Mitogen-activated protein kinase (MAPK)

Critical Care Medicine

Volumn 33, Issue 12 SUPPL., 2005, Pages

  Cuschieri, Joseph ^a   Maier, Ronald V ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 2; GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; RAF PROTEIN; RAS PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ADULT RESPIRATORY DISTRESS SYNDROME; APOPTOSIS; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; ENZYME ACTIVATION; ENZYME SUBSTRATE; HUMAN; INFLAMMATION; INTENSIVE CARE; MULTIPLE ORGAN FAILURE; OSMOTIC STRESS; OXIDATIVE STRESS; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 28944450314     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000191714.39495.A6     Document Type: Article

References (18)

1. Johnson GB, Brunn GJ, Samstein B, et al: New insight into the pathogenesis of sepsis and the sepsis syndrome. Surgery 2005; 137:393-395
2. Pinsky MR: Dysregulation of the immune response in severe sepsis. Am J Med Sci 2004; 328:220-229
3. Robinson MJ, Cobb MH: Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 1997; 9:180-186
4. Kolch W: Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 2000; 351(Pt 2):289-305
5. Cuschieri J, Gourlay D, Garcia I, et al: Slow channel calcium inhibition blocks proinflammatory gene signaling and reduces macrophage responsiveness. J Trauma 2002; 52:434-442
6. Cobb MH, Hepler JE, Cheng M, et al: The mitogen-activated protein kinases, ERK1 and ERK2. Semin Cancer Biol 1994; 5:261-268
7. Cuschieri J, Bulger E, Garcia I, et al: Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. Shock 2005; 23:99-106
8. Raingeaud J, Gupta S, Rogers JS, et al: Proinflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J Biol Chem 1995; 270:7420-7426
9. Chen Z, Gibson TB, Robinson F, et al: MAP kinases. Chem Rev 2001; 101:2449-2476
10. Larsen JK, Yamboliev IA, Weber LA, et al: Phosphorylation of the 27-kDa heat shock protein via p38 MAP kinase and MAPKAP kinase in smooth muscle. Am J Physiol 1997; 273(5 Pt 1):L930-L940
11. Ma W, Lim W, Gee K, et al: The p38 mitogen-activated kinase pathway regulates the human interleukin-10 promoter via the activation of Sp1 transcription factor in lipopolysaccharide-stimulated human macrophages. J Biol Chem 2001; 276:13664-13674
12. Lyons A, Kelly JL, Rodrick ML, et al: Major injury induces increased production of interleukin-10 by cells of the immune system with a negative impact on resistance to infection. Ann Surg 1997; 226:450-458; discussion 458-460
13. Lahti A, Jalonen U, Kankaanranta H, et al: c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. Mol Pharmacol 2003; 64:308-315
14. Wang X, Rao J, Studzinski GP: Inhibition of p38 MAP kinase activity up-regulates multiple MAP kinase pathways and potentiates 1,25-dihydroxyvitamin D(3)-induced differentiation of human leukemia HL60 cells. Exp Cell Res 2000; 258:425-437
15. Alexander M, Daniel T, Chaudry IH, et al: MAP kinases differentially regulate the expression of macrophage hyperactivity after thermal injury. J Cell Physiol 2004; 201:35-44
16. Rosengart MR, Nathens AB, Arbabi S, et al: Mitogen-activated protein kinases in the intensive care unit: Prognostic potential. Ann Surg 2003; 237:94-100
17. Heagy W, Hansen C, Nieman K, et al: Impaired mitogen-activated protein kinase activation and altered cytokine secretion in endotoxin-tolerant human monocytes. J Trauma 2000; 49:806-814
18. van den Blink B, Juffermans NP, ten Hove T, et al: p38 Mitogen-activated protein kinase inhibition increases cytokine release by macrophages in vitro and during infection in vivo. J Immunol 2001; 166:582-587