Statin-induced heme oxygenase-1 increases NF-κB activation and oxygen radical production in cultured neuronal cells exposed to lipopolysaccharide

Toxicological Sciences

Volumn 102, Issue 1, 2008, Pages 150-159

  Hsieh, Ching Hua ^a   Jeng, Seng Feng ^a   Hsieh, Min Wei ^a   Chen, Yi Chun ^a   Rau, Cheng Shyuan ^a   Lu, Tsu Hsiang ^a   Chen, Shun Sheng ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Heme oxygenase 1 (HO 1); Lipopolysaccharide (LPS); Nuclear factor kappa B (NF B); RNA interference (RNAi); Simvastatin; Zinc protoporphyrin (ZnPP)

Indexed keywords

CARBON MONOXIDE; DEFEROXAMINE; FERRIC ION; HEME; HEME OXYGENASE 1; HEMOGLOBIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OXYGEN RADICAL; PROTOPORPHYRIN ZINC; SIMVASTATIN; SMALL INTERFERING RNA; SUPEROXIDE; SYNAPTOTAGMIN I;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EXPOSURE; NERVE CELL; NONHUMAN; PROTEIN PHOSPHORYLATION; RNA ANALYSIS; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DEFEROXAMINE; ENZYME INDUCTION; ENZYME INHIBITORS; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; I-KAPPA B PROTEINS; IRON; IRON CHELATING AGENTS; LIPOPOLYSACCHARIDES; MEMBRANE PROTEINS; MICE; NADP; NEURONS; NF-KAPPA B; PHOSPHORYLATION; PROTOPORPHYRINS; RATS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIMVASTATIN; TRANSCRIPTION FACTOR RELA;

EID: 39149140706     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm298     Document Type: Article

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