Dehydroepiandrosterone inhibits the death of immunostimulated rat C6 glioma cells deprived of glucose

Brain Research

Volumn 922, Issue 2, 2001, Pages 267-275

  Young Shin, Chan ^a   Choi, Ji Woong ^a   Sook Jang, Eun ^a   Ju, Chung ^b   Kim, Won Ki ^b   Kim, Hyoung Chun ^c   Choi, Chang Rak ^d   Ho Ko, Kwang ^a  

^a Seoul National University   (South Korea)

^b Ewha Womans University School of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

^d The Catholic University of Korea   (South Korea)

Author keywords

C6 glioma; Dehydroepiandrosterone; Glucose deprivation; Immunostimulation; Peroxynitrite

Indexed keywords

3 NITROTYROSINE; GLUCOSE; LINSIDOMINE; NITRIC OXIDE; PARAQUAT; PEROXYNITRITE; PRASTERONE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; GLIOMA CELL; HORMONE ACTION; IMMUNOREACTIVITY; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ASTROCYTES; BRAIN; BRAIN ISCHEMIA; CELL DEATH; CYTOKINES; DEHYDROEPIANDROSTERONE; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; GLIOMA; GLUCOSE; HERBICIDES; HUMANS; INTERFERON TYPE II; LIPOPOLYSACCHARIDES; METALLOPORPHYRINS; MOLSIDOMINE; NEURONS; NITRIC OXIDE; OXIDATIVE STRESS; PARAQUAT; PEROXYNITROUS ACID; SUPEROXIDE DISMUTASE; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0035924367     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(01)03185-7     Document Type: Article

References (47)

1. Dehydroepiandrosterone administration prevents the oxidative damage induced by acute hyperglycemia in rats
2. Dehydroepiandrosterone pretreatment protects rats against the pro-oxidant and necrogenic effects of carbon tetrachloride
3. Brain aromatase is neuroprotective
4. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage
5. Dehydroepiandrosterone and dehydroepiandrosterone sulfate as neuroactive neurosteroids
6. Brain-immune connection: Immuno-regulatory properties of CNS-resident cells
7. Protective effect of dehydroepiandrosterone against copper-induced lipid peroxidation in the rat
8. Hypoxia and vascular disorders of the nervous system
9. Potentiated glucose deprivation-induced death of astrocytes after induction of iNOS
10. Proliferation-dependent vulnerability of glucose-deprived astrocytes to nitric oxide-induced cytotoxicity
11. Protection by a manganese porphyrin of endogenous peroxynitrite-induced death of glial cells via inhibition of mitochondrial transmembrane potential decrease
12. Prolonged hypoxia during cell development protects mature manganese superoxide dismutase-deficient astrocytes from damage by oxidative stress
13. Neuronal death in cytokine-activated primary human brain cell culture: Role of tumor necrosis factor-alpha
14. 2+ channel current in freshly isolated hippocampal CA1 neurons
15. Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it
16. Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes
17. Adrenal secretion during major depression in 8- to 16-year-olds. I. Altered diurnal rhythms in salivary cortisol and dehydroepiandrosterone (DHEA) at presentation
18. Immunostimulated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism
19. Reactive oxygen species and the central nervous system
20. Nitric oxide, mitochondria and neurological disease
21. Low blood and synovial fluid levels of sulpho-conjugated steroids in rheumatoid arthritis
22. Adrenal secretion and major depression in 8- to 16-year-olds. II. Influence of co-morbidity at presentation
23. Glial cell type-specific responses to menadione-induced oxidative stress
24. Synergistic depletion of astrocytic glutathione by glucose deprivation and peroxynitrite: Correlation with mitochondrial dysfunction and subsequent cell death
25. Dehydroepiandrosterone (DHEA) and DHEA-sulfate (DHEAS) protect hippocampal neurons against excitatory amino acid-induced neurotoxicity
26. Dehydroepiandrosterone antagonizes the neurotoxic effects of corticosterone and translocation of stress-activated protein kinase 3 in hippocampal primary cultures
27. Effects of G6PD overexpression in NIH3T3 cells treated with tert-butyl hydroperoxide or paraquat
28. Simultaneous radioimmunoassay of progesterone, androst-4-enedione, pregnenolone, dehydroepiandrosterone and 17-hydroxyprogesterone in specific regions of human brain
29. The effect of depressing glial function in rat brain in situ on ion homeostasis, synaptic transmission, and neuron survival
30. Evaluation of the probe 2′,7′-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
31. Protection of a rat tracheal epithelial cell line from paraquat toxicity by inhibition of glucose-6-phosphate dehydrogenase
32. A receptor
33. Mesencephalic type astrocytes mediate the survival of substantia nigra dopaminergic neurons in culture
34. Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men
35. Characterization of 2′,7′-dichlorofluorescin fluorescence in dissociated mammalian brain neurons: Estimation on intracellular content of hydrogen peroxide
36. Dehydroepiandrosterone inhibits the spontaneous release of superoxide radical by alveolar macrophages in vitro in asbestosis
37. Measurement and characterization of superoxide generation in microglial cells: Evidence for an NADPH oxidase-dependent pathway
38. Studies on the effects of dehydroepiandrosterone and its metabolites on attack by castrated mice on lactating intruders
39. Differential changes in serum concentrations of androgens and estrogens (in relation with cortisol) in postmenopausal women with acute illness
40. Mesencephalic type 1 astrocytes rescue dopaminergic neurons from death induced by serum deprivation
41. Importance of glucose-6-phosphate dehydrogenase activity for cell growth
42. Importance of glucose-6-phosphate dehydrogenase activity in cell death
43. When cytokines get on your nerves: Cytokine networks and CNS pathologies
44. Estrogen-mediated neuroprotection after experimental stroke in male rats
45. Dehydroepiandrosterone and 16 alpha-Br-epiandrosterone inhibit 12-O-tetradecanoylphorbol-13-acetate stimulation of superoxide radical production by human polymorphonuclear leukocytes
46. DHEA inhibits cell growth and induces apoptosis in BV-2 cells and the effects are inversely associated with glucose concentration in the medium
47. Dehydroepiandrosterone: Biosynthesis and metabolism in the brain