Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29

Experimental Cell Research

Volumn 268, Issue 2, 2001, Pages 139-149

  Bauvy, Chantal ^a   Gane, Pierre ^b   Arico, Sébastien ^a   Codogno, Patrice ^a   Ogier Denis, Eric ^a  

^a INSERM   (France)

^b INSTITUT NATIONAL DE LA TRANSFUSION SANGUINE   (France)

Author keywords

Apoptosis; Autophagy; Caspase; Colon cancer; Cytochrome c; Mitochondria; Nonsteroidal anti inflammatory drug; Programmed cell death; Sulindac sulfide

Indexed keywords

3 METHYLADENINE; CASPASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; CYTOCHROME C; GUANOSINE TRIPHOSPHATASE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE; SULINDAC SULFIDE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN HT29; CHEMOSENSITIVITY; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME RELEASE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

EID: 0035881870     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5285     Document Type: Article

References (51)

1. Autophagy and related mechanisms of lysosome-mediated protein degradation
2. Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells
3. Autophagy and other vacuolar protein degradation mechanisms
4. Autophagy as a regulated pathway of cellular degradation
5. Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
6. Ultrastructural and immunocytochemical characterization of autophagic vacuoles in isolated hepatocytes: Effects of vinblastine and asparagine on vacuole distributions
7. Developmental cell death: Morphological diversity and multiple mechanisms
8. The relation of programmed cell death to development and reproduction: Comparative studies and an attempt at classification
9. Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells
10. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
11. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
12. Cell death: Programmed, apoptosis, necrosis, or other?
13. Autophagy is activated by apoptotic signalling in sympathetic neurons: An alternative mechanism of death execution
14. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
15. Effects of sulindac and its metabolites on growth and apoptosis in human mammary epithelial and breast carcinoma cell lines
16. Sulfone metabolite of sulindac inhibits mammary carcinogenesis
17. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells
18. Cyclooxygenase-2 and carcinogenesis
19. Colorectal cancer and nonsteroidal anti-inflammatory drugs
20. Nonsteroidal anti-inflammatory drugs and apoptosis in the gastrointestinal tract: Potential role of the pentose phosphate pathways
21. Cyclooxygenase, NSAIDs, and colorectal cancer
22. Nonsteroidal anti-inflammatory drugs (NSAIDs), cyclooxygenases, and the cell cycle. Their interactions in colon cancer
23. Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction
24. Differentiation-dependent autophagy controls the fate of newly synthesized N-linked glycoproteins in the colon adenocarcinoma HT-29 cell line
25. Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells
26. A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29
27. Guanine nucleotide exchange on heterotrimeric Gi3 protein controls autophagic sequestration in HT-29 cells
28. Activation of membrane-associated procaspase-3 is regulated by Bcl-2
29. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis
30. The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: Alterations in tumor suppressor and cell cycle-regulatory proteins
31. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
32. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells
33. Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase
34. AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
35. Regulation of neuronal survival by the serine-threonine protein kinase Akt
36. Control of the expression and activity of the Galpha-interacting protein (GAIP) in human intestinal cells
37. Proteases to die for
38. Apoptosis: Molecular aspects of cell death and disease
39. Cyclooxygenases: Structural, cellular, and molecular biology
40. Cyclooxygenase-1 and -2 isoenzymes
41. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
42. Ordering the cytochrome c-initiated caspase cascade: Hierarchical activation of caspases-2, -3, -6, -7, -8, and -10 in a caspase-9-dependent manner
43. Cytokine-induced apoptosis in epithelial HT-29 cells is independent of nitric oxide formation. Evidence for an interleukin-13-driven phosphatidylinositol 3-kinase-dependent survival mechanism
44. Interleukin-10 and interleukin-13 inhibit proinflammatory cytokine-induced ceramide production through the activation of phosphatidylinositol 3-kinase
45. Contribution of phosphatidylinositol 3-kinase to radiation resistance in human melanoma cells
46. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-kappaB in human endothelial cells
47. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli
48. Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway
49. Lack of cyclooxygenase-2 activity in HT-29 human colorectal carcinoma cells
50. The mitochondrial permeability transition in cell death: A common mechanism in necrosis, apoptosis and autophagy
51. Autophagy in embryonic erythroid cells: Its role in maturation