma cells from apoptosis induced by dopamine. Exp. Mol. Med., 2007, 39, 376-384.
    • (2007) Exp. Mol. Med , vol.39 , pp. 376-384
    • Lee, M.K.1    Kang, S.J.2    Poncz, M.3    Song, K.J.4    Park, K.S.5
  • 139
    • 20944445992 scopus 로고    scopus 로고
    • Unique properties of polyphenol stilbenes in the brain: More than direct antioxidant actions; gene/protein regulatory activity
    • Dore, S. Unique properties of polyphenol stilbenes in the brain: More than direct antioxidant actions; gene/protein regulatory activity. Neurosignals, 2005, 14, 61-70.
    • (2005) Neurosignals , vol.14 , pp. 61-70
    • Dore, S.1
  • 140
    • 0036751978 scopus 로고    scopus 로고
    • Algeri, S. A review of specific dietary antioxidants and the effects on biochemical mechanisms realted to neurodegenerative processes
    • Esposito, E.; Rotilio, D.; Di Matteo, V.; Di Giulio, C.; Cacchio, M.; Algeri, S. A review of specific dietary antioxidants and the effects on biochemical mechanisms realted to neurodegenerative processes. Neurobiol. Aging, 2002, 23, 719-735.
    • (2002) Neurobiol. Aging , vol.23 , pp. 719-735
    • Esposito, E.1    Rotilio, D.2    Di Matteo, V.3    Di Giulio, C.4    Cacchio, M.5
  • 141
    • 0036125827 scopus 로고    scopus 로고
    • Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain
    • Simonyi, A.; Woods, D.; Sun, A.Y.; Sun, G.Y. Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain. Alcohol Clin. Exp. Res., 2002, 26, 352-357.
    • (2002) Alcohol Clin. Exp. Res , vol.26 , pp. 352-357
    • Simonyi, A.1    Woods, D.2    Sun, A.Y.3    Sun, G.Y.4
  • 142
    • 0033580091 scopus 로고    scopus 로고
    • Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration
    • Sun, G.Y.; Xia, J.; Draczynska-Lusiak, B.; Simonyi, A.; Sun, A.Y. Grape polyphenols protect neurodegenerative changes induced by chronic ethanol administration. Neuroreport, 1999, 10, 93-96.
    • (1999) Neuroreport , vol.10 , pp. 93-96
    • Sun, G.Y.1    Xia, J.2    Draczynska-Lusiak, B.3    Simonyi, A.4    Sun, A.Y.5
  • 143
    • 0032850910 scopus 로고    scopus 로고
    • Dietary supplementation of grape polyphenols to rats ameliorates chronic etanol-induced changes in hepatic morphology without altering changes in hepatic lipids
    • Sun, G.Y.; Xia, J.; Xu, J.; Allenbrand, B.; Simonyi, A.; Rudeen, P.K. Dietary supplementation of grape polyphenols to rats ameliorates chronic etanol-induced changes in hepatic morphology without altering changes in hepatic lipids. J. Nutr., 1999, 129, 1814-1819.
    • (1999) J. Nutr , vol.129 , pp. 1814-1819
    • Sun, G.Y.1    Xia, J.2    Xu, J.3    Allenbrand, B.4    Simonyi, A.5    Rudeen, P.K.6
  • 144
    • 0030917448 scopus 로고    scopus 로고
    • Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells
    • Chanvitayapongs, S.; Draczynska-Lusiak, B.; Sun, A.Y. Amelioration of oxidative stress by antioxidants and resveratrol in PC12 cells. Neuroreport, 1997, 8, 1499-1502.
    • (1997) Neuroreport , vol.8 , pp. 1499-1502
    • Chanvitayapongs, S.1    Draczynska-Lusiak, B.2    Sun, A.Y.3
  • 145
    • 34250860632 scopus 로고    scopus 로고
    • Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex I and potassium deprivation in cerebellar neurons
    • Alvira, D.; Yeste-Velasco, M.; Folch, J.; Verdaguer, E.; Canudas, A.M.; Pallas, M. Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex I and potassium deprivation in cerebellar neurons. Neuroscience, 2007, 147, 746-756.
    • (2007) Neuroscience , vol.147 , pp. 746-756
    • Alvira, D.1    Yeste-Velasco, M.2    Folch, J.3    Verdaguer, E.4    Canudas, A.M.5    Pallas, M.6
  • 146
    • 0001936984 scopus 로고
    • The virgin field in psychoactive plant research
    • Schultes R.E. The virgin field in psychoactive plant research. Bol Mus Emilio Goeldi Ser Bot., 1990, 6(1), 7-82.
    • (1990) Bol Mus Emilio Goeldi Ser Bot , vol.6 , Issue.1 , pp. 7-82
    • Schultes, R.E.1


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