Potent, orally absorbed glucagon receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 5, 1999, Pages 641-646

  De Laszlo, Stephen E ^a   Hacker, Candice ^a   Li, Bing ^a   Kim, Dooseop ^a   MacCoss, Malcolm ^a   Mantlo, Nathan ^a   Pivnichny, James V ^a   Colwell, Larry ^a   Koch, Gregory E ^a   Cascieri, Margaret A ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 PIRYDYL) 5 (4 CHLOROPHENYL) 3 (5 BROMO 2 PROPYLOXYPHENYL)PYRROLE; CYCLIC AMP; GLUCAGON; GLUCAGON RECEPTOR; HORMONE RECEPTOR BLOCKING AGENT; IODINE 125; L 168049; MAGNESIUM ION; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; LIGAND BINDING; MOUSE; ORAL DRUG ADMINISTRATION; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; ENZYME INHIBITORS; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; PYRROLES; RECEPTORS, GLUCAGON; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA;

EID: 0033535449     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00081-5     Document Type: Article

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