Characterization of hepatic nitric oxide synthase: Identification as the cytokine-inducible form primarily regulated by oxidants

Molecular Pharmacology

Volumn 50, Issue 2, 1996, Pages 277-284

  Duval, Dawn L ^a   Miller, Danette R ^a   Collier, John ^a   Billings, Ruth E ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LIVER ENZYME; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; ENZYME INDUCTION; LIVER; LIVER MITOCHONDRION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; RAT; RECEPTOR AFFINITY;

ANIMALS; ANTIOXIDANTS; CELLS, CULTURED; CYTOKINES; ENZYME INDUCTION; LIVER; MALE; NF-KAPPA B; NITRIC OXIDE SYNTHASE; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029789321     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Moncada, S., and A. Higga. The L-arginine-nitric oxide pathway. N. Engl. J. Med. 329:2002-2012 (1993).
2. Geller, D. A., A. K. Nussler, M. DiSilvio, C. J. Lowenstein, R. A. Shapiro, S. C. Wang, and R. L. Simmons. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. USA 90:522-526 (1994).
3. Cunha, F. Q., W. Y. Weiser, J. R. David, D. W. Moss, S. Moncada, and F. Y. Liew. Recombinant migration inhibitory factor induces nitric oxide synthase in murine macrophages. J. Immunol. 150:1908-1912 (1993).
4. Radomski, M. W., R. M. J. Palmer, and S. Moncada, Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells. Proc. Natl. Acad. Sci. USA 87:10043-10047 (1990).
5. Kroncke, K. D., K. Fehsel, and V. Kolb-Bachofen. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activities. Biol. Chem. Hoppe-Seyler 376:327-343 (1995).
6. Forstermann, U., J. S. Pollock, H. H. H. W. Schmidt, M. Heller, and F. Murad. Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelial cells. Proc. Natl. Acad. Sci. USA 88:1788-1792 (1991).
7. Moncada, S., R. M. J. Palmer, and E. A. Higgs. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol. Rev. 43:109-142 (1991).
8. Abu-Soud, I. M., and D. J. Stuehr. Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer. Proc. Natl. Acad. Sci. USA 90:10769-10772 (1993).
9. Schoedon, G., M. Schneemann, N. Blau, C.-J. S. Edgell, and A. Schaffner. Modulation of human endothelial cell tetrahydrobiopterin synthesis by activating and deactivating cytokines: new perspectives on endothelium-derived relaxing factor. Biochem, Biophys, Res. Commun. 196:1343-1348 (1993).
10. Werner, E. R., G. Werner-Felmayer, D. Fuchs, A. Hausen, G. Reibnegger, J. J. Yim, and H. Wachter. Impact of tumour necrosis factor-β and interferon-γ on tetrahydrobiopterin synthesis in murine fibroblasts and macrophages. Biochem. J. 280:709-714 (1991).
11. Fukushima, T., and J. C. Nixon. Analysis of reduced forms of biopterin in biological tissues and fluids. Anal. Biochem. 102:176-188 (1980).
12. Knowles, R. G., M. Merrett, M. Salter, and S. Moncada. Differential induction of brain, lung, and liver nitric oxide synthase by endotoxin in the rat. Biochem. J. 270:833-836 (1990).
13. Stuehr, D. J., N. S. Kwon, and C. F. Nathan. FAD and GSH participate in macrophage synthesis of nitric oxide. Biochem. Biophys. Res. Commun. 168:558-565(1990).
14. Griscavage, J. M., N. E. Rogers, M. P. Sherman, and L. J. Ignarro. Inducible nitric oxide synthase from a rat alveolar macrophage cell line is inhibited by nitric oxide. J. Immunal. 151:6329-6337 (1993).
15. Duval, D. L., D. J. Sieg, and R. E. Billings. Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione. Arch. Biochem. Biophys. 316:699-706 (1995).
16. Adamson, G. M., and R. E. Billings. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes. Arch. Biochem. Biophys. 294: 223-229 (1992).
17. Xie, Q., R. Whisnant, and C. F. Nathan. Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon and bacterial lipopolysaccharide. J. Exp. Med. 177:1779-1784 (1993).
