Inhibitory effect of α-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages

Biochemical Pharmacology

Volumn 61, Issue 5, 2001, Pages 547-554

  Guo, Qiong ^a   Tirosh, Oren ^a   Packer, Lester ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Electron spin resonance; Glucose; Lipoic acid; Macrophages; Mitochondrial respiration; Nitric oxide

Indexed keywords

2 (N,N DIMETHYLAMINE) ETHYLAMIDO LIPOATE; ANTIMYCIN A1; DIHYDROLIPOATE; GAMMA INTERFERON; GLUCOSE; LIPOPOLYSACCHARIDE; NITRIC OXIDE; ROTENONE; SCAVENGER; THIOCTIC ACID; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL FREE SYSTEM; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; MACROPHAGE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REDUCTION; SYNTHESIS;

AMIDES; ANIMALS; ANTIOXIDANTS; CELL LINE; DRUG INTERACTIONS; ELECTRON SPIN RESONANCE SPECTROSCOPY; FREE RADICAL SCAVENGERS; GLUCOSE; MACROPHAGES; MICE; MITOCHONDRIA; NITRIC OXIDE; OXIDATION-REDUCTION; THIOCTIC ACID;

EID: 0035282654     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00569-4     Document Type: Article

References (23)

1. NO at work
2. Nitric oxide and mitochondrial respiration
3. Nitric oxide regulates mitochondrial respiration and cell functions by inhibiting cytochrome oxidase
4. Nitric oxide and cell death
5. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase
6. Cytosolic and mitochondrial systems for NADH- and NADPH-dependent reduction of α-lipoic acid
7. Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for α-lipoic acid enantiomers
8. Modulation of cellular reducing equivalent homeostasis by α-lipoic acid. Mechanisms and implications for diabetes and ischemic injury
9. Neuroprotective effects of α-lipoic acid and its positively charged amide analogue
10. Molecular biology and biochemistry of pyruvate dehydrogenase complexes
11. A positively charged α-lipoic acid analogue with increased cellular uptake and more potent immunomodulatory activity
12. Nitric oxide synthases reveal a role for calmodulin in controlling electron transfer
13. Cutting edge: Bacterial DNA and LPS act in synergy in inducing nitric oxide production in RAW 264.7 macrophages
14. Investigations on the pharmacokinetics of alpha-lipoic acid in healthy volunteers
15. Stimulation and inhibition of nitric oxide production in macrophages and neural cells as observed by spin trapping
16. EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages
17. Thioctic acid and dihydrolipoic acid are novel antioxidants which interact with reactive oxygen species
18. Lipoic and dihydrolipoic acids as antioxidants. A critical evaluation
19. Inhibition of NADPH supply by 6-aminonicotinamide: Effect on glutathione, nitric oxide and superoxide in J774 cells
20. The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen
21. Hydroperoxide metabolism in mammalian organs
22. 2+ network
23. Mitochondrial regulation of store-operated calcium signaling in T lymphocytes