18. Lowenstein, C. J., E. W. Alley, P. Raval, A. M. Snowman, S. H. Snyder, S. W. Russell, and W. J. Murphy. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl. Acad. Sci. USA 90:9730-9734 (1993).
19. Adcock, I. M., C. R. Brown, O. Kwon, and P. J. Barnes. Oxidative stress induces NFΚB DNA binding and inducible NOS mRNA in human epithelial cells. Biochem. Biophys. Res. Commun. 199:1518-1524 (1994).
20. Mulsch, A., B. Schray-Utz, P. I. Mordvintcev, S. Hauschildt, and R. Busse. Diethyldithiocarbamate inhibits induction of macrophage NO synthase. FEBS Lett. 321:215-218 (1993).
21. Ulich, T. R., K. Guo, B. Irwin, D. G. Remick, and G. N. Davatelis. Endotoxin-induced cytokine gene expression in vivo. II. Regulation of tumor necrosis factor and interleukin-1α/β expression and suppression. Am. J. Pathol. 137:1173-1185 (1990).
22. Ku, R. H., and R. E. Billings. The role of mitochondrial glutathione and protein sulfhydryls in formaldehyde toxicity in glutathione-depleted rat hepatocytes. Arch. Biochem. Biophys. 247:183-189 (1986).
23. Ding, A. H., C. F. Nathan, and D. J. Stuehr. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages: comparison of activating cytokines and evidence for independent production. J. Immunol. 141:2407-2412 (1988).
24. Bush, P. A., N. E. Gonzalez, J. M. Griscavage, and L. J. Ignarro. Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine. Biochem. Biophys. Res. Commun. 185:960-966 (1992).
25. Schreck, R., P. Rieber, and P. A. Baeuerle. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-ΚB transcription and HIV-1. EMBO J. 10:2247-2258 (1991).
26. Cho, H., Q. Xie, J. Calaycay, R. Mumford, K. Swiderek, T. Lee, and C. F. Nathan. Calmodulin is a subunit of nitric oxide synthase from macrophages. J. Exp. Med. 176:599-604 (1992).
27. Adamson, G. M., and R. E. Billings. Tumor necrosis factor: receptor binding and expression of receptors in cultured mouse hepatocytes. J. Pharmacol. Exp. Ther. 269:367-373 (1994).
28. Colletti, L. M., D. G. Remick, G. D. Burtch, S. L. Kunkel, R. M. Strieter, and D. A. J. Campbell. Role of tumor necrosis factor-α in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat. J. Clin. Invest. 85:1936-1943 (1990).
29. Sheehan, K. C. F., and R. D. Schreiber. The Synergy and Antagonism of Interferon-gamma and TNF (B. Beutler, ed.). Raven Press, New York, 145-178 (1992).
30. Hattori, M., A. Tugores, J. K. Westwick, L. Veloz, H. L. Leffert, M. Karin, and D. A. Brenner. Activation of activating protein 1 during hepatic acute phase response. Am. J. Physiol. 264:G95-G103 (1993).
31. Geller, D. A., P. D. Freeswick, D. Nguyen, A. K. Nussler, M. DiSilvio, R. A. Shapiro, S. C. Wang, R. L. Simmons, and T. R. Billiar. Differential induction of nitric oxide synthase in hepatocytes during endotoxemia and the acute-phase response. Arch. Surg. 129:165-171 (1994).
32. Matthews, J. R., N. Wakasugi, J. Virelizier, J. Yodoi, and R. T. Hay. Thioredoxin regulates the DNA binding activity of NF-KB by reduction of a disulphide bond involving cysteine 62. Nucleic Acids Res. 20:3821-3830 (1992).
33. Sherman, M. P., E. E. Aeberhard, V. Z. Wong, J. M. Griscavage, and L. J. Ignarro. Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191:1301-1308 (1993).
34. Schulze-Osthoff, K., R. Beyaert, V. Vandevoorde, G. Haegeman, and W. Fiers. Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF. EMBO J. 12:3095-3104 (1993).
35. Garcia-Ruiz, C., A. Colell, A. Morales, N. Kaplowitz, and J. C. FernandezCheca. Role of oxidative stress generated from the mitochondrial electron transport chain and mitochondrial function and activation of transcription factor nuclear factor-kappa B: studies with isolated mitochondria and rat hepatocytes. Mol. Pharmacol. 48:825-834 (1995).